Gene

KWMTBOMO14135  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011398

Annotation

putative_fatty_acyl_reductase_FAR12_[Spodoptera_litura]

Location

Bomo_Chr23(+):18652091-18675642      View in EpiBrowser

Full name

Fatty acyl-CoA reductase       + More
Putative fatty acyl-CoA reductase CG8306      

Location in the cell

PlasmaMembrane   Reliability : 3.341

CDS

ATGACGGAAGAGTCCTTAGTCCGCGCCTTTTATAGCGGGAAAAACTTTTTCATAACCGGCGGAACCGGCTTTGTCGGTTTATGTCTTATCGAGAAAATATTAAGATGCATTCCTGATGTTGGCAAAGTTTACTTATTAATGAGACCCAAGAAAGGAAAAGAAATATCTCAACGACTAGAGGAGTTTCCTAAAAACCTGGTCTTTGAGAAGCTTCTAGAAACGAACACAACGGATATCTTCAAGAAACTAGTCCCGATCTCTGGAGATGTAGGTGAGGCGAATCTAGGCCTAAGTCCTCAAGACCGGCAGCTGTTGATCGAGAACGTCAATGTGGTTATACATTCGGCGGCAACTTTAGATTTTCAAGAGAACTTAAGGCCCACTGTTAGAATTAATCTTCTTGGAACTAGGCAGGTTATGGGGCTGTGTAAAGAGATTAAGAATTTGAAGGTGATGATACACGTTTCATCGGCCTATGTCAATTCTTATTTAACGGAAGTTCACGAGAAGGTGTACCCTGAGCCGGAGGAGGTTGAGAAAGTTATATCTCTTGTCGGTACATTAAGTGATGAAGCTTTAGACGAAATTGAACCCAAGATATTGAAAGATCATCCGAACACCTACACGTTCACAAAGCATCTGGCTGAGCACGAGGTGGCGAAGTGTGCTGAGCTATTCCCTTGCACAATAGTCCGGCCAACGATGATCGTCGCCTCGTGGAAGGAGCCGGTGCCGGGCTGGACGTGCTCCAAGGTGGGACCTCAAGGATTCCTGATGGGAGCTTCGAAAGGTGTCGTGCGAAGGTTGCCGCTGGCGAAAGAGAACATCGCCGACTACATCCCGGTGGACGTGGTCGTGAACCAGTTGCTGGTCGCCGGATGGCACGCCGCCAGCGCACGGTCCGGCCTTACGGTGTATCACTGTTCGTCATCAACTCAGAAGCCGTTTAAGTGGTCGATGATAGAGTCTTCGATCAATGGAATGCTGCACAAGTATCCGCTGAAAAGCGCCGTCTGGTACCCTCATTTAAAATTCGTCCCCTCCCTGTGGCTGTTTCGTCTGTCGGCCATATTTGTCCATTTCTTCCCGGCGCTCCTCCTCGACATGATGCTGAGGGTGACCGGAGGCAGGCCCATATTAATACGCTTACACAAAAACGTCTGGAATTCCTTGAATCGCTTAGAAAAGTTTATATTTAGCGAGTGGAAGTTCCACAACACGAACACTCAGCAGCTCGCCAAGGAATTGAACAAGACGGACGCGCAAACATTCTTTATAGACATATCGAAGTTATATTGGGAAGAATACTTTATGAATCTCCACCTCGGCGTGAGAAGGTATCTGAACAACGAAAAGGAGGGTAATCTGAAAGCCGCCAGGAATAAGGATACTATATTAATGATATTCCATATTCTGTGGCAGATTTCGGTTCTGACTTTAGTTTGGTATTTGTTTTCGTGCGTATCAGGGCTCACGATGTTAGGATCGATCTGGATCGCTCCCATTATCTATTTTCTGTACAGTTGCTTGTGA

Protein

MTEESLVRAFYSGKNFFITGGTGFVGLCLIEKILRCIPDVGKVYLLMRPKKGKEISQRLEEFPKNLVFEKLLETNTTDIFKKLVPISGDVGEANLGLSPQDRQLLIENVNVVIHSAATLDFQENLRPTVRINLLGTRQVMGLCKEIKNLKVMIHVSSAYVNSYLTEVHEKVYPEPEEVEKVISLVGTLSDEALDEIEPKILKDHPNTYTFTKHLAEHEVAKCAELFPCTIVRPTMIVASWKEPVPGWTCSKVGPQGFLMGASKGVVRRLPLAKENIADYIPVDVVVNQLLVAGWHAASARSGLTVYHCSSSTQKPFKWSMIESSINGMLHKYPLKSAVWYPHLKFVPSLWLFRLSAIFVHFFPALLLDMMLRVTGGRPILIRLHKNVWNSLNRLEKFIFSEWKFHNTNTQQLAKELNKTDAQTFFIDISKLYWEEYFMNLHLGVRRYLNNEKEGNLKAARNKDTILMIFHILWQISVLTLVWYLFSCVSGLTMLGSIWIAPIIYFLYSCL

Description

Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Catalyzes the reduction of C16 or C18 fatty acyl-CoA to fatty alcohols.

Catalytic Activity

a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)

Similarity

Belongs to the fatty acyl-CoA reductase family.

Keywords

Complete proteome   Lipid biosynthesis   Lipid metabolism   Membrane   NADP   Oxidoreductase   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Putative fatty acyl-CoA reductase CG8306

Uniprot

H9JPE4   A0A1V0M876   A0A0N7I636   A0A291P0Q7   A0A0F6Q2Q1   A0A2A4IZZ9   + More
U5KFM7   A0A194PSM5   A0A0N0PDV0   A0A068FL38   A0A212FBG7   A0A2W1B969   A0A212EYE7   A0A1L8DYS9   Q172R4   A0A1L8DYC5   A0A023ETF4   A0A1J1IBB5   D2A661   A0A1Q3FZT6   U5EUB1   A0A182P921   A0A182MHZ9   A0A182YI95   A0A182INP8   A0A182REU0   A0A1W4WDB7   A0A182G2U6   A0A0T6BBP3   A0A182KEF1   A0A182QG39   A0A2M4CTJ0   A0A182NFR0   B4QI12   Q960W6   B3NPG6   B4P5Y2   A0A2M4BKN8   A0A182VXH7   A0A1W4UZG8   E0VLJ9   W8B8U4   A0A1I8PFQ8   B3MDK6   A0A0A1X3D7   A0A2M3ZGS4   A0A0K8U4W4   A0A034VMZ4   Q7QAN6   A0A182WVQ3   A0A182I9D2   A0A182ULQ0   A0A182FRU3   A0A195AUT8   B4MIV1   A0A2M4AEA3   T1PEQ6   A0A0L0BVY1   B4HT65   A0A2J7PM56   A0A195EUL6   A0A195D491   A0A158NHJ3   A0A0J7KCX1   B4JWM6   E2AKA0   A0A182S9E7   A0A0M3QVB2   A0A2J7PM50   A0A195E2Y1   A0A2A3EK40   B4LPA6   B4KSM7   A0A026WXC7   A0A1B0G7W7   A0A182KXL7   A0A1Y1L3Z2   A0A023F7V4   A0A1A9XXW0   A0A069DUT1   A0A1B0ARB9   D3TP92   K7J1Z9   A0A1A9VC93   A0A3B0JNJ2   A0A1B0ADD5   A0A224XB19   A0A232ED04   B5DZF8   B4H767   J3JXL3   N6U8U0   T1IBM7   A0A0P4VTV3   A0A1A9X2G6   E2B9J1   R4G4K5   A0A336L7B2   A0A336L5U1  

EC Number

1.2.1.84

Pubmed

19121390    28349297    26445454    28986331    24053512    26354079    + More
26385554    22118469    28756777    17510324    24945155    18362917    19820115    25244985    26483478    17994087    22936249    10731132    12537572    12537569    17550304    20566863    24495485    25830018    25348373    12364791    14747013    17210077    25315136    26108605    21347285    20798317    24508170    20966253    28004739    25474469    26334808    20353571    20075255    28648823    15632085    22516182    23537049    27129103   

EMBL

BABH01009957    BABH01009958    BABH01009959    KU755487    ARD71197.1    KT261706    + More
ALJ30246.1    MF687533    ATJ44459.1    KP237933    MF687592    AKD01786.1    ATJ44518.1    NWSH01004697    PCG64760.1    JX989159    AGR49318.1    KQ459593    KPI96436.1    KQ460036    KPJ18398.1    KJ622065    AID66653.1    AGBW02009321    OWR51076.1    KZ150256    PZC71788.1    AGBW02011568    OWR46481.1    GFDF01002632    JAV11452.1    CH477432    EAT41033.1    GFDF01002631    JAV11453.1    GAPW01001020    JAC12578.1    CVRI01000047    CRK97583.1    KQ971346    EFA04973.1    GFDL01001992    JAV33053.1    GANO01002400    JAB57471.1    AXCM01000911    JXUM01140195    JXUM01140196    JXUM01140197    KQ569024    KXJ68793.1    LJIG01002321    KRT84619.1    AXCN02000243    GGFL01004486    MBW68664.1    CM000362    CM002911    EDX07383.1    KMY94298.1    AE013599    AY051805    AAF57977.2    AAK93229.1    CH954179    EDV55733.1    CM000158    EDW91898.1    GGFJ01004474    MBW53615.1    DS235271    EEB14255.1    GAMC01020341    JAB86214.1    CH902619    EDV37469.1    GBXI01009037    JAD05255.1    GGFM01007005    MBW27756.1    GDHF01030723    JAI21591.1    GAKP01015802    JAC43150.1    AAAB01008888    EAA08778.5    APCN01003256    KQ976737    KYM75941.1    CH963719    EDW72040.1    GGFK01005721    MBW39042.1    KA647221    AFP61850.1    JRES01001254    KNC24210.1    CH480816    EDW48166.1    NEVH01024421    PNF17413.1    KQ981975    KYN31574.1    KQ976870    KYN07720.1    ADTU01015852    ADTU01015853    LBMM01009220    KMQ88298.1    CH916375    EDV98364.1    GL440209    EFN66141.1    CP012524    ALC42073.1    PNF17415.1    KQ979763    KYN19267.1    KZ288220    PBC32173.1    CH940648    EDW60215.1    CH933808    EDW10526.1    KK107069    EZA60710.1    CCAG010021505    GEZM01065851    GEZM01065850    JAV68304.1    GBBI01001418    JAC17294.1    GBGD01001194    JAC87695.1    JXJN01002308    JXJN01002309    EZ423244    ADD19520.1    OUUW01000001    SPP72768.1    GFTR01006830    JAW09596.1    NNAY01009801    OXU16229.1    CM000071    EDY69579.1    CH479216    EDW33600.1    BT127982    KB631749    AEE62944.1    ERL85791.1    APGK01044181    KB741021    ENN75017.1    ACPB03004980    GDKW01001168    JAI55427.1    GL446556    EFN87624.1    GAHY01001280    JAA76230.1    UFQS01002001    UFQT01002001    SSX12921.1    SSX32363.1    SSX12920.1    SSX32362.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000007151    UP000008820    + More
UP000183832    UP000007266    UP000075885    UP000075883    UP000076408    UP000075880    UP000075900    UP000192223    UP000069940    UP000249989    UP000075881    UP000075886    UP000075884    UP000000304    UP000000803    UP000008711    UP000002282    UP000075920    UP000192221    UP000009046    UP000095300    UP000007801    UP000007062    UP000076407    UP000075840    UP000075903    UP000069272    UP000078540    UP000007798    UP000095301    UP000037069    UP000001292    UP000235965    UP000078541    UP000078542    UP000005205    UP000036403    UP000001070    UP000000311    UP000075901    UP000092553    UP000078492    UP000242457    UP000008792    UP000009192    UP000053097    UP000092444    UP000075882    UP000092443    UP000092460    UP000002358    UP000078200    UP000268350    UP000092445    UP000215335    UP000001819    UP000008744    UP000030742    UP000019118    UP000015103    UP000091820    UP000008237   

PRIDE

H9JPE4    Q960W6   

Pfam

PF03015   Sterile        + More
PF07993   NAD_binding_4

Interpro

IPR026055   FAR        + More
IPR033640   FAR_C       
IPR036291   NAD(P)-bd_dom_sf       
IPR013120   Male_sterile_NAD-bd       

SUPFAM

SSF51735   SSF51735       

CDD

cd09071  FAR_C

ProteinModelPortal

H9JPE4   A0A1V0M876   A0A0N7I636   A0A291P0Q7   A0A0F6Q2Q1   A0A2A4IZZ9   + More
U5KFM7   A0A194PSM5   A0A0N0PDV0   A0A068FL38   A0A212FBG7   A0A2W1B969   A0A212EYE7   A0A1L8DYS9   Q172R4   A0A1L8DYC5   A0A023ETF4   A0A1J1IBB5   D2A661   A0A1Q3FZT6   U5EUB1   A0A182P921   A0A182MHZ9   A0A182YI95   A0A182INP8   A0A182REU0   A0A1W4WDB7   A0A182G2U6   A0A0T6BBP3   A0A182KEF1   A0A182QG39   A0A2M4CTJ0   A0A182NFR0   B4QI12   Q960W6   B3NPG6   B4P5Y2   A0A2M4BKN8   A0A182VXH7   A0A1W4UZG8   E0VLJ9   W8B8U4   A0A1I8PFQ8   B3MDK6   A0A0A1X3D7   A0A2M3ZGS4   A0A0K8U4W4   A0A034VMZ4   Q7QAN6   A0A182WVQ3   A0A182I9D2   A0A182ULQ0   A0A182FRU3   A0A195AUT8   B4MIV1   A0A2M4AEA3   T1PEQ6   A0A0L0BVY1   B4HT65   A0A2J7PM56   A0A195EUL6   A0A195D491   A0A158NHJ3   A0A0J7KCX1   B4JWM6   E2AKA0   A0A182S9E7   A0A0M3QVB2   A0A2J7PM50   A0A195E2Y1   A0A2A3EK40   B4LPA6   B4KSM7   A0A026WXC7   A0A1B0G7W7   A0A182KXL7   A0A1Y1L3Z2   A0A023F7V4   A0A1A9XXW0   A0A069DUT1   A0A1B0ARB9   D3TP92   K7J1Z9   A0A1A9VC93   A0A3B0JNJ2   A0A1B0ADD5   A0A224XB19   A0A232ED04   B5DZF8   B4H767   J3JXL3   N6U8U0   T1IBM7   A0A0P4VTV3   A0A1A9X2G6   E2B9J1   R4G4K5   A0A336L7B2   A0A336L5U1  

PDB

4W4T     E-value=1.11472e-10,     Score=161

KEGG

101741731    K13356 alcohol-forming fatty acyl-CoA reductase [EC:1.2.1.84] | (RefSeq) putative fatty acyl-CoA red

PATHWAY

04146    Peroxisome - Bombyx mori (domestic silkworm)

GO

GO:0006629   GO:0080019   GO:0102965   GO:0016021   GO:0035336   GO:0005777   GO:0010025   GO:0012505  

PANTHER

PTHR11011  

Subcellular location

Membrane  

Length:

510

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

62.96634

Exp number, first 60 AAs:

3.15539

Total prob of N-in:

0.12830

outside

1  -  348

TMhelix

349  -  367

inside

368  -  463

TMhelix

464  -  486

outside

487  -  490

TMhelix

491  -  508

inside

509  -  510

 

 

Pi

24.399326

Theta

25.471692

Tajima's D

0.215496

CLR

0.67544

CSRT

0.434378281085946

Interpretation

Uncertain