Gene

KWMTBOMO14054

Annotation

presenilin_enhancer_[Bombyx_mori]

Location

Bomo_Chr23(+):16977663-16983546      View in EpiBrowser

Full name

Gamma-secretase subunit pen-2      

Alternative Name

Presenilin enhancer protein 2

Location in the cell

PlasmaMembrane   Reliability : 3.833

CDS

ATGGATTTAAGTAAACTGCCGAACGATATGAAACTACAATTGTGCAAATCATATTTTAAAGTTGGTTGTCTGTTCCTACCGTTTGTGTGGGCGGTGAATGTGTGTTGGTTCTTCCGAGATGCATTTATAAAACCAGCATATGATGAGCAGAAACTAATAAAGAAATTTGTGATAATGAGTGCAATTGGAGCTTTCGTGTGGGCTGTTATATTGGTTACGTGGATTACGGTGTATCAAACAAACAGAGTGTCGTGGGGAGCTACAGGCGACGCACTATCCTTCATAGTACCTTTAGGACGAGCCTAG

Protein

MDLSKLPNDMKLQLCKSYFKVGCLFLPFVWAVNVCWFFRDAFIKPAYDEQKLIKKFVIMSAIGAFVWAVILVTWITVYQTNRVSWGATGDALSFIVPLGRA

Description

Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch. It probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.

Subunit

Component of the gamma-secretase complex, a complex composed of a presenilin (Psn) homodimer, nicastrin (Nct), Aph-1 and Pen-2.

Similarity

Belongs to the PEN-2 family.

Keywords

Complete proteome   Membrane   Notch signaling pathway   Reference proteome   Transmembrane   Transmembrane helix  

Feature

chain  Gamma-secretase subunit pen-2

Uniprot

Q2F5X1   A0A1E1WHM4   A0A194PSA5   A0A2H1VK38   A0A2W1BMJ0   A0A3S2M6R6   + More
S4P4B3   A0A194RJ04   A0A2A4K5L7   A0A212EYA0   B4LNL7   B3MBC9   A0A1W4UJV8   B4NN19   B4KM71   B4J5R5   B3NMP6   B4NSL5   A0A1Q3G2Q4   Q640D2   B4QCC0   A0A0B4LFM5   B4P4N7   Q86BE9   Q28GF7   A0A0N7Z955   R4G877   Q5PQA0   Q178A8   B4HNL1   U5EVA9   A0A0K8TPH9   E2BQH0   A0A067QRX9   A0A0K8VVP3   A0A023ECS1   A0A0C9QYR3   A0A224Y1G1   A0A0V0GB54   B5DZQ9   B4GIQ3   A0A2G9QEV9   A0A385JF77   A0A3B0JKK7   A0A1X9IXE3   A0A0A9VWP5   A0A088AD44   E0VLA5   A0A2A3ELV5   V9IHQ6   A0A1B6J8L5   R4V2K3   A0A1B6FN65   A0A182MW29   A0A158NK86   A0A139WGF1   A0A182JU72   A0A182QE36   A0A023FD68   A0A182NUB4   A0A2J7RA64   A0A1A9WJE2   W5JCM5   A0A195EHR5   F4W8I4   A0A182SWV9   A0A2M3ZLE9   A0A182Y057   A0A151I7U1   A0A182VK82   A0A182TTD2   A0A182L1J5   Q7Q3Y1   A0A2M4C4C1   A0A182RZT2   A0A182W754   A0A1B0BT68   A0A3B4G386   A0A3Q2VAI7   A0A3Q4HTN4   A0A3P8N743   A0A3P9C1U2   A0A224Z4M2   A0A131YIU7   L7M5X3   A0A131XHN3   A0A182PMN5   A0A182IKZ2   A0A1A9YG60   B6DDY1   A0A3Q3MLH6   A0A2M4AWT9   A0A182F3E4   A0A1I8N311   A0A1L8D8T5   A0A1B6M571   A0A023GDT2   G3MN57   A0A026X2M0   A0A3Q1HYZ0  

Pubmed

26354079    28756777    23622113    22118469    17994087    22936249    + More
27762356    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    17550304    12110170    12660785    20431018    27129103    17510324    26369729    20798317    24845553    24945155    15632085    27966611    25401762    26823975    20566863    21347285    18362917    19820115    20920257    23761445    21719571    25244985    20966253    12364791    14747013    17210077    25186727    28797301    26830274    25576852    28049606    19178717    25315136    22216098    24508170   

EMBL

DQ311302    ABD36246.1    GDQN01004555    JAT86499.1    KQ459593    KPI96321.1    + More
ODYU01002980    SOQ41161.1    KZ149962    PZC76292.1    RSAL01000024    RVE52238.1    GAIX01006054    JAA86506.1    KQ460152    KPJ17419.1    NWSH01000104    PCG79521.1    AGBW02011569    OWR46479.1    CH940648    EDW62197.1    CH902619    EDV36054.1    CH964282    EDW85758.1    CH933808    EDW08735.1    CH916367    EDW01841.1    CH954179    EDV55050.1    CH982321    CM002911    EDX15593.1    KMY94796.1    GFDL01000965    JAV34080.1    BC082697    BC106244    CM004479    AAH82697.1    AAI06245.1    OCT71113.1    CM000362    EDX07644.1    AE013599    AHN56361.1    CM000158    EDW91660.1    AF512426    BT030940    BT030980    AAMC01106331    AAMC01106332    AAMC01106333    BC121544    CR761406    KV460372    AAI21545.1    CAJ82298.1    OCA19673.1    GDKW01001491    JAI55104.1    ACPB03000917    GAHY01001452    JAA76058.1    BC087298    CM004478    AAH87298.1    OCT73485.1    CH477367    EAT42511.1    CH480816    EDW48430.1    GANO01001117    JAB58754.1    GDAI01001557    JAI16046.1    GL449769    EFN82028.1    KK853026    KDR12309.1    GDHF01009370    JAI42944.1    GAPW01006433    GAPW01006432    GAPW01006431    GAPW01006430    JAC07168.1    GBYB01005797    JAG75564.1    GFTR01001584    JAW14842.1    GECL01001607    JAP04517.1    CM000071    EDY69212.1    CH479183    EDW36373.1    KZ021941    PIO13671.1    MG213852    AXY96274.1    OUUW01000001    SPP75890.1    KY031988    APR62714.1    GBHO01044986    GDHC01002115    JAF98617.1    JAQ16514.1    DS235271    EEB14161.1    KZ288220    PBC32149.1    JR048367    AEY60643.1    GECU01012196    JAS95510.1    KC741153    AGM32977.1    GECZ01018122    JAS51647.1    AXCM01005370    ADTU01018740    KQ971345    KYB27078.1    AXCN02000768    GBBK01004671    JAC19811.1    NEVH01006578    PNF37725.1    ADMH02001549    ETN62102.1    KQ978881    KYN27795.1    GL887908    EGI69475.1    GGFM01008487    MBW29238.1    KQ978406    KYM94168.1    AAAB01008964    EAA12574.2    GGFJ01011036    MBW60177.1    JXJN01020015    GFPF01010775    MAA21921.1    GEDV01010706    JAP77851.1    GACK01006535    JAA58499.1    GEFH01002709    JAP65872.1    EU934350    ACI30128.1    GGFK01011946    MBW45267.1    GFDF01011226    JAV02858.1    GEBQ01008900    JAT31077.1    GBBM01003424    JAC31994.1    JO843308    AEO34925.1    KK107021    EZA62338.1   

Proteomes

UP000053268    UP000283053    UP000053240    UP000218220    UP000007151    UP000008792    + More
UP000007801    UP000192221    UP000007798    UP000009192    UP000001070    UP000008711    UP000000304    UP000186698    UP000000803    UP000002282    UP000008143    UP000015103    UP000008820    UP000001292    UP000008237    UP000027135    UP000001819    UP000008744    UP000268350    UP000005203    UP000009046    UP000242457    UP000075883    UP000005205    UP000007266    UP000075881    UP000075886    UP000075884    UP000235965    UP000091820    UP000000673    UP000078492    UP000007755    UP000075901    UP000076408    UP000078542    UP000075903    UP000075902    UP000075882    UP000007062    UP000075900    UP000075920    UP000092460    UP000261460    UP000264840    UP000261580    UP000265100    UP000265160    UP000075885    UP000075880    UP000092443    UP000261640    UP000069272    UP000095301    UP000053097    UP000265040   

PRIDE

Q2F5X1    Q86BE9   

Pfam

PF10251   PEN-2        + More
PF00400   WD40

Interpro

IPR019379   Gamma_Secretase_Asp_P_PEN2        + More
IPR036322   WD40_repeat_dom_sf       
IPR017986   WD40_repeat_dom       
IPR001680   WD40_repeat       
IPR015943   WD40/YVTN_repeat-like_dom_sf       

SUPFAM

SSF50978   SSF50978       

Gene 3D

2.130.10.10    

ProteinModelPortal

Q2F5X1   A0A1E1WHM4   A0A194PSA5   A0A2H1VK38   A0A2W1BMJ0   A0A3S2M6R6   + More
S4P4B3   A0A194RJ04   A0A2A4K5L7   A0A212EYA0   B4LNL7   B3MBC9   A0A1W4UJV8   B4NN19   B4KM71   B4J5R5   B3NMP6   B4NSL5   A0A1Q3G2Q4   Q640D2   B4QCC0   A0A0B4LFM5   B4P4N7   Q86BE9   Q28GF7   A0A0N7Z955   R4G877   Q5PQA0   Q178A8   B4HNL1   U5EVA9   A0A0K8TPH9   E2BQH0   A0A067QRX9   A0A0K8VVP3   A0A023ECS1   A0A0C9QYR3   A0A224Y1G1   A0A0V0GB54   B5DZQ9   B4GIQ3   A0A2G9QEV9   A0A385JF77   A0A3B0JKK7   A0A1X9IXE3   A0A0A9VWP5   A0A088AD44   E0VLA5   A0A2A3ELV5   V9IHQ6   A0A1B6J8L5   R4V2K3   A0A1B6FN65   A0A182MW29   A0A158NK86   A0A139WGF1   A0A182JU72   A0A182QE36   A0A023FD68   A0A182NUB4   A0A2J7RA64   A0A1A9WJE2   W5JCM5   A0A195EHR5   F4W8I4   A0A182SWV9   A0A2M3ZLE9   A0A182Y057   A0A151I7U1   A0A182VK82   A0A182TTD2   A0A182L1J5   Q7Q3Y1   A0A2M4C4C1   A0A182RZT2   A0A182W754   A0A1B0BT68   A0A3B4G386   A0A3Q2VAI7   A0A3Q4HTN4   A0A3P8N743   A0A3P9C1U2   A0A224Z4M2   A0A131YIU7   L7M5X3   A0A131XHN3   A0A182PMN5   A0A182IKZ2   A0A1A9YG60   B6DDY1   A0A3Q3MLH6   A0A2M4AWT9   A0A182F3E4   A0A1I8N311   A0A1L8D8T5   A0A1B6M571   A0A023GDT2   G3MN57   A0A026X2M0   A0A3Q1HYZ0  

PDB

6IYC     E-value=1.94056e-23,     Score=263

KEGG

692897    K06170 presenilin enhancer 2 | (RefSeq) presenilin enhancer

PATHWAY

04330    Notch signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0016021   GO:0035333   GO:0055037   GO:0006509   GO:0034205   GO:0070765   GO:0005770   GO:0007219   GO:0007220   GO:0097324   GO:0048066   GO:0043524  

PANTHER

PTHR16318  

Subcellular location

Membrane  

Length:

101

Number of predicted TMHs:

2

Exp number of AAs in TMHs:

45.03898

Exp number, first 60 AAs:

27.18877

Total prob of N-in:

0.91902

POSSIBLE N-term signal

sequence

inside

1  -  20

TMhelix

21  -  43

outside

44  -  55

TMhelix

56  -  78

inside

79  -  101

 

 

Pi

188.576937

Theta

194.805054

Tajima's D

0.789827

CLR

1.11934

CSRT

0.603869806509674

Interpretation

Uncertain