Gene

KWMTBOMO14055  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011231

Annotation

Sugar_phosphate_exchanger_2_[Papilio_machaon]

Location

Bomo_Chr23(-):16988713-17002782      View in EpiBrowser

Full name

Glucose-6-phosphate exchanger SLC37A2      

Alternative Name

Solute carrier family 37 member 2
cAMP-inducible protein 2

Location in the cell

PlasmaMembrane   Reliability : 4.934

CDS

ATGGTCGGTGTGAGTAGGGACGCGCCACTGGGTGTACAATGCATACAGAAATTGTATATCAAACTATGTCCTAGACTGCAGATCAACAGATTGAGATGGTACCAAGTCAGCGTCCTAATACTGACCTACTTCACGTATATGACGTACCATTTGACGAGGAAACCTATATCGGTGGTCAAAAGCGTCCTCCATCAGAACTGCAGTAGTCTGACACCGCCCCCCGACGTCGACCCGACCGATGACCAATGGTGTAATTGGGCGCCGTTCAATACGACGGACGCGAACACGTTATTAGGAACATTGGATTCCGCCTTCCTGTTCTCATACGCGGGCGCCATGTTTGTTTCTGGCATGATAGCCGAGAGAGTGGACTTACGCTATTTCCTCTCCCTGGGCATGCTCACGTCGGCCATATTTTGCTATCTGTTCGGCATCGGACGAACATACAATATTCATAACATTTATTATTATTTAATCGTTCAGGCTGGAGCCGGTATCGCCCAGACCACTGGCTGGCCGGGTACCGTTGCCACAGTAGGTAAATGGTTCGGGAATACAAAGAAAGGATTGATTTTCGGCGTTTGGAACTCTCACACGTCGCTTGGTAACATTTTGGGTACCCTCATGGCAGCCGAATACGTGGACAAAGACTGGAGCCTCTCATTCATATACCCTGGCCTCATGATGGGCGCAGTCGGCTTCGTGATCTGGCTGTTTCTCGTCCCGGAACCTAAATACGTGGGCCTGGTCCCTGGAGAACGGAATACTCCCATCAGACAATGCACCAAGTCTGATGAAGAGGATGAAGCAGAAATCGTCAGCCACGATGCTGAACCGACCCAAGTTCTAGTCGGAGACCAGGGTGCAAGTCTAAGAAGTAACAGGTATTCGGCTAACACGCAACACGAGGAGCCCACCGAGCACACCTCGCTGCTCCGCCGCCCCTCGCTCTCCGGGAGCAGCGCCGTGTCTCTGTCCAGGGCGCTCTCCATCCCAGGAGTGGTGGAGTTCTCTCTCTCGTTATTCTTCGCCAAACTAGTCAGCTATACATTCTTGTATTGGCTGCCGTTGTACATAAAGACATCGACTAACCTAACAGCCAAGCAATCTGGCAAGCTAAGCATAGTGTTCGACGTGGGCGGGGCTGTGGGCGCGATCCTGGCGGGGCTCGTGTCCGACTGCACGGGCTGTCCCGGAATCGTCTGCGTGGTTTTTTATATGCTCTGCGCGCCCTCGCTCCTCGTTTACCAGACCTGGGGAGCCAGCTCGTATACACTGAACGTTTGGCTGTTGATATTAAGCGGTGTGCTCGTGAACGGTCCTTACGCGCTCATCACTACTGCCGTTAGCGCGGAGTTAGGTACACATAGCAGTCTGGCTGGTAATTCCCAGGCTCTGGCGACGGTCACCGCCATTATTGACGGCACTGGGAGTGTTGGTGCGGCCATAGGGCCCATGCTGGCCGGCATCGTCTCCAGCTCGGGGTCGTGGTCCTACGTGTTCTACATGCTCATAGCGTGTAACTACATGGCGCTGTTCCTCTTATTAAGGATAGCGAAATCGGAAATAGCCAAATTGAAACAGGAGAGACGCATAGCATCACCTCCTAGAGTCAGAATAGAATAA

Protein

MVGVSRDAPLGVQCIQKLYIKLCPRLQINRLRWYQVSVLILTYFTYMTYHLTRKPISVVKSVLHQNCSSLTPPPDVDPTDDQWCNWAPFNTTDANTLLGTLDSAFLFSYAGAMFVSGMIAERVDLRYFLSLGMLTSAIFCYLFGIGRTYNIHNIYYYLIVQAGAGIAQTTGWPGTVATVGKWFGNTKKGLIFGVWNSHTSLGNILGTLMAAEYVDKDWSLSFIYPGLMMGAVGFVIWLFLVPEPKYVGLVPGERNTPIRQCTKSDEEDEAEIVSHDAEPTQVLVGDQGASLRSNRYSANTQHEEPTEHTSLLRRPSLSGSSAVSLSRALSIPGVVEFSLSLFFAKLVSYTFLYWLPLYIKTSTNLTAKQSGKLSIVFDVGGAVGAILAGLVSDCTGCPGIVCVVFYMLCAPSLLVYQTWGASSYTLNVWLLILSGVLVNGPYALITTAVSAELGTHSSLAGNSQALATVTAIIDGTGSVGAAIGPMLAGIVSSSGSWSYVFYMLIACNYMALFLLLRIAKSEIAKLKQERRIASPPRVRIE

Description

Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction.
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.

Similarity

Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.

Keywords

Antiport   Endoplasmic reticulum   Glycoprotein   Membrane   Sugar transport   Transmembrane   Transmembrane helix   Transport   Complete proteome   Reference proteome   Alternative splicing  

Feature

chain  Glucose-6-phosphate exchanger SLC37A2
splice variant  In isoform 2.

Uniprot

H9JNX7   A0A2A4K796   S4PG65   A0A194RIN1   A0A2W1BPS8   A0A194PTM2   + More
A0A212EYC1   V5G149   U5EYR0   A0A1L8DEG4   A0A1L8DEE7   A0A1J1HEC3   B5DZT7   A0A0J9RHJ4   A0A182I3Z8   A0A0J9RHY9   A0A182VN99   A0A1S4GSV1   A0A182QWB3   A0A1Q3FET0   A0A0P6IU38   B4LJ73   A0A0M4EAF6   B3MBW3   B4KPN5   A0A2J7RA61   A0A0Q9WF52   A0A3B0JJS2   K7J9X4   A0A0K8TRF3   A0A1Y1L9S1   A0A0L0C398   A0A026X4K1   F4W8I5   A0A1B6CYK1   A0A232EY76   A0A336MD68   A0A158NK87   W8BDN8   A0A151X6V3   A0A2M3ZGR6   A0A2H8TRE2   A0A0C9S1X4   J9JZY9   A0A0C9RN09   A0A154PEL7   A0A0A1XMM3   A0A0T6BG83   L7MGN9   A0A087THG0   A0A293LFS8   A0A0A9Z9F6   A0A1Z5KUC7   A0A2R5LCR2   T1ITN0   A0A091MLT5   A0A287AX11   F1S792   A0A023GL22   G3QC20   T1KTK4   A0A2I0LKM6   A0A094K6H7   A0A224Z984   A0A2L2XV11   A0A250YJB3   A0A131XUA5   A0A131Z340   A0A1L8FL62   Q8AVC3   H0XDM4   V5HBS4   A0A1S3HEH3   A0A091GL21   B7P1P9   A0A2I2V274   Q5M7K3   U3JS55   M3WME2   D3ZS16   A0A096MJU4   G1TM56   A0A151NG61   A0A1V4J5Y7   A0A060X0T7   A0A3Q3LN32   A0A384A803   A0A2Y9M344   A0A341B128   A0A341B4J1   A0A0P5YGK1   A0A0P5U1B8   A0A1S3RLR0   A0A0P5AWV8   A0A0P4ZA98   A0A0P4YS78   A0A0P5ABS6   H3BZK9   A0A091S8C7   Q9WU81  

Pubmed

19121390    23622113    26354079    28756777    22118469    15632085    + More
17994087    22936249    12364791    26999592    18057021    20075255    26369729    28004739    26108605    24508170    21719571    28648823    21347285    24495485    25830018    25576852    25401762    26823975    28528879    23371554    28797301    26561354    28087693    26830274    27762356    25765539    17975172    15057822    22673903    21993624    22293439    24755649    15496914    11004510    16141072    15489334    19144319    21183079   

EMBL

BABH01009782    NWSH01000104    PCG79520.1    GAIX01003772    JAA88788.1    KQ460152    + More
KPJ17417.1    KZ149962    PZC76291.1    KQ459593    KPI96323.1    AGBW02011569    OWR46480.1    GALX01004726    JAB63740.1    GANO01000187    JAB59684.1    GFDF01009253    JAV04831.1    GFDF01009252    JAV04832.1    CVRI01000001    CRK86179.1    CM000071    EDY68860.2    CM002911    KMY95492.1    KMY95493.1    APCN01002258    KMY95496.1    AAAB01008960    AXCN02000453    GFDL01008989    JAV26056.1    GDUN01000668    JAN95251.1    CH940648    EDW61509.2    CP012524    ALC42046.1    CH902619    EDV36134.2    KPU76023.1    CH933808    EDW09145.2    NEVH01006578    PNF37728.1    KRF80020.1    KRF80021.1    OUUW01000001    SPP73476.1    AAZX01002316    GDAI01000887    JAI16716.1    GEZM01062532    JAV69618.1    JRES01000960    KNC26727.1    KK107021    EZA62339.1    GL887908    EGI69476.1    GEDC01018738    JAS18560.1    NNAY01001679    OXU23239.1    UFQT01000957    SSX28176.1    ADTU01018740    GAMC01018670    GAMC01018668    GAMC01018666    GAMC01018664    JAB87889.1    KQ982472    KYQ56111.1    GGFM01006940    MBW27691.1    GFXV01004367    MBW16172.1    GBYB01014826    GBYB01014829    JAG84593.1    JAG84596.1    ABLF02031697    ABLF02031704    GBYB01014827    JAG84594.1    KQ434889    KZC10305.1    GBXI01004290    GBXI01002509    JAD10002.1    JAD11783.1    LJIG01000767    KRT86173.1    GACK01002047    JAA62987.1    KK115248    KFM64549.1    GFWV01002634    MAA27364.1    GBHO01040619    GBHO01001697    GBRD01016946    GBRD01016944    GDHC01006275    JAG02985.1    JAG41907.1    JAG48881.1    JAQ12354.1    GFJQ02008345    JAV98624.1    GGLE01003011    MBY07137.1    AFFK01019224    KK829881    KFP75706.1    AEMK02000070    GACC01000284    JAA74300.1    GBBM01000837    JAC34581.1    CAEY01000544    AKCR02000248    PKK17982.1    KL340436    KFZ52551.1    GFPF01011966    MAA23112.1    IAAA01007095    LAA00009.1    GFFW01001149    JAV43639.1    GEFM01004902    JAP70894.1    GEDV01003681    JAP84876.1    CM004478    OCT72330.1    BC042235    AAQR03130538    GANP01003573    JAB80895.1    KL448280    KFO81854.1    ABJB010784831    DS617675    EEC00521.1    AANG04000369    CR762105    BC088593    CAJ83734.1    AGTO01010976    AABR07069787    AAGW02009637    AKHW03003120    KYO35816.1    LSYS01009023    OPJ67464.1    FR904886    CDQ73198.1    GDIP01058050    GDIQ01090640    JAM45665.1    JAN04097.1    GDIP01119134    JAL84580.1    GDIP01193432    JAJ29970.1    GDIP01217323    GDIP01043248    LRGB01002167    JAJ06079.1    KZS08847.1    GDIP01227871    JAI95530.1    GDIP01205736    JAJ17666.1    KK943602    KFQ52621.1    AF121081    AK028984    AK031045    AK079414    AK079823    BC022752    BC063326    AK220151   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000183832    + More
UP000001819    UP000075840    UP000075903    UP000075886    UP000008792    UP000092553    UP000007801    UP000009192    UP000235965    UP000268350    UP000002358    UP000037069    UP000053097    UP000007755    UP000215335    UP000005205    UP000075809    UP000007819    UP000076502    UP000054359    UP000008227    UP000007635    UP000015104    UP000053872    UP000186698    UP000005225    UP000085678    UP000053760    UP000001555    UP000011712    UP000008143    UP000016665    UP000002494    UP000001811    UP000050525    UP000190648    UP000193380    UP000261660    UP000261681    UP000248483    UP000252040    UP000087266    UP000076858    UP000007303    UP000000589   

PRIDE

H9JNX7    L7MGN9    F1S792    V5HBS4    Q5M7K3    D3ZS16    + More
Q9WU81   

Pfam

PF07690   MFS_1        + More
PF01496   V_ATPase_I

Interpro

IPR036259   MFS_trans_sf        + More
IPR011701   MFS       
IPR000849   Sugar_P_transporter       
IPR020846   MFS_dom       
IPR002490   V-ATPase_116kDa_su       

SUPFAM

SSF103473   SSF103473       

CDD

cd06174  MFS

ProteinModelPortal

H9JNX7   A0A2A4K796   S4PG65   A0A194RIN1   A0A2W1BPS8   A0A194PTM2   + More
A0A212EYC1   V5G149   U5EYR0   A0A1L8DEG4   A0A1L8DEE7   A0A1J1HEC3   B5DZT7   A0A0J9RHJ4   A0A182I3Z8   A0A0J9RHY9   A0A182VN99   A0A1S4GSV1   A0A182QWB3   A0A1Q3FET0   A0A0P6IU38   B4LJ73   A0A0M4EAF6   B3MBW3   B4KPN5   A0A2J7RA61   A0A0Q9WF52   A0A3B0JJS2   K7J9X4   A0A0K8TRF3   A0A1Y1L9S1   A0A0L0C398   A0A026X4K1   F4W8I5   A0A1B6CYK1   A0A232EY76   A0A336MD68   A0A158NK87   W8BDN8   A0A151X6V3   A0A2M3ZGR6   A0A2H8TRE2   A0A0C9S1X4   J9JZY9   A0A0C9RN09   A0A154PEL7   A0A0A1XMM3   A0A0T6BG83   L7MGN9   A0A087THG0   A0A293LFS8   A0A0A9Z9F6   A0A1Z5KUC7   A0A2R5LCR2   T1ITN0   A0A091MLT5   A0A287AX11   F1S792   A0A023GL22   G3QC20   T1KTK4   A0A2I0LKM6   A0A094K6H7   A0A224Z984   A0A2L2XV11   A0A250YJB3   A0A131XUA5   A0A131Z340   A0A1L8FL62   Q8AVC3   H0XDM4   V5HBS4   A0A1S3HEH3   A0A091GL21   B7P1P9   A0A2I2V274   Q5M7K3   U3JS55   M3WME2   D3ZS16   A0A096MJU4   G1TM56   A0A151NG61   A0A1V4J5Y7   A0A060X0T7   A0A3Q3LN32   A0A384A803   A0A2Y9M344   A0A341B128   A0A341B4J1   A0A0P5YGK1   A0A0P5U1B8   A0A1S3RLR0   A0A0P5AWV8   A0A0P4ZA98   A0A0P4YS78   A0A0P5ABS6   H3BZK9   A0A091S8C7   Q9WU81  

PDB

1PW4     E-value=5.869e-08,     Score=138

KEGG

101738720    K13783 MFS transporter, OPA family, solute carrier family 37 (glycerol-3-phosphate transporter), mem

GO

GO:0016021   GO:0022857   GO:0055085   GO:0033179   GO:0015078   GO:0015991   GO:0061513   GO:0030176   GO:0015760   GO:0008643   GO:0035435   GO:0015794   GO:0006127   GO:0006072   GO:0015169   GO:0005215   GO:0006810   GO:0000166   GO:0006812   GO:0019829   GO:0005507   GO:0004713   GO:0016491   GO:0015930  

PANTHER

PTHR11629  

Subcellular location

Endoplasmic reticulum membrane  

Length:

541

Number of predicted TMHs:

12

Exp number of AAs in TMHs:

243.56186

Exp number, first 60 AAs:

18.80214

Total prob of N-in:

0.76245

POSSIBLE N-term signal

sequence

inside

1  -  32

TMhelix

33  -  52

outside

53  -  97

TMhelix

98  -  120

inside

121  -  126

TMhelix

127  -  149

outside

150  -  153

TMhelix

154  -  176

inside

177  -  188

TMhelix

189  -  211

outside

212  -  220

TMhelix

221  -  240

inside

241  -  336

TMhelix

337  -  359

outside

360  -  373

TMhelix

374  -  392

inside

393  -  398

TMhelix

399  -  421

outside

422  -  430

TMhelix

431  -  453

inside

454  -  464

TMhelix

465  -  487

outside

488  -  496

TMhelix

497  -  519

inside

520  -  541

 

 

Pi

200.379554

Theta

171.767351

Tajima's D

0.648146

CLR

0.654955

CSRT

0.56087195640218

Interpretation

Uncertain