Gene

KWMTBOMO14136  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011190

Annotation

PREDICTED:_MAP_kinase-activated_protein_kinase_2_isoform_X3_[Bombyx_mori]

Location

Bomo_Chr23(-):18686986-18709690      View in EpiBrowser

Full name

MAP kinase-activated protein kinase 2      

Location in the cell

Cytoplasmic   Reliability : 2.374

CDS

ATGAGTAATTTCGCGAAAATTGTCAAAACTACGCCGATTACAGATGATTACGACATCTCAAATACAGTCCTCGGCCTTGGGATCAATGGAAAGGTTCTAGAATGCAAAGAGAAGAAGTCCGGCTTGAAGCGAGCGCTGAAGGTGCTACACGACAGCGTGAAAGCGAGAAGAGAAGTTGAACTACACTGGAGAGCTAGTGGATGCAAACACATAGTGGAGGTTATCGATGTATACGAGAACGCTTACGGCGGCAAGACCTGTCTTCTAGTCGTGATGGAATGTATGGACGGTGGCGAGCTGTTCCAGAGGATCCAGGATAACAGGGACGGTGCCTTCACGGAGAGACAGGCCGCAGAGATAATGCACTCGATCTGTGTTGCCGTGAGGCACCTACACGACACGAACATCGCCCACCGAGACATCAAACCCGAGAACCTCTTGTACTCAAGCATGGAGCCGAATGCGGTGCTCAAGCTCACGGACTTTGGTTTCGCTAAGGAGACCTTATCGCCGGCAGACACTCTCCAGACCCCATGCTACACGCCCTACTACGTCGCGCCCGAGGTCTTGGGCCCGGAGAAGTACGACAAGTCCTGCGACATCTGGTCCCTGGGCGTCGTGATGTATATACTGCTGTGCGGATTCCCACCGTTCTACTCCAACCATGGTCTCGCCATATCGCCTGGCATGAAAAAGCGAATCCGTCTGGGCCAATACGATTTTCCTGATCCGGAATGGTCGAGCGTTTCATCGGAAGCGAAGAATCTCATCCGGGGAATGCTCTCCGTCGATCCAGCCAAGAGGATGACCATACAGCAAGTAATGTCCAGTCCCTGGGTGCGGCAGTACACCCAGGTCCCGCAGACGCCCCTCTACACGAACACGCTGCTGCGTGAGGCCGGAGACGCGTGGCCCGACGTCCAGGATGAGATGACCCGCTCCCTCGCCACCATGAGGGTAGACTACGACCAGGTGCAAATAAAAGCTTTGGAGCAAAGCAATAATTCGTTGTTGAACAAACGCCGCAACAAGGTCGGAGCTTGA

Protein

MSNFAKIVKTTPITDDYDISNTVLGLGINGKVLECKEKKSGLKRALKVLHDSVKARREVELHWRASGCKHIVEVIDVYENAYGGKTCLLVVMECMDGGELFQRIQDNRDGAFTERQAAEIMHSICVAVRHLHDTNIAHRDIKPENLLYSSMEPNAVLKLTDFGFAKETLSPADTLQTPCYTPYYVAPEVLGPEKYDKSCDIWSLGVVMYILLCGFPPFYSNHGLAISPGMKKRIRLGQYDFPDPEWSSVSSEAKNLIRGMLSVDPAKRMTIQQVMSSPWVRQYTQVPQTPLYTNTLLREAGDAWPDVQDEMTRSLATMRVDYDQVQIKALEQSNNSLLNKRRNKVGA

Description

Its physiological substrate seems to be the small heat shock protein (HSP27/HSP25).

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Similarity

Belongs to the protein kinase superfamily.
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.

Keywords

ATP-binding   Complete proteome   Kinase   Nucleotide-binding   Phosphoprotein   Reference proteome   Transferase  

Feature

chain  MAP kinase-activated protein kinase 2

Uniprot

A0A3S2P7M1   A0A194PSZ7   A0A0N1PH98   H9JNT6   A0A2A4JPW1   A0A212F2X2   + More
A0A2Z5TTQ8   B0X8H2   A0A023ETB8   Q16VX5   A0A182G249   A0A1Q3FBE0   A0A067R510   A0A1W4W974   A0A2M3Z816   A0A2M4BRJ3   A0A2M4AI95   W5JW45   U5EXV7   A0A182IPG1   A0A182FB48   V5GG78   A0A1Q3FBF3   Q7PZG1   T1PCC1   A0A084WIN7   A0A182L515   A0A182Q9P0   A0A0K8TRC3   A0A182UTA7   A0A1Y1JRI9   A0A0A1X982   A0A0A1WM18   B3MSG4   A0A0L7QRK9   A0A0L0C5E4   A0A310SI95   A0A0K8UMP7   A0A034W2Y4   A0A026W2M7   A0A3L8DUY5   A0A1I8NV91   A0A1B0ANB7   A0A0A1WYP3   A0A1A9ZI97   W8BHW7   W8BAR5   A0A1A9XH30   A0A1A9VRQ4   Q2PQP1   E0VA03   D6W792   A0A034W5L6   B4NDG1   A0A1A9WCL1   A0A1W4V9F9   A0A0M3QYY5   A0A088AL91   A0A0M8ZYP2   A0A0K8V787   A0A1S4H7T4   W8BYG9   W8BMW4   A0A336LRW2   A0A0R3P205   B4GU23   Q29FS7   A0A3B0JAY1   A0A023F5L3   T1HSL5   B4PZB0   A0A151IW72   A0A0C9R8P5   A0A1L8DKP1   A0A195BFR2   A0A195F5T6   A0A158NQU6   A0A3B0JC42   A0A0V0GBV3   A4V402   P49071   A0A0C9PNY7   A0A232EK98   A0A154P715   T1DG44   A0A2P6KXQ4   B3NSW5   A0A131XEN3   T1IP72   B4L6L7   A0A1B6C1L8   A0A0A9YEI8   A0A0A9YKH5   B4M7K7   A0A224YSY5   L7M5D4   H6WVQ3   B7P6Y3   A0A2C9GPE3   A0A1E1XAZ8  

EC Number

2.7.11.1

Pubmed

26354079    19121390    22118469    26760975    24945155    17510324    + More
26483478    24845553    20920257    23761445    12364791    25315136    24438588    20966253    26369729    28004739    25830018    17994087    26108605    25348373    24508170    30249741    24495485    16907828    20353571    20566863    18362917    19820115    15632085    23185243    25474469    17550304    21347285    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    7590268    28648823    28049606    25401762    26823975    28797301    25576852    28503490   

EMBL

RSAL01000005    RVE54400.1    KQ459593    KPI96437.1    KQ460036    KPJ18397.1    + More
BABH01009960    BABH01009961    BABH01009962    NWSH01000812    PCG74087.1    AGBW02010656    OWR48095.1    FX985858    BBA93745.1    DS232489    EDS42508.1    GAPW01001974    JAC11624.1    CH477579    EAT38738.1    JXUM01039433    JXUM01039434    JXUM01039435    JXUM01039436    JXUM01039437    KQ561204    KXJ79358.1    GFDL01010216    JAV24829.1    KK852888    KDR14327.1    GGFM01003894    MBW24645.1    GGFJ01006564    MBW55705.1    GGFK01007180    MBW40501.1    ADMH02000120    ETN67748.1    GANO01002342    JAB57529.1    GALX01005512    JAB62954.1    GFDL01010144    JAV24901.1    AAAB01008986    EAA00097.4    KA645775    AFP60404.1    ATLV01023941    KE525347    KFB50081.1    AXCN02001090    GDAI01000679    JAI16924.1    GEZM01102743    JAV51812.1    GBXI01006806    JAD07486.1    GBXI01014420    JAC99871.1    CH902622    EDV34719.1    KQ414775    KOC61262.1    JRES01000902    KNC27456.1    KQ767803    OAD53300.1    GDHF01024669    GDHF01013214    JAI27645.1    JAI39100.1    GAKP01009888    GAKP01009887    GAKP01009886    JAC49064.1    KK107459    EZA50340.1    QOIP01000004    RLU23699.1    JXJN01000784    GBXI01010652    JAD03640.1    GAMC01008208    JAB98347.1    GAMC01008210    JAB98345.1    DQ307182    EZ422652    ABC25082.1    ADD18928.1    AAZO01000300    DS235004    EEB10209.1    KQ971307    EFA11394.1    GAKP01009889    JAC49063.1    CH964239    EDW82867.1    CP012528    ALC48429.1    KQ435794    KOX73800.1    GDHF01017530    JAI34784.1    GAMC01008209    JAB98346.1    GAMC01008207    JAB98348.1    UFQS01000086    UFQS01001813    UFQT01000086    UFQT01001813    SSW99081.1    SSX12431.1    SSX19463.1    CH379065    KRT07240.1    CH479190    EDW26043.1    EAL31502.2    KRT07241.1    OUUW01000003    SPP77633.1    GBBI01002264    JAC16448.1    ACPB03011259    CM000162    EDX01077.1    KRK05936.1    KRK05937.1    KQ980874    KYN12040.1    GBYB01012734    JAG82501.1    GFDF01007174    JAV06910.1    KQ976500    KYM83005.1    KQ981810    KYN35434.1    ADTU01023616    ADTU01023617    SPP77632.1    GECL01000664    JAP05460.1    AE014298    BT125824    AAF46078.3    ADR83709.1    ADV37631.1    AFH07250.1    U20757    GBYB01002853    GBYB01005607    JAG72620.1    JAG75374.1    NNAY01003847    OXU18773.1    KQ434827    KZC07623.1    GAKT01000036    JAA93026.1    MWRG01003861    PRD31093.1    CH954180    EDV45934.1    GEFH01003916    JAP64665.1    JH431250    CH933812    EDW06013.1    GEDC01029907    JAS07391.1    GBHO01013558    GBRD01002876    GDHC01014190    JAG30046.1    JAG62945.1    JAQ04439.1    GBHO01013559    GDHC01021654    JAG30045.1    JAP96974.1    CH940653    EDW62774.1    GFPF01009582    MAA20728.1    GACK01006725    JAA58309.1    JQ316171    AFB81371.1    ABJB010261730    ABJB010322677    ABJB010335658    ABJB010425035    ABJB010435100    ABJB010542994    ABJB010771991    ABJB011000595    DS648558    EEC02355.1    APCN01002416    GFAC01002775    JAT96413.1   

Proteomes

UP000283053    UP000053268    UP000053240    UP000005204    UP000218220    UP000007151    + More
UP000002320    UP000008820    UP000069940    UP000249989    UP000027135    UP000192223    UP000000673    UP000075880    UP000069272    UP000007062    UP000095301    UP000030765    UP000075882    UP000075886    UP000075903    UP000007801    UP000053825    UP000037069    UP000053097    UP000279307    UP000095300    UP000092460    UP000092445    UP000092443    UP000078200    UP000009046    UP000007266    UP000007798    UP000091820    UP000192221    UP000092553    UP000005203    UP000053105    UP000001819    UP000008744    UP000268350    UP000015103    UP000002282    UP000078492    UP000078540    UP000078541    UP000005205    UP000000803    UP000215335    UP000076502    UP000008711    UP000009192    UP000008792    UP000001555    UP000075840   

PRIDE

H9JNT6    A4V402    P49071   

Pfam

PF00069   Pkinase

Interpro

IPR017441   Protein_kinase_ATP_BS        + More
IPR027442   MAPKAPK_C       
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       
IPR000719   Prot_kinase_dom       

SUPFAM

SSF56112   SSF56112       

Gene 3D

4.10.1170.10    

ProteinModelPortal

A0A3S2P7M1   A0A194PSZ7   A0A0N1PH98   H9JNT6   A0A2A4JPW1   A0A212F2X2   + More
A0A2Z5TTQ8   B0X8H2   A0A023ETB8   Q16VX5   A0A182G249   A0A1Q3FBE0   A0A067R510   A0A1W4W974   A0A2M3Z816   A0A2M4BRJ3   A0A2M4AI95   W5JW45   U5EXV7   A0A182IPG1   A0A182FB48   V5GG78   A0A1Q3FBF3   Q7PZG1   T1PCC1   A0A084WIN7   A0A182L515   A0A182Q9P0   A0A0K8TRC3   A0A182UTA7   A0A1Y1JRI9   A0A0A1X982   A0A0A1WM18   B3MSG4   A0A0L7QRK9   A0A0L0C5E4   A0A310SI95   A0A0K8UMP7   A0A034W2Y4   A0A026W2M7   A0A3L8DUY5   A0A1I8NV91   A0A1B0ANB7   A0A0A1WYP3   A0A1A9ZI97   W8BHW7   W8BAR5   A0A1A9XH30   A0A1A9VRQ4   Q2PQP1   E0VA03   D6W792   A0A034W5L6   B4NDG1   A0A1A9WCL1   A0A1W4V9F9   A0A0M3QYY5   A0A088AL91   A0A0M8ZYP2   A0A0K8V787   A0A1S4H7T4   W8BYG9   W8BMW4   A0A336LRW2   A0A0R3P205   B4GU23   Q29FS7   A0A3B0JAY1   A0A023F5L3   T1HSL5   B4PZB0   A0A151IW72   A0A0C9R8P5   A0A1L8DKP1   A0A195BFR2   A0A195F5T6   A0A158NQU6   A0A3B0JC42   A0A0V0GBV3   A4V402   P49071   A0A0C9PNY7   A0A232EK98   A0A154P715   T1DG44   A0A2P6KXQ4   B3NSW5   A0A131XEN3   T1IP72   B4L6L7   A0A1B6C1L8   A0A0A9YEI8   A0A0A9YKH5   B4M7K7   A0A224YSY5   L7M5D4   H6WVQ3   B7P6Y3   A0A2C9GPE3   A0A1E1XAZ8  

PDB

4TYH     E-value=2.14801e-139,     Score=1269

KEGG

101742228    K04443 mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1] | (RefSeq) MAP kina

GO

GO:0005524   GO:0004674   GO:0004672   GO:0016021   GO:0004683   GO:0009931   GO:0051019   GO:0046777   GO:0005516   GO:0035556   GO:0018105   GO:0005634   GO:0005737   GO:0009651   GO:0046328   GO:0045793   GO:0006468   GO:0008017   GO:0016887   GO:0019829   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

Length:

347

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

14.17872

Exp number, first 60 AAs:

0.00089

Total prob of N-in:

0.48337

outside

1  -  347

 

 

Pi

20.050406

Theta

15.745031

Tajima's D

-0.773119

CLR

1.096556

CSRT

0.181240937953102

Interpretation

Uncertain