Gene

KWMTBOMO14161

Pre Gene Modal

BGIBMGA011177

Annotation

PREDICTED:_43_kDa_receptor-associated_protein_of_the_synapse_homolog?_partial_[Bombyx_mori]

Location

Bomo_Chr23(-):19538204-19553389      View in EpiBrowser

Full name

P-type phospholipid transporter       + More
43 kDa receptor-associated protein of the synapse homolog      

Location in the cell

Mitochondrial   Reliability : 1.851 Nuclear   Reliability : 1.415

CDS

ATGTCGTGGGACTCTATCGAGTCACGTGACTTTCTCGGCGGAGTGCCGGCGCATCAGTTATCAGCCACACGTCTTCTCAGTTCACCAGATCCGTCGAGACACCATCTCGATGAGACGCAAGAAGTATATCCATTTTCGGAGGAATACCCAGGACCGGCTTCGGCCAGGAATGGCGCGTTGCGCTGGGGCGCGAGGTTCGGTCCGGCCCACCGACCACCGGCCTCTGGGCTGCTGGATTGCTTCCGAGTTTGCCGGTCTAGACTCGACCAGTACCTGGCCAGGCGGAAGATTGAACGCGGGGTCCGTCTGTACGGTCAGAACGAGCAGCGCCAGGCCGTCAAGGTATGGCTGTCAGCGTTGCGCGGCGTCAGACACAGAAACGACAAGTTCGCCCTCTTAGGACATCTGTACCAGGCGTACATGGACTTTGGGAAGTACAGAGAATCGTTGGAGTTCGCAAACAGACAACTAGGTATTTCCGAAGAGCTGGACTCCGCTCCGATGCGGGCCGAGGCGTACCTCAACTTGGCGAGGGCTCACCAAACCCTGGGCGGGCTGGACAGAGCTCTCTCGTACGCCCGCCACGCTCTGTACAACGACTGCGGCGGCGGCTCCACGGCCGGCTACGTCCACCTCACCGTGGCCTCCGTGAGCTTAGAGCTCGGAGCTTTCTCCAAGGCCATGGACGGCTTCCAGAAAGCTCTTGCAGTGGCGCAGGCGCAGAACGACAACACGCTATTGCTACAGGTGTACGTGGGTCTGTCTGAGCTGTGGCGGCGGCTGCGGGACGCGGAGCGCGCGGTGGCGTGCGCGGCGCGGGCCTGCGACCTGGGCCGGGGCCCGCGCGCCGCCGACCTCAACACGCGTCACCACCGCACGGCGCTGCTGCAAATGGCGGCCGCCTTGCGCGCCCGCGGCGAGCTCGGAGACGCGCACGACTACTGCAACGAGGCGCTGCGGCTGGCGGCGGTGGCCGGGGACCAGGGCTGCTACGCTCGCGCCGTCCGCATCGCCGGCGACGTCTACCGACGGAAGTGCGACGTCGGCAAAGCTCTCAGGCACTACGAAGTGGCCATGGGCGCGGGCCAGGCATTAGGCGACCGTCTGGCCCAGATGGAGGCCATGGACGGCGCCGCGCGCTGCCTGGAGGCTCTCCGTCTGCAGAACAGGATCTGCAACTGTCGTCCGCTCGAGTTCAACACGAGATTACTGGAAGTCGCCACTTCCGTCGGAGCCAAGATGCTGGTACGACGGGTTCGACTCCGCCTAGCCGAGATCTACACCGCGTTGGGCGACAACAAGGCTGCAGCGAGGCAGAAAAGAGCCGCGGCCGCCTGGGGAGCCCCGGCCTGCGCCCGATGCAGGGAGCCGCTCGCGGAGCAGCCCGAGCCGCTGGCGGCGTTGCCGTGCGCGCACATCGTGCACCACGCGTGA

Protein

MSWDSIESRDFLGGVPAHQLSATRLLSSPDPSRHHLDETQEVYPFSEEYPGPASARNGALRWGARFGPAHRPPASGLLDCFRVCRSRLDQYLARRKIERGVRLYGQNEQRQAVKVWLSALRGVRHRNDKFALLGHLYQAYMDFGKYRESLEFANRQLGISEELDSAPMRAEAYLNLARAHQTLGGLDRALSYARHALYNDCGGGSTAGYVHLTVASVSLELGAFSKAMDGFQKALAVAQAQNDNTLLLQVYVGLSELWRRLRDAERAVACAARACDLGRGPRAADLNTRHHRTALLQMAAALRARGELGDAHDYCNEALRLAAVAGDQGCYARAVRIAGDVYRRKCDVGKALRHYEVAMGAGQALGDRLAQMEAMDGAARCLEALRLQNRICNCRPLEFNTRLLEVATSVGAKMLVRRVRLRLAEIYTALGDNKAAARQKRAAAAWGAPACARCREPLAEQPEPLAALPCAHIVHHA

Description

Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction.

Catalytic Activity

ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).

Similarity

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
Belongs to the ligand-gated ion channel (TC 1.A.9) family.
Belongs to the RAPsyn family.

Keywords

Complete proteome   Metal-binding   Reference proteome   Repeat   TPR repeat   Ubl conjugation   Zinc   Zinc-finger  

Feature

chain  43 kDa receptor-associated protein of the synapse homolog

Uniprot

A0A0N0PDY7   H9JNS3   A0A2H1VFP7   A0A0C9S063   D2A4B4   A0A088AU77   + More
A0A2A3EP21   A0A3L8DIN3   W8BUF7   W8CDP2   A0A034WI23   A0A0J9S128   B4NHM1   B4IIX3   B3P9S6   F4WQN1   Q7K4Y8   B4PW15   A0A151WV73   E2A7I6   E2BYH2   A0A3B0KT43   A0A1W4VIM2   B4MEZ9   A0A3B0K4F4   A0A310SFW0   B4H875   Q29CY0   K7IML0   B4JZW5   B4L7B4   A0A026WPI6   A0A195D194   A0A0L7RAU4   A0A0J9S0T6   A0A195BRF3   B3MZZ4   A0A2J7PLY3   A0A0M4ES75   A0A158NRZ9   A0A195ERG6   E9IHY2   A0A0M9A2Y4   A0A195D819   A0A1J1HXJ0   A0A1J1HZI4   E0VSU8   A0A336MFR4   A0A3B0K482   A0A1W4VHV8   A0A0A9XSG1   A0A2P8Y3Y9   B4R2F8   U4UZJ4   T1J5G7   R7UF25   A0A0N5ATC2   A0A2A6CT05   A0A0N4V4A9   A0A2G9V5Q0   A0A016UEW2   F1KZS1   A0A1I7TV07   A0A0N4UKH6   A0A2A2LPU3   E3LQX7   A8XCH4   G0NR17   A0A2A2LPD5   A0A2P4V7M8   A0A261BPL8   A0A1S3H1K5   A0A2A2LPB4   Q09485   A0A2A2LP52   A0A0B2V6M7   A0A183V9A1   A0A2A2JR22   K7H5E4   A0A1I7VLE5   A0A0N4YCI1   A0A2G5UZP1   A0A158PFP0   A0A2G5UZP6   A0A1I7RPI5   A0A0N4TVD9   A0A2G5UZR7   A0A044VIV9  

EC Number

7.6.2.1

Pubmed

26354079    19121390    18362917    19820115    30249741    24495485    + More
25348373    22936249    17994087    21719571    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    20798317    18057021    20479145    15632085    23185243    20075255    24508170    21347285    21282665    20566863    25401762    26823975    29403074    23537049    23254933    18806794    25730766    21685128    14624247    26114425    26394399    9851916    19158078    25217238    21909270   

EMBL

KQ460036    KPJ18415.1    BABH01010020    BABH01010021    ODYU01002323    SOQ39668.1    + More
GBYB01013846    JAG83613.1    KQ971348    EFA04813.2    KZ288203    PBC33467.1    QOIP01000007    RLU20294.1    GAMC01001600    JAC04956.1    GAMC01001602    GAMC01001601    GAMC01001599    JAC04955.1    GAKP01005167    GAKP01005166    JAC53785.1    CM002916    KMZ07253.1    CH964272    EDW83590.2    CH480845    EDW50914.1    CH954184    EDV45239.1    GL888275    EGI63394.1    AE014135    AY051576    AAF59332.2    AAF59333.2    AAK93000.1    CM000161    EDW99320.1    KRK04908.1    KQ982711    KYQ51754.1    GL437329    EFN70683.1    GL451478    EFN79256.1    OUUW01000017    SPP89026.1    CM000831    CH940665    ACY70527.1    EDW71100.1    KRF85349.1    SPP89025.1    KQ775154    OAD52290.1    CH479221    EDW34875.1    CH475397    EAL29280.1    KRT05198.1    KRT05199.1    CH916380    EDV90981.1    CH933813    EDW10908.1    KRG07266.1    KK107152    EZA57004.1    KQ977041    KYN06174.1    KQ414617    KOC68042.1    KMZ07252.1    KQ976424    KYM88536.1    CH902637    EDV44785.2    NEVH01024421    PNF17345.1    CP012527    ALC48126.1    ADTU01024378    ADTU01024379    KQ981993    KYN30850.1    GL763300    EFZ19824.1    KQ435752    KOX76205.1    KQ981153    KYN09035.1    CVRI01000035    CRK92741.1    CRK92740.1    DS235758    EEB16454.1    UFQT01001076    SSX28770.1    SPP89027.1    GBHO01020705    GDHC01018505    GDHC01010813    JAG22899.1    JAQ00124.1    JAQ07816.1    PYGN01000955    PSN38963.1    CM000365    EDX15209.1    KI208086    ERL95790.1    JH431861    AMQN01001390    KB302197    ELU04574.1    ABKE03000020    PDM81354.1    UXUI01007913    VDD89887.1    KZ344986    PIO77799.1    JARK01001381    EYC13138.1    JI168699    ADY43375.1    UYYG01000053    VDN52321.1    LIAE01006535    PAV87997.1    DS268413    NMWX01000827    EFP07774.1    OZF76061.1    HE600914    CAP30416.2    GL379929    EGT36014.1    PAV87999.1    LFJK02001230    POM33298.1    NIPN01000105    OZG11665.1    PAV87998.1    FO080625    PAV87996.1    JPKZ01002363    KHN77154.1    UYWY01024328    VDM48642.1    LIAE01010286    PAV64061.1    UYSL01021291    VDL77839.1    PDUG01000002    PIC44997.1    UYYA01003809    VDM55829.1    PIC44998.1    UZAD01013320    VDN93953.1    PIC44999.1    CMVM020000306   

Proteomes

UP000053240    UP000005204    UP000007266    UP000005203    UP000242457    UP000279307    + More
UP000007798    UP000001292    UP000008711    UP000007755    UP000000803    UP000002282    UP000075809    UP000000311    UP000008237    UP000268350    UP000192221    UP000008792    UP000008744    UP000001819    UP000002358    UP000001070    UP000009192    UP000053097    UP000078542    UP000053825    UP000078540    UP000007801    UP000235965    UP000092553    UP000005205    UP000078541    UP000053105    UP000078492    UP000183832    UP000009046    UP000245037    UP000000304    UP000030742    UP000014760    UP000046393    UP000232936    UP000038041    UP000274131    UP000024635    UP000095282    UP000038040    UP000274756    UP000218231    UP000008281    UP000216624    UP000008549    UP000008068    UP000237256    UP000216463    UP000085678    UP000001940    UP000031036    UP000050794    UP000267007    UP000005237    UP000095285    UP000038043    UP000271162    UP000230233    UP000050601    UP000267027    UP000095284    UP000038020    UP000278627    UP000024404   

PRIDE

H9JNS3    Q7K4Y8   

Pfam

PF10579   Rapsyn_N        + More
PF13181   TPR_8
PF16212   PhoLip_ATPase_C
PF16209   PhoLip_ATPase_N
PF16454   PI3K_P85_iSH2
PF00017   SH2
PF00620   RhoGAP
PF13639   zf-RING_2
PF13176   TPR_7
PF07064   RIC1
PF02932   Neur_chan_memb
PF02931   Neur_chan_LBD
PF00097   zf-C3HC4
PF12862   ANAPC5

Interpro

IPR019568   Rapsyn_myristoylation/link_N        + More
IPR001841   Znf_RING       
IPR013026   TPR-contain_dom       
IPR013083   Znf_RING/FYVE/PHD       
IPR011990   TPR-like_helical_dom_sf       
IPR019734   TPR_repeat       
IPR001237   Postsynaptic       
IPR023298   ATPase_P-typ_TM_dom_sf       
IPR032498   PI3K_P85_iSH2       
IPR036860   SH2_dom_sf       
IPR008250   ATPase_P-typ_transduc_dom_A_sf       
IPR008936   Rho_GTPase_activation_prot       
IPR001757   P_typ_ATPase       
IPR000198   RhoGAP_dom       
IPR023299   ATPase_P-typ_cyto_dom_N       
IPR006539   P-type_ATPase_IV       
IPR032631   P-type_ATPase_N       
IPR036412   HAD-like_sf       
IPR000980   SH2       
IPR023214   HAD_sf       
IPR032630   P_typ_ATPase_c       
IPR018303   ATPase_P-typ_P_site       
IPR018000   Neurotransmitter_ion_chnl_CS       
IPR006201   Neur_channel       
IPR009771   Ribosome_control_1       
IPR036734   Neur_chan_lig-bd_sf       
IPR001965   Znf_PHD       
IPR006202   Neur_chan_lig-bd       
IPR006028   GABAA/Glycine_rcpt       
IPR006029   Neurotrans-gated_channel_TM       
IPR036719   Neuro-gated_channel_TM_sf       
IPR018957   Znf_C3HC4_RING-type       
IPR026000   Apc5_dom       
IPR002219   PE/DAG-bd       

SUPFAM

SSF48452   SSF48452        + More
SSF81665   SSF81665       
SSF56784   SSF56784       
SSF55550   SSF55550       
SSF81653   SSF81653       
SSF48350   SSF48350       
SSF63712   SSF63712       
SSF90112   SSF90112       

Gene 3D

1.25.40.10     3.30.40.10     1.10.555.10     3.30.505.10     3.40.1110.10     3.40.50.1000     2.70.170.10    

ProteinModelPortal

A0A0N0PDY7   H9JNS3   A0A2H1VFP7   A0A0C9S063   D2A4B4   A0A088AU77   + More
A0A2A3EP21   A0A3L8DIN3   W8BUF7   W8CDP2   A0A034WI23   A0A0J9S128   B4NHM1   B4IIX3   B3P9S6   F4WQN1   Q7K4Y8   B4PW15   A0A151WV73   E2A7I6   E2BYH2   A0A3B0KT43   A0A1W4VIM2   B4MEZ9   A0A3B0K4F4   A0A310SFW0   B4H875   Q29CY0   K7IML0   B4JZW5   B4L7B4   A0A026WPI6   A0A195D194   A0A0L7RAU4   A0A0J9S0T6   A0A195BRF3   B3MZZ4   A0A2J7PLY3   A0A0M4ES75   A0A158NRZ9   A0A195ERG6   E9IHY2   A0A0M9A2Y4   A0A195D819   A0A1J1HXJ0   A0A1J1HZI4   E0VSU8   A0A336MFR4   A0A3B0K482   A0A1W4VHV8   A0A0A9XSG1   A0A2P8Y3Y9   B4R2F8   U4UZJ4   T1J5G7   R7UF25   A0A0N5ATC2   A0A2A6CT05   A0A0N4V4A9   A0A2G9V5Q0   A0A016UEW2   F1KZS1   A0A1I7TV07   A0A0N4UKH6   A0A2A2LPU3   E3LQX7   A8XCH4   G0NR17   A0A2A2LPD5   A0A2P4V7M8   A0A261BPL8   A0A1S3H1K5   A0A2A2LPB4   Q09485   A0A2A2LP52   A0A0B2V6M7   A0A183V9A1   A0A2A2JR22   K7H5E4   A0A1I7VLE5   A0A0N4YCI1   A0A2G5UZP1   A0A158PFP0   A0A2G5UZP6   A0A1I7RPI5   A0A0N4TVD9   A0A2G5UZR7   A0A044VIV9  

PDB

5A7D     E-value=0.0127467,     Score=91

KEGG

101743372    no KO assigned | (RefSeq) 43 kDa receptor-associated protein of the synapse homolog

GO

GO:0033130   GO:0007268   GO:0043495   GO:0045202   GO:0007271   GO:0008270   GO:0016021   GO:0005524   GO:0000287   GO:0007165   GO:0004012   GO:0005230   GO:0004888   GO:0005886   GO:0046872   GO:0035556   GO:0005515   GO:0030126   GO:0005488   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

PANTHER

PTHR24092   PTHR18945  

Length:

477

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0453100000000001

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00597

outside

1  -  477

 

 

Pi

18.032183

Theta

17.294459

Tajima's D

-1.159722

CLR

107.295977

CSRT

0.107644617769112

Interpretation

Uncertain