Gene

KWMTBOMO14100

Pre Gene Modal

BGIBMGA011207

Annotation

fatty_acyl-CoA_reductase_12?_partial_[Helicoverpa_assulta]

Location

Bomo_Chr23(-):17906476-17938132      View in EpiBrowser

Full name

Fatty acyl-CoA reductase      

Location in the cell

PlasmaMembrane   Reliability : 3.062

CDS

ATGGCGCCCGTTGCTATCGAAGAAAACTATATTAAAACAAATGAATTGAGCACGAAGATATCGCGGATCATGGAGGATTATAAAGAGAGTAATTACTGCGGGGATTGCGAACACAACATTTACAATGTGAACGAAGACACGAACCAGGATGTAAACATGTCGGAAGTGCAAAGGTTTTACAGCGGAAAAAATGTTTTGATTACCGGCGGGACTGGCTTCCTTGGTAAAGTTTTGATCGAGAAACTATTGAGGAGCTGCCCCGGCGTGGAGAACCTCTATTTACTAGTCAGACAAAAGAAAGGAAAAGATATTTATACGAGAATCGAAGAAATATTCGAAGATCCGGTTTTCGACCGCTTAAAAACACAAGTGCCGAAGTTTAGGCACAAGATCGTTGTGGTGCCAGCTGACTGCGAGGCCGCGGGGCTCGGATTGACACTGTCAGACAGGCATATGCTCACCGAAAAGGTGAACATAATTTTCCACTCGGCGGCCACAGTGAAATTTGACGAGCACCTTCGAGCGGCACTGACCACTAACGTGAGGGCGCCATTGCATCTGCTGCGGCTGGCGCGGGACATGAGGAAGCTCGATGTTCTGATGCACATCTCAACAGCGTACTCTAACTCTCACCTGCCCAAGATCGAGGAGAAGTTCTACGCCTGTGAACCGACCTGTCAGCAGTTGGAAACCACCATCAGCAAACTTAGCGACGAGCAAATCAACGCAATGTTACCGAAGATTCTTGGACCCTGGCCAAACACTTATACGTTTACGAAGGCGCTAGCCGAGAAGGAGATCAGGGTGAACGCCAACGGGGTGCCCGTGGGCATCTTCAGACCGGCCATCGTCACGTCGACCTGCAAGGAGCCATTGAAGAGTTGGGTGGACAACATGTACGGGCCGACAGGTGTCGCAGTTGGCAGTGGTACGGGGATCCTCCGGACGCTGCAGTGCGATGGCTCCGTCACGGCCGACATAGTACCGGTCGATGCTGTGGTCAACTGTCTTATATGCGCTGCGAAATCGGTCCATAGCACATACGCAAAAAGTCGGCGGCCCATCGATCCACCGATCTTCAATTACGTCAGTTCAGTCGAAAACAGGATAACCTGGGGCGATTTCATGAAGCACAACATGGAAATGATCGATCGAAATCCTTTCAGTGATGCTGTGTGGTACATTTCCCTGCGTCTAACGCGATCAGCCATTCTGAATAACCTCTATATATTATTCTTACACCTCATACCTGCTCTACTAGTGGATACACTCGCAATATGTCTAGGAAGAAAACCAAAAATGCTCAAAGTTTACAAGAAGATACATAAGTTCTCATCGGTCTTATCGTATTTCACGACGAGAGAGATAAGTTTTTGCAACACGAGAACGAGGGAGCTCTGGGATCAAACGACCGTCGAGGATAAAGAGCTGTTCCCGTTCAGCATGGCGGAGGTTAACTGGGAGGAGTACTTCGAGAGCTACTTGGCCGGCATCAGGCGTTACCTGTTCAAAGAGAGCGACGAGATGCTACCGAGAGCCAGGATAAAGTGGAAAAGATTATACTATTTGCATCAGATAGCAAAAATTATTTTTCTGCTCCTGGCTGTTTATACTCTGTGGTCGATCTTATCGTTAATGTGGTAA

Protein

MAPVAIEENYIKTNELSTKISRIMEDYKESNYCGDCEHNIYNVNEDTNQDVNMSEVQRFYSGKNVLITGGTGFLGKVLIEKLLRSCPGVENLYLLVRQKKGKDIYTRIEEIFEDPVFDRLKTQVPKFRHKIVVVPADCEAAGLGLTLSDRHMLTEKVNIIFHSAATVKFDEHLRAALTTNVRAPLHLLRLARDMRKLDVLMHISTAYSNSHLPKIEEKFYACEPTCQQLETTISKLSDEQINAMLPKILGPWPNTYTFTKALAEKEIRVNANGVPVGIFRPAIVTSTCKEPLKSWVDNMYGPTGVAVGSGTGILRTLQCDGSVTADIVPVDAVVNCLICAAKSVHSTYAKSRRPIDPPIFNYVSSVENRITWGDFMKHNMEMIDRNPFSDAVWYISLRLTRSAILNNLYILFLHLIPALLVDTLAICLGRKPKMLKVYKKIHKFSSVLSYFTTREISFCNTRTRELWDQTTVEDKELFPFSMAEVNWEEYFESYLAGIRRYLFKESDEMLPRARIKWKRLYYLHQIAKIIFLLLAVYTLWSILSLMW

Description

Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.

Catalytic Activity

a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)

Similarity

Belongs to the fatty acyl-CoA reductase family.

Uniprot

A0A2A4JEW8   A0A291P0J6   A0A0F6Q315   A0A212F4X1   A0A1L8D6A1   D9D5H8   + More
D7P5E2   A0A194PTE7   A0A1B0CRM9   A0A336LZ97   A0A1J1IJD8   A0A336MV31   A0A336LCJ1   K7J6N4   A0A0M9ABB1   A0A1Y1LHX9   A0A232F2D0   K7J6N1   A0A195BRC5   A0A195C2N5   A0A195EZP6   A0A151X2I2   F4W5T8   E9I8G2   A0A195DFI7   A0A232EYC4   A0A310S4M5   D9MX52   A0A2A3E309   V9IIS7   A0A2J7RNA3   A0A067QQS7   E2AKQ3   A0A182YL41   A0A0A1X8B9   A0A084VIN8   A0A1W4W338   A0A2M4AFE5   B0XFN3   A0A1Q3FRD7   A0A0T6BI28   A0A034VW62   A0A0K8TZJ6   A0A0C9PMV0   E2BHA7   D2A5T7   D2A5A7   A0A182L4K5   Q7PZ52   Q174U8   A0A0A1X6J9   A0A067R2Y2   A0A2J7RNB9   U4UI33   A0A0L7RAS9   A0A0T6BDN9   A0A1B6EVR8   B4J1S4   A0A0K8V946   A0A1B6DLK7   D9D5H5   A0A1J1J054   A0A1B6EX35   A0A1B6I9B4   J9K312   A0A1B6CR01   A0A0P0EGI7   A0A1B6KC16   N6UAI6   J9JSM4   B4LFP2   A0A3Q8FRZ7   A0A1B6HWN6   A0A0C9RDR2   A0A0C9QIY9   A0A1V0M882   A0A1A9UNE0   A0A068FRD3   A0A2W1BMW7   A0A0F6Q2Q6   D2A5E7   A0A3Q8G169   A0A194RHP3   A0A1V0M874   A0A2S2R0X5   A0A0P0EM43   K7J7I5   K7J7I3   A0A1B6J450   A0A2J7QR94   A0A1A9Y6E7   J9JUR6   A0A2S2QSR0   A0A2H8TGZ2   K7J6M9   A0A158NHD8  

EC Number

1.2.1.84

Pubmed

28986331    22118469    20534481    26354079    20075255    28004739    + More
28648823    21719571    21282665    20542116    24845553    20798317    25244985    25830018    24438588    25348373    18362917    19820115    20966253    12364791    14747013    17210077    17510324    23537049    17994087    26445454    28349297    26385554    28756777    21347285   

EMBL

NWSH01001831    PCG69973.1    MF687537    ATJ44463.1    KP237937    MF687595    + More
AKD01790.1    ATJ44521.1    AGBW02010301    OWR48770.1    GEYN01000143    JAV01986.1    GU808254    ADI82778.1    GQ907231    ADD62438.1    KQ459593    KPI96248.1    AJWK01024997    AJWK01024998    AJWK01024999    UFQS01000315    UFQT01000315    SSX02758.1    SSX23130.1    CVRI01000054    CRL00357.1    UFQS01002712    UFQT01002712    SSX14582.1    SSX33980.1    SSX14581.1    SSX33979.1    KQ435694    KOX80980.1    GEZM01061226    JAV70627.1    NNAY01001243    OXU24628.1    KQ976417    KYM89582.1    KQ978379    KYM94471.1    KQ981905    KYN33349.1    KQ982576    KYQ54647.1    GL887695    EGI70414.1    GL761538    EFZ23139.1    KQ980903    KYN11612.1    NNAY01001641    OXU23345.1    KQ776822    OAD52165.1    HM536636    ADI87412.1    KZ288460    PBC25481.1    JR049440    AEY60965.1    NEVH01002545    PNF42320.1    KK853504    KDR07123.1    GL440368    EFN65993.1    GBXI01015281    GBXI01013342    GBXI01011681    GBXI01007379    GBXI01001263    JAC99010.1    JAD00950.1    JAD02611.1    JAD06913.1    JAD13029.1    ATLV01013376    KE524854    KFB37832.1    GGFK01006146    MBW39467.1    DS232946    EDS26914.1    GFDL01004901    JAV30144.1    LJIG01000405    KRT86535.1    GAKP01013214    GAKP01013207    JAC45738.1    GDHF01032442    GDHF01031317    GDHF01019601    JAI19872.1    JAI20997.1    JAI32713.1    GBYB01002483    JAG72250.1    GL448287    EFN84876.1    KQ971345    EFA05024.1    EFA05103.1    AAAB01008986    EAA00047.4    CH477405    EAT41616.1    GBXI01007761    JAD06531.1    KK852740    KDR17399.1    PNF42309.1    KB632225    ERL90271.1    KQ414617    KOC68027.1    LJIG01001484    KRT85456.1    GECZ01027740    JAS42029.1    CH916366    EDV98004.1    GDHF01016918    JAI35396.1    GEDC01010770    JAS26528.1    GU808251    ADI82775.1    CVRI01000065    CRL05837.1    GECZ01027241    JAS42528.1    GECU01024246    JAS83460.1    ABLF02017029    GEDC01021312    JAS15986.1    KT261704    ALJ30244.1    GEBQ01030984    JAT08993.1    APGK01036693    KB740941    ENN77646.1    CH940647    EDW70360.2    MG573167    AWJ25029.1    GECU01028612    JAS79094.1    GBYB01014704    JAG84471.1    GBYB01014703    JAG84470.1    KU755485    ARD71195.1    KJ622062    AID66650.1    KZ149959    PZC76399.1    KP237938    MF687591    AKD01791.1    ATJ44517.1    EFA05090.1    MG573162    AWJ25024.1    KQ460152    KPJ17348.1    KU755476    ARD71186.1    GGMS01014433    MBY83636.1    KT261695    ALJ30235.1    GECU01013749    JAS93957.1    NEVH01011924    PNF31087.1    ABLF02040078    GGMS01011572    MBY80775.1    GFXV01001581    MBW13386.1    ADTU01015701    ADTU01015702   

Proteomes

UP000218220    UP000007151    UP000053268    UP000092461    UP000183832    UP000002358    + More
UP000053105    UP000215335    UP000078540    UP000078542    UP000078541    UP000075809    UP000007755    UP000078492    UP000005203    UP000242457    UP000235965    UP000027135    UP000000311    UP000076408    UP000030765    UP000192223    UP000002320    UP000008237    UP000007266    UP000075882    UP000007062    UP000008820    UP000030742    UP000053825    UP000001070    UP000007819    UP000019118    UP000008792    UP000078200    UP000053240    UP000092443    UP000005205   

Pfam

PF07993   NAD_binding_4        + More
PF03015   Sterile

Interpro

IPR026055   FAR        + More
IPR013120   Male_sterile_NAD-bd       
IPR036291   NAD(P)-bd_dom_sf       
IPR033640   FAR_C       

SUPFAM

SSF51735   SSF51735       

CDD

cd09071  FAR_C

ProteinModelPortal

A0A2A4JEW8   A0A291P0J6   A0A0F6Q315   A0A212F4X1   A0A1L8D6A1   D9D5H8   + More
D7P5E2   A0A194PTE7   A0A1B0CRM9   A0A336LZ97   A0A1J1IJD8   A0A336MV31   A0A336LCJ1   K7J6N4   A0A0M9ABB1   A0A1Y1LHX9   A0A232F2D0   K7J6N1   A0A195BRC5   A0A195C2N5   A0A195EZP6   A0A151X2I2   F4W5T8   E9I8G2   A0A195DFI7   A0A232EYC4   A0A310S4M5   D9MX52   A0A2A3E309   V9IIS7   A0A2J7RNA3   A0A067QQS7   E2AKQ3   A0A182YL41   A0A0A1X8B9   A0A084VIN8   A0A1W4W338   A0A2M4AFE5   B0XFN3   A0A1Q3FRD7   A0A0T6BI28   A0A034VW62   A0A0K8TZJ6   A0A0C9PMV0   E2BHA7   D2A5T7   D2A5A7   A0A182L4K5   Q7PZ52   Q174U8   A0A0A1X6J9   A0A067R2Y2   A0A2J7RNB9   U4UI33   A0A0L7RAS9   A0A0T6BDN9   A0A1B6EVR8   B4J1S4   A0A0K8V946   A0A1B6DLK7   D9D5H5   A0A1J1J054   A0A1B6EX35   A0A1B6I9B4   J9K312   A0A1B6CR01   A0A0P0EGI7   A0A1B6KC16   N6UAI6   J9JSM4   B4LFP2   A0A3Q8FRZ7   A0A1B6HWN6   A0A0C9RDR2   A0A0C9QIY9   A0A1V0M882   A0A1A9UNE0   A0A068FRD3   A0A2W1BMW7   A0A0F6Q2Q6   D2A5E7   A0A3Q8G169   A0A194RHP3   A0A1V0M874   A0A2S2R0X5   A0A0P0EM43   K7J7I5   K7J7I3   A0A1B6J450   A0A2J7QR94   A0A1A9Y6E7   J9JUR6   A0A2S2QSR0   A0A2H8TGZ2   K7J6M9   A0A158NHD8  

PDB

4W4T     E-value=1.29228e-09,     Score=152

KEGG

101740654    K13356 alcohol-forming fatty acyl-CoA reductase [EC:1.2.1.84] | (RefSeq) putative fatty acyl-CoA red

PATHWAY

04146    Peroxisome - Bombyx mori (domestic silkworm)

GO

GO:0102965   GO:0016021   GO:0080019   GO:0006629   GO:0035336   GO:0005777   GO:0010025  

PANTHER

PTHR11011  

Length:

547

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

44.92843

Exp number, first 60 AAs:

0.00218

Total prob of N-in:

0.00304

outside

1  -  406

TMhelix

407  -  429

inside

430  -  519

TMhelix

520  -  542

outside

543  -  547

 

 

Pi

169.765228

Theta

135.416726

Tajima's D

0.893203

CLR

0.345507

CSRT

0.628818559072046

Interpretation

Uncertain