Gene

KWMTBOMO14082  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011217

Annotation

fatty-acyl_CoA_reductase_1_[Ostrinia_nubilalis]

Location

Bomo_Chr23(-):17558655-17570967      View in EpiBrowser

Full name

Fatty acyl-CoA reductase      

Location in the cell

Mitochondrial   Reliability : 1.161 PlasmaMembrane   Reliability : 1.146

CDS

ATGCGGCCTAAGAAATCCGTGAGCCCGGACAAAAGACTGGCTCAATTGTATTCTACTCCTTGCTTCGATAGGCTTCGCAAAGAAAAACCTGGCGTGTTTCAGTCCAAAGTCCTCGTTGTGCCTGGAGATGTAATGGAAGATGGATTAGGTTTATCAGACGAAGACAGGAAACTTCTCGCCGAACGAGTGAATATTGTCTTTCATATAGCTGCTAGTGTGAGATTCGATGACCCCTTGAAGTACGCGGTCAGATTAAACTTGAACGGGACGAAGGAAGTCGTGGAACTAGCTAAGAGTATGCACAACCTATCTTCATTCGTTCACGTGTCGACTAGCTACTCAAACACCAACCGCGAGGTCATCGAGGAGGTGATGTATCCCCCTCACGCTGACTGGAGGGACACCCTGGAGATCTGCGAGAAACTTGACGAGCACACGCTGAGGGTTATGACTCCAAAATATCTCGGAGAGTTGCCCAATACGTACACCTTCAGCAAGCAGTTAGCTGAACACGCTGTATATGAGCAGAGAGGACAACTGCCTGCTGTTATAGTTAGACCGTCTATAGTAATAGCGAGCGCTGATGAACCAATTAGCGGTTGGATTGAGAATTTCAATGGCCCCGTTGGAATATTTGTCGCTTGCGGAAAAGGCATAATGCGTACGTTGTATACGAAGCCAGATATTGTATCTGATTACATACCGGTGGATATATGCGCGAAGAACATTATAGTCGCTGCCTGGGCTAGAGGAACGAAGCCTCTAGAAAGCTCGGACGACGTTGAGATATACAATTGCTGTTCTGGTGAGCTGAACCAAATTAATATCCAGGACCTGATCGAGATGGCCAAGGAGGTAGGCGCCAGTGTCCCCCTGAATGACGCCTTGTGGACAATTGGAGGAAGCATCACCACCTCGGAAAAACTATACTACATCAGGGTATTGGTCCAACATCTCTTGCCGGCGATTTTTGTTGACATAGTCCTTCGTATATTCGGCAAAAAGCCTATGCTCTTCAAAATTCAAAGAAGAATCTACATAGCGAATCTAGCGCTTCGGTATTATATAACGAAGCAATGGACCTTCGAAAATAAAAACTTCCTCGCGCTCAGATCTAAATTACTAGAGCAGGATAAAAAACAATTCTATTACCTACTCGAGGGTAGAGATAAAAAGGATTATTTCTTGAAATGCTGCATCGGTGGAAGGAGGTATCTGATGAAAGAGAGAGACGAAGACATCCCTAAAGCGAAGCTCCGATTTCAGAGAATGATGGTCCTCGACAAGACAGTGCAAGTAATATTCTATGGATTACTCCTATGGTGGTCCATCAAAATATTTAATTATTATTTCGGACTCTACTGTAATTTTTTTGTAGCCTGA

Protein

MRPKKSVSPDKRLAQLYSTPCFDRLRKEKPGVFQSKVLVVPGDVMEDGLGLSDEDRKLLAERVNIVFHIAASVRFDDPLKYAVRLNLNGTKEVVELAKSMHNLSSFVHVSTSYSNTNREVIEEVMYPPHADWRDTLEICEKLDEHTLRVMTPKYLGELPNTYTFSKQLAEHAVYEQRGQLPAVIVRPSIVIASADEPISGWIENFNGPVGIFVACGKGIMRTLYTKPDIVSDYIPVDICAKNIIVAAWARGTKPLESSDDVEIYNCCSGELNQINIQDLIEMAKEVGASVPLNDALWTIGGSITTSEKLYYIRVLVQHLLPAIFVDIVLRIFGKKPMLFKIQRRIYIANLALRYYITKQWTFENKNFLALRSKLLEQDKKQFYYLLEGRDKKDYFLKCCIGGRRYLMKERDEDIPKAKLRFQRMMVLDKTVQVIFYGLLLWWSIKIFNYYFGLYCNFFVA

Description

Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.

Catalytic Activity

a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain primary fatty alcohol + CoA + 2 NADP(+)

Similarity

Belongs to the fatty acyl-CoA reductase family.

Uniprot

A0A3S2NWB0   D9D5H4   A0A2A4K2X0   A0A291P0T9   A0A291P0W8   A0A194PTF8   + More
A0A1L8D6J1   A0A291P0S7   A0A2A4K2J5   A0A194RP84   A0A2H1W7P9   A0A2H1VIF0   A0A212F0B3   A0A1W4WCD3   D6WYQ7   A0A182YH19   A0A182W5X8   A0A182RVQ2   A0A2W1BB54   A0A182FJU1   A0A182QWR0   A0A1S4F214   A0A1Q3FZP3   A0A182T8Q8   A0A1Q3FZV2   A0A182HAJ7   Q7Q2V5   A0A182MZT1   A0A182H739   A0A1B0D476   E2ANI0   A0A084VR72   A0A2J7RI68   A0A182PWI9   A0A067QZV4   B0WYE5   A0A232EY48   A0A2J7RI66   A0A151X3W7   Q17I01   A0A182M7X1   A0A1B6CCS7   A0A3L8DK87   A0A0A9Y3V1   A0A336M1N3   A0A193CHN5   A0A2P8Y5S4   A0A0L7RAZ7   E2BYG6   X1WJJ1   A0A336MN30   B4MEM2   F4WQP0   A0A1B6DEA6   A0A2J7RI77   A0A1B6EWI8   B4L1G7   A0A0L0CAW3   A0A0M4FAK5   D9MWM8   A0A1I8P540   T1PK20   A0A1I8NAX1   A0A088AU73   A0A1W4UW92   K7IMK8   A0A023F0J0   A0A2S2Q9S1   A0A026WLT8   A0A034WLE4   B3MY80   A0A3B0J6S2   W8C494   B4H0C0   Q29H47   A0A0J7K250   A0A158NRZ6   B4JM90   A0A2J7PLY4   A0A1J1HS41   T1I5B7   A0A224XJQ7   A0A0C9PTE7   B4Q1E3   A0A1B6IBF2   A0A336KKV2   B4MTB8   A0A310S7P0   W5JL84   B0WB95   B0WB93   Q17AH3   A0A1I8PJD5   Q17AH5   A0A2M4BL52  

EC Number

1.2.1.84

Pubmed

28986331    26354079    22118469    18362917    19820115    25244985    + More
28756777    17510324    26483478    12364791    14747013    17210077    20798317    24438588    24845553    28648823    30249741    25401762    27271970    29403074    17994087    21719571    26108605    20542116    25315136    20075255    25474469    24508170    25348373    24495485    15632085    21347285    17550304    20920257    23761445   

EMBL

RSAL01000135    RVE46259.1    GU808250    ADI82774.1    NWSH01000254    PCG77992.1    + More
MF687544    ATJ44470.1    MF687600    ATJ44526.1    KQ459593    KPI96258.1    GEYN01000142    JAV01987.1    MF687543    ATJ44469.1    PCG77993.1    KQ459875    KPJ19658.1    ODYU01006856    SOQ49078.1    ODYU01002489    SOQ40034.1    AGBW02011124    OWR47189.1    KQ971357    EFA08449.1    KZ150519    PZC70617.1    AXCN02001406    GFDL01002010    JAV33035.1    GFDL01002009    JAV33036.1    JXUM01122828    KQ566648    KXJ69945.1    AAAB01008967    EAA13114.5    JXUM01115484    JXUM01115485    KQ565885    KXJ70568.1    AJVK01024160    GL441227    EFN65009.1    ATLV01015505    KE525018    KFB40466.1    NEVH01003505    PNF40529.1    KK852809    KDR15980.1    DS232187    EDS37022.1    NNAY01001677    OXU23253.1    PNF40528.1    KQ982562    KYQ54969.1    CH477244    EAT46275.1    AXCM01002370    GEDC01026034    JAS11264.1    QOIP01000007    RLU20840.1    GBHO01016745    GBRD01003868    JAG26859.1    JAG61953.1    UFQS01000395    UFQT01000395    SSX03595.1    SSX23960.1    KU963290    ANN23960.1    PYGN01000896    PSN39593.1    KQ414617    KOC68039.1    GL451478    EFN79250.1    ABLF02038949    ABLF02038951    ABLF02038964    ABLF02057284    UFQT01001371    SSX30233.1    CH940664    EDW62997.1    GL888275    EGI63403.1    GEDC01013326    JAS23972.1    PNF40526.1    GECZ01027461    JAS42308.1    CH933810    EDW06688.2    JRES01000755    KNC28614.1    CP012528    ALC49445.1    HM483392    ADJ56409.1    KA648435    AFP63064.1    GBBI01003720    JAC14992.1    GGMS01005285    MBY74488.1    KK107152    EZA57010.1    GAKP01002566    JAC56386.1    CH902632    EDV32574.1    OUUW01000003    SPP77737.1    GAMC01005674    JAC00882.1    CH479200    EDW29715.1    CH379064    EAL31911.1    LBMM01016171    KMQ84518.1    ADTU01024364    ADTU01024365    ADTU01024366    CH916371    EDV91851.1    NEVH01024421    PNF17348.1    CVRI01000020    CRK90871.1    ACPB03003261    GFTR01006368    JAW10058.1    GBYB01004642    GBYB01004643    JAG74409.1    JAG74410.1    CM000162    EDX02432.1    GECU01023474    JAS84232.1    UFQS01000581    UFQT01000581    SSX05119.1    SSX25480.1    CH963851    EDW75357.2    KQ776822    OAD52159.1    ADMH02001118    ETN64063.1    DS231878    EDS42239.1    EDS42237.1    CH477335    EAT43249.1    EAT43247.1    GGFJ01004658    MBW53799.1   

Proteomes

UP000283053    UP000218220    UP000053268    UP000053240    UP000007151    UP000192223    + More
UP000007266    UP000076408    UP000075920    UP000075900    UP000069272    UP000075886    UP000075901    UP000069940    UP000249989    UP000007062    UP000075884    UP000092462    UP000000311    UP000030765    UP000235965    UP000075885    UP000027135    UP000002320    UP000215335    UP000075809    UP000008820    UP000075883    UP000279307    UP000245037    UP000053825    UP000008237    UP000007819    UP000008792    UP000007755    UP000009192    UP000037069    UP000092553    UP000095300    UP000095301    UP000005203    UP000192221    UP000002358    UP000053097    UP000007801    UP000268350    UP000008744    UP000001819    UP000036403    UP000005205    UP000001070    UP000183832    UP000015103    UP000002282    UP000007798    UP000000673   

Pfam

PF03015   Sterile        + More
PF07993   NAD_binding_4
PF01084   Ribosomal_S18
PF02809   UIM
PF02770   Acyl-CoA_dh_M
PF13519   VWA_2
PF02771   Acyl-CoA_dh_N
PF00441   Acyl-CoA_dh_1
PF12796   Ank_2

Interpro

IPR036291   NAD(P)-bd_dom_sf        + More
IPR013120   Male_sterile_NAD-bd       
IPR033640   FAR_C       
IPR026055   FAR       
IPR036870   Ribosomal_S18_sf       
IPR001648   Ribosomal_S18       
IPR003903   UIM_dom       
IPR009075   AcylCo_DH/oxidase_C       
IPR036465   vWFA_dom_sf       
IPR006091   Acyl-CoA_Oxase/DH_cen-dom       
IPR009100   AcylCoA_DH/oxidase_NM_dom       
IPR037069   AcylCoA_DH/ox_N_sf       
IPR036250   AcylCo_DH-like_C       
IPR013786   AcylCoA_DH/ox_N       
IPR006089   Acyl-CoA_DH_CS       
IPR002035   VWF_A       
IPR002110   Ankyrin_rpt       
IPR036770   Ankyrin_rpt-contain_sf       
IPR020683   Ankyrin_rpt-contain_dom       

SUPFAM

SSF51735   SSF51735        + More
SSF46911   SSF46911       
SSF56645   SSF56645       
SSF53300   SSF53300       
SSF47203   SSF47203       
SSF48403   SSF48403       

Gene 3D

4.10.640.10     1.10.540.10     3.40.50.410     1.25.40.20    

CDD

cd09071  FAR_C
cd00204  ANK

ProteinModelPortal

A0A3S2NWB0   D9D5H4   A0A2A4K2X0   A0A291P0T9   A0A291P0W8   A0A194PTF8   + More
A0A1L8D6J1   A0A291P0S7   A0A2A4K2J5   A0A194RP84   A0A2H1W7P9   A0A2H1VIF0   A0A212F0B3   A0A1W4WCD3   D6WYQ7   A0A182YH19   A0A182W5X8   A0A182RVQ2   A0A2W1BB54   A0A182FJU1   A0A182QWR0   A0A1S4F214   A0A1Q3FZP3   A0A182T8Q8   A0A1Q3FZV2   A0A182HAJ7   Q7Q2V5   A0A182MZT1   A0A182H739   A0A1B0D476   E2ANI0   A0A084VR72   A0A2J7RI68   A0A182PWI9   A0A067QZV4   B0WYE5   A0A232EY48   A0A2J7RI66   A0A151X3W7   Q17I01   A0A182M7X1   A0A1B6CCS7   A0A3L8DK87   A0A0A9Y3V1   A0A336M1N3   A0A193CHN5   A0A2P8Y5S4   A0A0L7RAZ7   E2BYG6   X1WJJ1   A0A336MN30   B4MEM2   F4WQP0   A0A1B6DEA6   A0A2J7RI77   A0A1B6EWI8   B4L1G7   A0A0L0CAW3   A0A0M4FAK5   D9MWM8   A0A1I8P540   T1PK20   A0A1I8NAX1   A0A088AU73   A0A1W4UW92   K7IMK8   A0A023F0J0   A0A2S2Q9S1   A0A026WLT8   A0A034WLE4   B3MY80   A0A3B0J6S2   W8C494   B4H0C0   Q29H47   A0A0J7K250   A0A158NRZ6   B4JM90   A0A2J7PLY4   A0A1J1HS41   T1I5B7   A0A224XJQ7   A0A0C9PTE7   B4Q1E3   A0A1B6IBF2   A0A336KKV2   B4MTB8   A0A310S7P0   W5JL84   B0WB95   B0WB93   Q17AH3   A0A1I8PJD5   Q17AH5   A0A2M4BL52  

PDB

4W4T     E-value=0.001627,     Score=99

KEGG

101739190    K13356 alcohol-forming fatty acyl-CoA reductase [EC:1.2.1.84] | (RefSeq) putative fatty acyl-CoA red

PATHWAY

04146    Peroxisome - Bombyx mori (domestic silkworm)

GO

GO:0102965   GO:0016021   GO:0006629   GO:0080019   GO:0010025   GO:0005777   GO:0035336   GO:0003735   GO:0006412   GO:0005840   GO:0003995   GO:0050660  

PANTHER

PTHR11011  

Length:

460

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

38.83979

Exp number, first 60 AAs:

0.00017

Total prob of N-in:

0.05650

outside

1  -  430

TMhelix

431  -  453

inside

454  -  460

 

 

Pi

152.337565

Theta

139.287121

Tajima's D

0.628739

CLR

0.414322

CSRT

0.556522173891305

Interpretation

Uncertain