Gene

KWMTBOMO14157  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011180

Annotation

nonclathrin_coat_protein_gamma2-COP_[Bombyx_mori]

Location

Bomo_Chr23(-):19481013-19485149      View in EpiBrowser

Full name

Coatomer subunit gamma       + More
Nipped-B protein      

Alternative Name

Gamma-coat protein

Location in the cell

Golgi   Reliability : 2.794

CDS

ATGAGCTCTCTCAAGCGAGATGTTAAGGATGAAGATGATAACAGCAGTAACCCATACCAGAATCTCGATAAAACTATAGTACTTCAAGAAACACGAGAGTTTAATCAAACGCTCGTTATCCCGAGAAAATGTTCATTAATACTTACGAAAATACTGTATTTACTGAATCAAGGCGAAAATTTCACCACTCAGGAGGCTACGGACGCTTTCTTTGCGACAACAAAACTGTTTCAGTCCAAAGAAATCATGCTGCGACGTATGGTTTATCTTTGCATCAAAGAACTGAGTAAATTGGCGCAAGATGTGATCATAGTGACTTCCTCTTTGACTAAAGACATGACCGGTAAAGAGGATCTGTACCGGGCGGCCGCAATAAGAGCGTTGTGCAGCATCACGGACGCCTCTATGCTACAAGCTATCGAACGATATATGAAACAGGCGATTGTGGACAAGAACCCGGCCGTCAGTTCTGCGGCATTAGTCTCTGCGCTTCATTTGTCTTCTACCGCACCGGATCTTGTTCGGCGATGGGCTAATGAAGCTCAGGAAACAATCAATTCGGACAATGCGATGGTGTCGTATCACGCATTGGGTGTTCTGGTATTATCGCGTCGAAATGATAAGTTATCTACAGTTAAACTGGTGACACGACTTTCTAAGTCCCACATAAAATCACCATACTCCCTCTGCTTGCTTATACGTTTAGCTGCTCAGCTATGTGACGGTGATGATTCTGAAGCATCTCAACCTTACATAGACTTTATAGAGTGCTGCTTACGTCATAAATCTGAAATGGTTATCTATGAGGCGGCCCATGCAATCGTCAACTTGAGAAAGACCGCCCGGGATCTTGCTCCGGCAGTATCAGTTTTGCAATTGTTCTGCAGCTCTTCGAAGGCGGCTCTCAGATTGGCTGGAGCCAGGACTTTGGCCCGGTTGACGACAGAACACCCTACAGCAGTCGCTGCATGCGCTATTGACTTGGAAAACTTAATCTCAGATTCTAATCGGTCCGTGGCGACCTTAGCTGTAACAACGCTATTAGCGACAGGCGCAGAAAGTTCCGTGGACAGGCTGATGAAGCAGATTTCGAGCTTTGTATCGGAAATTCCAGATGAGTTCAAAATAATCGTCGTCAGAGCCATCAGGCAGCTGTGCAGCAAGTTCCCGAGGAAGCATCAGTCGCTGGCTGCATTCTTAGCCGGAATGTTGAGAGACGAAGGTGGCCTGGAATACAAAGCAGCTATAGCCGACGCGATTATAGCTTTGGTCGAAGAAAATCCTGACGCTAAAGAAACAGGACTGTCTCATTTATGCGAGTTCATTGAAGATTGCGAGCACACGGCATTGGCAGTTCGTATACTGCATCTGTTGGGACGAGAAGGTCCTAAGTCTCGTCACCCGTCAAGATATATAAGATTCATTTACAATAGAGTTATTTTGGAGTCCGGCCCGGTCAGAGCCGCGGCAGTTTCCGCCGTAGCACAGTTCGGAGCACAAGTACCGGAACTATTGCCAAATATCAAGGTGTTATTGGCTCGCTGTCAGTTAGACGAAGAAGATGAAGTCAGAGATAGAGCAGTATATTACAGTACGATACTAGAGACCGAGAACCCTCAGCTCATCAATGATTTCATTGTTAATATACCGAAACCGAATGTGGTGTTGCTAGAAAAGGCCTTGAGAGATCATTTGTTGCACCCCGAAGAACCGTTTAATATTTTGTCCGTTCCGGCCGAGGAGGTGGTCAAGGAAACTAAAAAGCCTATAGTCGAAATCGAAGTTCGCAAACCGGTGCAAATGTCTATCGAAGAGATCTACGCTGAGCAGTTGGCTAAAATACCGGGCATCGAGAAATTAGGGCCGTTGTTCAAAACGAATTTGCCAATAGATCTGACCGAAGCGGAGATCGAGTACCGGGTTCGCGTAGTGAAACACGTGTACGCACGCCACGTTATATTCCAATTCGAATGCGTGAACACGTTGAACGATCAAATACTAGAGGACGTCCACGTCCGATTGGAAGTTCCACCAGAATACGAAATCAAATCTATCGTTCCTTGTCAGAAGCTGGTCTACAACACACAGGACAACGTTTTCGTGGTCGTCGAATACCCTTGCGCGTTTATAGACAGTTTGGGTTCGTTTATGGCTACGTTGGAGTTCGTCGTGCGCGACTGCGACCCTAATACCGGAACTCCGGACCCTGGCGAGGGTTACGCCGACTCTTATCCCCTGGAAGAGTTCGAAATGGGTTGTTCTGACCAGATCAGGGCTAGGGCTGGGGGAGACGATTGGGAACAGACTTGGGAGAGAGCTGCGAACGTTCCAGAAGCTAATGACACGTTCGTGTTGTCGCAGACCGATGTCGGTGACGCTGCGAAGGCTGTTTGCGAGCATCTCGGCCTCCCGAACGGTTCGATAAGCGGTGATGCAGTTAAGGAGATCCGTGGTGGGGGTATATTTAGGGGCGGGGCGCCGGTTTTGGTTAGAGCTCGCTTAGCGGGTAGCAGTGCTGGCGTCACTATGAAGTTATCGGCCCGATCACCCCGGGAAGACGTAGCTCAACTACTCTTGGCGGCTGTGGGTTAA

Protein

MSSLKRDVKDEDDNSSNPYQNLDKTIVLQETREFNQTLVIPRKCSLILTKILYLLNQGENFTTQEATDAFFATTKLFQSKEIMLRRMVYLCIKELSKLAQDVIIVTSSLTKDMTGKEDLYRAAAIRALCSITDASMLQAIERYMKQAIVDKNPAVSSAALVSALHLSSTAPDLVRRWANEAQETINSDNAMVSYHALGVLVLSRRNDKLSTVKLVTRLSKSHIKSPYSLCLLIRLAAQLCDGDDSEASQPYIDFIECCLRHKSEMVIYEAAHAIVNLRKTARDLAPAVSVLQLFCSSSKAALRLAGARTLARLTTEHPTAVAACAIDLENLISDSNRSVATLAVTTLLATGAESSVDRLMKQISSFVSEIPDEFKIIVVRAIRQLCSKFPRKHQSLAAFLAGMLRDEGGLEYKAAIADAIIALVEENPDAKETGLSHLCEFIEDCEHTALAVRILHLLGREGPKSRHPSRYIRFIYNRVILESGPVRAAAVSAVAQFGAQVPELLPNIKVLLARCQLDEEDEVRDRAVYYSTILETENPQLINDFIVNIPKPNVVLLEKALRDHLLHPEEPFNILSVPAEEVVKETKKPIVEIEVRKPVQMSIEEIYAEQLAKIPGIEKLGPLFKTNLPIDLTEAEIEYRVRVVKHVYARHVIFQFECVNTLNDQILEDVHVRLEVPPEYEIKSIVPCQKLVYNTQDNVFVVVEYPCAFIDSLGSFMATLEFVVRDCDPNTGTPDPGEGYADSYPLEEFEMGCSDQIRARAGGDDWEQTWERAANVPEANDTFVLSQTDVGDAAKAVCEHLGLPNGSISGDAVKEIRGGGIFRGGAPVLVRARLAGSSAGVTMKLSARSPREDVAQLLLAAVG

Description

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for limiting lipid storage in lipid droplets. Involved in the expansion of luminal extracellular matrices and apical membrane during tubulogenesis. Required in the tracheal epithelium for luminal protein secretion and diametric tube growth. In salivary glands, required for deposition of O-glycans and luminal extracellular matrix assembly. Required for epidermal morphogenesis and cuticle development.
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Required for limiting lipid storage in lipid droplets. Involved in the expansion of luminal extracellular matrices and apical membrane during tubulogenesis. Required in the tracheal epithelium for luminal protein secretion and diametric tube growth. In salivary glands, required for deposition of O-glycans and luminal extracellular matrix assembly. Required for epidermal morphogenesis and cuticle development (By similarity).

Subunit

Oligomeric complex.
Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

Similarity

Belongs to the COPG family.
Belongs to the SCC2/Nipped-B family.

Keywords

Alternative splicing   Complete proteome   Cytoplasm   Cytoplasmic vesicle   Endoplasmic reticulum   ER-Golgi transport   Golgi apparatus   Membrane   Protein transport   Reference proteome   Repeat   Transport  

Feature

chain  Coatomer subunit gamma
splice variant  In isoform A and isoform C.

Uniprot

H9JNS6   Q9NKX2   A0A2W1BER4   A0A2A4JXQ0   A0A2H1WIN6   A0A3S2LV40   + More
A0A1E1W6K7   A0A0L7LE61   A0A194PZ47   A0A0N1PIW6   A0A212F9T7   A0A2H1VY70   Q9NKX3   A0A212FD53   S4PDR5   A0A2A4JW01   A0A1E1WA37   A0A3S2NUQ9   H9ITA4   A0A0L7KGN8   A0A194QLD5   D6WZN0   A0A1L8DWC7   A0A1Y1K3A8   A0A1W4XWS4   A0A1W4VVW6   Q8I0G5-3   A0A067RRI8   A0A1S4EK05   A0A0B4KHL2   B4IJ02   Q29AE5   B3MSZ6   B4PNE7   A0A1W4W7X2   Q8I0G5-2   A0A2J7QYL1   B3P533   G4LU37   A0A034V598   A0A1A9YDP7   A0A1B0B319   A0A1A9ZSS0   A0A0P8XU24   A0A0L0BKH8   B4JHF3   A0A0K8VBR2   A0A0A1WN12   A0A3B0JJL6   A0A0R1EB90   Q8I0G5   A0A336LB12   B4M106   U5EXW3   A0A1I8P3V3   B4NAH4   A0A0K8TSF1   A0A1A9UTH5   A0A336LFZ9   B4K7Z2   E0VLD3   T1PGC9   A0A2M3Z008   A0A2M3Z005   A0A1I8MSK7   A0A2M3Z006   A0A3B0JIH4   A0A0M5IZI1   A0A2M4A194   A0A2M4BD79   A0A182F4S4   W5JWS0   A0A0P6AG54   A0A182GMC1   A0A0A1WTM0   A0A194PEY4   A0A0P6ISE4   W8B1R1   A0A1B0G192   A0A1Q3G384   A0A182VUJ0   A0A0P6FT53   A0A0N8E4G0   A0A182MK06   A0A182RAX4   A0A182L6H5   A0A0P6IGD4   A0A1S4H0Q2   A0A1J1J0M5   A0A023EWA4   T1IMS8   A0A023GM91   A0A2L2Y4S4   A0A232F7I9   A0A087UHC8   A0A224YTQ4   A0A131Z2X8   A0A224YVZ9   E2C367   A0A182Q0C2  

Pubmed

19121390    11018518    28756777    26227816    26354079    22118469    + More
23622113    18362917    19820115    28004739    10731132    12537572    12537569    16169286    19067489    18398480    18802472    24845553    12537568    12537573    12537574    16110336    17569856    17569867    17994087    15632085    17550304    25348373    26108605    25830018    26369729    20566863    25315136    20920257    23761445    26483478    26999592    24495485    20966253    12364791    24945155    26561354    28648823    28797301    26830274    20798317   

EMBL

BABH01010017    AB040670    BAA93048.2    KZ150337    PZC71320.1    NWSH01000384    + More
PCG76795.1    ODYU01008925    SOQ52929.1    RSAL01000005    RVE54419.1    GDQN01008422    JAT82632.1    JTDY01001569    KOB73496.1    KQ459593    KPI96430.1    KQ460036    KPJ18403.1    AGBW02009564    OWR50469.1    ODYU01005182    SOQ45790.1    AB040669    BAA93047.2    AGBW02009108    OWR51662.1    GAIX01004842    JAA87718.1    NWSH01000574    PCG75562.1    GDQN01007176    JAT83878.1    RSAL01000174    RVE45059.1    BABH01007296    JTDY01009845    KOB62497.1    KQ461196    KPJ06373.1    KQ971372    EFA09678.1    GFDF01003529    JAV10555.1    GEZM01094084    JAV55944.1    AF191563    AE014297    AY113545    BT001628    AAF05719.1    AAN14275.1    AAN71383.1    KK852470    KDR23235.1    AGB96524.1    CH480846    EDW50955.1    CM000070    EAL27405.1    CH902623    EDV30386.1    CM000160    EDW99229.2    NEVH01009087    PNF33659.1    CH954182    EDV52947.1    BT132667    AEQ05569.1    GAKP01020481    GAKP01020480    JAC38471.1    JXJN01007759    KPU72823.1    JRES01001712    KNC20586.1    CH916369    EDV92780.1    GDHF01016028    JAI36286.1    GBXI01014417    JAC99874.1    OUUW01000005    SPP80522.1    KRK04737.1    UFQS01002986    UFQT01002986    SSX15016.1    SSX34402.1    CH940650    EDW67417.2    GANO01000740    JAB59131.1    CH964232    EDW80788.1    GDAI01000316    JAI17287.1    UFQS01003479    UFQT01003479    SSX15677.1    SSX35036.1    CH933806    EDW14326.1    DS235271    EEB14189.1    KA647821    AFP62450.1    GGFM01001094    MBW21845.1    GGFM01001080    MBW21831.1    GGFM01001092    MBW21843.1    SPP80523.1    CP012526    ALC45581.1    GGFK01001201    MBW34522.1    GGFJ01001859    MBW51000.1    ADMH02000176    ETN67504.1    GDIP01043181    LRGB01003216    JAM60534.1    KZS03726.1    JXUM01074479    JXUM01074480    KQ562832    KXJ75044.1    GBXI01012296    JAD01996.1    KQ459605    KPI91926.1    GDUN01001107    JAN94812.1    GAMC01019354    GAMC01019353    JAB87201.1    CCAG010001934    GFDL01000768    JAV34277.1    GDIQ01060939    JAN33798.1    GDIQ01177398    GDIQ01062788    JAN31949.1    AXCM01001007    GDIQ01022262    JAN72475.1    AAAB01008984    CVRI01000066    CRL05888.1    GAPW01000182    JAC13416.1    JH431094    GBBM01000476    JAC34942.1    IAAA01008267    LAA03007.1    NNAY01000795    OXU26460.1    KK119796    KFM76767.1    GFPF01006825    MAA17971.1    GEDV01003741    JAP84816.1    GFPF01006824    MAA17970.1    GL452292    EFN77599.1    AXCN02000790   

Proteomes

UP000005204    UP000218220    UP000283053    UP000037510    UP000053268    UP000053240    + More
UP000007151    UP000007266    UP000192223    UP000192221    UP000000803    UP000027135    UP000079169    UP000001292    UP000001819    UP000007801    UP000002282    UP000235965    UP000008711    UP000092443    UP000092460    UP000092445    UP000037069    UP000001070    UP000268350    UP000008792    UP000095300    UP000007798    UP000078200    UP000009192    UP000009046    UP000095301    UP000092553    UP000069272    UP000000673    UP000076858    UP000069940    UP000249989    UP000092444    UP000075920    UP000075883    UP000075900    UP000075882    UP000183832    UP000215335    UP000054359    UP000008237    UP000075886   

PRIDE

H9JNS6    Q9NKX2    Q9NKX3    H9ITA4    D6WZN0    Q8I0G5    + More
Q29AE5    G4LU37    E0VLD3    E2C367   

Pfam

PF01602   Adaptin_N        + More
PF16381   Coatomer_g_Cpla
PF08752   COP-gamma_platf
PF12830   Nipped-B_C
PF12765   Cohesin_HEAT
PF00107   ADH_zinc_N
PF16884   ADH_N_2

Interpro

IPR013041   Clathrin_app_Ig-like_sf        + More
IPR002553   Clathrin/coatomer_adapt-like_N       
IPR037067   Coatomer_gsu_app_sf       
IPR009028   Coatomer/calthrin_app_sub_C       
IPR017106   Coatomer_gsu       
IPR011989   ARM-like       
IPR032154   Coatomer_g_Cpla       
IPR013040   Coatomer_gsu_app_Ig-like_dom       
IPR016024   ARM-type_fold       
IPR012295   TBP_dom_sf       
IPR026003   Cohesin_HEAT       
IPR024986   Nipped-B_C       
IPR033031   SCC2/Nipped-B       
IPR014190   PTGR1       
IPR036291   NAD(P)-bd_dom_sf       
IPR041694   ADH_N_2       
IPR011032   GroES-like_sf       
IPR013149   ADH_C       

SUPFAM

SSF49348   SSF49348        + More
SSF48371   SSF48371       
SSF55711   SSF55711       
SSF50129   SSF50129       
SSF51735   SSF51735       

Gene 3D

1.25.10.10     2.60.40.1480     3.30.310.10    

CDD

cd08294  leukotriene_B4_DH_like

ProteinModelPortal

H9JNS6   Q9NKX2   A0A2W1BER4   A0A2A4JXQ0   A0A2H1WIN6   A0A3S2LV40   + More
A0A1E1W6K7   A0A0L7LE61   A0A194PZ47   A0A0N1PIW6   A0A212F9T7   A0A2H1VY70   Q9NKX3   A0A212FD53   S4PDR5   A0A2A4JW01   A0A1E1WA37   A0A3S2NUQ9   H9ITA4   A0A0L7KGN8   A0A194QLD5   D6WZN0   A0A1L8DWC7   A0A1Y1K3A8   A0A1W4XWS4   A0A1W4VVW6   Q8I0G5-3   A0A067RRI8   A0A1S4EK05   A0A0B4KHL2   B4IJ02   Q29AE5   B3MSZ6   B4PNE7   A0A1W4W7X2   Q8I0G5-2   A0A2J7QYL1   B3P533   G4LU37   A0A034V598   A0A1A9YDP7   A0A1B0B319   A0A1A9ZSS0   A0A0P8XU24   A0A0L0BKH8   B4JHF3   A0A0K8VBR2   A0A0A1WN12   A0A3B0JJL6   A0A0R1EB90   Q8I0G5   A0A336LB12   B4M106   U5EXW3   A0A1I8P3V3   B4NAH4   A0A0K8TSF1   A0A1A9UTH5   A0A336LFZ9   B4K7Z2   E0VLD3   T1PGC9   A0A2M3Z008   A0A2M3Z005   A0A1I8MSK7   A0A2M3Z006   A0A3B0JIH4   A0A0M5IZI1   A0A2M4A194   A0A2M4BD79   A0A182F4S4   W5JWS0   A0A0P6AG54   A0A182GMC1   A0A0A1WTM0   A0A194PEY4   A0A0P6ISE4   W8B1R1   A0A1B0G192   A0A1Q3G384   A0A182VUJ0   A0A0P6FT53   A0A0N8E4G0   A0A182MK06   A0A182RAX4   A0A182L6H5   A0A0P6IGD4   A0A1S4H0Q2   A0A1J1J0M5   A0A023EWA4   T1IMS8   A0A023GM91   A0A2L2Y4S4   A0A232F7I9   A0A087UHC8   A0A224YTQ4   A0A131Z2X8   A0A224YVZ9   E2C367   A0A182Q0C2  

PDB

5NZV     E-value=0,     Score=2015

KEGG

692402    K17267 coatomer subunit gamma | (RefSeq) Copg2; coatomer subunit gamma

GO

GO:0006886   GO:0000139   GO:0030126   GO:0016192   GO:0005198   GO:0015031   GO:0030663   GO:0009306   GO:0005794   GO:0006891   GO:0005783   GO:0072384   GO:0006888   GO:0016020   GO:0005793   GO:0035147   GO:0036063   GO:0005801   GO:0007436   GO:0010883   GO:0007424   GO:0030198   GO:0035149   GO:0007112   GO:0000281   GO:0035158   GO:0008362   GO:0016021   GO:0003682   GO:0007049   GO:0010468   GO:0005634   GO:0032440   GO:0047522   GO:0030117   GO:0005488   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

PANTHER

PTHR10261   PTHR21704  

Subcellular location

Cytoplasm  
Golgi apparatus membrane  
Cytoplasmic vesicle  
COPI-coated vesicle membrane  
Endoplasmic reticulum   The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.   With evidence from 1 publications.
Nucleus  

Length:

863

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.048

Exp number, first 60 AAs:

0.00428

Total prob of N-in:

0.00221

outside

1  -  863

 

 

Pi

15.288518

Theta

13.583737

Tajima's D

0.577613

CLR

0.881021

CSRT

0.549472526373681

Interpretation

Uncertain