Gene

KWMTBOMO14070

Pre Gene Modal

BGIBMGA011378

Annotation

PREDICTED:_lysosomal_alpha-mannosidase-like_[Bombyx_mori]

Location

Bomo_Chr23(+):17260282-17263223      View in EpiBrowser

Full name

Alpha-mannosidase       + More
Lysosomal alpha-mannosidase      

Alternative Name

Lysosomal acid alpha-mannosidase
Mannosidase alpha class 2B member 1
Mannosidase alpha-B

Location in the cell

Extracellular   Reliability : 2.076 Nuclear   Reliability : 1.453

CDS

ATGGTACTATATGGCACAGACGAAGATATAGAGTATCAACTAGTGCCTCTCCCGGCTGCAGTACTAAGTCTTACTGGGCGAACGTCTTCGGCGATCCAGGAGTTGTGTTTTGAAGCAGAGAACATTCCACCCCTGGGGTACACTTCATATTACGTCACGCTTGTCCGTGATCAACTGGAAGAAAACGAATACGCCAAGAAATCAGCTAAGGGCCACGTCGAGGCGGAACAAGAGGTCGCCACTTCTATATCCAATGAGTATCTCAAAATCTCGATCGAACAATCCACTGGTCTGCTGTCTTCCATCCAACACGTTGATGGGGTATCAATAGCTGTATCTCAGAACTTCCACTACTACGGTCAGGGTAAGAGCAGTCAGCAGTCAGGAGCCTATAGCTTCAGGCCAGAGACGCAGCGACCAGTGCCGGTCACCGACAAGGCCACTTACAACGTGGTACGAGGTACGCTGATAAAAGAGATCAGACAAAGATTCAATGATTGGGTGTCCCAGGTCATAAGATTGTACCGTGGCGAGGAGTTTGTTGAGCTTGAGTGGATTATAGGCCCGGTTCCTGTAGGGACAGACTTGGGAAAAGAAGTCGTGATGCTGTTCTCAACTAACATCAGCAACAGCGGAGAATTCTTCACGGATTCCAACTCGCGACAGATGATGAAACGGACCTGTTGGAACGAGACGACTAGTGAGTTGAAGCAAAGCTTTAATAAAAGTAGAACTTCTGACGTTTAA

Protein

MVLYGTDEDIEYQLVPLPAAVLSLTGRTSSAIQELCFEAENIPPLGYTSYYVTLVRDQLEENEYAKKSAKGHVEAEQEVATSISNEYLKISIEQSTGLLSSIQHVDGVSIAVSQNFHYYGQGKSSQQSGAYSFRPETQRPVPVTDKATYNVVRGTLIKEIRQRFNDWVSQVIRLYRGEEFVELEWIIGPVPVGTDLGKEVVMLFSTNISNSGEFFTDSNSRQMMKRTCWNETTSELKQSFNKSRTSDV

Description

Necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover.

Catalytic Activity

Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Cofactor

Zn(2+)

Similarity

Belongs to the glycosyl hydrolase 38 family.

Keywords

Complete proteome   Disease mutation   Disulfide bond   Glycoprotein   Glycosidase   Hydrolase   Lysosome   Metal-binding   Polymorphism   Reference proteome   Signal   Zinc  

Feature

chain  Alpha-mannosidase

Uniprot

H9JPC4   A0A2A4IXJ1   A0A2H1VKW2   A0A194PYQ5   A0A194RQK5   A0A2W1BMA0   + More
A0A0N0PAB2   B4G755   A0A1W7RA88   A0A1J1I5Z3   A0A1J1I212   B4MUA9   A0A182NTB6   A0A2M4A654   A0A1A9W6T1   T1DKM1   A0A2M4AA63   A0A0K8UDG9   A0A1S4FBS2   Q178W0   A0A0K8VXG8   A0A2M4A8S3   A0A0K8V7P4   A0A336M0Y1   B3MJI9   A0A0P8XGR3   A0A3B0JH89   A0A0K8WDF9   A0A0K8VT60   A0A1J1HED6   A0A182T218   A0A0K8U3N4   A0A0K8VTI9   A0A0K8UEK7   A0A034V6I7   A0A182K5Y1   A0A0C9RC73   D3TLE1   A0A182QYP4   A0A0J9R086   A0A0F8AN86   B4HWQ4   T1DPQ0   B4Q9B2   A0A182F0V2   W5JQI4   A0A0C9RFA7   A0A3B0K7V8   A0A3B0JH41   A0A3B0JHP2   A0A2M4BBR5   A0A2M4BBT1   A0A2M4BB44   A0A1A9ZH71   A0A2M4BB57   A0A2M4BAP9   A0A1W4UG04   A0A182P6H2   A0A1W4UUP0   A0A182WFK9   A0A2M4CKL5   A0A1A9VXF3   A0A0A1XEF2   A0A2D4PM28   A0A182MB09   A0A0A1WZV2   A0A336KYX3   A0A1A9XCE3   A0A1W7RG41   B4LVB7   A0A182YPT8   A0A1W4WS90   A0A0Q9WJC0   A0A182RK94   A0A293L9C5   A0A1B0B0M4   A0A1B0G2D6   A0A1I8M2X1   A0A1I8M2X3   A0A0C3SFZ0   Q8VHC8   A0A084VFG4   A0A2D4G6W3   D6WI18   A0A182X605   M3ZDS7   A0A087ZZ79   A0A182KMH3   A0A084VFG7   A0A182UGZ7   A0A182VJW0   A0A182UU05   A0A1W4WHJ3   A0A2D4PM26   A0A1Y1KHF4   A0A1S4GYN8   A0A2L2Y8M2   Q5TS83   A0A0Q5WN53   M7BNC3  

EC Number

3.2.1.-
3.2.1.24

Pubmed

19121390    26354079    28756777    17994087    17510324    25348373    + More
20353571    22936249    25835551    20920257    23761445    25830018    26358130    25244985    25315136    21993624    11959458    24438588    18362917    19820115    23542700    20966253    28004739    12364791    26561354    23624526   

EMBL

BABH01009810    NWSH01004815    PCG64677.1    ODYU01002940    SOQ41072.1    KQ459593    + More
KPI96285.1    KQ459875    KPJ19679.1    KZ150153    PZC72813.1    KQ459002    KPJ04400.1    CH479180    EDW28309.1    GFAH01000335    JAV48054.1    CVRI01000038    CRK93801.1    CRK93802.1    CH963857    EDW76035.2    GGFK01002914    MBW36235.1    GAMD01000881    JAB00710.1    GGFK01004311    MBW37632.1    GDHF01027706    JAI24608.1    CH477358    EAT42739.1    GDHF01008727    JAI43587.1    GGFK01003882    MBW37203.1    GDHF01017576    JAI34738.1    UFQT01000391    SSX23894.1    CH902620    EDV32357.1    KPU73915.1    OUUW01000006    SPP81717.1    GDHF01003182    JAI49132.1    GDHF01010271    GDHF01002021    JAI42043.1    JAI50293.1    CVRI01000001    CRK86319.1    GDHF01030990    JAI21324.1    GDHF01010454    JAI41860.1    GDHF01027225    GDHF01012263    JAI25089.1    JAI40051.1    GAKP01021245    JAC37707.1    GBYB01004536    JAG74303.1    EZ422243    ADD18519.1    AXCN02000717    CM002910    KMY89556.1    KQ041358    KKF27907.1    CH480818    EDW52449.1    GAMD01001740    JAA99850.1    CM000361    EDX04554.1    KMY89555.1    ADMH02000752    ETN65165.1    GBYB01011777    JAG81544.1    SPP81716.1    SPP81714.1    SPP81715.1    GGFJ01001332    MBW50473.1    GGFJ01001331    MBW50472.1    GGFJ01001133    MBW50274.1    GGFJ01001132    MBW50273.1    GGFJ01000993    MBW50134.1    GGFL01001607    MBW65785.1    GBXI01004996    JAD09296.1    IACN01081384    LAB59085.1    AXCM01004170    GBXI01009935    JAD04357.1    UFQS01001264    UFQT01001264    SSX10043.1    SSX29765.1    GDAY02001327    JAV50100.1    CH940649    EDW63296.2    KRF81022.1    GFWV01000333    MAA25063.1    JXJN01006781    CCAG010023722    AAKN02038626    AY036153    AY036154    AY036155    ATLV01012389    KE524787    KFB36708.1    IACJ01116926    LAA55510.1    KQ971332    EEZ99703.1    ATLV01012390    KFB36711.1    IACN01081383    LAB59082.1    GEZM01085309    JAV60008.1    AAAB01008944    IAAA01017255    LAA03680.1    EAL40242.3    CH954177    KQS70602.1    KB522805    EMP37225.1   

Proteomes

UP000005204    UP000218220    UP000053268    UP000053240    UP000008744    UP000183832    + More
UP000007798    UP000075884    UP000091820    UP000008820    UP000007801    UP000268350    UP000075901    UP000075881    UP000075886    UP000001292    UP000000304    UP000069272    UP000000673    UP000092445    UP000192221    UP000075885    UP000075920    UP000078200    UP000075883    UP000092443    UP000008792    UP000076408    UP000192223    UP000075900    UP000092460    UP000092444    UP000095301    UP000005447    UP000030765    UP000007266    UP000076407    UP000002852    UP000005203    UP000075882    UP000075902    UP000075903    UP000007062    UP000008711    UP000031443   

PRIDE

H9JPC4    Q8VHC8   

Pfam

PF07748   Glyco_hydro_38C        + More
PF01074   Glyco_hydro_38N
PF09261   Alpha-mann_mid
PF17677   Glyco_hydro38C2

Interpro

IPR037094   Glyco_hydro_38_cen_sf        + More
IPR027291   Glyco_hydro_38_N_sf       
IPR028995   Glyco_hydro_57/38_cen_sf       
IPR011682   Glyco_hydro_38_C       
IPR013780   Glyco_hydro_b       
IPR011013   Gal_mutarotase_sf_dom       
IPR011330   Glyco_hydro/deAcase_b/a-brl       
IPR000602   Glyco_hydro_38_N       
IPR015341   Glyco_hydro_38_cen       
IPR041147   GH38_C       

SUPFAM

SSF88713   SSF88713        + More
SSF88688   SSF88688       
SSF74650   SSF74650       

Gene 3D

1.20.1270.50     2.60.40.1180     3.20.110.10    

ProteinModelPortal

H9JPC4   A0A2A4IXJ1   A0A2H1VKW2   A0A194PYQ5   A0A194RQK5   A0A2W1BMA0   + More
A0A0N0PAB2   B4G755   A0A1W7RA88   A0A1J1I5Z3   A0A1J1I212   B4MUA9   A0A182NTB6   A0A2M4A654   A0A1A9W6T1   T1DKM1   A0A2M4AA63   A0A0K8UDG9   A0A1S4FBS2   Q178W0   A0A0K8VXG8   A0A2M4A8S3   A0A0K8V7P4   A0A336M0Y1   B3MJI9   A0A0P8XGR3   A0A3B0JH89   A0A0K8WDF9   A0A0K8VT60   A0A1J1HED6   A0A182T218   A0A0K8U3N4   A0A0K8VTI9   A0A0K8UEK7   A0A034V6I7   A0A182K5Y1   A0A0C9RC73   D3TLE1   A0A182QYP4   A0A0J9R086   A0A0F8AN86   B4HWQ4   T1DPQ0   B4Q9B2   A0A182F0V2   W5JQI4   A0A0C9RFA7   A0A3B0K7V8   A0A3B0JH41   A0A3B0JHP2   A0A2M4BBR5   A0A2M4BBT1   A0A2M4BB44   A0A1A9ZH71   A0A2M4BB57   A0A2M4BAP9   A0A1W4UG04   A0A182P6H2   A0A1W4UUP0   A0A182WFK9   A0A2M4CKL5   A0A1A9VXF3   A0A0A1XEF2   A0A2D4PM28   A0A182MB09   A0A0A1WZV2   A0A336KYX3   A0A1A9XCE3   A0A1W7RG41   B4LVB7   A0A182YPT8   A0A1W4WS90   A0A0Q9WJC0   A0A182RK94   A0A293L9C5   A0A1B0B0M4   A0A1B0G2D6   A0A1I8M2X1   A0A1I8M2X3   A0A0C3SFZ0   Q8VHC8   A0A084VFG4   A0A2D4G6W3   D6WI18   A0A182X605   M3ZDS7   A0A087ZZ79   A0A182KMH3   A0A084VFG7   A0A182UGZ7   A0A182VJW0   A0A182UU05   A0A1W4WHJ3   A0A2D4PM26   A0A1Y1KHF4   A0A1S4GYN8   A0A2L2Y8M2   Q5TS83   A0A0Q5WN53   M7BNC3  

PDB

1O7D     E-value=3.30004e-28,     Score=309

KEGG

101738761    K12311 lysosomal alpha-mannosidase [EC:3.2.1.24] | (RefSeq) lysosomal alpha-mannosidase-like

GO

GO:0006013   GO:0004559   GO:0030246   GO:0046872   GO:0004571   GO:0016021   GO:0007611   GO:0005764   GO:0005774   GO:0006517   GO:0015923   GO:0003824   GO:0005975   GO:0019829   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

Subcellular location

Lysosome  

Length:

248

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.01112

Exp number, first 60 AAs:

0.0097

Total prob of N-in:

0.03489

outside

1  -  248

 

 

Pi

191.793624

Theta

156.070463

Tajima's D

0.973348

CLR

0.117649

CSRT

0.656667166641668

Interpretation

Uncertain