Gene

KWMTBOMO14122

Pre Gene Modal

BGIBMGA011393

Annotation

PREDICTED:_serine/threonine-protein_kinase_BRSK2_[Bombyx_mori]

Location

Bomo_Chr23(+):18267362-18276451      View in EpiBrowser

Full name

DNA mismatch repair protein      

Location in the cell

Cytoplasmic   Reliability : 1.657 Mitochondrial   Reliability : 1.411

CDS

ATGGATAGTGGGTCGGCGACAACGACTGAGGCCTACCAATACGTAGGGCCCTTCCGGCTGGAGAAAACCTTAGGGAAGGGGCAAACAGGTCTAGTCAAGCTCGGGGTACATTGCGTGACGGGAAAGAAAGTGGCCATCAAGATTATCAACAGAGAGAAACTCAGCGAATCTGTGTTGACGAAGGTCGAAAGGGAAATAGCTATAATGAAATTAATTGAGCATCCCCACGTGCTCGGACTGTCCGACGTTTATGAAAATAAGAAATATTTGTATCTAGTTTTAGAGCACGTAAGCGGAGGCGAGCTGTTCGACTACTTAGTGAAGAAGGGCCGACTCACGCCGAAAGAGGCTCGGAGATTTTTCAGACAAATTATATCCGCCCTAGATTTCTGTCATAGTCACTCGATTTGCCACAGGGACTTAAAGCCGGAGAACTTGCTCCTAGACGAACGGAACAACATCAAGATTGCAGATTTCGGGATGGCCTCCCTCCAGCCGGCCGGGTCGCTGCTGGAAACTTCTTGCGGGAGTCCGCATTACGCTTGCCCCGAAGTCATACGGGTCATGCCCCAATATGTCCAGTTCCTTATAGATAATACATAA

Protein

MDSGSATTTEAYQYVGPFRLEKTLGKGQTGLVKLGVHCVTGKKVAIKIINREKLSESVLTKVEREIAIMKLIEHPHVLGLSDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARRFFRQIISALDFCHSHSICHRDLKPENLLLDERNNIKIADFGMASLQPAGSLLETSCGSPHYACPEVIRVMPQYVQFLIDNT

Description

Component of the post-replicative DNA mismatch repair system (MMR).

Similarity

Belongs to the protein kinase superfamily.
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Belongs to the DNA mismatch repair MutS family.

Uniprot

A0A194RQQ3   A0A2W1BES3   A0A3S2NM17   B4PD12   A0A146L3K3   A0A1B0CQI3   + More
A0A1A9W506   E1ZUV7   A0A088ARN5   A0A0L0CLZ6   A0A3L8E0G9   A0A182VAT9   A0A182J379   A0A151IGG1   A0A1S4EY07   A0A151WFE5   B4QLQ9   Q17M45   F4WM56   A0A195BDB0   A0A1I8Q331   A0A182KST8   A0A1I8Q339   A0A1I8N898   A0A195DCL6   A0A195FVZ0   Q7PV95   A0A182Y1X2   A0A158P3J7   A0A0L7RD24   A0A1B6D1M0   B4GRJ7   A0A084WB46   A0A2P2IGK7   A0A182MR70   K7IXS0   D2A4R1   A0A310SSE5   A0A0K8VF51   A0A0N8P0Y1   A0A0Q9X0L8   A0A3B0KMI4   A0A1W4VMZ6   A0A1W4VAZ2   A0A0R3P3T7   A0A3B0KA80   B5DPG7   M9PFM1   A0A0R1E7J2   A0A0Q5U654   A0A0R1ECS1   A0A0Q5UJT7   B3M9V3   A0A3B0KFC4   B4MXV5   M9PFS3   A0A1W4VBA3   Q9VUV4   A0A226CXU9   A0A1W4VPC2   B3NDN8   B4ITX3   A0A1B6D6G2   W8AXQ4   A0A1I8HJU7   W8BKG0   A0A0P5W749   A0A0P4XXJ2   E0VSU4   A0A0J9RVY5   A0A0P5IGB4   A0A2S2NLE4   B4J1V9   A0A0J9ULZ1   B4LDB8   E9FRJ6   A0A154PA70   A0A336N0U3   A0A2S2N893   A0A2H8TI99   A0A0A9WQZ3   A0A2R8QFR1   A0A182FUF5   A0A182HPY6   A0A182XDA3   R7UCJ1   A0A0P4XWS9   A0A0P5BTU3   A0A1A8UKI6   A0A0N7ZZ22   A0A182H6A7   A0A0P5ACD0   A0A0P4XEC5   A0A182RGL3   A0A0P6DKI6   A0A0P5BN49   A0A0P4Z1A7   A0A0P5ZPK0   A0A3B3BWE9   A0A0P5VP32  

Pubmed

26354079    28756777    17994087    17550304    26823975    20798317    + More
26108605    30249741    17510324    21719571    20966253    25315136    12364791    25244985    21347285    24438588    20075255    18362917    19820115    15632085    23185243    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    24495485    26392545    20566863    22936249    21292972    25401762    23594743    23254933    26483478    29451363   

EMBL

KQ459875    KPJ19640.1    KZ150153    PZC72811.1    RSAL01000005    RVE54391.1    + More
CM000159    EDW94944.2    GDHC01015535    JAQ03094.1    AJWK01023619    GL434297    EFN75049.1    JRES01000306    KNC32459.1    QOIP01000002    RLU25983.1    KQ977726    KYN00311.1    KQ983219    KYQ46552.1    CM000363    EDX10608.1    CH477208    EAT47800.1    GL888217    EGI64700.1    KQ976519    KYM82175.1    KQ980989    KYN10582.1    KQ981264    KYN44009.1    AAAB01008986    EAA00228.5    ADTU01001329    KQ414614    KOC68862.1    GEDC01017724    JAS19574.1    CH479188    EDW40382.1    ATLV01022312    KE525331    KFB47440.1    IACF01007493    LAB73076.1    AXCM01000926    KQ971344    EFA05190.2    KQ760869    OAD58767.1    GDHF01014852    JAI37462.1    CH902618    KPU78388.1    CH963876    KRF98534.1    OUUW01000009    SPP85018.1    CH379069    KRT07785.1    SPP85020.1    EDY73513.1    KRT07784.1    AE014296    AGB94595.1    CH891734    KRK05248.1    CH954178    KQS44153.1    KRK05249.1    KQS44154.1    EDV40144.1    SPP85019.1    EDW76874.1    AGB94594.1    AAF49569.3    LNIX01000048    OXA38155.1    EDV52171.1    EDW99836.1    KRK05250.1    GEDC01016026    JAS21272.1    GAMC01012795    JAB93760.1    GAMC01012794    JAB93761.1    GDIP01090371    JAM13344.1    GDIP01235372    JAI88029.1    DS235758    EEB16450.1    CM002912    KMY99876.1    GDIQ01212828    JAK38897.1    GGMR01005329    MBY17948.1    CH916366    EDV98039.1    KMY99875.1    CH940647    EDW71025.1    GL732523    EFX90176.1    KQ434856    KZC08733.1    UFQS01004145    UFQT01000829    UFQT01004145    SSX16209.1    SSX27442.1    SSX35535.1    GGMR01000824    MBY13443.1    GFXV01000996    GFXV01001317    GFXV01001936    MBW12801.1    MBW13122.1    MBW13741.1    GBHO01033758    JAG09846.1    AL935197    APCN01003284    AMQN01001733    KB305005    ELU01498.1    GDIP01239675    JAI83726.1    GDIP01180711    JAJ42691.1    HAEJ01007375    SBS47832.1    GDIP01198561    JAJ24841.1    JXUM01026850    JXUM01026851    JXUM01026852    JXUM01026853    JXUM01026854    JXUM01026855    JXUM01026856    JXUM01026857    JXUM01026858    JXUM01026859    KQ560769    KXJ80957.1    GDIP01201168    JAJ22234.1    GDIP01242306    JAI81095.1    GDIP01169411    GDIQ01076381    JAJ53991.1    JAN18356.1    GDIP01182362    JAJ41040.1    GDIP01219814    JAJ03588.1    GDIP01054080    JAM49635.1    GDIP01097420    JAM06295.1   

Proteomes

UP000053240    UP000283053    UP000002282    UP000092461    UP000091820    UP000000311    + More
UP000005203    UP000037069    UP000279307    UP000075903    UP000075880    UP000078542    UP000075809    UP000000304    UP000008820    UP000007755    UP000078540    UP000095300    UP000075882    UP000095301    UP000078492    UP000078541    UP000007062    UP000076408    UP000005205    UP000053825    UP000008744    UP000030765    UP000075883    UP000002358    UP000007266    UP000007801    UP000007798    UP000268350    UP000192221    UP000001819    UP000000803    UP000008711    UP000198287    UP000095280    UP000009046    UP000001070    UP000008792    UP000000305    UP000076502    UP000000437    UP000069272    UP000075840    UP000076407    UP000014760    UP000069940    UP000249989    UP000075900    UP000261560   

PRIDE

M9PFM1    Q9VUV4   

Pfam

PF00069   Pkinase        + More
PF00595   PDZ
PF00640   PID
PF00782   DSPc
PF05190   MutS_IV
PF05192   MutS_III
PF00488   MutS_V
PF05188   MutS_II

Interpro

IPR017441   Protein_kinase_ATP_BS        + More
IPR008271   Ser/Thr_kinase_AS       
IPR000719   Prot_kinase_dom       
IPR011009   Kinase-like_dom_sf       
IPR017348   PIM1/2/3       
IPR015940   UBA       
IPR006020   PTB/PI_dom       
IPR011993   PH-like_dom_sf       
IPR001478   PDZ       
IPR036034   PDZ_sf       
IPR000387   TYR_PHOSPHATASE_dom       
IPR020422   TYR_PHOSPHATASE_DUAL_dom       
IPR000340   Dual-sp_phosphatase_cat-dom       
IPR029021   Prot-tyrosine_phosphatase-like       
IPR020417   Atypical_DUSP       
IPR017261   DNA_mismatch_repair_MutS/MSH       
IPR036187   DNA_mismatch_repair_MutS_sf       
IPR007861   DNA_mismatch_repair_MutS_clamp       
IPR036678   MutS_con_dom_sf       
IPR000432   DNA_mismatch_repair_MutS_C       
IPR007696   DNA_mismatch_repair_MutS_core       
IPR007860   DNA_mmatch_repair_MutS_con_dom       
IPR027417   P-loop_NTPase       

SUPFAM

SSF56112   SSF56112        + More
SSF50156   SSF50156       
SSF52799   SSF52799       
SSF52540   SSF52540       
SSF48334   SSF48334       

Gene 3D

2.30.29.30     3.90.190.10     3.30.420.110    

CDD

cd00127  DSPc

ProteinModelPortal

A0A194RQQ3   A0A2W1BES3   A0A3S2NM17   B4PD12   A0A146L3K3   A0A1B0CQI3   + More
A0A1A9W506   E1ZUV7   A0A088ARN5   A0A0L0CLZ6   A0A3L8E0G9   A0A182VAT9   A0A182J379   A0A151IGG1   A0A1S4EY07   A0A151WFE5   B4QLQ9   Q17M45   F4WM56   A0A195BDB0   A0A1I8Q331   A0A182KST8   A0A1I8Q339   A0A1I8N898   A0A195DCL6   A0A195FVZ0   Q7PV95   A0A182Y1X2   A0A158P3J7   A0A0L7RD24   A0A1B6D1M0   B4GRJ7   A0A084WB46   A0A2P2IGK7   A0A182MR70   K7IXS0   D2A4R1   A0A310SSE5   A0A0K8VF51   A0A0N8P0Y1   A0A0Q9X0L8   A0A3B0KMI4   A0A1W4VMZ6   A0A1W4VAZ2   A0A0R3P3T7   A0A3B0KA80   B5DPG7   M9PFM1   A0A0R1E7J2   A0A0Q5U654   A0A0R1ECS1   A0A0Q5UJT7   B3M9V3   A0A3B0KFC4   B4MXV5   M9PFS3   A0A1W4VBA3   Q9VUV4   A0A226CXU9   A0A1W4VPC2   B3NDN8   B4ITX3   A0A1B6D6G2   W8AXQ4   A0A1I8HJU7   W8BKG0   A0A0P5W749   A0A0P4XXJ2   E0VSU4   A0A0J9RVY5   A0A0P5IGB4   A0A2S2NLE4   B4J1V9   A0A0J9ULZ1   B4LDB8   E9FRJ6   A0A154PA70   A0A336N0U3   A0A2S2N893   A0A2H8TI99   A0A0A9WQZ3   A0A2R8QFR1   A0A182FUF5   A0A182HPY6   A0A182XDA3   R7UCJ1   A0A0P4XWS9   A0A0P5BTU3   A0A1A8UKI6   A0A0N7ZZ22   A0A182H6A7   A0A0P5ACD0   A0A0P4XEC5   A0A182RGL3   A0A0P6DKI6   A0A0P5BN49   A0A0P4Z1A7   A0A0P5ZPK0   A0A3B3BWE9   A0A0P5VP32  

PDB

4YOM     E-value=3.10117e-92,     Score=859

KEGG

101741779    K08796 BR serine/threonine kinase [EC:2.7.11.1] | (RefSeq) serine/threonine-protein kinase BRSK2

GO

GO:0004674   GO:0005524   GO:0004672   GO:0043066   GO:0005737   GO:0005634   GO:0050321   GO:0007409   GO:0030010   GO:0006468   GO:0035556   GO:0007528   GO:0006487   GO:0000226   GO:0004683   GO:0005813   GO:0008138   GO:0030983   GO:0006298   GO:0042626   GO:0016887   GO:0019829   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

Length:

200

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00550999999999999

Exp number, first 60 AAs:

0.00179

Total prob of N-in:

0.13265

outside

1  -  200

 

 

Pi

350.221568

Theta

172.840822

Tajima's D

4.019002

CLR

0.340368

CSRT

0.998650067496625

Interpretation

Uncertain