Gene

KWMTBOMO14059

Pre Gene Modal

BGIBMGA011229

Annotation

PREDICTED:_NADH_dehydrogenase_[ubiquinone]_1_alpha_subcomplex_assembly_factor_3_[Papilio_polytes]

Location

Bomo_Chr23(-):17033147-17048902      View in EpiBrowser

Full name

DNA polymerase       + More
S-adenosylmethionine sensor upstream of mTORC1      

Alternative Name

Probable methyltransferase BMT2 homolog

Location in the cell

Cytoplasmic   Reliability : 1.125 Mitochondrial   Reliability : 1.323

CDS

ATGTTTCAAAATACAATAAGGCATATCAACGTTTTATCAAAAAGAAAACTTCCTATTTTGAGTTTTACACGTACCAAAGCAGCGTACGAAGGAGAGGGCAAGACGACTGTGAGAGTTCTGAACAACGAATATGACCTCGGACTAATGATTGACTCTTTTGCTACTTATGGCTTCAAGTTAAACAACGGCATCACAGTTTTAGGACCTATGGCCATATTTCCAAGAACGGTATTATCTTGGCAAGTCGCAGATTCGGATGACGTCACCGAGGAGTCCCTGAAGCTGTTCAAACTGCTCGAGCCTAGAATCGATCTGCTTATCTTAGGCTTGGATACGACGGATCGTTCGAAAATAGACAAAGCATTCAGGGCGGCCCGCGCGAACGAATTGAACATCGAAATCTTGGCAACAGAACACGCATGTTCCACATTCAACTTCCTGAACGCAGAGGGCAGATCCGTGGCTGCTGCCCTGATACCACCGTTCAAAGTCAACATGAACGAAGACGATATGCTTGAAGTGAAGATGCACTACAGTGATATATTCCAGAAAGGATTCTCGAAGCCTTCAGGGAAATAA

Protein

MFQNTIRHINVLSKRKLPILSFTRTKAAYEGEGKTTVRVLNNEYDLGLMIDSFATYGFKLNNGITVLGPMAIFPRTVLSWQVADSDDVTEESLKLFKLLEPRIDLLILGLDTTDRSKIDKAFRAARANELNIEILATEHACSTFNFLNAEGRSVAAALIPPFKVNMNEDDMLEVKMHYSDIFQKGFSKPSGK

Description

S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase.

Catalytic Activity

a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)

Cofactor

[4Fe-4S] cluster

Similarity

Belongs to the DNA polymerase type-B family.
Belongs to the BMT2 family.

Uniprot

A0A194PYW2   A0A194RIX3   A0A2A4JHQ1   A0A2W1BPT6   A0A212FD82   A0A2H1VTP6   + More
A0A182GMI0   A0A1Q3FGE1   J3JXA2   B0WKL7   B0XLX7   A0A0K8URV5   A0A0L7L739   Q7QFV4   A0A182UCW5   A0A182VM34   A0A182LAP0   A0A182WV37   A0A182I8R1   A0A0A1XFM0   Q16XR7   U5EV21   A0A1Y1NCV0   A0A182P765   A0A084VC13   A0A182VXT2   A0A182NFV5   A0A182XXC0   A0A182JNQ3   B4KMD7   B4LNX6   A0A182Q9R6   A0A224XLX3   A0A182RQP5   A0A182JFZ4   W5JHC1   A0A2M4AY75   B4MRP9   A0A1D2NGN4   A0A2P8YKV0   A0A2M4C1G6   A0A069DPU6   A0A0V0G5Q0   A0A0A9W973   A0A1L8DWL4   B3MCL0   D6WK37   A0A1B0G3M5   Q292R7   B4GCX2   A0A0K8TSG8   A0A1L8DWU0   A0A1L8DWP0   A0A0P4VML8   B4J634   A0A1A9UDK1   A0A1W4UME1   A0A1B0GLC6   A0A3B0IYT7   A0A067R8Z8   B4I8U8   A0A0M4EIJ7   A0A3B0IYJ6   Q9W1H9   B3NPU0   A0A0L0CQQ2   A0A2M3ZDG3   B4QB10   B4PA84   A0A336MSR5   A0A1B0D502   A0A1B0BCM8   A0A1A9Y7Z2   A0A087U8W1   A0A1I8Q109   A0A1L8ECH8   A0A1B6CZ84   A0A1I8N0K6   A0A1L8E986   A0A2R5LDU3   A0A293M8Z8   E9H068   A0A2L2YEI8   A0A0P5PVI4   A0A0P6JLX5   A0A1J1IBL5   A0A232F1C2   A0A131YWF7   A0A162NRU7   A0A2R7VTT7   A0A0P4VXY1   A0A0P5YC68   A0A1A9WW31   A0A1E1WW09   A0A131XDA2   A0A1B6MFV0   A0A023G5R3   A0A224YUJ3  

EC Number

2.7.7.7

Pubmed

26354079    28756777    22118469    26483478    22516182    23537049    + More
26227816    12364791    14747013    17210077    20966253    25830018    17510324    28004739    24438588    25244985    17994087    20920257    23761445    27289101    29403074    26334808    25401762    26823975    18362917    19820115    15632085    26369729    27129103    24845553    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    26108605    22936249    17550304    25315136    21292972    26561354    28648823    26830274    28503490    28049606    28797301   

EMBL

KQ459593    KPI96345.1    KQ460152    KPJ17389.1    NWSH01001410    PCG71339.1    + More
KZ149962    PZC76301.1    AGBW02009108    OWR51658.1    ODYU01004375    SOQ44190.1    JXUM01074654    KQ562843    KXJ75028.1    GFDL01008426    JAV26619.1    APGK01032733    BT127871    KB740848    KB631797    AEE62833.1    ENN78710.1    ERL86209.1    DS231974    EDS29948.1    DS234896    EDS35440.1    GDHF01022887    JAI29427.1    JTDY01002591    KOB71144.1    AAAB01008844    EAA05972.2    APCN01003108    GBXI01004556    JAD09736.1    CH477534    EAT39375.1    GANO01003606    JAB56265.1    GEZM01011790    JAV93437.1    ATLV01009976    KE524560    KFB35507.1    CH933808    EDW09825.1    CH940648    EDW61145.1    AXCN02000249    GFTR01002940    JAW13486.1    ADMH02001495    ETN62315.1    GGFK01012410    MBW45731.1    CH963850    EDW74788.1    LJIJ01000043    ODN04420.1    PYGN01000522    PSN44879.1    GGFJ01009687    MBW58828.1    GBGD01003178    JAC85711.1    GECL01002713    JAP03411.1    GBHO01042204    GBHO01029750    GBRD01003389    GDHC01008226    JAG01400.1    JAG13854.1    JAG62432.1    JAQ10403.1    GFDF01003243    JAV10841.1    CH902619    EDV36244.1    KQ971342    EFA04623.2    CCAG010010932    CM000071    EAL24794.1    CH479181    EDW31510.1    GDAI01000296    JAI17307.1    GFDF01003198    JAV10886.1    GFDF01003242    JAV10842.1    GDKW01002505    JAI54090.1    CH916367    EDW01892.1    AJWK01034746    OUUW01000001    SPP73155.1    KK852618    KDR20135.1    CH480824    EDW57023.1    CP012524    ALC42610.1    SPP73154.1    AE013599    AY119235    AAF47082.1    AAM51095.1    CH954179    EDV56881.1    JRES01000153    KNC33764.1    GGFM01005835    MBW26586.1    CM000362    CM002911    EDX08447.1    KMY96141.1    CM000158    EDW92410.1    UFQT01002082    SSX32601.1    AJVK01025011    JXJN01012064    KK118761    KFM73800.1    GFDG01002378    JAV16421.1    GEDC01018519    JAS18779.1    GFDG01003630    JAV15169.1    GGLE01003381    MBY07507.1    GFWV01012087    MAA36816.1    GL732580    EFX74747.1    IAAA01028667    IAAA01028668    LAA06548.1    GDIQ01123606    JAL28120.1    GDIQ01014558    JAN80179.1    CVRI01000047    CRK97603.1    NNAY01001262    OXU24576.1    GEDV01005712    JAP82845.1    LRGB01000547    KZS18213.1    KK854085    PTY10944.1    GDRN01099349    JAI58780.1    GDIP01059772    JAM43943.1    GFAC01007975    JAT91213.1    GEFH01005020    JAP63561.1    GEBQ01010098    GEBQ01005202    JAT29879.1    JAT34775.1    GBBM01006279    JAC29139.1    GFPF01010122    MAA21268.1   

Proteomes

UP000053268    UP000053240    UP000218220    UP000007151    UP000069940    UP000249989    + More
UP000019118    UP000030742    UP000002320    UP000037510    UP000007062    UP000075902    UP000075903    UP000075882    UP000076407    UP000075840    UP000008820    UP000075885    UP000030765    UP000075920    UP000075884    UP000076408    UP000075881    UP000009192    UP000008792    UP000075886    UP000075900    UP000075880    UP000000673    UP000007798    UP000094527    UP000245037    UP000007801    UP000007266    UP000092444    UP000001819    UP000008744    UP000001070    UP000078200    UP000192221    UP000092461    UP000268350    UP000027135    UP000001292    UP000092553    UP000000803    UP000008711    UP000037069    UP000000304    UP000002282    UP000092462    UP000092460    UP000092443    UP000054359    UP000095300    UP000095301    UP000000305    UP000183832    UP000215335    UP000076858    UP000091820   

PRIDE

Q9W1H9   

Pfam

PF04430   DUF498        + More
PF08996   zf-DNA_Pol
PF03104   DNA_pol_B_exo1
PF00136   DNA_pol_B
PF12254   DNA_pol_alpha_N
PF11942   Spt5_N
PF00467   KOW
PF11968   Bmt2
PF03439   Spt5-NGN

Interpro

IPR036748   MTH938-like_sf        + More
IPR007523   NDUFAF3/AAMDC       
IPR034095   NDUF3       
IPR042087   DNA_pol_B_C       
IPR023211   DNA_pol_palm_dom_sf       
IPR015088   Znf_DNA-dir_DNA_pol_B_alpha       
IPR012337   RNaseH-like_sf       
IPR017964   DNA-dir_DNA_pol_B_CS       
IPR006134   DNA-dir_DNA_pol_B_multi_dom       
IPR038256   Pol_alpha_znc_sf       
IPR024647   DNA_pol_a_cat_su_N       
IPR006133   DNA-dir_DNA_pol_B_exonuc       
IPR036397   RNaseH_sf       
IPR006172   DNA-dir_DNA_pol_B       
IPR041973   KOW_Spt5_1       
IPR022581   Spt5_N       
IPR041975   KOW_Spt5_2       
IPR041978   KOW_Spt5_5       
IPR021867   Bmt2/SAMTOR       
IPR005100   NGN-domain       
IPR041977   KOW_Spt5_4       
IPR014722   Rib_L2_dom2       
IPR029063   SAM-dependent_MTases       
IPR005824   KOW       
IPR039385   NGN_Euk       
IPR036735   NGN_dom_sf       
IPR024945   Spt5_C_dom       
IPR006645   NGN_dom       
IPR041976   KOW_Spt5_3       
IPR008991   Translation_prot_SH3-like_sf       
IPR039659   SPT5       

SUPFAM

SSF64076   SSF64076        + More
SSF53098   SSF53098       
SSF53335   SSF53335       
SSF50104   SSF50104       

Gene 3D

3.40.1230.10     1.10.132.60     1.10.3200.20     3.30.420.10     3.90.1600.10     2.30.30.30     3.30.70.940    

CDD

cd05125  Mth938_2P1-like
cd06084  KOW_Spt5_4
cd06083  KOW_Spt5_3
cd06085  KOW_Spt5_5
cd06081  KOW_Spt5_1
cd06082  KOW_Spt5_2
cd09888  NGN_Euk

ProteinModelPortal

A0A194PYW2   A0A194RIX3   A0A2A4JHQ1   A0A2W1BPT6   A0A212FD82   A0A2H1VTP6   + More
A0A182GMI0   A0A1Q3FGE1   J3JXA2   B0WKL7   B0XLX7   A0A0K8URV5   A0A0L7L739   Q7QFV4   A0A182UCW5   A0A182VM34   A0A182LAP0   A0A182WV37   A0A182I8R1   A0A0A1XFM0   Q16XR7   U5EV21   A0A1Y1NCV0   A0A182P765   A0A084VC13   A0A182VXT2   A0A182NFV5   A0A182XXC0   A0A182JNQ3   B4KMD7   B4LNX6   A0A182Q9R6   A0A224XLX3   A0A182RQP5   A0A182JFZ4   W5JHC1   A0A2M4AY75   B4MRP9   A0A1D2NGN4   A0A2P8YKV0   A0A2M4C1G6   A0A069DPU6   A0A0V0G5Q0   A0A0A9W973   A0A1L8DWL4   B3MCL0   D6WK37   A0A1B0G3M5   Q292R7   B4GCX2   A0A0K8TSG8   A0A1L8DWU0   A0A1L8DWP0   A0A0P4VML8   B4J634   A0A1A9UDK1   A0A1W4UME1   A0A1B0GLC6   A0A3B0IYT7   A0A067R8Z8   B4I8U8   A0A0M4EIJ7   A0A3B0IYJ6   Q9W1H9   B3NPU0   A0A0L0CQQ2   A0A2M3ZDG3   B4QB10   B4PA84   A0A336MSR5   A0A1B0D502   A0A1B0BCM8   A0A1A9Y7Z2   A0A087U8W1   A0A1I8Q109   A0A1L8ECH8   A0A1B6CZ84   A0A1I8N0K6   A0A1L8E986   A0A2R5LDU3   A0A293M8Z8   E9H068   A0A2L2YEI8   A0A0P5PVI4   A0A0P6JLX5   A0A1J1IBL5   A0A232F1C2   A0A131YWF7   A0A162NRU7   A0A2R7VTT7   A0A0P4VXY1   A0A0P5YC68   A0A1A9WW31   A0A1E1WW09   A0A131XDA2   A0A1B6MFV0   A0A023G5R3   A0A224YUJ3  

KEGG

101738355    K09008 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 | (RefSeq) NADH dehydrog

GO

GO:0032981   GO:0005743   GO:0046872   GO:0006273   GO:0003697   GO:0005658   GO:0003887   GO:0001882   GO:0019103   GO:0003688   GO:1902975   GO:0006272   GO:0017076   GO:0003682   GO:0051539   GO:0008168   GO:0032784   GO:0006357  

PANTHER

PTHR21192   PTHR11125  

Subcellular location

Nucleus  

Length:

192

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.32489

Exp number, first 60 AAs:

0.11497

Total prob of N-in:

0.24519

outside

1  -  192

 

 

Pi

130.59664

Theta

136.830433

Tajima's D

0.316169

CLR

0.495138

CSRT

0.457727113644318

Interpretation

Uncertain