Gene

KWMTBOMO14019

Pre Gene Modal

BGIBMGA011250

Annotation

PREDICTED:_wee1-like_protein_kinase_[Amyelois_transitella]

Location

Bomo_Chr23(-):16058041-16068078      View in EpiBrowser

Full name

Wee1-like protein kinase      

Location in the cell

Nuclear   Reliability : 3.797

CDS

ATGAAAACAGGACTAAACAATAAGCACAATTCGTCTGAATTGTCTGTCGAGACATCTTGTGACATGTCGGATCCTTTTAACATATTTTCTGATAATTTGAGCCCGATACCAGCGTCCATTGTGCCTAGGAAGCTAGATTTTAGTAATCTGGACGATGATGACGGCATCAGAGATGAATCCCAGGCGCCTGTATCTCACAGCCCACCTTATAAGAGAGTCAGAGCCTTGAGGTTGTTCGACAGTCCTCACACTCCAAAGACGCTCTTAGAGAAGTGTTCGACACCGACTCATCATCCGCCCAGGACGAGACTGTTCCCGCCCAAGATCAACGTGCAAACAGGAATGCCATCAGGCTCGAGCCACCACCTCCATCCGCCATCTGGTGACGACGACAGCGCGCTCGGCAGTCTACCCCCGGACGAACTGGACGAGTCCCGGCTGACCGTAAGGCGTCCTATTGCCAACATCAATCCTTTCACGCCTGATGGTCAAGCGTTAAACAAAAAGAAACGTGCCTTATCCAAGACTCCGACCTGGGACGGCACGCCCGAGCAGCCGGCCAAAAGACTAAGGGAATCGAATATATCCCGTTACAACGTGGAGTTCATAGAGCTGGGAGTCATCGGACGCGGGCAGTTCGGGCGCGTCACCCGGTGCGTCAACAAACTGGACGGCTGCGTCTACGCCCTCAAGCGCTCCCTGCGCCCCGTGGCGGGCTCCGCCGCCGAGCGCGCCGCCCTCACCGAGGTATACGCGCATGCCGCCCTGGGGAAACATCCGCACGTGGTCAGATACTACTCGGCCTGGGCGGAGGACGATCACATGATAATCCAGAACGAGTACTGCGACGGAGGCTCCTTACAGCTGAAGATGGAGGACGGGCCGCTGCCGGAGAGCGAACTCCTCATACTACTCTCACACATAGCTGCAGGACTCGCCTATATACACTCCCAGCAACTAGTACACATGGACGTGAAGCCCGGTAACATATTCATATGCAGCGGTGACGTGGACGCCTGCAGGGAGTCAGACGACGGCTACGACGACGAGGAACCAGCTCCTAATCATAAATATAAAATCGGTGACCTAGGTCATGTGACATGTGTATCTTCGCCCGCTGTAGAGGAAGGCGACTGCAGGTACCTACCCAAGGAAGTCTTACACGAAGACTTTTCGCAGTTACCTAAAGCTGACATATTTGCTTTTGGTTTGACGTTATTCGAGGCAGCTGGAGGGGGACCATTACCTAAAAACGGACAAAAATGGCACGATTACAGGGACGGAAAATTACCAGATTTGCCAAACTTGTCCAGAGAGTTCAATGATCTCCTCAAGAGCATGGTGGACCCGTCTCCGAGCGCGCGTCCGTCAGCGCGTCGCCTGCGTCGCATGGCGTGGCGGGGCGGGGCGTGGCGCGGCGTGGCGGCGCCGATCAAGTCGCGGGCGCAGCTACGGCGCGAGCTCGCCGCCGCCAACATGAAGAACGAGTTGCTCGCCAGGAAGCTACACGATGCTGCCAAATGCATCAAGTCGTTGACCCCCAGCCTCGAGTCCAGCAAGTTCCGGACGCGCTCCGCCGCCAAGAGGACGCAGAAGCCGCGAATCGACACTTGCCTCTCTGACGTGTTGCAGCTCTGA

Protein

MKTGLNNKHNSSELSVETSCDMSDPFNIFSDNLSPIPASIVPRKLDFSNLDDDDGIRDESQAPVSHSPPYKRVRALRLFDSPHTPKTLLEKCSTPTHHPPRTRLFPPKINVQTGMPSGSSHHLHPPSGDDDSALGSLPPDELDESRLTVRRPIANINPFTPDGQALNKKKRALSKTPTWDGTPEQPAKRLRESNISRYNVEFIELGVIGRGQFGRVTRCVNKLDGCVYALKRSLRPVAGSAAERAALTEVYAHAALGKHPHVVRYYSAWAEDDHMIIQNEYCDGGSLQLKMEDGPLPESELLILLSHIAAGLAYIHSQQLVHMDVKPGNIFICSGDVDACRESDDGYDDEEPAPNHKYKIGDLGHVTCVSSPAVEEGDCRYLPKEVLHEDFSQLPKADIFAFGLTLFEAAGGGPLPKNGQKWHDYRDGKLPDLPNLSREFNDLLKSMVDPSPSARPSARRLRRMAWRGGAWRGVAAPIKSRAQLRRELAAANMKNELLARKLHDAAKCIKSLTPSLESSKFRTRSAAKRTQKPRIDTCLSDVLQL

Description

Acts as a negative regulator of entry into mitosis (G2 to M transition) (PubMed:8573790, PubMed:15581871). This kinase specifically phosphorylates and inactivates cyclin B1-complexed CDC2 (PubMed:8573790, PubMed:15581871).

Catalytic Activity

ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]

Cofactor

Mg(2+)

Similarity

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.
Belongs to the protein kinase superfamily.

Keywords

ATP-binding   Cell cycle   Cell division   Complete proteome   Kinase   Magnesium   Metal-binding   Mitosis   Nucleotide-binding   Nucleus   Phosphoprotein   Reference proteome   Transferase   Tyrosine-protein kinase  

Feature

chain  Wee1-like protein kinase

Uniprot

A0A2A4JB00   H9JNZ6   A0A2H1VSN7   A0A212EWP7   A0A194PTK5   A0A194RJB9   + More
A0A2P8XSC1   A0A3L8DJY4   A0A026W5Q4   A0A151IU29   A0A067QT31   A0A2A3E3T4   V9IMG9   A0A088APQ2   A0A0L7QQC4   F4WRG5   A0A195BF95   A0A158NR80   A0A151IFT3   D2A450   A0A232FF47   A0A2J7QNA3   A0A310SLR0   A0A0C9R5U9   K7IMJ6   A0A151X4Q6   E9IRX2   E2BG89   U4UID6   N6TR03   A0A0M9A289   A0A195FK08   A0A0P4X1V9   A0A1U8YL09   E2A0D9   A0A1Y1MBC7   A0A1I8MRR1   Q16Q78   A0A1A9W029   A0A0P6IW24   A0A0J7KE79   A0A182MPL5   A0A182XZM1   A0A182GDM2   A0A0L0BQK2   A0A1B0D3L0   A0A1I8PBF7   A0A3R7MPB8   Q7Q3B5   A0A1B0FF84   A0A1B0A507   A0A336LPW6   A0A1B0BJH5   A0A1A9XGV3   A0A1A9V9L0   H2YY57   A0A131YJK9   A0A224ZBU3   A0A224Z5K3   A0A1E1X7Z4   A0A1E1XM85   A0A2B4SG00   L7MDD7   A0A3M6TKX9   A0A131XBK8   A0A0K8UY39   A0A3B0K135   B4HXZ5   B4KJW8   A0A084VI26   A0A0J9QY48   A0A034VEX8   B4LRP4   H2YY55   W8BEX8   A0A1W4UC26   B4N065   M9PB57   P54350   H2YY56   A0A0P6A009   A0A0P5USI7   B3N5Y7   B4Q533   B4NZZ5   W5J7L9   E9G3U2   B4JQL4   A0A1Z5L8B5   A0A0P4ZZD3   A0A0N8CPH6   A0A1J1J1S1   A0A182UVY8   A0A1S3IJQ4   A0A0P5IQ28   A0A182F1R0   A0A0P5PLK6  

EC Number

2.7.10.2

Pubmed

19121390    22118469    26354079    29403074    30249741    24508170    + More
24845553    21719571    21347285    18362917    19820115    28648823    20075255    21282665    20798317    23537049    28004739    25315136    17510324    26999592    25244985    26483478    26108605    12364791    26830274    28797301    28503490    29209593    25576852    30382153    28049606    17994087    24438588    22936249    25348373    24495485    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    8573790    12537569    15581871    18327897    17550304    20920257    23761445    21292972    28528879   

EMBL

NWSH01002069    PCG69255.1    BABH01009712    ODYU01004221    SOQ43871.1    AGBW02011924    + More
OWR45909.1    KQ459593    KPI96308.1    KQ460152    KPJ17435.1    PYGN01001429    PSN34900.1    QOIP01000007    RLU20754.1    KK107390    EZA51400.1    KQ980970    KYN10917.1    KK852971    KDR13088.1    KZ288391    PBC26375.1    JR052917    AEY61816.1    KQ414786    KOC60827.1    GL888285    EGI63236.1    KQ976504    KYM82884.1    ADTU01023818    KQ977771    KYN00017.1    KQ971348    EFA05807.2    NNAY01000356    OXU28937.1    NEVH01013198    PNF30062.1    KQ763867    OAD54667.1    GBYB01008167    JAG77934.1    KQ982540    KYQ55415.1    GL765283    EFZ16644.1    GL448116    EFN85297.1    KB630089    KB632310    ERL83379.1    ERL92128.1    APGK01055295    KB741261    ENN71650.1    KQ435789    KOX74463.1    KQ981522    KYN40597.1    GDRN01023973    JAI67753.1    KU866456    AMP81927.1    GL435586    EFN73076.1    GEZM01036186    JAV82911.1    CH477758    EAT36552.1    GDUN01000589    JAN95330.1    LBMM01008914    KMQ88534.1    AXCM01003593    JXUM01056418    KQ561910    KXJ77197.1    JRES01001511    KNC22360.1    AJVK01002947    AJVK01002948    AJVK01002949    AJVK01002950    AJVK01002951    QCYY01000835    ROT82384.1    AAAB01008964    EAA12306.4    CCAG010014240    UFQT01000108    SSX20106.1    JXJN01015395    GEDV01009074    JAP79483.1    GFPF01013378    MAA24524.1    GFPF01013379    MAA24525.1    GFAC01003816    JAT95372.1    GFAA01003238    JAU00197.1    LSMT01000086    PFX28296.1    GACK01002798    JAA62236.1    RCHS01003431    RMX41941.1    GEFH01005033    JAP63548.1    GDHF01020856    JAI31458.1    OUUW01000006    SPP81560.1    CH480818    EDW51925.1    CH933807    EDW12571.2    ATLV01013264    KE524849    KFB37620.1    CM002910    KMY88644.1    GAKP01017091    JAC41861.1    CH940649    EDW64646.2    GAMC01006665    JAB99890.1    CH963920    EDW78000.2    AE014134    AGB92703.1    U17223    AY118942    GDIP01049490    JAM54225.1    GDIP01110142    JAL93572.1    CH954177    EDV59146.1    CM000361    EDX04025.1    CM000157    EDW87822.1    ADMH02002119    ETN58794.1    GL732531    EFX85928.1    CH916372    EDV99194.1    GFJQ02003450    JAW03520.1    GDIP01206330    GDIP01078305    JAJ17072.1    GDIP01111639    JAL92075.1    CVRI01000066    CRL06288.1    GDIQ01209554    JAK42171.1    GDIQ01132192    JAL19534.1   

Proteomes

UP000218220    UP000005204    UP000007151    UP000053268    UP000053240    UP000245037    + More
UP000279307    UP000053097    UP000078492    UP000027135    UP000242457    UP000005203    UP000053825    UP000007755    UP000078540    UP000005205    UP000078542    UP000007266    UP000215335    UP000235965    UP000002358    UP000075809    UP000008237    UP000030742    UP000019118    UP000053105    UP000078541    UP000000311    UP000095301    UP000008820    UP000091820    UP000036403    UP000075883    UP000076408    UP000069940    UP000249989    UP000037069    UP000092462    UP000095300    UP000283509    UP000007062    UP000092444    UP000092445    UP000092460    UP000092443    UP000078200    UP000007875    UP000225706    UP000275408    UP000268350    UP000001292    UP000009192    UP000030765    UP000008792    UP000192221    UP000007798    UP000000803    UP000008711    UP000000304    UP000002282    UP000000673    UP000000305    UP000001070    UP000183832    UP000075903    UP000085678    UP000069272   

PRIDE

H9JNZ6    P54350   

Pfam

PF00069   Pkinase        + More
PF13593   SBF_like

Interpro

IPR017164   Wee1-like_protein_kinase        + More
IPR000719   Prot_kinase_dom       
IPR011009   Kinase-like_dom_sf       
IPR008271   Ser/Thr_kinase_AS       
IPR017441   Protein_kinase_ATP_BS       
IPR038770   Na+/solute_symporter_sf       
IPR016833   Put_Na-Bile_cotransptr       

SUPFAM

SSF56112   SSF56112       

Gene 3D

1.20.1530.20    

ProteinModelPortal

A0A2A4JB00   H9JNZ6   A0A2H1VSN7   A0A212EWP7   A0A194PTK5   A0A194RJB9   + More
A0A2P8XSC1   A0A3L8DJY4   A0A026W5Q4   A0A151IU29   A0A067QT31   A0A2A3E3T4   V9IMG9   A0A088APQ2   A0A0L7QQC4   F4WRG5   A0A195BF95   A0A158NR80   A0A151IFT3   D2A450   A0A232FF47   A0A2J7QNA3   A0A310SLR0   A0A0C9R5U9   K7IMJ6   A0A151X4Q6   E9IRX2   E2BG89   U4UID6   N6TR03   A0A0M9A289   A0A195FK08   A0A0P4X1V9   A0A1U8YL09   E2A0D9   A0A1Y1MBC7   A0A1I8MRR1   Q16Q78   A0A1A9W029   A0A0P6IW24   A0A0J7KE79   A0A182MPL5   A0A182XZM1   A0A182GDM2   A0A0L0BQK2   A0A1B0D3L0   A0A1I8PBF7   A0A3R7MPB8   Q7Q3B5   A0A1B0FF84   A0A1B0A507   A0A336LPW6   A0A1B0BJH5   A0A1A9XGV3   A0A1A9V9L0   H2YY57   A0A131YJK9   A0A224ZBU3   A0A224Z5K3   A0A1E1X7Z4   A0A1E1XM85   A0A2B4SG00   L7MDD7   A0A3M6TKX9   A0A131XBK8   A0A0K8UY39   A0A3B0K135   B4HXZ5   B4KJW8   A0A084VI26   A0A0J9QY48   A0A034VEX8   B4LRP4   H2YY55   W8BEX8   A0A1W4UC26   B4N065   M9PB57   P54350   H2YY56   A0A0P6A009   A0A0P5USI7   B3N5Y7   B4Q533   B4NZZ5   W5J7L9   E9G3U2   B4JQL4   A0A1Z5L8B5   A0A0P4ZZD3   A0A0N8CPH6   A0A1J1J1S1   A0A182UVY8   A0A1S3IJQ4   A0A0P5IQ28   A0A182F1R0   A0A0P5PLK6  

PDB

1X8B     E-value=1.04159e-75,     Score=722

KEGG

100134918    no KO assigned | (RefSeq) Sir-2; sid-1-related gene2

GO

GO:0000287   GO:0005634   GO:0004715   GO:0005524   GO:0000278   GO:0004674   GO:0046872   GO:0007093   GO:0004713   GO:0004672   GO:0016021   GO:0016301   GO:0051642   GO:0051225   GO:0051299   GO:0045736   GO:0018108   GO:0006468   GO:0051301   GO:0001700   GO:0007067   GO:0016491   GO:0015930  

Subcellular location

Nucleus  

Length:

545

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.02412

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00536

outside

1  -  545

 

 

Pi

228.907337

Theta

198.068714

Tajima's D

0.478698

CLR

0.063602

CSRT

0.510024498775061

Interpretation

Uncertain