Gene

KWMTBOMO13991  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011268

Annotation

coproporphirynogen_oxidase_[Bombyx_mori]

Location

Bomo_Chr23(-):15390684-15396826      View in EpiBrowser

Full name

Oxygen-dependent coproporphyrinogen-III oxidase      

Location in the cell

Cytoplasmic   Reliability : 2.565

CDS

ATGAAAGAAATAATGCAACTTAAGAACTATATGGCAAACCCAATCACACCAGTTGAACAATTAGAGCAAAACAAAGATGATATGAAGACACAAATGGAATTACTCATCATGAGGATTCAAGCAGAATTCTGCAGGGCTTTGGAGAAAGAGGAAGACAAGGCATGGGAAGATGAAAAATCTGTGGAAGATTATGATTTTGACAATGATGTTTACATGACATGGCCGGAAGCAAAGTTTACAGTAGACAGATGGACCCGTAAAGAAGGAGGTGGTGGAATCACTTGTGTTCTACAAGACGGCAGAGTCTTTGAGAAAGCAGGAGTGAATATATCAGTTGTCTCCGGGAAACTTCCTCCAGCTGCCATTCAGCAGATGCGGAGCAGAGGCAAGAATCTACAAAACGCAGAGCTCCCGTTTTTTGCAGCCGGTGTGAGTGCCGTCATCCACCCAAGGAACCCCATGGTCCCCACCATCCACTTCAACTATAGATACTTTGAGGTCCAGGATAAGAATGGGGTCCAGTGGTGGTTCGGAGGCGGCACCGATCTGACCCCGTATTATCTGAACGAGGACGACGCTCTTCACTTCCATCTAACCTTGAAGCACGCGTGTGACGATCACGATTCATCGTATTATGCTAGATTCAAGAAATGGTGCGATGATTACTTCTACATTCCCCACCGCGGTGAAAGGCGAGGGGTCGGAGGGATATTCTTTGATGACCTGGACACTCCCAACCAGCAAGCTGCCTTCGCCTTCGTCACCTCCTGCGCTGAAGCAGTCATACCCAGCTACGTGCCTCTAGTTAAGAAGCACAAAGACGACGCTTACGGCTACCACGAGCGTCAATGGCAGTTGCTCAGACGAGGGAGATATGTGGAGTTCAATCTCATATACGACAGAGGAACAAAGTTTGGGCTGCACACTCCTGAAGCTAGATACGAATCAATACTGATGTCGCTTCCCCTTAACGCTAAATGGGAATATATGCACCAAGTCCAACCGAACTCTGAAGAAGAAAAACTGTTGAAAATCCTAAAAGAACCTAAAGATTGGCTTCAAATAGAGGATAAAAAGCGGTCTAATGCATAG

Protein

MKEIMQLKNYMANPITPVEQLEQNKDDMKTQMELLIMRIQAEFCRALEKEEDKAWEDEKSVEDYDFDNDVYMTWPEAKFTVDRWTRKEGGGGITCVLQDGRVFEKAGVNISVVSGKLPPAAIQQMRSRGKNLQNAELPFFAAGVSAVIHPRNPMVPTIHFNYRYFEVQDKNGVQWWFGGGTDLTPYYLNEDDALHFHLTLKHACDDHDSSYYARFKKWCDDYFYIPHRGERRGVGGIFFDDLDTPNQQAAFAFVTSCAEAVIPSYVPLVKKHKDDAYGYHERQWQLLRRGRYVEFNLIYDRGTKFGLHTPEARYESILMSLPLNAKWEYMHQVQPNSEEEKLLKILKEPKDWLQIEDKKRSNA

Description

Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX (By similarity).

Catalytic Activity

coproporphyrinogen III + 2 H(+) + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX

Subunit

Homodimer.

Similarity

Belongs to the aerobic coproporphyrinogen-III oxidase family.

Keywords

Complete proteome   Heme biosynthesis   Oxidoreductase   Porphyrin biosynthesis   Reference proteome  

Feature

chain  Oxygen-dependent coproporphyrinogen-III oxidase

Uniprot

H9JP14   Q2F5S7   A0A2A4JQJ3   A0A2H1VTC1   A0A0N0PBW8   A0A2A4JRB2   + More
A0A212FHU5   S4P7D7   A0A194QHW6   K7J6L0   A0A232F1M9   A0A151IBQ3   A0A0M8ZTB0   E9J2E8   F4WVS1   A0A195DBU7   A0A158NMQ4   A0A0L7R4T1   A0A151I0W1   A0A1B0CSC7   A0A182H450   A0A151JTZ8   A0A1B6JDU0   A0A0J7L2P3   A0A224XSD1   A0A1B6CSF4   E2ALM0   A0A0A9YSU1   Q16JA9   A0A1Y1K271   E2BSA7   A0A1L8DZJ8   A0A2J7RNP6   A0A1B6GQL4   A0A1L8E008   A0A087ZND6   A0A1B0D4Z3   A0A067RFM9   A0A2A3E615   A0A0K8V4R4   A0A034WE27   A0A2P8XXJ8   W8C3K8   A0A026WNH9   A0A023FAM8   A0A3L8DHV6   A0A0P4VQY7   T1I053   A0A1Q3F933   B0WG12   B4JPS8   A0A1I8MEW0   A0A1D2NDH9   A0A0L0BQ89   A0A1B0FEW8   D3TQ81   A0A154PFQ7   B4NZY0   A0A1W4UBM6   A0A1A9VIU2   A0A1A9Z414   U5EWJ1   B4Q5A5   B3N675   J3JTU5   N6U8J8   X2J9R2   Q9V3D2   B4LRF3   A0A182P601   A0A2S2QFD7   B4KJU1   R4WPN8   J9JNY5   A0A1I8PRG4   A0A182R2Q8   Q29JW9   A0A1A9WXG3   A0A1J1IPS8   A0A182MLR9   A0A182VF43   A0A084VZS8   A0A182QNT8   A0A182LI79   Q7Q2P4   A0A182HXH5   A0A182YI37   A0A182WZV7   A0A182TMW7   A0A182JS40   A0A182WAQ7   A0A1W4X779   A0A3B0K942   A0A182NNB7   B4MZ18   A0A182T0K3   A0A0M4EED6   B3MKT0   V4A1R5   A0A1B0BJ76  

EC Number

1.3.3.3

Pubmed

19121390    26354079    22118469    23622113    20075255    28648823    + More
21282665    21719571    21347285    26483478    20798317    25401762    26823975    17510324    28004739    24845553    25348373    29403074    24495485    24508170    25474469    30249741    27129103    17994087    25315136    27289101    26108605    20353571    17550304    22936249    22516182    23537049    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    10731138    23691247    15632085    24438588    20966253    12364791    14747013    17210077    25244985    23254933   

EMBL

BABH01009643    BABH01009644    DQ311346    ABD36290.1    NWSH01000772    PCG74307.1    + More
ODYU01004315    SOQ44059.1    KQ460880    KPJ11526.1    PCG74306.1    AGBW02008466    OWR53287.1    GAIX01004674    JAA87886.1    KQ458761    KPJ05102.1    AAZX01001311    NNAY01001214    OXU24706.1    KQ978078    KYM97172.1    KQ435897    KOX69203.1    GL767845    EFZ13003.1    GL888394    EGI61691.1    KQ981010    KYN10312.1    ADTU01020669    KQ414657    KOC65781.1    KQ976593    KYM79650.1    AJWK01025898    JXUM01108787    KQ565264    KXJ71161.1    KQ981936    KYN32768.1    GECU01010316    JAS97390.1    LBMM01001227    KMQ96689.1    GFTR01005535    JAW10891.1    GEDC01020950    JAS16348.1    GL440609    EFN65629.1    GBHO01008325    GBRD01005130    GDHC01009278    JAG35279.1    JAG60691.1    JAQ09351.1    CH478020    EAT34350.1    GEZM01100269    GEZM01100268    JAV52927.1    GL450157    EFN81420.1    GFDF01002201    JAV11883.1    NEVH01002149    PNF42456.1    GECZ01005126    JAS64643.1    GFDF01002202    JAV11882.1    AJVK01011670    KK852498    KDR22641.1    KZ288357    PBC27150.1    GDHF01020278    GDHF01018448    GDHF01001903    GDHF01001217    JAI32036.1    JAI33866.1    JAI50411.1    JAI51097.1    GAKP01006558    GAKP01006557    GAKP01006556    JAC52395.1    PYGN01001198    PSN36732.1    GAMC01006024    JAC00532.1    KK107152    EZA57216.1    GBBI01000277    JAC18435.1    QOIP01000007    RLU20035.1    GDKW01001152    JAI55443.1    ACPB03019516    GFDL01010961    JAV24084.1    DS231922    EDS26653.1    CH916372    EDV98908.1    LJIJ01000089    ODN03026.1    JRES01001533    KNC22227.1    CCAG010000397    EZ423583    ADD19859.1    KQ434885    KZC10040.1    CM000157    EDW87807.1    GANO01002932    JAB56939.1    CM000361    CM002910    EDX04038.1    KMY88669.1    CH954177    EDV59162.1    BT126654    AEE61617.1    APGK01044452    KB741026    KB631924    ENN74927.1    ERL87148.1    AE014134    AHN54212.1    AF160897    CH940649    EDW64623.1    GGMS01007255    MBY76458.1    CH933807    EDW12544.1    AK417631    BAN20846.1    ABLF02015212    ABLF02015215    CH379062    EAL32842.1    CVRI01000057    CRL02223.1    AXCM01000075    ATLV01018955    KE525256    KFB43472.1    AXCN02001904    AAAB01008968    EAA13292.4    EDO63510.1    APCN01005305    OUUW01000006    SPP81541.1    CH963913    EDW77414.1    CP012523    ALC38480.1    CH902620    EDV31611.1    KB202953    ESO87246.1    JXJN01015341   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000053268    UP000002358    + More
UP000215335    UP000078542    UP000053105    UP000007755    UP000078492    UP000005205    UP000053825    UP000078540    UP000092461    UP000069940    UP000249989    UP000078541    UP000036403    UP000000311    UP000008820    UP000008237    UP000235965    UP000005203    UP000092462    UP000027135    UP000242457    UP000245037    UP000053097    UP000279307    UP000015103    UP000002320    UP000001070    UP000095301    UP000094527    UP000037069    UP000092444    UP000076502    UP000002282    UP000192221    UP000078200    UP000092445    UP000000304    UP000008711    UP000019118    UP000030742    UP000000803    UP000008792    UP000075885    UP000009192    UP000007819    UP000095300    UP000075900    UP000001819    UP000091820    UP000183832    UP000075883    UP000075903    UP000030765    UP000075886    UP000075882    UP000007062    UP000075840    UP000076408    UP000076407    UP000075902    UP000075881    UP000075920    UP000192223    UP000268350    UP000075884    UP000007798    UP000075901    UP000092553    UP000007801    UP000030746    UP000092460   

PRIDE

H9JP14    Q2F5S7    X2J9R2    Q9V3D2   

Pfam

PF01218   Coprogen_oxidas        + More
PF00076   RRM_1
PF15519   RBM39linker

Interpro

IPR036406   Coprogen_oxidase_aer_sf        + More
IPR001260   Coprogen_oxidase_aer       
IPR018375   Coprogen_oxidase_CS       
IPR016059   DNA_ligase_ATP-dep_CS       
IPR029123   RBM39_linker       
IPR035979   RBD_domain_sf       
IPR000504   RRM_dom       
IPR012677   Nucleotide-bd_a/b_plait_sf       
IPR006509   RBM39_SF       

SUPFAM

SSF102886   SSF102886        + More
SSF54928   SSF54928       

Gene 3D

3.40.1500.10     3.30.70.330    

ProteinModelPortal

H9JP14   Q2F5S7   A0A2A4JQJ3   A0A2H1VTC1   A0A0N0PBW8   A0A2A4JRB2   + More
A0A212FHU5   S4P7D7   A0A194QHW6   K7J6L0   A0A232F1M9   A0A151IBQ3   A0A0M8ZTB0   E9J2E8   F4WVS1   A0A195DBU7   A0A158NMQ4   A0A0L7R4T1   A0A151I0W1   A0A1B0CSC7   A0A182H450   A0A151JTZ8   A0A1B6JDU0   A0A0J7L2P3   A0A224XSD1   A0A1B6CSF4   E2ALM0   A0A0A9YSU1   Q16JA9   A0A1Y1K271   E2BSA7   A0A1L8DZJ8   A0A2J7RNP6   A0A1B6GQL4   A0A1L8E008   A0A087ZND6   A0A1B0D4Z3   A0A067RFM9   A0A2A3E615   A0A0K8V4R4   A0A034WE27   A0A2P8XXJ8   W8C3K8   A0A026WNH9   A0A023FAM8   A0A3L8DHV6   A0A0P4VQY7   T1I053   A0A1Q3F933   B0WG12   B4JPS8   A0A1I8MEW0   A0A1D2NDH9   A0A0L0BQ89   A0A1B0FEW8   D3TQ81   A0A154PFQ7   B4NZY0   A0A1W4UBM6   A0A1A9VIU2   A0A1A9Z414   U5EWJ1   B4Q5A5   B3N675   J3JTU5   N6U8J8   X2J9R2   Q9V3D2   B4LRF3   A0A182P601   A0A2S2QFD7   B4KJU1   R4WPN8   J9JNY5   A0A1I8PRG4   A0A182R2Q8   Q29JW9   A0A1A9WXG3   A0A1J1IPS8   A0A182MLR9   A0A182VF43   A0A084VZS8   A0A182QNT8   A0A182LI79   Q7Q2P4   A0A182HXH5   A0A182YI37   A0A182WZV7   A0A182TMW7   A0A182JS40   A0A182WAQ7   A0A1W4X779   A0A3B0K942   A0A182NNB7   B4MZ18   A0A182T0K3   A0A0M4EED6   B3MKT0   V4A1R5   A0A1B0BJ76  

PDB

2AEX     E-value=5.20773e-120,     Score=1102

KEGG

692932    K00228 coproporphyrinogen III oxidase [EC:1.3.3.3] | (RefSeq) coproporphirynogen oxidase

PATHWAY

00860    Porphyrin and chlorophyll metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0006779   GO:0004109   GO:0016021   GO:0051103   GO:0003909   GO:0042803   GO:0006783   GO:0006782   GO:0005739   GO:0003723   GO:0006397   GO:0005634   GO:0005856   GO:0016311   GO:0016791   GO:0007166   GO:0016020   GO:0004713   GO:0016491   GO:0015930   GO:0055114  

PANTHER

PTHR10755  

Length:

363

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.29221

Exp number, first 60 AAs:

0

Total prob of N-in:

0.04637

outside

1  -  363

 

 

Pi

281.166643

Theta

219.959697

Tajima's D

0.889685

CLR

0.330709

CSRT

0.628818559072046

Interpretation

Uncertain