Gene

KWMTBOMO14061

Pre Gene Modal

BGIBMGA011228

Annotation

PREDICTED:_multidrug_resistance_protein_homolog_49-like_[Bombyx_mori]

Location

Bomo_Chr23(-):17062172-17086662      View in EpiBrowser

Full name

Multidrug resistance protein 1       + More
Bile salt export pump      

Alternative Name

ATP-binding cassette sub-family B member 1
P-glycoprotein 1
ATP-binding cassette sub-family B member 11
Sister of P-glycoprotein

Location in the cell

Mitochondrial   Reliability : 1.408 PlasmaMembrane   Reliability : 1.881

CDS

ATGGACGCTTTAGTGGAAGACTCCAGGGCGTTTGGATTGGCTAGCGTGGTGATCATGATAATGCAGATGACGACTGCCGCGTTTGCCGTCATCACGGCGAACTGGGCCGCTACTAGAATGGTAACAAGATTACGTCTTCGGATCCTGCGATCGGTATTAAGTCAAGAGATAGCATTTTTCGATACAAACACTACAATGAATTTCGCGTCGACGTTGACAGAGGACATGGAGAAGCTACAAGCGGGAGTGGGGGAGCATGTCGTGATGACGACATACTTAGCCGGGACGGTTGTGTGTGGCTCAGCTCTATCTCTTTCATACGGCTGGGAGCTGACATTAGCCGGGCTCTCTGTGGTTCCTGTTGCTATCCTTGTCGCAACAGTTGTTGCTAAGTACCAAACTAAATGTTCGACCAATGAGGTGGTGGCGTACGGAGTTGCCGGAAGAATAGTCGAGGAGGTATTGTCTGCTATTAGGACAGTAAGGGCTTATGGTGGAGAGGAACTTGAAGTTAAAAGGTACTCGGAAGCTCTAAAGCCAGCGGCCTCACACGCTCGTCGTCGTGGTCTCTGGGCTGGGGCGGGTTCAGGTCTTGGCTGGCTGCTCACCTACAGTCTAAACGCTATAGTCCTGGCTTACGGAACAGCTTTATGCGTCAGAGACTCGGATCTACCCCCAGAAGAACAGGATTACCATCCTGGCATCATGGTTACTATTCTGTTCTGCACTTTCGTGGCGGCGCAGAATATAGCGATGTGCAACCCTCATCTGGAGATATTCTCGACGGCGCGTGGAGCTGCCAAATCTCTATTCAAGCTAATCGAGAGGAAGTCCAATATCGACGCACTGGAGAACGTAGGAGTTAAGCCGGAGAGCTTCAGAGGCGATATCCAGTTCGAGAATCTGTACTTCAATTACCCTTCGAGACCCGACGTGAAGGTCCTAAGGGGGCTGACCCTCAAGATATCAGCGGGGGAGACAGTGGCCCTAGTCGGTTCCTCGGGCTGCGGTAAGTCGACGCTGCTGCAACTCCTGCAGAGGATGTACGAGCCCGAAACTGGACGAGTAGTTGTTGATGGCCATCCCCTAAACAAACTTCATCTGCACCATTTCAGGAAGAGCATAGGCGTGGTCGGCCAAGAACCAGTGCTCTTCTGCGGAACGATCAGAGAGAACATCACTTTCGGGATGGACGACGTCACAGAGGAACAGATGATCGAGGCAGCCAAAACTGCGCACGCGCATCAATTCATCACCAAACTCGCAAATGGCTATGACACCATGCTGGGAGAGCGCGGCGCTGCCCTATCTGGTGGACAGAAGCAGAGAATCGCGATAGCACGTGCCATAGTCAGACGTCCCGCTGTCTTGCTATTGGACGAGCCGACTTCTGCGCTAGACCCTGCTGCTGAGAAACAGGTCCAAGCAGCCCTGGACGCAGCTAGTAAAGGGCGCACCACACTCGTAGTCTCGCACAGACTATCGACCATTGCAAATGCTTCAAAGATCGTCTACATCGAACAAGGATCCGTGTTGGAGCAGGGAACTCATGCGGAACTGCTAGAGAAAAAAGGAAATTACTGGAAATTGCTCAACGAAGATCTGACTAGCAAGAGCATAGCAGCCACGTTATCAGCGGCCGGAAACGATGATGACGACGAGGTACTAGAGACTGTTGAAGAATGTCGTTTCCGAAGGTCCGTCAGCAGACAATCGATGCATCGAGAATCTATGAATCGGAACCACTTCGTGCGGGGCAGTCGCCGATTGAGGTCCATCTCATCGGCCCATCTGCCGGTCACCGCTGTGCCCGATCTCCTCAACTACGTGGAACCGGAAGAGACGGAAGACGAATCAGTCCCAGAGGTGTCCAGCTTGGCGCTGATGAAGCTGAACGCTCCGGAGTGGCCGCTGCTGATGGGCGGTGGCGTCGCCTCATTCTTGGTCGGTTCAACGATGCCGATATTCGCTTTGCTCTTCTCCAAATTATACGGGATGTTCGCCTCTGATGACACGGACGCGATCCTCGAGCAGTCGCAGCTGTATGCGGGACTCTTCGCCGGAGTCGCGGCCGCCTGCGGGATCGTCAACTTCCTCCAGACGTGGCTCCTGAGCAAGGCCGGCTCCAAGCTCACCGACAGACTGAGAGAGCACAGTTTCAGGAACTATTTGAAACAGGAGCAAGGCTGGTTTGACGAGCAAGCTAATTCTGTCGGGGCTCTCTGCGCCAGACTCTCCTCTGACTGCGCTGCTGTACAAGGAGCTACAGGTACCAAATTGGGGACGGTGCTCCAAGGCGTGAGCACGATGGTTATCGGTGTCGGACTGGCAATGGCATACTCGTGGAAGATGACATTAGTTAGCCTGACAAGCGTTCCTTGTGTCATGGGCGCCATCTATCTCGAAGGCTACGTGAACAAACGCACCGAAGAGAAACAGAAGAAAGCGATAGAGCACGCTTCGCGCGTCGCCACTGAAGCAGTACTGAACGTGCGCACCGTACAGAGCCTGGGTGTGGAGCTGACAGTCTTGGAGAAGTACGAACGCGCGCTGATGGGGGGTGGCGGTAGAGGGGGGAGTGGCGCAATGCGAGGCGCGGTGTACGGGGCGTGTCTGTGCGCACCTACGCTCGGTTACGCCGTGTCGTTAGCCTACGGAGGCTATCTCATCGCAACCGAAGGCCTGCACTATGAATACGCTATTCTGGTGTCCGAGGCGCTGATCTACGGAGCGTGGATGCTGGCTGAAGCGCTCTCATTCGCGCCAAACTTCGCCGCCGCCAAGCGCTCTGGGGCCAGGATCATTAATGCCCTAGCCAGGGAACCGAAGATCGTAACTGAACCAACAGCGAAGGATGAACCAGCATGGACCGCGAAAGGAGAGGTTAACTTCTCTGATTTACACTTCAACTATCCAACTCGGCCTTCAGTGCCGGTCCTGCGAGGCCTGAACCTTCAGCTCAAGGCCGGGCGCACTGTAGCGCTCGTCGGGGCCAGCGGCTGCGGGAAATCCACTCTGATGCACCTTATCATGAGGAGCTATGACCCTACTAAAGGCAAAGTTGAACTAGACGGGAGAGATATAAAGCGCGATCTTTCGCTGCCCAGTCTGAGATCGAACCTGGGACTCGTGCAACAAGAACCAGCGCTTTTCGAACGTTCAATCAGGGAAAATATTGCATACGGAGACAATTCACGGGATGTGACCTTGGAAGAGATTATAGACGCTGCGAAACAAGCGAACGTACACGGTTTTGTGGCGGGCTTACCTTTGGGCTACGAAACGAAGCTGGGACAAGGCGGAGCTGCTCTGTCCGGGGGACAGAAGCAGAGGATCGCGATCGCAAGGGCCTTGGTACGAAACCCGAGGGTTTTGCTACTGGACGAAGCCACATCAGCCTTGGATGCTTCCAGTGAAAAGGTGGTGCAAAGCGCTCTGGAAGTCGCCGCCAAAGATCGAACGACAATTATAATAGCTCATCGACTAGCTACGATCAGACATGCACACACGATATGCGTGGTCGAGAACGGAGTCATAGCCGAAAGCGGATCACATGACGAGCTGGTCCGAAAACGTGGACTTTACTGGGAATTATTGCAGCAGCAAGGACCCTCGGAAGCGAAAGCGTGA

Protein

MDALVEDSRAFGLASVVIMIMQMTTAAFAVITANWAATRMVTRLRLRILRSVLSQEIAFFDTNTTMNFASTLTEDMEKLQAGVGEHVVMTTYLAGTVVCGSALSLSYGWELTLAGLSVVPVAILVATVVAKYQTKCSTNEVVAYGVAGRIVEEVLSAIRTVRAYGGEELEVKRYSEALKPAASHARRRGLWAGAGSGLGWLLTYSLNAIVLAYGTALCVRDSDLPPEEQDYHPGIMVTILFCTFVAAQNIAMCNPHLEIFSTARGAAKSLFKLIERKSNIDALENVGVKPESFRGDIQFENLYFNYPSRPDVKVLRGLTLKISAGETVALVGSSGCGKSTLLQLLQRMYEPETGRVVVDGHPLNKLHLHHFRKSIGVVGQEPVLFCGTIRENITFGMDDVTEEQMIEAAKTAHAHQFITKLANGYDTMLGERGAALSGGQKQRIAIARAIVRRPAVLLLDEPTSALDPAAEKQVQAALDAASKGRTTLVVSHRLSTIANASKIVYIEQGSVLEQGTHAELLEKKGNYWKLLNEDLTSKSIAATLSAAGNDDDDEVLETVEECRFRRSVSRQSMHRESMNRNHFVRGSRRLRSISSAHLPVTAVPDLLNYVEPEETEDESVPEVSSLALMKLNAPEWPLLMGGGVASFLVGSTMPIFALLFSKLYGMFASDDTDAILEQSQLYAGLFAGVAAACGIVNFLQTWLLSKAGSKLTDRLREHSFRNYLKQEQGWFDEQANSVGALCARLSSDCAAVQGATGTKLGTVLQGVSTMVIGVGLAMAYSWKMTLVSLTSVPCVMGAIYLEGYVNKRTEEKQKKAIEHASRVATEAVLNVRTVQSLGVELTVLEKYERALMGGGGRGGSGAMRGAVYGACLCAPTLGYAVSLAYGGYLIATEGLHYEYAILVSEALIYGAWMLAEALSFAPNFAAAKRSGARIINALAREPKIVTEPTAKDEPAWTAKGEVNFSDLHFNYPTRPSVPVLRGLNLQLKAGRTVALVGASGCGKSTLMHLIMRSYDPTKGKVELDGRDIKRDLSLPSLRSNLGLVQQEPALFERSIRENIAYGDNSRDVTLEEIIDAAKQANVHGFVAGLPLGYETKLGQGGAALSGGQKQRIAIARALVRNPRVLLLDEATSALDASSEKVVQSALEVAAKDRTTIIIAHRLATIRHAHTICVVENGVIAESGSHDELVRKRGLYWELLQQQGPSEAKA

Catalytic Activity

ATP + H(2)O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).

Subunit

Interacts with PSMB5. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.
Interacts with HAX1.

Similarity

Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

Keywords

3D-structure   Alternative splicing   ATP-binding   Cell membrane   Complete proteome   Glycoprotein   Membrane   Nucleotide-binding   Phosphoprotein   Polymorphism   Reference proteome   Repeat   Translocase   Transmembrane   Transmembrane helix   Transport  

Feature

chain  Multidrug resistance protein 1
splice variant  In isoform 2.
sequence variant  In dbSNP:rs28381804.

Uniprot

H9JNX4   A0A212EWQ3   A0A194PSR0   A0A2W1BMH9   A0A194RIJ9   S4PS85   + More
G1N7X9   A1L471   A4D1D2   P08183   A0A3Q1MIC7   A0A3Q1LSK6   A0A3Q1MB23   A0A3Q1M4U7   A0A3Q1N4W6   A0A2I3RUL7   G3X771   A0A2J8LGL5   P08183-2   A0A3Q1LLE7   R0LA26   H0W664   A0A2I3SAW5   A0A286Y4X3   U3J638   A0A2K6F8D6   H3BX23   H3DLX8   A0A286Y222   G1T8G4   A0A2K6F8D9   A0A3Q3W6X8   Q59GY9   A0A1L8FW23   A0A3Q1MBX4   A0A1S3AAJ5   A0A3Q1EGM2   H0XA28   A0A1L8FJP3   A0A2I4AN87   A0A3Q3G900   A0A2B4SKX2   A0A3M6TT74   F6WP30   A0A3Q2WEY9   A0A3Q4MRI3   A0A3S2MFJ1   T2MH87   A0A1S3G2B0   G3WW89   A0A2Y9I3G6   A0A3B4DV36   G1SFA7   G5C8Q9   V5RGD6   M3W5B1   A0A3B3R2U8   A0A0G2STD5   A0A2D0R8W3   A0A0U3J9B3   A0A0G2STH1   A0A3B3D0M8   A0A2I2UZR1   W6RT37   A0A0U3JI91   O88331   I3M9U5   A0A2P1EA62   O70127   A0A3B3D028   A0A3B4DWT2   M0R4J2   G3PLC2   A0A3P9IEA7   F7E6I5   A0A3B3Y5I2   A0A1S3ARM6   F7E6I9   A0A3B3VYW6   K7G9F4   A0A3Q1J7X7   A0A3Q4I317   A0A3Q3JNF8   A0A3B4YQJ3   A0A3Q3JNL0   H0V6N1   I3K1B5   A0A3Q2ZSG3   C7DPK6   A0A3G2BZ64   W5LHI0   A0A091DI45   A0A3P8SCQ9   S4RF62   A0A2I4AN49   A0A3Q3EZW1   A0A3Q4HYM2   A0A2Y9IA97   S4RP00  

EC Number

7.6.2.2

Pubmed

19121390    22118469    26354079    28756777    23622113    20838655    + More
15489334    11181995    12690205    2876781    1967175    9038218    14702039    12853948    1972623    2568832    11258197    15488952    18669648    21269460    24333728    2897240    9473242    10790226    10716719    11240981    15618700    15618713    11829140    14610718    16959974    19393038    16136131    21993624    23749191    15496914    27762356    30382153    18464734    25186727    24065732    21709235    21993625    17975172    29240929    26047617    26472499    29451363    28645914    9545351    15159385    22673903    15057822    17554307    17381049    25329095   

EMBL

BABH01009789    BABH01009790    AGBW02011924    OWR45901.1    KQ459593    KPI96347.1    + More
KZ149962    PZC76282.1    KQ460152    KPJ17387.1    GAIX01014073    JAA78487.1    BC130424    AAI30425.1    EU852583    CH236949    CH471091    ACF94687.1    EAL24173.1    EAW76942.1    M14758    M29447    M29424    M29425    M29426    M29427    M29428    M29429    M29430    M29431    M29432    M29433    M29434    M29435    M29436    M29437    M29438    M29439    M29440    M29441    M29442    M29443    M29444    M29445    M29446    AF016535    EU854148    AY910577    AK290159    AC002457    AC005068    M37724    M37725    X58723    AC188793    NBAG03000292    PNI46390.1    PNI46391.1    KB742957    EOB02509.1    AAKN02015613    AAKN02015614    AAKN02015615    AAKN02015616    PNI46392.1    ADON01060606    AAGW02061962    AAGW02061963    AB208970    BAD92207.1    CM004476    OCT75761.1    AAQR03012493    AAQR03012494    AAQR03012495    CM004478    OCT71794.1    LSMT01000057    PFX30016.1    RCHS01002978    RMX44531.1    CM012457    RVE58009.1    HAAD01005239    CDG71471.1    AEFK01112012    AEFK01112013    AEFK01112014    AEFK01112015    AEFK01112016    AEFK01112017    AEFK01112018    AEFK01112019    AAGW02004142    AAGW02004143    AAGW02004144    JH173922    GEBF01000776    EHB17920.1    JAO02857.1    KF601333    AHB33636.1    AANG04001482    KM232919    AKC42134.1    KP725019    ALU63321.1    KM232927    AKC42142.1    HG917100    CDM63421.1    KP725033    ALU63335.1    AF010597    AAC24753.1    AGTP01000190    AGTP01000191    MG254896    AVL26215.1    U69487    AABR07052465    AABR07052466    AABR07052467    AABR07052468    AABR07052469    AABR07052470    AABR07052471    AAPN01001001    AAPN01001002    AAPN01001003    AAPN01001004    AAPN01001005    AAPN01001006    AAPN01001007    AAPN01001008    AGCU01170418    AGCU01170419    AGCU01170420    AGCU01170421    AGCU01170422    AGCU01170423    AGCU01170424    AGCU01170425    AAKN02005698    AERX01005839    AERX01005840    GQ169125    ACU12846.1    MH420554    AYM45158.1    KN124048    KFO22476.1   

Proteomes

UP000005204    UP000007151    UP000053268    UP000053240    UP000001645    UP000005640    + More
UP000009136    UP000002277    UP000005447    UP000016666    UP000233160    UP000007303    UP000001811    UP000261620    UP000186698    UP000079721    UP000257200    UP000005225    UP000192220    UP000264800    UP000225706    UP000275408    UP000002279    UP000264840    UP000261580    UP000081671    UP000007648    UP000248481    UP000261440    UP000006813    UP000011712    UP000261540    UP000221080    UP000261560    UP000005215    UP000002494    UP000007635    UP000265200    UP000261480    UP000261500    UP000007267    UP000265040    UP000261600    UP000261360    UP000005207    UP000018467    UP000028990    UP000265080    UP000245300    UP000261660   

PRIDE

H9JNX4    A1L471    A4D1D2    P08183    Q59GY9    O70127    + More
M0R4J2   

Pfam

PF00664   ABC_membrane        + More
PF00005   ABC_tran

Interpro

IPR003439   ABC_transporter-like        + More
IPR039421   Type_I_exporter       
IPR017871   ABC_transporter_CS       
IPR036640   ABC1_TM_sf       
IPR011527   ABC1_TM_dom       
IPR027417   P-loop_NTPase       
IPR003593   AAA+_ATPase       
IPR030275   MDR3       
IPR030258   MDR1       
IPR030278   BSEP       

SUPFAM

SSF90123   SSF90123        + More
SSF52540   SSF52540       

Gene 3D

1.20.1560.10    

ProteinModelPortal

H9JNX4   A0A212EWQ3   A0A194PSR0   A0A2W1BMH9   A0A194RIJ9   S4PS85   + More
G1N7X9   A1L471   A4D1D2   P08183   A0A3Q1MIC7   A0A3Q1LSK6   A0A3Q1MB23   A0A3Q1M4U7   A0A3Q1N4W6   A0A2I3RUL7   G3X771   A0A2J8LGL5   P08183-2   A0A3Q1LLE7   R0LA26   H0W664   A0A2I3SAW5   A0A286Y4X3   U3J638   A0A2K6F8D6   H3BX23   H3DLX8   A0A286Y222   G1T8G4   A0A2K6F8D9   A0A3Q3W6X8   Q59GY9   A0A1L8FW23   A0A3Q1MBX4   A0A1S3AAJ5   A0A3Q1EGM2   H0XA28   A0A1L8FJP3   A0A2I4AN87   A0A3Q3G900   A0A2B4SKX2   A0A3M6TT74   F6WP30   A0A3Q2WEY9   A0A3Q4MRI3   A0A3S2MFJ1   T2MH87   A0A1S3G2B0   G3WW89   A0A2Y9I3G6   A0A3B4DV36   G1SFA7   G5C8Q9   V5RGD6   M3W5B1   A0A3B3R2U8   A0A0G2STD5   A0A2D0R8W3   A0A0U3J9B3   A0A0G2STH1   A0A3B3D0M8   A0A2I2UZR1   W6RT37   A0A0U3JI91   O88331   I3M9U5   A0A2P1EA62   O70127   A0A3B3D028   A0A3B4DWT2   M0R4J2   G3PLC2   A0A3P9IEA7   F7E6I5   A0A3B3Y5I2   A0A1S3ARM6   F7E6I9   A0A3B3VYW6   K7G9F4   A0A3Q1J7X7   A0A3Q4I317   A0A3Q3JNF8   A0A3B4YQJ3   A0A3Q3JNL0   H0V6N1   I3K1B5   A0A3Q2ZSG3   C7DPK6   A0A3G2BZ64   W5LHI0   A0A091DI45   A0A3P8SCQ9   S4RF62   A0A2I4AN49   A0A3Q3EZW1   A0A3Q4HYM2   A0A2Y9IA97   S4RP00  

PDB

6QEX     E-value=0,     Score=2058

KEGG

101738993    K05658 ATP-binding cassette, subfamily B (MDR/TAP), member 1 [EC:7.6.2.2] | (RefSeq) multidrug resis

PATHWAY

02010    ABC transporters - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0005524   GO:0042626   GO:0090554   GO:0055085   GO:0047484   GO:0016324   GO:2001225   GO:0005215   GO:0090555   GO:0045332   GO:0099040   GO:0000086   GO:0042493   GO:0070062   GO:0016020   GO:1901529   GO:0072089   GO:0009986   GO:0099038   GO:0005886   GO:0005925   GO:0005829   GO:0005654   GO:0046581   GO:1901557   GO:0032782   GO:0061092   GO:1903413   GO:0055088   GO:0032376   GO:0015629   GO:0015722   GO:0045177   GO:0015126   GO:0015721   GO:0043627   GO:0005794   GO:0000139   GO:0015238   GO:0046618   GO:0006979   GO:0016887   GO:0006810   GO:0019829   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

PANTHER

PTHR24221   PTHR24221:SF241   PTHR24221:SF251   PTHR24221:SF165  

Subcellular location

Cell membrane  
Membrane  

Length:

1209

Number of predicted TMHs:

9

Exp number of AAs in TMHs:

226.62869

Exp number, first 60 AAs:

23.04362

Total prob of N-in:

0.03635

POSSIBLE N-term signal

sequence

outside

1  -  14

TMhelix

15  -  37

inside

38  -  81

TMhelix

82  -  104

outside

105  -  107

TMhelix

108  -  130

inside

131  -  188

TMhelix

189  -  211

outside

212  -  637

TMhelix

638  -  660

inside

661  -  680

TMhelix

681  -  703

outside

704  -  783

TMhelix

784  -  806

inside

807  -  866

TMhelix

867  -  889

outside

890  -  898

TMhelix

899  -  921

inside

922  -  1209

 

 

Pi

223.304007

Theta

151.128947

Tajima's D

1.585554

CLR

0.407243

CSRT

0.806509674516274

Interpretation

Uncertain