Gene

KWMTBOMO14099  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011387

Annotation

PREDICTED:_lachesin_[Amyelois_transitella]

Location

Bomo_Chr23(+):17876043-17902277      View in EpiBrowser

Full name

Lachesin      

Location in the cell

PlasmaMembrane   Reliability : 1.562

CDS

ATGGATCGAAATATTTACGTTTACGTTTTTTACACTTTACTATTGTATTTCACTTGTAATGTATCAGCCCAACGGACACCAACAATCTCGCACATCACACAAGAGCAGATCAGGGATATCGGAGGCCAGGTAGACCTGGAATGTTCCGTGCATTATGCACAAGAGTTTCCTGTTGTCTGGACCAAACGCGATCGTTTGAAGACGATCGAATCGATACCCCTGTCGACCAACGCCGGGCTCATCATCAAGGACTCTAGGTTCTCGCTGCGCCACGACGAGGCAACGGCCACGTTTACGCTCTCCATCAGGGATATTCAAGAGAACGACGCCGGCTGGTACCAGTGCCAAGTGCTGATGTCCATAAGCAATAAGATCGCCGCTGAAGTGGAGCTCCAGGTCAGGAGGCCCCCCATTATATCGGACAATTCCACCAGGTCAATCGTCGCTAGTGAAGGGGAAAGTGTTCAAATGGAATGCTACGCTGGTGGCTTCCCGCCCCCGAAGATATCCTGGCGCCGCGAGAACAACGCCATCCTGCCGACGGGCGGCTCCATCTACAGGGGCAACGTGCTGAAGATAAGCGCCGTCCACAAGGAGGATCGTGGCACTTATTACTGCGTGGCGGACAATGGCGTCGGCAAAGGCGCCCGTCGCAACATCAACCTCGAGGTGGAATTCGCGCCCGTCATCTCCGTGCCCCGCCCGCGCCTCTCCCAGGCCCTCCAATACGACATGGACCTGGAGTGCCACGTGGAGGCCTACCCGCCGCCTGCCATCACCTGGCTGAAAGATGGCATCCAGCTTTCGAACAACCAACATTATAGGATCTCGCATTTCGCAACGGCGGACGAGTTCACGGACACCACGATCAGGGTTATCACGATCGAGAAGCGACAGTACGGGCTGTTCACGTGCAAAGCTCAGAATAAGCTGGGCACCGCGGAAGGGAACGTCGAGCTCACAGAATCCATTATACCCGTGTGCCCTCCCGCCTGCGGCCAGGCGCGGTACGGAGGCGCCGCGGCCGTGGCGCCCTCTGTAGGGACTGTCCTTGCTTTGTTGGGGCTGTACGTGGGAATGGCTTTTAGAAGAATCACCAATACCAAACATTAA

Protein

MDRNIYVYVFYTLLLYFTCNVSAQRTPTISHITQEQIRDIGGQVDLECSVHYAQEFPVVWTKRDRLKTIESIPLSTNAGLIIKDSRFSLRHDEATATFTLSIRDIQENDAGWYQCQVLMSISNKIAAEVELQVRRPPIISDNSTRSIVASEGESVQMECYAGGFPPPKISWRRENNAILPTGGSIYRGNVLKISAVHKEDRGTYYCVADNGVGKGARRNINLEVEFAPVISVPRPRLSQALQYDMDLECHVEAYPPPAITWLKDGIQLSNNQHYRISHFATADEFTDTTIRVITIEKRQYGLFTCKAQNKLGTAEGNVELTESIIPVCPPACGQARYGGAAAVAPSVGTVLALLGLYVGMAFRRITNTKH

Description

Required for normal tracheal development and maintenance of the trans-epithelial diffusion barrier. Functions as a homophilic cell-adhesion molecule. May play a role in early neuronal differentiation and axon outgrowth.

Keywords

Cell adhesion   Cell membrane   Direct protein sequencing   Disulfide bond   Glycoprotein   GPI-anchor   Immunoglobulin domain   Lipoprotein   Membrane   Repeat   Signal   Complete proteome   Developmental protein   Reference proteome  

Feature

chain  Lachesin
propeptide  Removed in mature form

Uniprot

A0A2A4JEZ3   S4PE94   A0A194RP80   A0A194PSG5   A0A1Y1KFY5   A0A212F4V7   + More
E0VLF8   A0A1Y1KGJ7   D2A4T5   A0A2J7RT88   Q26474   A0A1W4X5H3   V9IKJ5   A0A088AD67   A0A3L8DYV5   A0A336KA52   U5EKE0   A0A067RG08   A0A224XST1   K7J4Y7   A0A1L8E4B6   A0A1S3DEJ8   T1HFD8   A0A232ETM3   E2ABV3   E9IXZ9   A0A2A3ELN1   F4WM47   A0A158P3U6   A0A151XA30   Q16W85   A0A1S4FLW2   A0A310SYQ7   A0A2W1B7C4   E2BCH3   A0A195FU83   A0A1I8JVG0   A0A023EQI4   A0A1B6E1A0   A0A1I8JVS8   A0A1Y9IVE3   A0A2S2QLK8   A0A195BDA2   T1PFT8   A0A2M3Z7D2   A0A2M3Z7P5   A0A0N0U3C9   A0A023ERP4   A0A0A9YFY8   A0A2M4ADA2   A0A2H8TWD4   A0A0L0C2H5   A0A1I8PYN4   W8AXG6   A0A1Y1KAK4   A0A0A1XS42   A0A2M4DM53   A0A1Q3FP08   A0A2W1B9N7   A0A2M4BRC7   A0A034W1E0   B0WNS4   Q7QJG1   A0A0K8UJD3   A0A1J1IV80   A0A0N7ZL50   A0A0N7ZVU9   A0A0P5CX73   B3MEM8   A0A0P4YT49   A0A0N8CKI0   B4MFG8   A0A0P5A0D4   A0A0P5A673   A0A3B0J3T0   A0A0P5PR45   A0A0N8CL30   A0A0P5X3D3   A0A2J7RT94   A0A0P6ABA2   A0A0P6I961   A0A0P5HBU1   A0A0P4Z5Y1   Q28Y34   A0A0K8TRV7   A0A195DCH4   B4MYB0   A0A0C9PP76   A0A0P5UWH1   A0A1B0G0D9   E9GM88   A0A026W5J6   J9K778   A0A0J9RC05   B4P596   B3NS03   Q24372   A0A2S2P7T5   A0A1W4U6M0   B4KR82  

Pubmed

23622113    26354079    28004739    22118469    20566863    18362917    + More
19820115    8223276    30249741    24845553    20075255    28648823    20798317    21282665    21719571    21347285    17510324    28756777    24945155    25315136    25401762    26823975    26108605    24495485    25830018    25348373    12364791    17994087    15632085    26369729    21292972    24508170    22936249    17550304    10731132    12537572    12537569    14681183   

EMBL

NWSH01001831    PCG69972.1    GAIX01003266    JAA89294.1    KQ459875    KPJ19653.1    + More
KQ459593    KPI96252.1    GEZM01087701    JAV58525.1    AGBW02010301    OWR48771.1    DS235271    EEB14214.1    GEZM01087700    JAV58526.1    KQ971344    EFA05180.1    NEVH01000006    PNF44050.1    L13256    JR049625    AEY61021.1    QOIP01000002    RLU25403.1    UFQS01000164    UFQT01000164    SSX00682.1    SSX21062.1    GANO01001849    JAB58022.1    KK852658    KDR19146.1    GFTR01005397    JAW11029.1    GFDF01000712    JAV13372.1    ACPB03021649    NNAY01002270    OXU21667.1    GL438382    EFN69091.1    GL766836    EFZ14560.1    KZ288220    PBC32182.1    GL888217    EGI64691.1    ADTU01001341    KQ982353    KYQ57214.1    CH477572    EAT38865.1    KQ759773    OAD62917.1    KZ150256    PZC71792.1    GL447283    EFN86599.1    KQ981264    KYN44018.1    GAPW01002235    JAC11363.1    GEDC01017258    GEDC01005603    JAS20040.1    JAS31695.1    GGMS01009385    MBY78588.1    KQ976519    KYM82165.1    KA647682    AFP62311.1    GGFM01003685    MBW24436.1    GGFM01003707    MBW24458.1    KQ435888    KOX69521.1    GAPW01002234    JAC11364.1    GBHO01041170    GBHO01041169    GBHO01013058    GBRD01017715    GBRD01017714    GDHC01018522    JAG02434.1    JAG02435.1    JAG30546.1    JAG48112.1    JAQ00107.1    GGFK01005443    MBW38764.1    GFXV01006047    MBW17852.1    JRES01000975    KNC26558.1    GAMC01012905    JAB93650.1    GEZM01087703    GEZM01087702    JAV58522.1    GBXI01014726    GBXI01000562    JAC99565.1    JAD13730.1    GGFL01014427    MBW78605.1    GFDL01005716    JAV29329.1    KZ150311    PZC71461.1    GGFJ01006478    MBW55619.1    GAKP01009576    JAC49376.1    DS232014    EDS31915.1    AAAB01008807    EAA04652.4    GDHF01025517    JAI26797.1    CVRI01000059    CRL03046.1    GDIP01234737    JAI88664.1    GDIP01207545    JAJ15857.1    GDIP01168452    JAJ54950.1    CH902619    EDV35492.1    GDIP01224796    JAI98605.1    GDIP01122807    GDIP01110009    JAL80907.1    CH940667    EDW57139.1    GDIP01222342    GDIP01218592    GDIP01201893    GDIP01130953    GDIP01105305    GDIP01102459    GDIP01094558    GDIP01084663    GDIP01080909    GDIP01047422    LRGB01000261    JAJ04810.1    KZS19971.1    GDIP01203491    JAJ19911.1    OUUW01000001    SPP73993.1    GDIQ01145689    JAL06037.1    GDIP01121207    JAL82507.1    GDIP01078314    JAM25401.1    PNF44049.1    GDIP01031756    JAM71959.1    GDIQ01024557    JAN70180.1    GDIQ01230100    JAK21625.1    GDIP01219987    JAJ03415.1    CM000071    EAL26132.3    GDAI01000720    JAI16883.1    KQ980989    KYN10591.1    CH963894    EDW77099.2    GBYB01002993    JAG72760.1    GDIP01107851    JAL95863.1    CCAG010016559    GL732552    EFX79321.1    KK107399    EZA51347.1    ABLF02038223    CM002911    KMY93214.1    CM000158    EDW90758.1    CH954179    EDV56305.2    L13255    AE013599    AY051829    BT003177    GGMR01012871    MBY25490.1    CH933808    EDW08269.1   

Proteomes

UP000218220    UP000053240    UP000053268    UP000007151    UP000009046    UP000007266    + More
UP000235965    UP000192223    UP000005203    UP000279307    UP000027135    UP000002358    UP000079169    UP000015103    UP000215335    UP000000311    UP000242457    UP000007755    UP000005205    UP000075809    UP000008820    UP000008237    UP000078541    UP000075903    UP000076407    UP000075920    UP000078540    UP000095301    UP000053105    UP000037069    UP000095300    UP000002320    UP000007062    UP000183832    UP000007801    UP000008792    UP000076858    UP000268350    UP000001819    UP000078492    UP000007798    UP000092444    UP000000305    UP000053097    UP000007819    UP000002282    UP000008711    UP000000803    UP000192221    UP000009192   

PRIDE

Q24372   

Pfam

PF07679   I-set        + More
PF07686   V-set

Interpro

IPR036179   Ig-like_dom_sf        + More
IPR003598   Ig_sub2       
IPR013783   Ig-like_fold       
IPR003599   Ig_sub       
IPR007110   Ig-like_dom       
IPR013098   Ig_I-set       
IPR013106   Ig_V-set       

SUPFAM

SSF48726   SSF48726       

Gene 3D

2.60.40.10    

ProteinModelPortal

A0A2A4JEZ3   S4PE94   A0A194RP80   A0A194PSG5   A0A1Y1KFY5   A0A212F4V7   + More
E0VLF8   A0A1Y1KGJ7   D2A4T5   A0A2J7RT88   Q26474   A0A1W4X5H3   V9IKJ5   A0A088AD67   A0A3L8DYV5   A0A336KA52   U5EKE0   A0A067RG08   A0A224XST1   K7J4Y7   A0A1L8E4B6   A0A1S3DEJ8   T1HFD8   A0A232ETM3   E2ABV3   E9IXZ9   A0A2A3ELN1   F4WM47   A0A158P3U6   A0A151XA30   Q16W85   A0A1S4FLW2   A0A310SYQ7   A0A2W1B7C4   E2BCH3   A0A195FU83   A0A1I8JVG0   A0A023EQI4   A0A1B6E1A0   A0A1I8JVS8   A0A1Y9IVE3   A0A2S2QLK8   A0A195BDA2   T1PFT8   A0A2M3Z7D2   A0A2M3Z7P5   A0A0N0U3C9   A0A023ERP4   A0A0A9YFY8   A0A2M4ADA2   A0A2H8TWD4   A0A0L0C2H5   A0A1I8PYN4   W8AXG6   A0A1Y1KAK4   A0A0A1XS42   A0A2M4DM53   A0A1Q3FP08   A0A2W1B9N7   A0A2M4BRC7   A0A034W1E0   B0WNS4   Q7QJG1   A0A0K8UJD3   A0A1J1IV80   A0A0N7ZL50   A0A0N7ZVU9   A0A0P5CX73   B3MEM8   A0A0P4YT49   A0A0N8CKI0   B4MFG8   A0A0P5A0D4   A0A0P5A673   A0A3B0J3T0   A0A0P5PR45   A0A0N8CL30   A0A0P5X3D3   A0A2J7RT94   A0A0P6ABA2   A0A0P6I961   A0A0P5HBU1   A0A0P4Z5Y1   Q28Y34   A0A0K8TRV7   A0A195DCH4   B4MYB0   A0A0C9PP76   A0A0P5UWH1   A0A1B0G0D9   E9GM88   A0A026W5J6   J9K778   A0A0J9RC05   B4P596   B3NS03   Q24372   A0A2S2P7T5   A0A1W4U6M0   B4KR82  

PDB

6EG1     E-value=6.1668e-34,     Score=360

KEGG

101740067    no KO assigned | (RefSeq) lachesin

GO

GO:0016021   GO:0005886   GO:0031225   GO:0007155   GO:0035160   GO:0005918   GO:0042803   GO:0016331   GO:0035151   GO:0007156   GO:0019991   GO:0061343   GO:0007424   GO:0005515   GO:0006508   GO:0042626   GO:0016887   GO:0019829   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 23,         Likelihood:  0.979972

 

 

Length:

370

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

38.2137699999999

Exp number, first 60 AAs:

16.05793

Total prob of N-in:

0.76214

POSSIBLE N-term signal

sequence

inside

1  -  4

TMhelix

5  -  24

outside

25  -  339

TMhelix

340  -  362

inside

363  -  370

 

 

Pi

270.40823

Theta

187.881939

Tajima's D

1.865534

CLR

0.369461

CSRT

0.857857107144643

Interpretation

Uncertain