Gene

KWMTBOMO14008

Pre Gene Modal

BGIBMGA011258

Annotation

PREDICTED:_metabotropic_glutamate_receptor_5-like_[Bombyx_mori]

Location

Bomo_Chr23(-):15833263-15833861      View in EpiBrowser

Full name

Metabotropic glutamate receptor 1      

Location in the cell

Extracellular   Reliability : 1.069 Mitochondrial   Reliability : 1.421

CDS

ATGTTGGAGGTGTTAGCGGTGCTGGTGACTGCGCTGCTGGTTCCCGCGGACGCGGAGCGGGCCGTGGTGCGGGGCGCAGTGCGACTGGGAGCCCTGTTCGCAGTGCACGGAGCGCCCGCGGAGGCCGGCGCTCGCTGCGGGCCCGTGCGGGAGCACTACGGAATCCAGCGCGTGGAGGCAACGCTGCGGGCGTTAGATGCAATCAACGCGGACGGATCGCTCCTGCCGGGACTGCAGCTGGGCGCCGAGCTCCGCGACTCGTGCTGGGCGCCCTCAACCGCGCTCCGAGAGACCATCGAGCTGGTGCGAGACGCCATCGCCCCGGCACGTGCGCGTCAGCACTCGCCAGCAGCCTCCGCCGCTAACTGCACTTCGGTATACGATATGCTTTATGCTCTTATCGGTTTTTATCGATGA

Protein

MLEVLAVLVTALLVPADAERAVVRGAVRLGALFAVHGAPAEAGARCGPVREHYGIQRVEATLRALDAINADGSLLPGLQLGAELRDSCWAPSTALRETIELVRDAIAPARARQHSPAASAANCTSVYDMLYALIGFYR

Subunit

Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP (By similarity).

Similarity

Belongs to the G-protein coupled receptor 3 family.

Keywords

Alternative splicing   Cell membrane   Complete proteome   Disulfide bond   G-protein coupled receptor   Glycoprotein   Membrane   Phosphoprotein   Receptor   Reference proteome   Signal   Transducer   Transmembrane   Transmembrane helix  

Feature

chain  Metabotropic glutamate receptor 1
splice variant  In isoform 3.

Uniprot

H9JP04   A0A2H1VBH7   V5I6D0   A0A087UMR8   A0A2I0U879   D2HKF5   + More
H9FJ34   X1WE31   A0A2P4T7C1   L5KGK8   A0A1J0FAU4   A0A1L8HJI1   Q1ZZG7   G3WUM8   A0A061IJ43   G1NIV0   A0A2K5U693   A0A2K5YDW9   P97772-3   L5MDQ1   A0A3M0KP77   I7G6G0   A0A0D9RX30   G3PCT4   A0A3Q2GRW9   L9LDV8   S9YAF4   A0A0P7TWJ2   A0A226PQQ4   A0A2P4SZW7   A0A3B3RBI0   D6WA59   F6VEM8   H3A0A3   A0A3B3RBE6   A0A1S3SR73   A0A1S3SR84   A0A1S3SR79  

Pubmed

19121390    20010809    25319552    23594743    23258410    27762356    + More
16943768    21709235    23929341    20838655    10581402    15489334    16452087    21183079    17194215    19892987    23385571    23149746    24621616    29240929    18362917    19820115    18464734    9215903   

EMBL

BABH01009694    ODYU01001660    SOQ38193.1    GALX01008400    JAB60066.1    KK120608    + More
KFM78657.1    KZ506016    PKU42238.1    GL192950    EFB26564.1    JU330887    AFE74643.1    BX296541    CR392011    FO704565    PPHD01006327    POI32246.1    KB030797    ELK09648.1    KU986886    APC26115.1    CM004468    OCT96228.1    DQ417741    ABD74423.1    AEFK01173063    KE667936    ERE84461.1    AQIA01050144    AQIA01050145    AQIA01050146    AQIA01050147    AQIA01050148    AQIA01050149    AQIA01050150    AQIA01050151    AQIA01050152    AF320126    BC067057    BC079566    U89891    KB101593    ELK36481.1    QRBI01000106    RMC12810.1    AB172892    BAE89954.1    AQIB01119431    AQIB01119432    AQIB01119433    AQIB01119434    AQIB01119435    AQIB01119436    AQIB01119437    AQIB01119438    AQIB01119439    AQIB01119440    KB320384    ELW72894.1    KB016759    EPY84451.1    JARO02014523    KPP58158.1    AWGT02000025    OXB82416.1    PPHD01014481    POI29657.1    KQ971312    EEZ98591.1    AAPN01225187    AAPN01225188    AAPN01225189    AAPN01225190    AAPN01225191    AAPN01225192    AAPN01225193    AAPN01225194    AAPN01225195    AFYH01196982    AFYH01196983    AFYH01196984    AFYH01196985    AFYH01196986    AFYH01196987    AFYH01196988    AFYH01196989    AFYH01196990    AFYH01196991   

Proteomes

UP000005204    UP000054359    UP000000437    UP000010552    UP000186698    UP000007648    + More
UP000030759    UP000001645    UP000233100    UP000233140    UP000000589    UP000269221    UP000029965    UP000007635    UP000002281    UP000011518    UP000034805    UP000198419    UP000261540    UP000007266    UP000002279    UP000008672    UP000087266   

PRIDE

H9JP04    P97772   

Pfam

PF01094   ANF_receptor        + More
PF07562   NCD3G
PF00003   7tm_3
PF10606   GluR_Homer-bdg

Interpro

IPR001828   ANF_lig-bd_rcpt        + More
IPR028082   Peripla_BP_I       
IPR000337   GPCR_3       
IPR017979   GPCR_3_CS       
IPR001256   GPCR_3_mtglu_rcpt_1       
IPR011500   GPCR_3_9-Cys_dom       
IPR038550   GPCR_3_9-Cys_sf       
IPR000162   GPCR_3_mtglu_rcpt       
IPR017978   GPCR_3_C       
IPR000202   GPCR_3_mtglu_rcpt_5       
IPR019588   Metabotropic_Glu_rcpt_Homer-bd       

SUPFAM

SSF53822   SSF53822       

Gene 3D

2.10.50.30    

ProteinModelPortal

H9JP04   A0A2H1VBH7   V5I6D0   A0A087UMR8   A0A2I0U879   D2HKF5   + More
H9FJ34   X1WE31   A0A2P4T7C1   L5KGK8   A0A1J0FAU4   A0A1L8HJI1   Q1ZZG7   G3WUM8   A0A061IJ43   G1NIV0   A0A2K5U693   A0A2K5YDW9   P97772-3   L5MDQ1   A0A3M0KP77   I7G6G0   A0A0D9RX30   G3PCT4   A0A3Q2GRW9   L9LDV8   S9YAF4   A0A0P7TWJ2   A0A226PQQ4   A0A2P4SZW7   A0A3B3RBI0   D6WA59   F6VEM8   H3A0A3   A0A3B3RBE6   A0A1S3SR73   A0A1S3SR84   A0A1S3SR79  

PDB

1ISS     E-value=6.46155e-22,     Score=250

KEGG

101737079    no KO assigned | (RefSeq) metabotropic glutamate receptor 5-like

GO

GO:0004930   GO:0016021   GO:0051966   GO:0099530   GO:0008066   GO:0098839   GO:0099583   GO:0007216   GO:0005887   GO:0005886   GO:0000187   GO:0001639   GO:0098685   GO:0043025   GO:0007626   GO:0005634   GO:0071257   GO:0019233   GO:0038038   GO:0099061   GO:0000186   GO:0043197   GO:0042734   GO:0051930   GO:0098872   GO:0014069   GO:0045211   GO:0019722   GO:0043408   GO:0038037   GO:0030425   GO:0043005   GO:0030424   GO:0098978   GO:0042802   GO:0051482   GO:0099055   GO:0030331   GO:0007186   GO:0016020   GO:0004713   GO:0016491   GO:0015930  

Subcellular location

Cell membrane  

SignalP

Position:   1 - 18,         Likelihood:  0.966121

 

 

Length:

138

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.52046

Exp number, first 60 AAs:

0.13501

Total prob of N-in:

0.05374

outside

1  -  138

 

 

Pi

314.877895

Theta

209.541321

Tajima's D

1.578818

CLR

135.782516

CSRT

0.801709914504275

Interpretation

Uncertain