Silkworm Genome Informatics Database

Gene

KWMTBOMO14013

Pre Gene Modal

BGIBMGA011351

Annotation

PREDICTED:_importin_subunit_alpha-5-like_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr23(+):15941349-15954293 View in EpiBrowser

Full name

Importin subunit alpha + More
Importin subunit alpha-1

Alternative Name

Importin alpha P1
Karyopherin subunit alpha-2
Pendulin
Pore targeting complex 58 kDa subunit
RAG cohort protein 1
SRP1-alpha

Location in the cell

Cytoplasmic Reliability : 2.655

CDS

ATGGCTGAACGAACCTCGAGATTGTCATCGTACAAAAACGCCGGTCAGGGTACCACAGAGTTGCGTCGCAAACGTGCAGAGCTCAGTGTGGCGTTACGAAAACAGGCTCGAGATGAACAACTCCTTAAGAGGCGTGCAATGTCCCCGGAGACTGAAACTCCTGTGGAAACAGAGAAAGTCATGACGCCTGAAGAAATTCTGGAGGAACTCAAATCACAAGACCTAACCAGAAAGACAAATGCAGCACGAGCAGCTCGCAGAATGCTGTCTCGCGAACAGAAACCACCCATCTCTATTATGGTTAATGCAGGAGTCATTAAGCCTTTGGTTGAAGCTTTGGATCATGATGAATGTAGCGATCTACAGTTTGAAGCAGCATGGGCTCTCACCAATATTGCTTCAGGCACCCGACAACATACCATGGCTGTTGTTGATGGTGGAGCTGTACCCAAACTAATAAGCCTTTTAGGTCAAGGCGGTGTGGTCGGAGAACAGTGCGCATGGGCACTGGGGAACATAGCTGGAGACGGCCCGGAGACTAGAGATATGATCCTAAATGCAGGAATAATGCAGGCCTTGGTGCCACTTCTAAATGCACAAACTCCAACCAGTCAACTGAGAATAGCTGTTTGGACTTACAGTAACCTTTGCAGAAACAAAAACCCTCTAGTGCAATTCGATCTTGTAGCCCCGGCTCTACCTTACATTTCTGATTTATTGGAAATATCAGATCAAGATGTGCTTGCGGACTCATGCTGGGCATTGTCATATCTGACAGACGGCCCCAATGAGCGCATAGAAGGGGTGCAGACTACCAGACATCTGCTGCCGCGTCTCGTTTCTCTACTAGAACACCCAGCACCTGCAGTCGCCACACCAGCACTGCGAGCTTTAGGAAATATGCTCACCGGCTCAGATATACAGACAGACCGTTGCCTGGATGCCGACTGCCTTAAACCCATAAGTCGTCTCCTGTCTGCATCTCCTGCTCTCAGTAAGGAAGCTGCGTGGGCTTGCAGCAACGTGTTCGCGGGAACAGCACCACAGATACAGAGAGCTATCGACAGCGGGGTGCTGGAGCCAATCGCTAGGGTCCTGGTGCATCATGACATCAAGTGCCAGAAGGAAGCGGCCTGGGCCATTACAAACCTGTGTCTTGGAGGCACCCCTGAACAACTGGACGCCATGCTGTCCTGTGATATTCTGTCGCCGTACTGCGCCCTGCTCCAGGCCAGGGATCACCGAGCCATCATCGTAGTGCTGGATGGACTCACTCATCTATTGCAGGCTGCGGCGAAATACGATCAAGTTAGAGGAATGTGCATAAAGTTGGAAGAGATTGGCGCTCTGGACCAAATTGAGAACCTACAACAACATGAAAATGAACAGATTTACAAGAAGAGCATCCACATCCTGGACTCCTACTTTATGGAGGAGGAGGACGCCAGCACGCAGCCCGCTCACGACCACGAGCAGTATCAGTTCAGGACAAATGATGCAGCCATACACTTCTAG

Protein

MAERTSRLSSYKNAGQGTTELRRKRAELSVALRKQARDEQLLKRRAMSPETETPVETEKVMTPEEILEELKSQDLTRKTNAARAARRMLSREQKPPISIMVNAGVIKPLVEALDHDECSDLQFEAAWALTNIASGTRQHTMAVVDGGAVPKLISLLGQGGVVGEQCAWALGNIAGDGPETRDMILNAGIMQALVPLLNAQTPTSQLRIAVWTYSNLCRNKNPLVQFDLVAPALPYISDLLEISDQDVLADSCWALSYLTDGPNERIEGVQTTRHLLPRLVSLLEHPAPAVATPALRALGNMLTGSDIQTDRCLDADCLKPISRLLSASPALSKEAAWACSNVFAGTAPQIQRAIDSGVLEPIARVLVHHDIKCQKEAAWAITNLCLGGTPEQLDAMLSCDILSPYCALLQARDHRAIIVVLDGLTHLLQAAAKYDQVRGMCIKLEEIGALDQIENLQQHENEQIYKKSIHILDSYFMEEEDASTQPAHDHEQYQFRTNDAAIHF

Description

Functions in nuclear protein import.

Subunit

Heterodimer; with KPNB1 (By similarity). Component of a complex containing CSE1L, RAN and KPNA2 (By similarity). Interacts directly with CSE1L (By similarity). Interacts with PLAG1 (By similarity). Interacts with APEX1 (via N-terminus) (By similarity). Interacts with FRG1 (via N-terminus) (By similarity). Interacts with ARL4A, CTNNBL1 and NBN (By similarity). Interacts with ANP32E (PubMed:10692581). Interacts with SNAI1 (via zinc fingers) (PubMed:21454664). Interacts with SNAI2 (via zinc fingers) (By similarity). Interacts with BAG6 (By similarity).

Similarity

Belongs to the importin alpha family.

Keywords

3D-structure Acetylation Complete proteome Cytoplasm Nucleus Phosphoprotein Protein transport Reference proteome Repeat Transport

Feature

chain Importin subunit alpha

Uniprot

H9JP97 A0A2A4JN93 A0A2W1BIN8 A0A2H1VR97 A0A3S2LQ84 S4NSS8 + More
A0A212FAA8 A0A194PU68 A0A067R8N3 A0A0L8IFP3 A0A2J7Q2F6 A0A023GN20 D6W9Y1 E9HIZ6 A0A0C9QEA7 A0A293LI01 A0A2R7VT69 A0A162D863 A0A3R7MW69 A0A1W5SYL0 A0A2T7P427 A0A1Z5KUS0 A0A023FLW3 A0A0N8BUW5 A0A2J7QW02 A0A0A9Y1I6 A0A0P6DHD4 A0A0N8DRU5 A0A0P5J2Q7 A0A0P6G9R1 A0A0P6H5C9 A0A2R5L6T4 A0A1S3J0Y8 A0A224Z1Y4 A0A131Z1H2 Q52L97 P52293 A0A2J7Q2E4 A0A154P240 Q6P6T9 V5H465 A0A1Q3G0A9 A0A384AFI2 M0R7I0 R7UAQ7 I3LS70 L5KLQ0 A0A0P6H5R7 A0A0P4WFV1 A0A0P6E150 A0A1S3H041 A0A2A3EUF1 A0A2Y9FL72 A0A026WD89 C6K7I0 H0VVB1 A0A2Y9KR50 A0A1B6EDV8 A0A2U4C3S8 A0A0P5UMX3 Q16KJ6 A0A340XCT9 A0A0P6IWF6 A0A0L7QZN9 B4F6X3 A0A0P5LI37 A0A341CRR5 A0A2Y9PDA8 A0A2Y9G4Z0 E2R6L9 A0A3Q7WT66 A0A384CAI1 A0A3Q7Q2I8 G9L0V5 A0A0N8DZA3 A0A250YJD2 T1I4F5 A0A158NVJ2 D2HQA5 G5BVE9 A0A232F353 Q9Z0N9 G3HCT1 A0A340XCA9 A0A0N8CPS0 G1TAI0 I3NFF1 A0A2K5QC64 A0A0P5SAA9 A0A1B6KPA9 W5JAT1 A0A0V0G9W1 A0A2K6DKA3 A0A2K5TLF5 F7DZP0 A0A2K5EU02 A0A182GKX8 A0A0P5SIM6 Q5R5I8 A0A2Y9DGP6

Pubmed

19121390 28756777 23622113 22118469 26354079 24845553 + More
18362917 19820115 21292972 28528879 25401762 26823975 28797301 26830274 10349636 11042159 11076861 11217851 12466851 12040188 15489334 16141073 21183079 7641681 7565597 8631802 10692581 21454664 10764582 10201409 11448961 16222336 15057822 15632090 16906019 25765539 23254933 30723633 23258410 24508170 30249741 22720010 21993624 17510324 16341006 24813606 23236062 28087693 21347285 20010809 21993625 28648823 21804562 20920257 23761445 17431167 25319552 26483478

EMBL

BABH01009707 NWSH01000978 PCG73289.1 KZ150299 PZC71543.1 ODYU01003796 + More
SOQ43002.1 RSAL01000031 RVE51586.1 GAIX01013932 JAA78628.1 AGBW02009498 OWR50685.1 KQ459593 KPI96299.1 KK852667 KDR18936.1 KQ415813 KOG00311.1 NEVH01019371 PNF22757.1 GBBM01000875 JAC34543.1 KQ971312 EEZ98092.1 GL732658 EFX68294.1 GBYB01012743 JAG82510.1 GFWV01001690 MAA26420.1 KK854063 PTY10529.1 LRGB01002285 KZS08204.1 QCYY01002333 ROT71188.1 KX058564 ARE72527.1 PZQS01000006 PVD28160.1 GFJQ02008133 JAV98836.1 GBBK01002333 JAC22149.1 GDIP01228734 GDIQ01142539 GDIQ01047463 JAI94667.1 JAL09187.1 NEVH01009768 PNF32767.1 GBHO01018103 GBRD01007349 GDHC01015874 GDHC01006125 JAG25501.1 JAG58472.1 JAQ02755.1 JAQ12504.1 GDIQ01077245 JAN17492.1 GDIP01007087 JAM96628.1 GDIQ01206304 JAK45421.1 GDIQ01036581 JAN58156.1 GDIQ01024371 JAN70366.1 GGLE01001098 MBY05224.1 GFPF01009078 MAA20224.1 GEDV01003915 JAP84642.1 BC094011 AK139850 AK147135 AK165577 AK166577 AK166790 AK166982 AK167551 AK169283 CH466558 AAH94011.1 BAE24160.1 BAE27705.1 BAE38268.1 BAE39616.1 EDL34317.1 D55720 U12270 U34229 BC003274 BC006720 PNF22758.1 KQ434787 KZC05288.1 AABR07030596 BC062026 BC089787 AY779026 CH473948 AAH62026.1 AAH89787.1 AAX07453.1 EDM06420.1 GANP01006663 JAB77805.1 GFDL01001821 JAV33224.1 AABR07062820 CH473947 EDM02653.1 AMQN01001860 KB306105 ELU00226.1 AEMK02000080 DQIR01098316 HDA53792.1 KB030661 ELK12455.1 GDIQ01045662 JAN49075.1 GDRN01058375 JAI65606.1 GDIQ01081099 JAN13638.1 KZ288186 PBC34836.1 KK107261 QOIP01000012 EZA53933.1 RLU16170.1 GQ166956 ACS34960.1 AAKN02045226 GEDC01020927 GEDC01001228 JAS16371.1 JAS36070.1 GDIP01110888 JAL92826.1 CH477953 EAT34836.1 GEBF01007338 JAN96294.1 KQ414679 KOC64063.1 BC168046 AAI68046.1 GDIQ01194412 JAK57313.1 AAEX03006362 JP022186 AES10784.1 GDIQ01077244 JAN17493.1 GFFW01001043 JAV43745.1 ACPB03011108 ADTU01002889 ADTU01002890 ACTA01040192 GL193167 EFB29186.1 JH172089 EHB13260.1 NNAY01001176 OXU24857.1 AJ130946 CAB37408.1 JH000285 EGV99155.1 GDIP01110887 JAL92827.1 AAGW02039989 AGTP01052629 AGTP01052630 GDIQ01096398 JAL55328.1 GEBQ01026710 JAT13267.1 ADMH02001647 ETN61562.1 GECL01002071 JAP04053.1 AQIA01028421 JSUE03017295 JU334436 JU475525 JV047011 AFE78189.1 AFH32329.1 AFI37082.1 JXUM01013418 KQ560376 KXJ82724.1 GDIP01139299 JAL64415.1 CR860871 CAH92978.1

Proteomes

UP000005204 UP000218220 UP000283053 UP000007151 UP000053268 UP000027135 + More
UP000053454 UP000235965 UP000007266 UP000000305 UP000076858 UP000283509 UP000245119 UP000085678 UP000000589 UP000076502 UP000002494 UP000261681 UP000014760 UP000008227 UP000010552 UP000081671 UP000242457 UP000053097 UP000279307 UP000005447 UP000248482 UP000245320 UP000008820 UP000265300 UP000053825 UP000252040 UP000248483 UP000248481 UP000002254 UP000286642 UP000261680 UP000291021 UP000286641 UP000015103 UP000005205 UP000008912 UP000006813 UP000215335 UP000001075 UP000001811 UP000005215 UP000233040 UP000000673 UP000233120 UP000233100 UP000006718 UP000233020 UP000069940 UP000249989 UP000248480

PRIDE

H9JP97 P52293 V5H465 M0R7I0 C6K7I0 G3HCT1 + More

Pfam

PF16186   Arm_3        + More
PF00514   Arm
PF01749   IBB

Interpro

IPR036975   Importin-a_IBB_sf        + More
IPR000225   Armadillo
IPR002652   Importin-a_IBB
IPR011989   ARM-like
IPR016024   ARM-type_fold
IPR032413   Arm_3
IPR024931   Importing_su_alpha

SUPFAM

SSF48371 SSF48371

Gene 3D

1.20.5.690 1.25.10.10

ProteinModelPortal

H9JP97 A0A2A4JN93 A0A2W1BIN8 A0A2H1VR97 A0A3S2LQ84 S4NSS8 + More
A0A212FAA8 A0A194PU68 A0A067R8N3 A0A0L8IFP3 A0A2J7Q2F6 A0A023GN20 D6W9Y1 E9HIZ6 A0A0C9QEA7 A0A293LI01 A0A2R7VT69 A0A162D863 A0A3R7MW69 A0A1W5SYL0 A0A2T7P427 A0A1Z5KUS0 A0A023FLW3 A0A0N8BUW5 A0A2J7QW02 A0A0A9Y1I6 A0A0P6DHD4 A0A0N8DRU5 A0A0P5J2Q7 A0A0P6G9R1 A0A0P6H5C9 A0A2R5L6T4 A0A1S3J0Y8 A0A224Z1Y4 A0A131Z1H2 Q52L97 P52293 A0A2J7Q2E4 A0A154P240 Q6P6T9 V5H465 A0A1Q3G0A9 A0A384AFI2 M0R7I0 R7UAQ7 I3LS70 L5KLQ0 A0A0P6H5R7 A0A0P4WFV1 A0A0P6E150 A0A1S3H041 A0A2A3EUF1 A0A2Y9FL72 A0A026WD89 C6K7I0 H0VVB1 A0A2Y9KR50 A0A1B6EDV8 A0A2U4C3S8 A0A0P5UMX3 Q16KJ6 A0A340XCT9 A0A0P6IWF6 A0A0L7QZN9 B4F6X3 A0A0P5LI37 A0A341CRR5 A0A2Y9PDA8 A0A2Y9G4Z0 E2R6L9 A0A3Q7WT66 A0A384CAI1 A0A3Q7Q2I8 G9L0V5 A0A0N8DZA3 A0A250YJD2 T1I4F5 A0A158NVJ2 D2HQA5 G5BVE9 A0A232F353 Q9Z0N9 G3HCT1 A0A340XCA9 A0A0N8CPS0 G1TAI0 I3NFF1 A0A2K5QC64 A0A0P5SAA9 A0A1B6KPA9 W5JAT1 A0A0V0G9W1 A0A2K6DKA3 A0A2K5TLF5 F7DZP0 A0A2K5EU02 A0A182GKX8 A0A0P5SIM6 Q5R5I8 A0A2Y9DGP6

PDB

5V5P E-value=1.59137e-111, Score=1031

KEGG

101747136 K15043 importin subunit alpha-2 | (RefSeq) importin subunit alpha-5-like

GO

GO:0008565 GO:0005737 GO:0006606 GO:0005634 GO:0061608 GO:0015031 GO:1903902 GO:0006607 GO:0098892 GO:0075506 GO:0005654 GO:0005829 GO:0070491 GO:0010494 GO:0099527 GO:0042826 GO:0098978 GO:0008139 GO:0043657 GO:0006886 GO:0046015 GO:0005515 GO:0005488 GO:0016020 GO:0004713 GO:0016491 GO:0015930 GO:0140142

Subcellular location

Cytoplasm
Nucleus

Length:

504

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00997999999999999

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00418

outside

1 - 504

Pi

290.324293

Theta

188.742158

Tajima's D

0.999514

CLR

0.30374

CSRT

0.661616919154042

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics