Gene

KWMTBOMO14000  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011344

Annotation

cathepsin_D_precursor_[Bombyx_mori]

Location

Bomo_Chr23(+):15710462-15717281      View in EpiBrowser

Full name

Lysosomal aspartic protease      

Location in the cell

Lysosomal   Reliability : 1.415 PlasmaMembrane   Reliability : 1.634

CDS

ATGGGAAAGATATCTTTATTTTTTTTGGCGCTGATCGCCAGCTCCGTAATGGCACTATATAGGGTGCCATTACATCGTATGAAAACTGCGAGAACCCACTTTCATGAGGTTGGCACTGAACTGGAGCTGTTGAGATTAAAATACGATGTGACTGGCCCTTCACCCGAACCATTGTCAAATTATCTTGATGCTCAGTACTACGGAGTGATCAGTATCGGCACGCCGCCGCAGTCGTTCAAGGTGGTATTCGACACCGGATCCTCCAACCTCTGGGTGCCTTCCAAAAAGTGCCACTACACCAACATCGCTTGTTTGCTGCACAACAAGTACGACAGCCGCAAGTCCAAGACGTACGTCGCGAATGGCACCCAGTTCGCGATACAGTACGGCTCCGGCAGCCTCTCCGGCTTCCTCTCCACTGATGATGTCACCGTGGGCGGGCTCAAGGTGCGGCGCCAGACGTTCGCCGAGGCCGTGTCGGAGCCCGGGCTTGCCTTCGTGGCCGCCAAGTTCGACGGGATCCTCGGGATGGCCTTCAGCACTATCGCAGTGGACCATGTGACCCCGGTGTTCGACAACATGGTGGCTCAGGGACTCGTGCAGCCCGTCTTCTCGTTCTATCTCAACAGGGACCCCGGGGCGACAACGGGCGGCGAGTTGCTGCTGGGCGGCTCCGACCCCGCCCACTACCGAGGCGACCTCGTACGGGTGCCCCTACTCCGGGACACGTACTGGGAGTTCCACATGGACTCTGTCAATGTCAACGCTAGCCGCTTCTGTGCCCAGGGCTGCTCGGCCATCGCCGACACGGGCACGTCGCTGATCGCCGGGCCCTCCAAGGAGGTGGAAGCCCTCAACGCGGCGGTGGGCGCCACGGCCATCGCCTTCGGGCAGTACGTCGTGGACTGCAGCCTCATACCGCACCTGCCGCGAGTCACCTTTACCATCGCCGGGAACGACTTCACGCTCGAGGGCAACGACTACGTGCTCCGGGTGGCACAATTCGGGCACACGGTGTGCCTGTCCGGCTTCATGGCGCTGGACGTGCCGAAGCCCATGGGCCCGCTGTGGATCCTGGGGGACGTGTTCATCGGCAAGTACTACACGGAGTTCGACGCGGGGAACCGCCAGCTCGGGTTCGCGCCCGCCGTGTGA

Protein

MGKISLFFLALIASSVMALYRVPLHRMKTARTHFHEVGTELELLRLKYDVTGPSPEPLSNYLDAQYYGVISIGTPPQSFKVVFDTGSSNLWVPSKKCHYTNIACLLHNKYDSRKSKTYVANGTQFAIQYGSGSLSGFLSTDDVTVGGLKVRRQTFAEAVSEPGLAFVAAKFDGILGMAFSTIAVDHVTPVFDNMVAQGLVQPVFSFYLNRDPGATTGGELLLGGSDPAHYRGDLVRVPLLRDTYWEFHMDSVNVNASRFCAQGCSAIADTGTSLIAGPSKEVEALNAAVGATAIAFGQYVVDCSLIPHLPRVTFTIAGNDFTLEGNDYVLRVAQFGHTVCLSGFMALDVPKPMGPLWILGDVFIGKYYTEFDAGNRQLGFAPAV

Description

May degrade organelles involved in the biosynthesis and secretion of vitellogenin.

Subunit

Homodimer.

Similarity

Belongs to the peptidase A1 family.

Keywords

Aspartyl protease   Complete proteome   Direct protein sequencing   Disulfide bond   Glycoprotein   Hydrolase   Lysosome   Protease   Reference proteome   Signal   Zymogen  

Feature

propeptide  Removed in mature form
chain  Lysosomal aspartic protease

Uniprot

Q4U5S3   Q7Z1E4   H9JP90   A0A1V0QH26   A0A2A4JQ09   A0A1E1W6M6   + More
A0A0N1INL3   A0A194QFM2   S4PGV2   A0A212FHV4   D6WC03   I1SSK5   A0A0T6B690   A0A182M8M9   A0A182PIB9   A0A1Q3FMT4   A0A182RHW4   A0A1V1FTJ3   V5GZE0   A0A0P4WKX9   A0A182JS20   B0XCF4   A0A084W3C8   W5JA18   A0A182JLY7   A0A182FSH0   A0A026VXU6   A0A2M4A7Z0   A0A2M4BQE4   T1DGD1   A0A2M4BQE2   A0A182N564   A0A182UVI2   A0A2M4BQE6   A0A2M3YZT8   A0A182YK81   A0A067RRR8   A0A182LCN7   A0A182IIQ3   A0A2M3YZL0   A0A2Y9D3T3   F5HIR1   A0A2M3ZE34   Q03168   W8BWQ3   A0A2J7PIK0   A0A2K7P6A4   A0A023ER88   A0A1W4WWJ7   A0A2L2Y403   A0A0K8U1U4   A0A2L2Y439   A0A0C9QXW8   A0A2I9LNV0   A0A1L8DTP4   A0A1L8DTI5   A0A182VQN5   C7AAS7   A0A182G4T3   V9N1V7   C8YZ52   A0A3S2LSS3   A0A154PHM3   A0A1L8DTI1   A0A1L8DTH6   A0A1E1WVU9   A0A140KPR6   A0A232ETM9   A0A1L8EEU1   A0A182QAK4   A0A1I8PL28   A0A0C9RFL2   A0A0A1XL62   T1PE31   A0A1B0CG28   B9X0K9   A0A2S1TY87   A0A336M4R6   F8RNZ8   A0A142G5I9   A0A0L0BPP9   A0A2P6KFM7   K9L8I5   A0A0U1X041   A0A3R7SR07   A0A0H4KC31   A0A0C9RXE2   A0A2L2Y0H5   K7J796   A0A2A3E6X5   V9IGZ8   A0A087TRE3   C3YUT2   A9U937   A0A087TX10   B3MG95   C1C0P0   A0A1A9WMP6   A0A1W4WB73   U5EX48  

EC Number

3.4.23.-

Pubmed

19121390    28351737    26354079    23622113    22118469    18362917    + More
19820115    28410430    24438588    20920257    23761445    24508170    30249741    25244985    24845553    20966253    12364791    14747013    17210077    1400492    17510324    24495485    24945155    26561354    29248469    19446566    26483478    20169386    28648823    25553591    25830018    25315136    19809173    29709775    26108605    26116442    20075255    18563158    17994087   

EMBL

DQ010007    AAY43135.1    AY297160    DQ417605    AAP50847.1    ABE03014.1    + More
BABH01009676    KX827245    ARE67826.1    NWSH01000934    PCG73490.1    GDQN01008439    GDQN01001742    JAT82615.1    JAT89312.1    KQ460973    KPJ10102.1    KQ459144    KPJ03745.1    GAIX01003487    JAA89073.1    AGBW02008466    OWR53297.1    KQ971309    EEZ99098.1    JF759824    AEC03508.1    LJIG01009636    KRT82683.1    AXCM01001650    GFDL01006262    JAV28783.1    FX985412    BAX07425.1    GALX01002603    JAB65863.1    GDRN01010976    JAI67898.1    DS232688    EDS44784.1    ATLV01019917    KE525285    KFB44722.1    ADMH02001856    ETN60836.1    KK107599    QOIP01000012    EZA48592.1    RLU15934.1    GGFK01003529    MBW36850.1    GGFJ01006166    MBW55307.1    GAMD01002816    JAA98774.1    GGFJ01006164    MBW55305.1    GGFJ01006165    MBW55306.1    GGFM01001000    MBW21751.1    KK852463    KDR23365.1    APCN01002154    GGFM01000944    MBW21695.1    AAAB01008794    EAA03535.2    EGK96172.1    EGK96173.1    EGK96174.1    GGFM01006021    MBW26772.1    M95187    CH477377    GAMC01012916    JAB93639.1    NEVH01025127    PNF16139.1    GAPW01001930    JAC11668.1    IAAA01003060    LAA02891.1    GDHF01031828    JAI20486.1    IAAA01003061    LAA02898.1    GBYB01000545    JAG70312.1    GFWZ01000072    MBW20062.1    GFDF01004317    JAV09767.1    GFDF01004318    JAV09766.1    FJ360435    ACO56332.1    JXUM01042568    KQ561330    KXJ78954.1    JX508644    AGJ03549.1    FJ943775    ACV53024.1    RSAL01000241    RVE43661.1    KQ434912    KZC11376.1    GFDF01004315    JAV09769.1    GFDF01004316    JAV09768.1    GEMQ01000039    JAT91150.1    LN794623    CEO43690.1    NNAY01002254    OXU21720.1    GFDG01001552    JAV17247.1    AXCN02000174    GBXR01000060    JAG85166.1    GBXI01002188    JAD12104.1    KA646400    AFP61029.1    AJWK01010668    AB457169    BAH24176.1    MG547692    AWI66593.1    UFQT01000526    SSX24990.1    HM989013    AEI58896.1    KP262355    AMQ98967.1    JRES01001567    KNC21943.1    MWRG01013265    PRD25128.1    JF748720    AFE48185.1    KF900154    AIF27797.1    QCYY01002311    ROT71313.1    KR061518    AKO90276.1    GBYB01012571    JAG82338.1    IAAA01000183    IAAA01000184    LAA01638.1    KZ288369    PBC26791.1    JR045291    AEY59947.1    KK116397    KFM67682.1    GG666554    EEN55983.1    EF213114    ABQ10738.1    KK117137    KFM69649.1    CH902619    EDV37798.1    BT080419    ACO14843.1    GANO01001122    JAB58749.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000007151    UP000007266    + More
UP000075883    UP000075885    UP000075900    UP000075881    UP000002320    UP000030765    UP000000673    UP000075880    UP000069272    UP000053097    UP000279307    UP000075884    UP000075903    UP000076408    UP000027135    UP000075882    UP000075840    UP000076407    UP000007062    UP000008820    UP000235965    UP000192223    UP000075920    UP000069940    UP000249989    UP000283053    UP000076502    UP000215335    UP000075886    UP000095300    UP000095301    UP000092461    UP000037069    UP000283509    UP000002358    UP000242457    UP000054359    UP000001554    UP000007801    UP000091820    UP000192221   

PRIDE

Q4U5S3    Q7Z1E4    H9JP90    Q03168   

Pfam

PF07966   A1_Propeptide        + More
PF00026   Asp
PF06278   CNDH2_N
PF16858   CNDH2_C
PF06859   Bin3

Interpro

IPR001969   Aspartic_peptidase_AS        + More
IPR012848   Aspartic_peptidase_N       
IPR001461   Aspartic_peptidase_A1       
IPR033121   PEPTIDASE_A1       
IPR021109   Peptidase_aspartic_dom_sf       
IPR031737   CNDH2_C       
IPR009378   H2_N       
IPR034129   Cathepsin_D-like       
IPR029063   SAM-dependent_MTases       
IPR010675   Bin3_C       
IPR024160   BIN3_SAM-bd_dom       

SUPFAM

SSF50630   SSF50630        + More
SSF53335   SSF53335       

Gene 3D

2.40.70.10    

CDD

cd05485  Cathepsin_D_like

ProteinModelPortal

Q4U5S3   Q7Z1E4   H9JP90   A0A1V0QH26   A0A2A4JQ09   A0A1E1W6M6   + More
A0A0N1INL3   A0A194QFM2   S4PGV2   A0A212FHV4   D6WC03   I1SSK5   A0A0T6B690   A0A182M8M9   A0A182PIB9   A0A1Q3FMT4   A0A182RHW4   A0A1V1FTJ3   V5GZE0   A0A0P4WKX9   A0A182JS20   B0XCF4   A0A084W3C8   W5JA18   A0A182JLY7   A0A182FSH0   A0A026VXU6   A0A2M4A7Z0   A0A2M4BQE4   T1DGD1   A0A2M4BQE2   A0A182N564   A0A182UVI2   A0A2M4BQE6   A0A2M3YZT8   A0A182YK81   A0A067RRR8   A0A182LCN7   A0A182IIQ3   A0A2M3YZL0   A0A2Y9D3T3   F5HIR1   A0A2M3ZE34   Q03168   W8BWQ3   A0A2J7PIK0   A0A2K7P6A4   A0A023ER88   A0A1W4WWJ7   A0A2L2Y403   A0A0K8U1U4   A0A2L2Y439   A0A0C9QXW8   A0A2I9LNV0   A0A1L8DTP4   A0A1L8DTI5   A0A182VQN5   C7AAS7   A0A182G4T3   V9N1V7   C8YZ52   A0A3S2LSS3   A0A154PHM3   A0A1L8DTI1   A0A1L8DTH6   A0A1E1WVU9   A0A140KPR6   A0A232ETM9   A0A1L8EEU1   A0A182QAK4   A0A1I8PL28   A0A0C9RFL2   A0A0A1XL62   T1PE31   A0A1B0CG28   B9X0K9   A0A2S1TY87   A0A336M4R6   F8RNZ8   A0A142G5I9   A0A0L0BPP9   A0A2P6KFM7   K9L8I5   A0A0U1X041   A0A3R7SR07   A0A0H4KC31   A0A0C9RXE2   A0A2L2Y0H5   K7J796   A0A2A3E6X5   V9IGZ8   A0A087TRE3   C3YUT2   A9U937   A0A087TX10   B3MG95   C1C0P0   A0A1A9WMP6   A0A1W4WB73   U5EX48  

PDB

5UX4     E-value=7.26518e-110,     Score=1015

KEGG

692768    K01379 cathepsin D [EC:3.4.23.5] | (RefSeq) CatD, Cathd; cathepsin D

PATHWAY

04140    Autophagy - animal - Bombyx mori (domestic silkworm)
04142    Lysosome - Bombyx mori (domestic silkworm)

GO

GO:0004190   GO:0005764   GO:0030163   GO:0006508   GO:0008219   GO:0008168   GO:0050829   GO:0045476   GO:0005856   GO:0016311   GO:0016791   GO:0007166   GO:0016020   GO:0004713   GO:0016491   GO:0015930  

PANTHER

PTHR13683  

Subcellular location

Lysosome  

SignalP

Position:   1 - 18,         Likelihood:  0.944100

 

 

Length:

384

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

18.68471

Exp number, first 60 AAs:

16.67796

Total prob of N-in:

0.61737

POSSIBLE N-term signal

sequence

inside

1  -  4

TMhelix

5  -  24

outside

25  -  384

 

 

Pi

204.207023

Theta

171.201316

Tajima's D

0.333796

CLR

12.138697

CSRT

0.460876956152192

Interpretation

Uncertain