Gene

KWMTBOMO14029  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011360

Annotation

Putative_glycogen_[starch]_synthase_[Papilio_machaon]

Location

Bomo_Chr23(+):16204169-16217073      View in EpiBrowser

Full name

Glycogen [starch] synthase      

Alternative Name

Glycogen synthase

Location in the cell

Cytoplasmic   Reliability : 2.017

CDS

ATGTCAAAGGATCGCAGCTCGAGGCGGTTCTATCGTGCGGAGTCCACTCATGATCTGTCGTCATTCATGGACCGCGGCCGCGCCGCCAGCGACGAGAACAGATGGACCTTCGAGTGCGCCTGGGAAGTCGCCAACAAAGTTGGCGGTATTTATACGGTAATAAGATCGAAAGCATTCGTCTCCACTGAAGAAATGGGAGACAACTATTGCTTGCTTGGTCCGTATAAGGAGCAATGCGCGCGAACTGAAGTCGAAGAGGGAGAGTTCCCCTCCGACTCCCCCCTGTTGACAGCCGTTAACGCCATGAGGAGTAAAGGTTACAAGTTACACACGGGCACTTGGCTGGTAGATGGGAACCCTCAAATAGTTCTTTTCGACATCGGGTCTGGGGCGTGGCAGTTGGATGCTTACAAGCAGGAGCTATGGGACACTTGCTCCGTCGGCATCCCGCATCTCGACGTGGAGGCCAACGACGCCGTGATCCTAGGGTTCATGGTCGCGCAGTTCATAAGCGAGTTCCGCGAGGCGGTGGAGGGGCGCGGTGGGGTGCCGGCTCGCGTGGTGGCGCAGTTCCACGAGTGGCAGGCGGGAATCGGGCTCATCGTTCTAAGGGTACGCCATGTTGACGTGGCGACCGTATTCACGACTCACGCGACGCTCCTCGGCAGATACCTCTGCGCTGGCAACACAGACTTCTACAATAACCTGGATAAGTTCTCTGTGGACGAGGAGGCGGGAAAGAGACAGATATACCACCGCTACTGCATGGAGCGGGCCGCCTCGCACATGGCACACATCTTCACCACCGTCTCCGACATCACGGGATACGAAGCCGAGTACTTGCTCAAACGGAAGCCGGACATCATCACCCCGAACGGTTTGAACGTGAAGAAATTCTCGGCGCTGCACGAGTTCCAGAACCTGCACGCCCTCGCCAAGGACAAGATACACGAATTCGTTAGGGGACATTTTTACGGGTAA

Protein

MSKDRSSRRFYRAESTHDLSSFMDRGRAASDENRWTFECAWEVANKVGGIYTVIRSKAFVSTEEMGDNYCLLGPYKEQCARTEVEEGEFPSDSPLLTAVNAMRSKGYKLHTGTWLVDGNPQIVLFDIGSGAWQLDAYKQELWDTCSVGIPHLDVEANDAVILGFMVAQFISEFREAVEGRGGVPARVVAQFHEWQAGIGLIVLRVRHVDVATVFTTHATLLGRYLCAGNTDFYNNLDKFSVDEEAGKRQIYHRYCMERAASHMAHIFTTVSDITGYEAEYLLKRKPDIITPNGLNVKKFSALHEFQNLHALAKDKIHEFVRGHFYG

Description

Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.
Transfers the glycosyl residue from UDPG to the non-reducing end of alpha-1,4-glucan. In larval skeletal muscle, isoform B is required for the formation of autophagosomes during starvation and during cloroquine-induced vacuolar myopathy.

Catalytic Activity

[(1->4)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + H(+) + UDP

Subunit

Isoform B interacts with Atg8a upon starvation.

Similarity

Belongs to the glycosyltransferase 3 family.

Keywords

Alternative splicing   Complete proteome   Cytoplasmic vesicle   Glycogen biosynthesis   Glycosyltransferase   Phosphoprotein   Reference proteome   Transferase  

Feature

chain  Glycogen [starch] synthase
splice variant  In isoform B.

Uniprot

H9JPA6   A0A194RQV1   A0A2A4IX43   A0A2H1VWK1   A0A212EVT8   F2Q6J8   + More
A0A154P9X4   A0A195C3G8   A0A195AVG9   A0A026X010   A0A195ETM8   A0A3L8E0G6   A0A2J7RI90   A0A151WGI9   A0A195E342   A0A2J7RI94   F4WA55   A0A0N0BF19   A0A067QZJ4   E2BGV0   A0A1B6CWL5   C0KJJ5   A0A088ARU9   E2A8G5   A0A1B6KQ54   A0A1B6GZ27   A0A0L7RDK2   E0VIZ4   A0A2A3EK09   A0A182GDP6   A0A1J1IEQ0   Q17DG0   A0A1I8MXF1   A0A0L0CI26   A0A1I8NQ95   T1PHM8   A0A034VCR1   A0A0M5L067   B4JV20   B3M1A8   B4LZW3   A0A182Y6H3   A0A1I8NQA2   A0A182SE67   A0A0V0GA99   B4NKT6   A0A182RBY9   A0A182M1X1   B4KDK1   A0A023F5E3   A0A0A1WWC2   A0A182XAS3   W8BIE7   A0A182UQB3   A0A182LEP3   A0A182U3D5   Q7QCE1   A0A182HSL9   A0A0Q9WF19   A0A182JSF2   A0A0Q9WV23   A0A2M4AQU9   A0A182F701   A0A1Q3FEZ8   A0A1B0C8D5   A0A0T6AW96   A0A182NZU9   A0A1Y1NDJ9   B4HE19   T1IBT2   A0A0M5J9F3   A0A1W4W0A6   A0A224X8N4   A0A182W0Y2   A0A0Q9WY51   A0A0Q9X5D7   A0A3B0JMS6   D2A654   A0A182QDI6   W5JVQ3   A0A182NRI9   A0A3B0JT03   A0A2P8XAU2   A0A3B0JRC6   B4QZ52   D5SHR2   B4PS90   B3P0Q7   Q9VFC8   A0A1W4VN51   A0A1Q3FEX8   B0WDW2   Q296I4   A0A3B0JMR5   U5ET57   A0A2H8TKY8   B4GF43   A0A0R1E850   A0A0R3NIA9   Q9VFC8-2  

EC Number

2.4.1.11

Pubmed

19121390    26354079    22118469    24508170    30249741    21719571    + More
24845553    20798317    20566863    26483478    17510324    25315136    26108605    25348373    17994087    25244985    25474469    25830018    24495485    20966253    12364791    14747013    17210077    28004739    18362917    19820115    20920257    23761445    29403074    17550304    10731132    12537572    12537569    17372656    18327897    24265594    15632085   

EMBL

BABH01009723    BABH01009724    KQ459875    KPJ19685.1    NWSH01006076    PCG63683.1    + More
ODYU01004881    SOQ45209.1    AGBW02012131    OWR45581.1    FJ809918    ADA53796.1    KQ434856    KZC08736.1    KQ978350    KYM94723.1    KQ976737    KYM75969.1    KK107069    EZA60734.1    KQ981975    KYN31605.1    QOIP01000002    RLU26147.1    NEVH01003505    PNF40545.1    KQ983167    KYQ46941.1    KQ979763    KYN19294.1    PNF40546.1    GL888041    EGI68911.1    KQ435814    KOX72681.1    KK852809    KDR15979.1    GL448228    EFN85082.1    GEDC01019480    GEDC01012728    JAS17818.1    JAS24570.1    FJ609646    ACM78946.1    GL437593    EFN70285.1    GEBQ01026407    JAT13570.1    GECZ01002111    JAS67658.1    KQ414614    KOC68865.1    DS235215    EEB13350.1    KZ288222    PBC32105.1    JXUM01010235    KQ560302    KXJ83162.1    CVRI01000048    CRK98691.1    CH477295    EAT44424.1    JRES01000344    KNC32063.1    KA647393    AFP62022.1    GAKP01018683    JAC40269.1    KR075826    ALE20545.1    CH916374    EDV91340.1    CH902617    EDV42135.1    CH940650    EDW67191.1    GECL01001052    JAP05072.1    CH964272    EDW84147.2    AXCM01000202    CH933806    EDW13835.1    GBBI01002358    JAC16354.1    GBXI01010958    JAD03334.1    GAMC01008058    JAB98497.1    AAAB01008859    EAA08045.3    APCN01000295    KRF83149.1    KRF99982.1    GGFK01009657    MBW42978.1    GFDL01008930    JAV26115.1    AJWK01000444    LJIG01022657    KRT79402.1    GEZM01005726    GEZM01005725    JAV95963.1    CH480815    EDW42111.1    ACPB03004993    CP012526    ALC46911.1    GFTR01007741    JAW08685.1    KRG00661.1    KRG00660.1    OUUW01000007    SPP83535.1    KQ971346    EFA05468.1    AXCN02001457    ADMH02000177    ETN67493.1    SPP83532.1    PYGN01006873    PSN29113.1    SPP83533.1    CM000364    EDX12880.1    BT124863    ADG03448.1    CM000160    EDW97510.1    CH954181    EDV48955.1    AE014297    AY052005    GFDL01008941    JAV26104.1    DS231902    EDS45043.1    CM000070    EAL28473.3    SPP83534.1    GANO01002077    JAB57794.1    GFXV01002875    MBW14680.1    CH479182    EDW34228.1    KRK03794.1    KRT00745.1   

Proteomes

UP000005204    UP000053240    UP000218220    UP000007151    UP000076502    UP000078542    + More
UP000078540    UP000053097    UP000078541    UP000279307    UP000235965    UP000075809    UP000078492    UP000007755    UP000053105    UP000027135    UP000008237    UP000005203    UP000000311    UP000053825    UP000009046    UP000242457    UP000069940    UP000249989    UP000183832    UP000008820    UP000095301    UP000037069    UP000095300    UP000001070    UP000007801    UP000008792    UP000076408    UP000075901    UP000007798    UP000075900    UP000075883    UP000009192    UP000076407    UP000075903    UP000075882    UP000075902    UP000007062    UP000075840    UP000075881    UP000069272    UP000092461    UP000075885    UP000001292    UP000015103    UP000092553    UP000192221    UP000075920    UP000268350    UP000007266    UP000075886    UP000000673    UP000075884    UP000245037    UP000000304    UP000002282    UP000008711    UP000000803    UP000002320    UP000001819    UP000008744   

PRIDE

H9JPA6    D5SHR2    Q9VFC8   

Pfam

PF05693   Glycogen_syn        + More
PF09104   BRCA-2_OB3
PF00634   BRCA2
PF09103   BRCA-2_OB1
PF09169   BRCA-2_helical

Interpro

IPR008631   Glycogen_synth        + More
IPR036315   BRCA2_hlx_sf       
IPR015188   BRCA2_OB_3       
IPR015252   BRCA2_hlx       
IPR002093   BRCA2_repeat       
IPR012340   NA-bd_OB-fold       
IPR015187   BRCA2_OB_1       
IPR015205   Tower_dom       

SUPFAM

SSF81872   SSF81872        + More
SSF50249   SSF50249       

CDD

cd04493  BRCA2DBD_OB1
cd03793  GT1_Glycogen_synthase_GSY2_lik

ProteinModelPortal

H9JPA6   A0A194RQV1   A0A2A4IX43   A0A2H1VWK1   A0A212EVT8   F2Q6J8   + More
A0A154P9X4   A0A195C3G8   A0A195AVG9   A0A026X010   A0A195ETM8   A0A3L8E0G6   A0A2J7RI90   A0A151WGI9   A0A195E342   A0A2J7RI94   F4WA55   A0A0N0BF19   A0A067QZJ4   E2BGV0   A0A1B6CWL5   C0KJJ5   A0A088ARU9   E2A8G5   A0A1B6KQ54   A0A1B6GZ27   A0A0L7RDK2   E0VIZ4   A0A2A3EK09   A0A182GDP6   A0A1J1IEQ0   Q17DG0   A0A1I8MXF1   A0A0L0CI26   A0A1I8NQ95   T1PHM8   A0A034VCR1   A0A0M5L067   B4JV20   B3M1A8   B4LZW3   A0A182Y6H3   A0A1I8NQA2   A0A182SE67   A0A0V0GA99   B4NKT6   A0A182RBY9   A0A182M1X1   B4KDK1   A0A023F5E3   A0A0A1WWC2   A0A182XAS3   W8BIE7   A0A182UQB3   A0A182LEP3   A0A182U3D5   Q7QCE1   A0A182HSL9   A0A0Q9WF19   A0A182JSF2   A0A0Q9WV23   A0A2M4AQU9   A0A182F701   A0A1Q3FEZ8   A0A1B0C8D5   A0A0T6AW96   A0A182NZU9   A0A1Y1NDJ9   B4HE19   T1IBT2   A0A0M5J9F3   A0A1W4W0A6   A0A224X8N4   A0A182W0Y2   A0A0Q9WY51   A0A0Q9X5D7   A0A3B0JMS6   D2A654   A0A182QDI6   W5JVQ3   A0A182NRI9   A0A3B0JT03   A0A2P8XAU2   A0A3B0JRC6   B4QZ52   D5SHR2   B4PS90   B3P0Q7   Q9VFC8   A0A1W4VN51   A0A1Q3FEX8   B0WDW2   Q296I4   A0A3B0JMR5   U5ET57   A0A2H8TKY8   B4GF43   A0A0R1E850   A0A0R3NIA9   Q9VFC8-2  

PDB

4QLB     E-value=1.26879e-111,     Score=1030

KEGG

101736417    K00693 glycogen synthase [EC:2.4.1.11] | (RefSeq) glycogen [starch] synthase

GO

GO:0005978   GO:0004373   GO:0000724   GO:0016021   GO:0061723   GO:0009267   GO:0071329   GO:0045819   GO:0005737   GO:0009744   GO:0005977   GO:0031410   GO:0005776   GO:0045747   GO:0000287   GO:0004715   GO:0005634   GO:0007067   GO:0004713   GO:0016491   GO:0015930  

PANTHER

PTHR10176  

Subcellular location

  

Length:

326

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05076

Exp number, first 60 AAs:

0.0022

Total prob of N-in:

0.07869

outside

1  -  326

 

 

Pi

226.380973

Theta

173.905088

Tajima's D

0.904812

CLR

0.015949

CSRT

0.631968401579921

Interpretation

Uncertain