Gene

KWMTBOMO14130

Pre Gene Modal

BGIBMGA011395

Annotation

PREDICTED:_fatty_acyl-CoA_reductase_1_[Papilio_xuthus]

Location

Bomo_Chr23(+):18523472-18558507      View in EpiBrowser

Full name

Fatty acyl-CoA reductase       + More
Putative fatty acyl-CoA reductase CG5065      

Location in the cell

PlasmaMembrane   Reliability : 2.044

CDS

ATGGCGTCTTGTGTTGGCGCGAATTATTCAAGCGGCAGTGACTACACCCCGGTCGCCGAGTTCTATGCGGAGAAATCGGTTTTTGTCACGGGCGGCACCGGCTTCATGGGGAAGGTCCTTGTCGAGAAACTGCTTAGGAGTTGTCCGAAAATAAAGAAGATATACCTGTTGATGCGACCGAAGCGAGGACAGGACGTCGCGTCACGACTAACGGAGCTGACCCAGTCACCATTGTTCGAGACTTTAAGGAAAGAACGACCTCAAGAATTAAACAAAATAGTGCCAATAGTCGGGGACATCACCGAGCCAGAGCTGGGCATCAGTCAGACCGATCAGATGCTGCTCTGTCAAATGGTGTCGGTGGTCTTCCACTCGGCTGCGACAGTGAAATTCGACGAGAAACTGAAGCTGTCCGTCACGATCAACATGCTCGGGACCCAGCAGCTCGTCCAGCTCTGCCATCGTATGCTCGGTCTTGTGGCTCTCGTTCACGTTTCGACGGCGTACTGCAACTGCGAGAGGGAGAGGGTCGAGGAGACGGTGTACGCGCCGCCGGCCGACCCGGGGCACGTGGTCGCGCTGGTGCAGACCCTGCCCGACGAGCTGGTGGACAGGATCACGCCGCACCTAGTCGTTCACAGGCCTAACACGTACACGTTCACGAAGGCTCTGGCCGAGGATATGCTGATCAAGGAGAGCGGGAACCTACCAGTTGCGATCGTACGACCTTCAATCGTGCTCTCCTCCGTTCGGGAGCCAGTGAAAGGTTGGGTCGACAACTGGAACGGTCCTAATGGCATCGTCGCCGCTGTGGGGAAGGGCATCTTCAGAACGATGCTGGGTTCCGGAGACAAGGTCGCTGACCTCGTCCCGGTCGATACCGTTATCAACCTGATGATCGTGTGCGCCTGGAGGACGCATTTAAGACGGGATCAGGGCGTCGTAGTTTACAACTGCTGCACCGGCCAACAGAATCCGATAACGTGGAAACGTTTTGTAAAATCAAGCTTCAAATACATGCGGAAACATCCTTTTACTGAAGTAGTTTGGTATCCTGGAGGTGACATCACCAGCAACAGGCTGAAGCACAACGTGCTGACGCTGATGCAGCATCGGGCGCCGGCTGTGCTCATGGACCTGGTCTCCAGGACCACTGGCAACAAGCCCATGATGGTCAGGGTTCAAAATAAGTTGGAGAAGGCGGCCGCCTGTCTGGAGTACTTCACCACGCGCCAGTGGTCGTTTGCGGACGACAACGTGCAGGCGCTCTGCTTGCTCCTGTCCCCCGAAGACAGGAGGACCTTCGACTTCGACGTGAAGAACATCGACTGGGACGCTTACATCGAGTCCTACGTGCTCGGGATCAGGAGGTTCTTGTTCAAAGAGAGCCCCGAGACGTTGCCCAAGTCCCGGTCGCTATTGAAGAGATTACACATAATCCATATACTAACTCAAGTAGCGGCCGTGTTCTTCATTTGGAGATTCCTGTTCTCCCGCTCGGAGGTCCTGCGCGGACTGTGGCGGCGCATCGTGGACCTGCTGACTCGCGCAGCCCGCCTCCTCGCCATAGCCTGA

Protein

MASCVGANYSSGSDYTPVAEFYAEKSVFVTGGTGFMGKVLVEKLLRSCPKIKKIYLLMRPKRGQDVASRLTELTQSPLFETLRKERPQELNKIVPIVGDITEPELGISQTDQMLLCQMVSVVFHSAATVKFDEKLKLSVTINMLGTQQLVQLCHRMLGLVALVHVSTAYCNCERERVEETVYAPPADPGHVVALVQTLPDELVDRITPHLVVHRPNTYTFTKALAEDMLIKESGNLPVAIVRPSIVLSSVREPVKGWVDNWNGPNGIVAAVGKGIFRTMLGSGDKVADLVPVDTVINLMIVCAWRTHLRRDQGVVVYNCCTGQQNPITWKRFVKSSFKYMRKHPFTEVVWYPGGDITSNRLKHNVLTLMQHRAPAVLMDLVSRTTGNKPMMVRVQNKLEKAAACLEYFTTRQWSFADDNVQALCLLLSPEDRRTFDFDVKNIDWDAYIESYVLGIRRFLFKESPETLPKSRSLLKRLHIIHILTQVAAVFFIWRFLFSRSEVLRGLWRRIVDLLTRAARLLAIA

Description

Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
Catalyzes the reduction of C16 or C18 fatty acyl-CoA to fatty alcohols.

Catalytic Activity

a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)

Similarity

Belongs to the fatty acyl-CoA reductase family.

Keywords

Complete proteome   Lipid biosynthesis   Lipid metabolism   Membrane   NADP   Oxidoreductase   Peroxisome   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Putative fatty acyl-CoA reductase CG5065

Uniprot

H9JPE1   A0A291P0J5   A0A0N1IPU7   A0A194PSL9   A0A212F418   A0A2A4JJ98   + More
A0A2J7PM67   A0A067R949   A0A1B6GUZ4   A0A1B6JB63   B3MDK3   E1JH83   A1ZAI5   B3NPG3   B4HT68   A0A0J9RE92   B4LPA3   A0A1W4UXP9   B4P5X9   B4KSN0   B4MIU8   A0A1B6KYT4   A0A0M4EVU9   A0A023F1V0   A0A069DV62   E0VLJ7   A0A3B0J1M1   K7J1Z7   A0A336MZZ9   B4JWM8   W8AXT4   A0A034VN48   A0A0K8U8F7   Q28WN8   A0A1J1IBH8   A0A336LRW3   B4H764   A0A0C9QJE0   A0A0A1WIW0   A0A1L8DYU2   A0A1B0CS61   A0A0L0BVZ6   A0A1A9X2G9   E2AKA1   T1PAL6   A0A1A9VQ82   A0A1I8M522   A0A151WGN3   A0A224XJF5   A0A195D193   A0A1B0ARC3   A0A1I8PNE0   A0A158NHJ4   A0A0J7KV18   A0A0A9WTX4   A0A026WZZ2   E2B9J0   A0A195E2A0   T1E2J9   A0A195ETJ3   E9J0E5   Q172Q8   A0A195C1J1   A0A023ETM2   A0A0L7QWX8   D2A660   A0A310SYR9   A0A0M8ZN21   V5GSY3   A0A2J7PLY4   Q172Q7   A0A1W4WEK2   A0A2A3EL05   V9IAG7   D9MWM7   A0A1B0G7W2   A0A2R7WZM3   A0A1B0ADE2   A0A1A9XXW3   A0A067RBR1   A0A1B6CB27   A0A2L2YHA0   A0A2S2PD11   A0A1Z3FT38   A0A1B6EM21   A0A226E5U8   A0A1B6G8A3   A0A3Q8FTW8   E0VSV6   A0A0A9VYR3   A0A2S2R203   A0A0A9VVQ7   A0A0K8V7R7   E9FTX3   A0A0P5M2C1   A0A0P5GW05   A0A0P6HB46   T1HPB8   A0A069DVI2  

EC Number

1.2.1.84

Pubmed

19121390    28986331    26354079    22118469    24845553    17994087    + More
18057021    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    22936249    17550304    25474469    26334808    20566863    20075255    24495485    25348373    15632085    25830018    26108605    20798317    25315136    21347285    25401762    26823975    24508170    30249741    24330624    21282665    17510324    24945155    18362917    19820115    20542116    26561354    28608990    21292972   

EMBL

BABH01009941    BABH01009942    BABH01009943    MF687541    ATJ44467.1    KQ460036    + More
KPJ18402.1    KQ459593    KPI96431.1    AGBW02010466    OWR48453.1    NWSH01001298    PCG71798.1    NEVH01024421    PNF17417.1    KK852807    KDR16086.1    GECZ01003528    JAS66241.1    GECU01011206    JAS96500.1    CH902619    EDV37466.1    KPU76846.1    AE013599    ACZ94440.1    AAF57974.1    CH954179    EDV55730.1    CH480816    EDW48169.1    CM002911    KMY94302.1    CH940648    EDW60212.2    CM000158    EDW91895.1    CH933808    EDW10529.2    CH963719    EDW72037.1    GEBQ01023412    JAT16565.1    CP012524    ALC42075.1    GBBI01003721    JAC14991.1    GBGD01001183    JAC87706.1    DS235271    EEB14253.1    OUUW01000001    SPP72772.1    UFQT01004920    SSX35816.1    CH916375    EDV98366.1    GAMC01012755    JAB93800.1    GAKP01015960    GAKP01015959    GAKP01015958    GAKP01015956    JAC42993.1    GDHF01029367    GDHF01008158    JAI22947.1    JAI44156.1    CM000071    EAL26629.1    CVRI01000047    CRK97592.1    UFQT01000095    SSX19701.1    CH479216    EDW33597.1    GBYB01014923    GBYB01014924    JAG84690.1    JAG84691.1    GBXI01017222    GBXI01017048    GBXI01015288    GBXI01014990    GBXI01003875    JAC97069.1    JAC97243.1    JAC99003.1    JAC99301.1    JAD10417.1    GFDF01002480    JAV11604.1    AJWK01025651    AJWK01025652    JRES01001254    KNC24212.1    GL440209    EFN66142.1    KA645200    AFP59829.1    KQ983167    KYQ46967.1    GFTR01006468    JAW09958.1    KQ976973    KYN06637.1    JXJN01002319    JXJN01002320    ADTU01015858    LBMM01002956    KMQ94136.1    GBHO01033661    GBHO01033660    GBRD01008049    GBRD01008048    GBRD01008047    GDHC01019056    GDHC01002516    JAG09943.1    JAG09944.1    JAG57772.1    JAP99572.1    JAQ16113.1    KK107069    QOIP01000002    EZA60709.1    RLU26126.1    GL446556    EFN87623.1    KQ979763    KYN19268.1    GALA01001195    JAA93657.1    KQ981975    KYN31575.1    GL767462    EFZ13704.1    CH477432    EAT41039.1    KQ978350    KYM94712.1    GAPW01000903    JAC12695.1    KQ414706    KOC63100.1    KQ971346    EFA04974.1    KQ759773    OAD62927.1    KQ436010    KOX67575.1    GALX01005113    JAB63353.1    PNF17348.1    EAT41040.1    KZ288220    PBC32174.1    JR038077    JR038078    AEY58108.1    AEY58109.1    HM483391    ADJ56408.1    CCAG010021504    KK855841    PTY24075.1    KDR16085.1    GEDC01026600    JAS10698.1    IAAA01029277    IAAA01029278    LAA07536.1    GGMR01014701    MBY27320.1    KY274178    ASC44542.1    GECZ01030782    JAS38987.1    LNIX01000006    OXA53032.1    GECZ01011099    JAS58670.1    MG573164    AWJ25026.1    DS235758    EEB16462.1    GBHO01043288    GBRD01007683    JAG00316.1    JAG58138.1    GGMS01014761    MBY83964.1    GBHO01043282    JAG00322.1    GDHF01017335    JAI34979.1    GL732524    EFX89565.1    GDIP01153633    GDIQ01163373    GDIQ01162077    LRGB01001937    JAJ69769.1    JAK89648.1    KZS09877.1    GDIQ01236900    JAK14825.1    GDIQ01022871    JAN71866.1    ACPB03012985    GBGD01001172    JAC87717.1   

Proteomes

UP000005204    UP000053240    UP000053268    UP000007151    UP000218220    UP000235965    + More
UP000027135    UP000007801    UP000000803    UP000008711    UP000001292    UP000008792    UP000192221    UP000002282    UP000009192    UP000007798    UP000092553    UP000009046    UP000268350    UP000002358    UP000001070    UP000001819    UP000183832    UP000008744    UP000092461    UP000037069    UP000091820    UP000000311    UP000078200    UP000095301    UP000075809    UP000078542    UP000092460    UP000095300    UP000005205    UP000036403    UP000053097    UP000279307    UP000008237    UP000078492    UP000078541    UP000008820    UP000053825    UP000007266    UP000053105    UP000192223    UP000242457    UP000005203    UP000092444    UP000092445    UP000092443    UP000198287    UP000000305    UP000076858    UP000015103   

PRIDE

H9JPE1    A1ZAI5   

Pfam

PF03015   Sterile        + More
PF07993   NAD_binding_4
PF03455   dDENN
PF02141   DENN

Interpro

IPR036291   NAD(P)-bd_dom_sf        + More
IPR033640   FAR_C       
IPR026055   FAR       
IPR013120   Male_sterile_NAD-bd       
IPR037516   Tripartite_DENN       
IPR005112   dDENN_dom       
IPR001194   cDENN_dom       

SUPFAM

SSF51735   SSF51735       

CDD

cd09071  FAR_C

ProteinModelPortal

H9JPE1   A0A291P0J5   A0A0N1IPU7   A0A194PSL9   A0A212F418   A0A2A4JJ98   + More
A0A2J7PM67   A0A067R949   A0A1B6GUZ4   A0A1B6JB63   B3MDK3   E1JH83   A1ZAI5   B3NPG3   B4HT68   A0A0J9RE92   B4LPA3   A0A1W4UXP9   B4P5X9   B4KSN0   B4MIU8   A0A1B6KYT4   A0A0M4EVU9   A0A023F1V0   A0A069DV62   E0VLJ7   A0A3B0J1M1   K7J1Z7   A0A336MZZ9   B4JWM8   W8AXT4   A0A034VN48   A0A0K8U8F7   Q28WN8   A0A1J1IBH8   A0A336LRW3   B4H764   A0A0C9QJE0   A0A0A1WIW0   A0A1L8DYU2   A0A1B0CS61   A0A0L0BVZ6   A0A1A9X2G9   E2AKA1   T1PAL6   A0A1A9VQ82   A0A1I8M522   A0A151WGN3   A0A224XJF5   A0A195D193   A0A1B0ARC3   A0A1I8PNE0   A0A158NHJ4   A0A0J7KV18   A0A0A9WTX4   A0A026WZZ2   E2B9J0   A0A195E2A0   T1E2J9   A0A195ETJ3   E9J0E5   Q172Q8   A0A195C1J1   A0A023ETM2   A0A0L7QWX8   D2A660   A0A310SYR9   A0A0M8ZN21   V5GSY3   A0A2J7PLY4   Q172Q7   A0A1W4WEK2   A0A2A3EL05   V9IAG7   D9MWM7   A0A1B0G7W2   A0A2R7WZM3   A0A1B0ADE2   A0A1A9XXW3   A0A067RBR1   A0A1B6CB27   A0A2L2YHA0   A0A2S2PD11   A0A1Z3FT38   A0A1B6EM21   A0A226E5U8   A0A1B6G8A3   A0A3Q8FTW8   E0VSV6   A0A0A9VYR3   A0A2S2R203   A0A0A9VVQ7   A0A0K8V7R7   E9FTX3   A0A0P5M2C1   A0A0P5GW05   A0A0P6HB46   T1HPB8   A0A069DVI2  

PDB

4W4T     E-value=7.72512e-14,     Score=189

KEGG

101741449    K13356 alcohol-forming fatty acyl-CoA reductase [EC:1.2.1.84] | (RefSeq) putative fatty acyl-CoA red

PATHWAY

04146    Peroxisome - Bombyx mori (domestic silkworm)

GO

GO:0006629   GO:0102965   GO:0016021   GO:0080019   GO:0005778   GO:0010025   GO:0008611   GO:0005777   GO:0005779   GO:0016301   GO:0035336  

PANTHER

PTHR11011  

Subcellular location

Peroxisome membrane  

Length:

524

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

18.95089

Exp number, first 60 AAs:

0.03318

Total prob of N-in:

0.01503

outside

1  -  478

TMhelix

479  -  498

inside

499  -  524

 

 

Pi

258.344806

Theta

167.049678

Tajima's D

1.725933

CLR

0.43583

CSRT

0.833758312084396

Interpretation

Uncertain