Gene

KWMTBOMO13988  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011270

Annotation

2-oxoisovalerate_dehydrogenase_subunit_alpha?_mitochondrial_[Papilio_xuthus]

Location

Bomo_Chr23(-):15357360-15361916      View in EpiBrowser

Full name

2-oxoisovalerate dehydrogenase subunit alpha      

Alternative Name

Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain

Location in the cell

Mitochondrial   Reliability : 2.01

CDS

ATGGCGTTGAAGACCGGAGCAAGTTTTGTCAAATTAAATGCTTTTCGACGGGCTGCTAGGCTTTTGTCGACGCGTACGAGGCCCGAAACGGCACAGAATGGCGGTGGTAAGATAGCAGAATTTCCTGGCGCAAGAGCACCGTACGTGAGTGAAATGAAATTCTTCAACGAAACTAGTTATGAGCCAATTCCGATTTATCGAGTTATGGATAATAACGGACAGATCATCGACAAAAATGAAGAACCGAACTTGGATAAGGCTACGCTGATTAACATGTACAAAACCATGGTACAACTGAGCCATATGGATAAAATTCTATATGAATCACAAAGACAAGGCCGCATTTCATTTTATATGACCAACTACGGCGAGGAGGGCATCCACATAGGCAGCGCCTCGGCACTCTCACCGAAAGATTTGGTCTTCAGTCAATACAGAGAAGTAGGAGTGTTTTTATACCGAGGGATGACTGTGACGGAACTTGTGAACCAGTGTTACGGAAACTGCGAGGATCCGGGGAAAGGGAGACAGATGCCGGTCCATTACGGAAGCAAGCACCACAACATGGTCACAATATCTAGTCCATTAGGAACACAAATGCCCCAGGCTGTTGGAGCCGCTTATGCCTACAAAAGAGTTCCGAATAACGACCGCTGCGTGATCTGCTACTTCGGTGACGGCGCTGCCTCGGAGGGCGATGCTCATGCGGCTTTCAACTTTGCCGCTACGTTAGATTGTCCTGTTATTATGCTGTGCAGAAACAACGGCTACGCGATATCTACACCCACAAGCGAACAATACCGCGGAGACGGCATCGCTTCTCGGGGACCAGCCCTGGGGCTCCACACGCTCAGAGTCGACGGGACCGACACTCTTGCGGTACACAATGCTGTGAAGAGAGCTAGAGACTTTACCGTAGCCAACAACAAGCCAGTACTCATTGAAGCTATGGCCTATCGTGTCGGGCATCATTCAACGTCTGACGATAGCAGCGCGTACAGGTCGGTGGAGGAGATACAAAAGTGGACCAAAGATGAGAGTCCTTTGCAGAAGTTCAAGCTTTATCTCGAACATAAAGGTTACTGGGACGCGGAGACTGAGAAGGCCTGGAGTAAGGAAGCAAGGGATACAGTGGTTAGAACCATGCAGGAAGCGGAAAAGAAAAAGAAACCAAACTGGAAAGAGATGCTAGAAGATGTCTACTATGAAATGCCACCCAGGCTTCAAAAACAAATGAAGCAAATGGAGGAACATCTAAAGAAGTATCCAGAGCATTACCCGCTCAATCAACACGAGAGCGATTGA

Protein

MALKTGASFVKLNAFRRAARLLSTRTRPETAQNGGGKIAEFPGARAPYVSEMKFFNETSYEPIPIYRVMDNNGQIIDKNEEPNLDKATLINMYKTMVQLSHMDKILYESQRQGRISFYMTNYGEEGIHIGSASALSPKDLVFSQYREVGVFLYRGMTVTELVNQCYGNCEDPGKGRQMPVHYGSKHHNMVTISSPLGTQMPQAVGAAYAYKRVPNNDRCVICYFGDGAASEGDAHAAFNFAATLDCPVIMLCRNNGYAISTPTSEQYRGDGIASRGPALGLHTLRVDGTDTLAVHNAVKRARDFTVANNKPVLIEAMAYRVGHHSTSDDSSAYRSVEEIQKWTKDESPLQKFKLYLEHKGYWDAETEKAWSKEARDTVVRTMQEAEKKKKPNWKEMLEDVYYEMPPRLQKQMKQMEEHLKKYPEHYPLNQHESD

Description

The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).

Catalytic Activity

3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-lipoyl-L-lysine + H(+) = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)-N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysine + CO2

Cofactor

thiamine diphosphate

Similarity

Belongs to the BCKDHA family.

Feature

chain  2-oxoisovalerate dehydrogenase subunit alpha

Uniprot

H9JP16   A0A194QJL5   B2DBJ6   A0A212FHS5   C3ZXF5   W8C6P1   + More
A0A182GJU0   E9G7A7   A0A164X3T2   W4YUZ6   A0A0P5FCW7   A0A0L0C6Y8   T1P8P0   A0A1I8PRX6   A0A1D1VN44   A0A0P4XDE8   H9G813   V4AHL2   A0A1L8F8Z5   A0A2G9SJ77   F7BVG6   B4GDS4   Q295J7   A0A0R1E2D7   B4NB33   B4PUQ4   A0A226DCN7   A0A3B0KDY4   B3NZQ5   A0A0P4WNK4   A0A1W0X2Y6   A0A0K8UZH3   A0A182PSW8   A0A1L8E0J9   Q9VHB8   A0A182QSS1   A0A1Q3F9R8   B4QWK8   C1BVS4   D6X542   A0A1W4VN32   A0A2M3Z6A5   A0A2M3Z657   T1IQP4   A0A1D2NKA3   A0A2M4BNE7   A0A182XVK2   B3M2F8   A0A182LC77   A0A0P7YCC9   A0A2M4BNB9   A0A182XE95   Q98UJ8   A0A2Y9E7P6   A0A182HJ26   A0A1W4YU45   S4R4D1   A0A182UHU6   A0A1D5NUJ3   A0A182JS64   A0A2I4CLF6   H0UTP1   A0A3Q2Y9B4   A0A2M3Z6N1   A0A1S3AKN6   B4K658   A0A182UN76   A0A3S1BQW4   A0A182LZ91   A0A2M4BNA6   A0A0B8RRX7   A0A2A2KR21   A0A210PU53   L8YCV6   A0A2A2KW39   H3BFU7   B0WYQ0   B4M4B1   A0A182NSD5   A0A1A7YB08   A0A3B4FHZ5   K1S4J4   A0A2M4BNB5   B4HJY4   I3J891   G3PHX0   A0A182W2T7   A0A3Q2WNF0   Q7PQR1   A0A0L8G146   A0A2M4AD89   A0A0M4EJ57   T1KA15   A0A3Q3FT86   A0A182FL64   A0A0D2WML6   A0A151MPF9   Q4VBU0   A0A0K2TBH9   Q16Z06  

EC Number

1.2.4.4

Pubmed

19121390    26354079    18712529    22118469    18563158    24495485    + More
26483478    21292972    26108605    25315136    27649274    21881562    23254933    27762356    20431018    17994087    15632085    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    18362917    19820115    27289101    25244985    20966253    11168412    15592404    21993624    25476704    28812685    23385571    9215903    22992520    25186727    12364791    14747013    17210077    22293439    23594743    17510324   

EMBL

BABH01009639    KQ458761    KPJ05105.1    AB264679    BAG30755.1    AGBW02008466    + More
OWR53290.1    GG666711    EEN42780.1    GAMC01004131    GAMC01004129    JAC02427.1    JXUM01068836    KQ562520    KXJ75720.1    GL732534    EFX84437.1    LRGB01001019    KZS13846.1    AAGJ04083947    AAGJ04083948    AAGJ04083949    AAGJ04083950    AAGJ04083951    AAGJ04083952    AAGJ04083953    AAGJ04083954    GDIQ01257318    JAJ94406.1    JRES01000819    KNC28173.1    KA645044    AFP59673.1    BDGG01000009    GAV03032.1    GDIP01245806    JAI77595.1    KB201755    ESO94690.1    CM004480    OCT68053.1    KV924665    PIO40165.1    AAMC01092292    CH479182    EDW34585.1    CM000070    EAL28714.1    CM000160    KRK03289.1    CH964232    EDW80997.1    EDW96671.1    LNIX01000025    OXA42594.1    OUUW01000008    SPP83886.1    CH954181    EDV49765.1    GDRN01057381    JAI65697.1    MTYJ01000021    OQV21811.1    GDHF01020250    JAI32064.1    GFDF01001867    JAV12217.1    AE014297    AY051542    AAF54398.1    AAK92966.1    AXCN02000238    GFDL01010786    JAV24259.1    CM000364    EDX13612.1    BT078703    ACO13127.1    KQ971382    EEZ97198.1    GGFM01003302    MBW24053.1    GGFM01003266    MBW24017.1    JH431312    LJIJ01000018    ODN05713.1    GGFJ01005434    MBW54575.1    CH902617    EDV43411.1    JARO02007511    KPP63866.1    GGFJ01005429    MBW54570.1    AB035083    BAB32665.1    APCN01002118    AADN05000777    AAKN02054853    GGFM01003403    MBW24154.1    CH933806    EDW14108.1    RQTK01000135    RUS86565.1    AXCM01000247    GGFJ01005428    MBW54569.1    GBSH01000125    JAG68899.1    LIAE01007889    PAV76395.1    NEDP02005491    OWF40037.1    KB364659    ELV12201.1    LIAE01007609    PAV78138.1    AFYH01010055    DS232196    EDS37160.1    CH940652    EDW59472.1    HADW01003901    HADX01005087    SBP27319.1    JH816160    EKC42336.1    GGFJ01005435    MBW54576.1    CH480815    EDW42868.1    AERX01055380    AAAB01008879    EAA08445.6    KQ424627    KOF70732.1    GGFK01005418    MBW38739.1    CP012526    ALC46871.1    CAEY01001893    KE346362    KJE91448.1    AKHW03005571    KYO26309.1    BX247864    BX649594    BC095157    BC164675    AAH95157.1    AAI64675.1    HACA01005464    HACA01005465    CDW22826.1    CH477505    EAT39862.1   

Proteomes

UP000005204    UP000053268    UP000007151    UP000001554    UP000069940    UP000249989    + More
UP000000305    UP000076858    UP000007110    UP000037069    UP000095301    UP000095300    UP000186922    UP000001646    UP000030746    UP000186698    UP000008143    UP000008744    UP000001819    UP000002282    UP000007798    UP000198287    UP000268350    UP000008711    UP000075885    UP000000803    UP000075886    UP000000304    UP000007266    UP000192221    UP000094527    UP000076408    UP000007801    UP000075882    UP000034805    UP000076407    UP000248480    UP000075840    UP000192224    UP000245300    UP000075902    UP000000539    UP000075881    UP000192220    UP000005447    UP000264820    UP000079721    UP000009192    UP000075903    UP000271974    UP000075883    UP000218231    UP000242188    UP000011518    UP000008672    UP000002320    UP000008792    UP000075884    UP000261460    UP000005408    UP000001292    UP000005207    UP000007635    UP000075920    UP000264840    UP000007062    UP000053454    UP000092553    UP000015104    UP000261660    UP000069272    UP000008743    UP000050525    UP000000437    UP000008820   

PRIDE

H9JP16    Q9VHB8   

Pfam

PF00400   WD40        + More
PF00676   E1_dh

Interpro

IPR011047   Quinoprotein_ADH-like_supfam        + More
IPR015943   WD40/YVTN_repeat-like_dom_sf       
IPR001017   DH_E1       
IPR017986   WD40_repeat_dom       
IPR001680   WD40_repeat       
IPR034616   BCKDH_E1-a       
IPR029061   THDP-binding       
IPR019775   WD40_repeat_CS       
IPR036322   WD40_repeat_dom_sf       

SUPFAM

SSF50998   SSF50998        + More
SSF52518   SSF52518       
SSF50978   SSF50978       

Gene 3D

2.130.10.10    

ProteinModelPortal

H9JP16   A0A194QJL5   B2DBJ6   A0A212FHS5   C3ZXF5   W8C6P1   + More
A0A182GJU0   E9G7A7   A0A164X3T2   W4YUZ6   A0A0P5FCW7   A0A0L0C6Y8   T1P8P0   A0A1I8PRX6   A0A1D1VN44   A0A0P4XDE8   H9G813   V4AHL2   A0A1L8F8Z5   A0A2G9SJ77   F7BVG6   B4GDS4   Q295J7   A0A0R1E2D7   B4NB33   B4PUQ4   A0A226DCN7   A0A3B0KDY4   B3NZQ5   A0A0P4WNK4   A0A1W0X2Y6   A0A0K8UZH3   A0A182PSW8   A0A1L8E0J9   Q9VHB8   A0A182QSS1   A0A1Q3F9R8   B4QWK8   C1BVS4   D6X542   A0A1W4VN32   A0A2M3Z6A5   A0A2M3Z657   T1IQP4   A0A1D2NKA3   A0A2M4BNE7   A0A182XVK2   B3M2F8   A0A182LC77   A0A0P7YCC9   A0A2M4BNB9   A0A182XE95   Q98UJ8   A0A2Y9E7P6   A0A182HJ26   A0A1W4YU45   S4R4D1   A0A182UHU6   A0A1D5NUJ3   A0A182JS64   A0A2I4CLF6   H0UTP1   A0A3Q2Y9B4   A0A2M3Z6N1   A0A1S3AKN6   B4K658   A0A182UN76   A0A3S1BQW4   A0A182LZ91   A0A2M4BNA6   A0A0B8RRX7   A0A2A2KR21   A0A210PU53   L8YCV6   A0A2A2KW39   H3BFU7   B0WYQ0   B4M4B1   A0A182NSD5   A0A1A7YB08   A0A3B4FHZ5   K1S4J4   A0A2M4BNB5   B4HJY4   I3J891   G3PHX0   A0A182W2T7   A0A3Q2WNF0   Q7PQR1   A0A0L8G146   A0A2M4AD89   A0A0M4EJ57   T1KA15   A0A3Q3FT86   A0A182FL64   A0A0D2WML6   A0A151MPF9   Q4VBU0   A0A0K2TBH9   Q16Z06  

PDB

2BEW     E-value=2.23835e-138,     Score=1262

KEGG

101746491    K00166 2-oxoisovalerate dehydrogenase E1 component alpha subunit [EC:1.2.4.4] | (RefSeq) 2-oxoisoval

PATHWAY

00280    Valine, leucine and isoleucine degradation - Bombyx mori (domestic silkworm)
00640    Propanoate metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0003826   GO:0003863   GO:0009083   GO:0005947   GO:0017086   GO:0046949   GO:0008152   GO:0016624   GO:0005840   GO:0006412   GO:0004888   GO:0007166   GO:0016020   GO:0004713   GO:0016491   GO:0015930  

PANTHER

PTHR43380:SF1  

Length:

434

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00167

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00257

outside

1  -  434

 

 

Pi

217.513308

Theta

147.846892

Tajima's D

0.072049

CLR

0.718342

CSRT

0.388330583470826

Interpretation

Uncertain