Gene

KWMTBOMO14043

Pre Gene Modal

BGIBMGA011369

Annotation

PREDICTED:_serine/threonine-protein_kinase_par-1-like_isoform_X3_[Bombyx_mori]

Location

Bomo_Chr23(+):16713363-16741017      View in EpiBrowser

Full name

Non-specific serine/threonine protein kinase      

Location in the cell

Nuclear   Reliability : 2.156

CDS

ATGGCCTGCAATATCAGCCCTATACACAAAAGCAAGCATTTCCCAATAGACCAGCTCGTGTGTGTCGGTAACTATGAACTTGAAAAGACTATAGGAACTGGTAACTTCGCCGTCGTAAAACTGGCTACACATGTTATTACTAAAAGTAAGGTCGCTATAAAAATAATTGACAAATCAAGATTAGATGAAGACAATTTGAAGAAGACATTCCGGGAAATAGCAATAATGAAGAGACTGAGTCATCCGCACATAGTTAGGTTATACCAGGTGATGGAGAGCACCCACACGATTTATTTAGTAACAGAATACGCACCGAACGGTGAAATATTTGATCACTTGGTGTCCAGGGGTCGTATGACGGAGTCGGAGGCGGCCCGAGCTTTCTCCCAGATGGTGGCCGCCGTGGGGTACTGCCACGCGAACGGTGTCGTCCATCGCGACCTAAAGGCTGAGAATTTACTGTTAGACAAAAACATGAACATAAAGTTAGCAGATTTCGGCTTCAGCAACGAATATAGAACCGGAGGAGCCCTGAGCACCTGGTGCGGGAGTCCTCCGTACGCAGCACCCGAGCTCTTCGAAGGGAGACAGTATGATGGACCCAAAGCCGACATTTGGTCACTGGGCGTCGTATTATACGTTCTGGTCTGCGGGGCGTTGCCGTTCGATGGGAACACCCTCCACGAGCTCAGGAACGTGGTCCTGAGCGGAAAGTTCCGAATACCGTACTTCATGTCACAAGAATGCGAAAATCTAATAAGGCATATGCTGGTCGTGGAACCGGAGAAGAGGTTATCCCTGCGCGGTGTTGCCAGGCACAGGTGGCTGGCGGCACACCAACCTGGGCCAGGACCGGGTGATCGAGATGCGTCGACCGGAGCCTGCATATGTCACACGTCTATGTCGCAGACCGAACCCGGGGCCTCGGAAACTGTTATGGCGCATTTGCTCACGCTCCCCGGGCTCACGAAGGAGCACGTACAACAGTCGGTGCAAGAAGAACGCTTCGATCACATATCGGCTATCTACCACCTCCTCATGGACAAGCTCGAACAGAGAAGCAGCGCCCGGAGTAGCCTGCAGCACAGAGATTCCCTGGACTCGACGACCGGTCTGCCGTTGGATCTCACTAGTTGTAAGAATTCGGAAGACGAGGAGATGGATGCGGAGGATTCTTCGATCCAGGATTCTCTGATATCGTTACCCAATCCTGAAGCGTCGGTGGACTACCTGACCGACGGACCCGAGGCTCTGGAGAAGTTCGGTGACGGCTCGATACCAGTTCAAGAGGAGCGGACCCAGCAGCCCGCCAGCACCGGCGAGCAGCACGCCACCAGGCGGCACACCGTGGGGCCCGGCGACTGCAGACACACACAGGGCGGCGAGCTGAGCGCGTGCGGGGCCGCGGTGTCCGCCGACCTGCGCCCCTCCCCCCTCTACGTATCCGCGCAGTTCAATGCCTCGCCGGACGTGTCGCTGCTGCCGAACACGAACCTAGCCGCCAAGCTGCCGGCCGTGCAGCACCAGCCCGCGCGCTACTTCAGCGTCAAGGACCAGCACCTGCTGAAGCCGCCGCACGCCATGCAGAGCCAAGGTACGAGCTACCTGCGGAGCTCCGTAAAGCAGTAA

Protein

MACNISPIHKSKHFPIDQLVCVGNYELEKTIGTGNFAVVKLATHVITKSKVAIKIIDKSRLDEDNLKKTFREIAIMKRLSHPHIVRLYQVMESTHTIYLVTEYAPNGEIFDHLVSRGRMTESEAARAFSQMVAAVGYCHANGVVHRDLKAENLLLDKNMNIKLADFGFSNEYRTGGALSTWCGSPPYAAPELFEGRQYDGPKADIWSLGVVLYVLVCGALPFDGNTLHELRNVVLSGKFRIPYFMSQECENLIRHMLVVEPEKRLSLRGVARHRWLAAHQPGPGPGDRDASTGACICHTSMSQTEPGASETVMAHLLTLPGLTKEHVQQSVQEERFDHISAIYHLLMDKLEQRSSARSSLQHRDSLDSTTGLPLDLTSCKNSEDEEMDAEDSSIQDSLISLPNPEASVDYLTDGPEALEKFGDGSIPVQEERTQQPASTGEQHATRRHTVGPGDCRHTQGGELSACGAAVSADLRPSPLYVSAQFNASPDVSLLPNTNLAAKLPAVQHQPARYFSVKDQHLLKPPHAMQSQGTSYLRSSVKQ

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine

Uniprot

A0A2A4K7A3   A0A2W1BMK5   A0A2A4K5M6   A0A212EZB9   H9JPB6   A0A194RIZ9   + More
A0A194PYU2   E0VPX8   K7ILZ4   A0A0L7QQB4   A0A0C9RV60   A0A0M9A067   A0A0C9QEA2   A0A151IQZ7   Q4QQA7   A0A232F6Z7   Q0IG70   A0A158NN80   A0A0A9Y3Q2   E2C476   A0A151HY62   A0A2A3E4E6   E2AQ24   A0A088APQ0   A0A224XLQ4   Q7Q5I9   A0A151X0P2   A0A195C3E7   A0NES6   B4HP02   A0A067R3B4   A0A026WRY8   A0A3L8DF00   A0A182YP73   A0A1J1HIR9   A0A182GE93   L7MMY1   A8DYI4   A0A336MWI8   A8DYI5   B4J7N2   A0A1B6H4M6   B3MBU0   L7LUJ6   A0A2S2NKQ2   A0A0B4LFW1   A1ZBC4   A0A023F273   A0A1S4G7H2   A0A0P8XMZ8   A0A0P8XMW6   A0A131XGE2   A0A131YQE6   A0A182QA15   B5DZ12   A0A0J9RFX1   A0A0J9U5M6   A0A084VXN3   B4P4A4   A0A0R1DS47   A0A0J9RG83   A0A0J9RHG4   A0A0R1DXK5   A0A0R1DRZ0   A0A2H8U050   A0A1L8DKS1   A0A154PEE2   L7LTW0   A0A1W4UA84   J9K8Y8   A0A1W4UNZ5   A0A1W4UA80   T1HPG7   A0A1E1X6R7   A0A0Q5VT30   B3NK99   B4KPL5   A0A1Y9IVD2   B4LJ49   A0A0Q5VKW8   A0A0Q5VLS1   A0A0Q9XKL0   A0A1I8Q3Z6   B4MJZ7   A0A0P5QAZ3   A0A1I8NCR8   A0A162RH65   A0A1I8NCR9   A0A1I8Q426   A0A0R3NS22   W8AKG4   A0A3B0JE14   A0A0R3NSH8   A0A0R3NLK6   T1JFK1   A0A0P4ZRN7   A0A0P5Y2V5  

EC Number

2.7.11.1

Pubmed

28756777    22118469    19121390    26354079    20566863    20075255    + More
10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    28648823    17510324    21347285    25401762    26823975    20798317    12364791    14747013    17210077    17994087    24845553    24508170    30249741    25244985    26483478    25576852    25474469    28049606    26830274    15632085    22936249    24438588    17550304    28503490    18057021    25315136    24495485   

EMBL

NWSH01000104    PCG79532.1    KZ149962    PZC76289.1    PCG79531.1    AGBW02011345    + More
OWR46801.1    BABH01009748    BABH01009749    BABH01009750    KQ460152    KPJ17414.1    KQ459593    KPI96325.1    DS235379    EEB15434.1    KQ414786    KOC60820.1    GBYB01012740    JAG82507.1    KQ435789    KOX74477.1    GBYB01012738    JAG82505.1    KQ981148    KYN09093.1    AE013599    BT023509    AAF57652.1    AAY84909.1    NNAY01000772    OXU26601.1    CH477261    EAT45687.1    ADTU01002507    ADTU01002508    ADTU01002509    ADTU01002510    ADTU01002511    ADTU01002512    ADTU01002513    ADTU01002514    ADTU01002515    ADTU01002516    GBHO01019479    GDHC01002131    JAG24125.1    JAQ16498.1    GL452426    EFN77247.1    KQ976747    KYM75320.1    KZ288391    PBC26364.1    GL441651    EFN64467.1    GFTR01007477    JAW08949.1    AAAB01008960    EAA11379.3    KQ982617    KYQ53809.1    KQ978350    KYM94703.1    EAU76597.1    CH480816    EDW48504.1    KK853026    KDR12311.1    KK107119    EZA58703.1    QOIP01000009    RLU18901.1    CVRI01000001    CRK86177.1    JXUM01009542    JXUM01009543    JXUM01009544    JXUM01010158    JXUM01010159    JXUM01010160    JXUM01010161    JXUM01010162    KQ560300    KQ560286    KXJ83174.1    KXJ83262.1    GACK01000070    JAA64964.1    ABV53845.2    UFQS01003371    UFQT01003371    SSX15571.1    SSX34934.1    ABV53846.2    CH916367    EDW02180.1    GECZ01000143    JAS69626.1    CH902619    EDV36111.2    GACK01009549    JAA55485.1    GGMR01005125    MBY17744.1    AHN56382.1    AAF57651.4    GBBI01003668    JAC15044.1    KPU76009.1    KPU76008.1    GEFH01002007    JAP66574.1    GEDV01007795    JAP80762.1    AXCN02000453    CM000071    EDY68850.2    CM002911    KMY94918.1    KMY94920.1    ATLV01018104    ATLV01018105    ATLV01018106    ATLV01018107    KE525212    KFB42727.1    CM000158    EDW91590.2    KRJ99976.1    KMY94921.1    KMY94919.1    KRJ99977.1    KRJ99975.1    GFXV01007327    MBW19132.1    GFDF01007140    JAV06944.1    KQ434889    KZC10232.1    GACK01009518    JAA55516.1    ABLF02031477    ABLF02031485    ACPB03001792    GFAC01004226    JAT94962.1    CH954179    KQS62101.1    EDV55121.2    CH933808    EDW09125.2    CH940648    EDW61485.2    KRF80009.1    KQS62102.1    KQS62100.1    KRG04456.1    CH963846    EDW72436.2    GDIQ01122665    JAL29061.1    LRGB01000189    KZS20507.1    KRT01765.1    GAMC01017435    JAB89120.1    OUUW01000001    SPP73500.1    KRT01763.1    KRT01764.1    JH432171    GDIP01208968    JAJ14434.1    GDIP01063740    JAM39975.1   

Proteomes

UP000218220    UP000007151    UP000005204    UP000053240    UP000053268    UP000009046    + More
UP000002358    UP000053825    UP000053105    UP000078492    UP000000803    UP000215335    UP000008820    UP000005205    UP000008237    UP000078540    UP000242457    UP000000311    UP000005203    UP000007062    UP000075809    UP000078542    UP000001292    UP000027135    UP000053097    UP000279307    UP000076408    UP000183832    UP000069940    UP000249989    UP000001070    UP000007801    UP000075886    UP000001819    UP000030765    UP000002282    UP000076502    UP000192221    UP000007819    UP000015103    UP000008711    UP000009192    UP000075920    UP000008792    UP000095300    UP000007798    UP000095301    UP000076858    UP000268350   

PRIDE

H9JPB6    Q4QQA7    A1ZBC4   

Pfam

PF02149   KA1        + More
PF00069   Pkinase
PF05033   Pre-SET
PF01429   MBD
PF00856   SET
PF18359   TUDOR_5
PF18358   Tudor_4

Interpro

IPR017441   Protein_kinase_ATP_BS        + More
IPR011009   Kinase-like_dom_sf       
IPR008271   Ser/Thr_kinase_AS       
IPR028375   KA1/Ssp2_C       
IPR001772   KA1_dom       
IPR000719   Prot_kinase_dom       
IPR034672   SIK       
IPR002999   Tudor       
IPR041291   TUDOR_5       
IPR016177   DNA-bd_dom_sf       
IPR001739   Methyl_CpG_DNA-bd       
IPR001214   SET_dom       
IPR003616   Post-SET_dom       
IPR041292   Tudor_4       
IPR007728   Pre-SET_dom       

SUPFAM

SSF103243   SSF103243        + More
SSF56112   SSF56112       
SSF54171   SSF54171       

CDD

cd14071  STKc_SIK

ProteinModelPortal

A0A2A4K7A3   A0A2W1BMK5   A0A2A4K5M6   A0A212EZB9   H9JPB6   A0A194RIZ9   + More
A0A194PYU2   E0VPX8   K7ILZ4   A0A0L7QQB4   A0A0C9RV60   A0A0M9A067   A0A0C9QEA2   A0A151IQZ7   Q4QQA7   A0A232F6Z7   Q0IG70   A0A158NN80   A0A0A9Y3Q2   E2C476   A0A151HY62   A0A2A3E4E6   E2AQ24   A0A088APQ0   A0A224XLQ4   Q7Q5I9   A0A151X0P2   A0A195C3E7   A0NES6   B4HP02   A0A067R3B4   A0A026WRY8   A0A3L8DF00   A0A182YP73   A0A1J1HIR9   A0A182GE93   L7MMY1   A8DYI4   A0A336MWI8   A8DYI5   B4J7N2   A0A1B6H4M6   B3MBU0   L7LUJ6   A0A2S2NKQ2   A0A0B4LFW1   A1ZBC4   A0A023F273   A0A1S4G7H2   A0A0P8XMZ8   A0A0P8XMW6   A0A131XGE2   A0A131YQE6   A0A182QA15   B5DZ12   A0A0J9RFX1   A0A0J9U5M6   A0A084VXN3   B4P4A4   A0A0R1DS47   A0A0J9RG83   A0A0J9RHG4   A0A0R1DXK5   A0A0R1DRZ0   A0A2H8U050   A0A1L8DKS1   A0A154PEE2   L7LTW0   A0A1W4UA84   J9K8Y8   A0A1W4UNZ5   A0A1W4UA80   T1HPG7   A0A1E1X6R7   A0A0Q5VT30   B3NK99   B4KPL5   A0A1Y9IVD2   B4LJ49   A0A0Q5VKW8   A0A0Q5VLS1   A0A0Q9XKL0   A0A1I8Q3Z6   B4MJZ7   A0A0P5QAZ3   A0A1I8NCR8   A0A162RH65   A0A1I8NCR9   A0A1I8Q426   A0A0R3NS22   W8AKG4   A0A3B0JE14   A0A0R3NSH8   A0A0R3NLK6   T1JFK1   A0A0P4ZRN7   A0A0P5Y2V5  

PDB

2QNJ     E-value=7.79955e-100,     Score=930

KEGG

101738182    K19009 serine/threonine-protein kinase SIK3 [EC:2.7.11.1] | (RefSeq) serine/threonine-protein kinase

GO

GO:0005524   GO:0004674   GO:0004683   GO:0004672   GO:0006468   GO:0005634   GO:0005737   GO:0042149   GO:0031588   GO:0032007   GO:0035556   GO:0016021   GO:0042594   GO:0042308   GO:0018107   GO:0010897   GO:0055088   GO:0008286   GO:0050802   GO:0005694   GO:0018024   GO:0003677   GO:0008270   GO:0000287   GO:0004715   GO:0007067   GO:0004713   GO:0016491   GO:0015930  

Subcellular location

Chromosome  
Nucleus  

Length:

542

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

2.3369

Exp number, first 60 AAs:

0.0043

Total prob of N-in:

0.11591

outside

1  -  542

 

 

Pi

188.50894

Theta

157.798856

Tajima's D

1.294746

CLR

0.250514

CSRT

0.739463026848658

Interpretation

Uncertain