Silkworm Genome Informatics Database

Gene

KWMTBOMO13958

Pre Gene Modal

BGIBMGA011283

Annotation

hypothetical_protein_KGM_08305_[Danaus_plexippus]

Location

Bomo_Chr23(-):14694440-14701897 View in EpiBrowser

Full name

SCY1-like protein 2

Alternative Name

Coated vesicle-associated kinase of 104 kDa

Location in the cell

Cytoplasmic Reliability : 1.18 PlasmaMembrane Reliability : 1.453

CDS

ATGGATGTTTTCAATAAATTTTATTCATCGGTCAGCAATACCGTGTCACAATTGTCTGGTGTCTTACCCGGAAACCCTGTAACAAGAGAGTTTGAAGCAACACAATTCATTGCGAGCGCTGGCCCAGGTCTACTATGGAAAATATACAAGGGATACAAAAAGTCAACAAAACAAGAAGCATCAATATTTGTGTTTGAGAAGAAGCAATTAGACAGATGGCAGAAGGCCGACAGAGACATAATGTTGGAGACTCTTAAAAGGGGTATAATACAGCTAACAAAACTACGACATCCGCAGATCTTAACTGTACAGCATAGCCTCGAAGAGAGTCGTGAGAGCTTAGCGTTCGCCACTGAACCAGTGTTTGCGAGCTTAGCCAATATACTAGGCTACACGGAAAATATGCCTCAACCAATACCTGGACATTTAACCAATTATAAACTCTTTGAACTTGAAATTAAATATGGATTGATGCAGATTGCAGAAGGCTTAGCGTTCTTACATACTGATGTCAAGCTACTACACAGAAATGTGTGCCCTGAGTCAATAATAGTTAACCAGCAGGGTGCTTGGAAAATATTTGGATTTGATTTTTGTGTTGCGAATCAAAACTCAGTAGGAGCGGCTCCATATTGGCCTTTTAATGAGTATTGTCAAGCTATGCATGCTCTCACACAGCCCTCACTAGACTATTTAGCTCCAGAATATATATTATCAGCATCACATTCACCGGCAAGTGATATATTTTCTCTTGGAATGGTTATATACGTACTGCACAGCACAGGCCATCAAACTTTAGGTAATATTGGAACGGATTACATGAAGTTCAAAAAATTTGTAAATGAAGTCAGAAATTTACCACAGTCCAGATTGTCATGTGTAGCTGAAGGTCTACGTGAATATGTCAAGTTGATGCTTAATTCGACACCAGAATTACGACCTGATCCACACCAATTTTTGAAGATCGCTTATTTTGAGGACGTGGGTGTGAAAACTTTGAATTATCTAGATTCTTTATTCCAATGGGATAACCTTCAAAAGTCTCAGTTCTACAAAGGTCTCCCACAGATAATTCAGAAAATGCCACACCGTATATGTATATACCGGATTTTGCCATGTCTAACCAAGGAATTTGTGAACCCTCCCATGGTTCCCTTTGTTCTACCAAACGTATTACTCATAGCTGAGAACTGTTCTAAAGAGGAATTTGTGAAACACATCTTACCGGTTCTGAAACCAGTCATGGTAGTTCAAGAACCCATCCAAATACTTCTAATATTCATGCAAAAGATGGAATTGCTTCTGAAGTTGACACCCGGTGATGAAATCAAAACGGATATCTTGCCAATGCTATACAGAGCTTTGGAATCAGATGCTCAACAGATACAAGAGTTGTGTTTGTCAGTTTTACCAACGTTTGCCTCATTGATTGATTATCCTGCTATGAAGAATGCTTTATTACCACGCATAAAAAAATTGTGTATGAGCACGAATTTTATTTCGGTTCGTGTAAATAGCTTGTTGTGCATTGGCAAACTCTTGGAGCATTTGGACAAATGGTTGGTGTTGGATGAGATAATACCGTTTTTGCCGAAAATACCTTCGAGGGAACCTGCTGTCTTAATGGGCATTTTAGGTATATATAAATTAGCTTTAAGTCATCAAAAACTAGGGATAACTAAGGAAGTCTTGGCCACAAAAGTGTTGCCATTCCTCATACCTCTATGCGTTGAGAATGGTTTGACTCTGACCCAGTTCAATGCGTTGGTCACACTGGTGAAACAGATGATTGCCAAAGTGGAGAGCGAGCATAGAGCTAAATTGGAACAGCTCAACTCTATACAGAACGAGTCCAGAGTGATGGAGCACGCCCTCTCGGCGGACCTGGGCCCCTCCCCGCTGGCGAGCCCCGCGCCGGACGTGCGGGCGGCGCCGCTGGGGGCGCGGGACGCGGGCTCCCTCAGCATCCAGGATAAACAGAGGATAGCTCAAGCGCAAGAATCTGTCCGGCAGTTTGCAAACCAGCATCAGCCGGCTCCGATCAGGGCGCCTCCTAAGTCGTCTCCTCCCAAACCTCTCGACCTCACGTCGTCTCTCTTACAGTCCAACCTCACGCAGCTGTCCACTCAGCAGGCCCGACCTGGTACCACGCCCGGTAGTCACTTCGCCCCCAATTACCACAGCAGTATGATCAGCACCATGGGTCACAGCACACTGGTGCTAAACCACGCCCAGGGCATGGGTGGCGCGCCGGGTACGGGGGCGGCGCCCGGCGCTGGCTGGCCCGCGACGCCGAACTCCAATTTCAACAACAAATGGGTGAACAACCAGAACTCTCACACAAACACGAGACAGGACTGGTCGGCCTTCGAGTCGCTCCTCCCCGACCAGAGCACGAACAATAATAAAAAAATGGCCGACAACGAAATGATGGATTTGTTGAGTTAA

Protein

MDVFNKFYSSVSNTVSQLSGVLPGNPVTREFEATQFIASAGPGLLWKIYKGYKKSTKQEASIFVFEKKQLDRWQKADRDIMLETLKRGIIQLTKLRHPQILTVQHSLEESRESLAFATEPVFASLANILGYTENMPQPIPGHLTNYKLFELEIKYGLMQIAEGLAFLHTDVKLLHRNVCPESIIVNQQGAWKIFGFDFCVANQNSVGAAPYWPFNEYCQAMHALTQPSLDYLAPEYILSASHSPASDIFSLGMVIYVLHSTGHQTLGNIGTDYMKFKKFVNEVRNLPQSRLSCVAEGLREYVKLMLNSTPELRPDPHQFLKIAYFEDVGVKTLNYLDSLFQWDNLQKSQFYKGLPQIIQKMPHRICIYRILPCLTKEFVNPPMVPFVLPNVLLIAENCSKEEFVKHILPVLKPVMVVQEPIQILLIFMQKMELLLKLTPGDEIKTDILPMLYRALESDAQQIQELCLSVLPTFASLIDYPAMKNALLPRIKKLCMSTNFISVRVNSLLCIGKLLEHLDKWLVLDEIIPFLPKIPSREPAVLMGILGIYKLALSHQKLGITKEVLATKVLPFLIPLCVENGLTLTQFNALVTLVKQMIAKVESEHRAKLEQLNSIQNESRVMEHALSADLGPSPLASPAPDVRAAPLGARDAGSLSIQDKQRIAQAQESVRQFANQHQPAPIRAPPKSSPPKPLDLTSSLLQSNLTQLSTQQARPGTTPGSHFAPNYHSSMISTMGHSTLVLNHAQGMGGAPGTGAAPGAGWPATPNSNFNNKWVNNQNSHTNTRQDWSAFESLLPDQSTNNNKKMADNEMMDLLS

Description

Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. May be a serine/threonine-protein kinase. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system (By similarity).

Subunit

Interacts with clathrin and AP2B1; the interaction mediates the association with the AP-2 complex.

Similarity

Belongs to the protein kinase superfamily.

Keywords

Alternative splicing Complete proteome Cytoplasm Cytoplasmic vesicle Endosome Golgi apparatus Membrane Phosphoprotein Reference proteome

Feature

chain SCY1-like protein 2
splice variant In isoform 2.

Uniprot

H9JP29 A0A2A4K326 A0A194RED9 C3PPH8 L7X0U8 A0A212FD13 + More
A0A2H1WQQ2 A0A194QJQ9 A0A0L7KPN1 A0A2J7RM58 A0A067R4B3 A0A1B6FQS3 A0A1B6CKK9 A0A1B6E991 A0A1B6L1H8 A0A336MCG6 A0A1J1HM38 A0A1Y1KQG8 A0A146MC09 A0A139W9X6 A0A0A9XT86 A0A0K8T0C0 A0A0V0G6A0 A0A069DWJ5 T1JAW7 A0A224X7C4 A0A2H8TK89 A0A0N7Z9M3 A0A1B6C9B0 A0A0P4VZY6 A0A2S2NWJ9 L7LUC3 L7M7E6 A0A2S2QHM1 J9K2R0 A0A131YWQ4 A0A151WN99 E2C7N5 A0A151K152 A0A131XIG2 A0A224Z2D5 A0A151IJ43 A0A0C9RB40 A0A131Y3L7 A0A0K2T2K1 V5IGB9 F4X5N9 A0A293LWB3 E2ARF9 T1I7A7 A0A158NAZ5 A0A1E1XMD2 A0A2R5LB14 A0A026WT40 A0A3L8DQQ8 E0VD61 E9J980 A0A3Q0IN91 A0A087SVX9 A0A034VDI5 W8B8F6 A0A0K8UJQ0 A0A0M4EKC0 A0A0N8DZP7 A0A164LW88 A0A0P6A9J4 B4M065 B4KDT3 A0A0A1XNH0 A0A0P6E3A3 A0A154PDM1 A0A1I8NCI8 E9FSN2 B3LXP2 A0A0L0BW30 B4JTB8 B4PQM0 Q9VAR0 A0A1I8PT15 A0A1W4VUA4 B4QZF0 A0A3B0K5V9 B4HZ42 Q298Z1 B3P5M9 A0A3B0K1F1 A0A0N1IT31 A0A0N8BSU9 B4NFA0 A0A2A3E7W5 A0A2K6FUU1 G5E8J9 Q8CFE4 D4A1Y0 H0WX83 A0A2I3TKS2 A0A2K5IV03 A0A0P6A4U5 A0A2I3GZE9 A0A2K6RXR2

Pubmed

19121390 26354079 23674305 22118469 26227816 24845553 + More
28004739 26823975 18362917 19820115 25401762 26334808 27129103 25576852 26830274 20798317 28049606 28797301 25765539 21719571 21347285 29209593 24508170 30249741 20566863 21282665 25348373 24495485 17994087 25830018 25315136 21292972 26108605 17550304 10731132 12537568 12537572 12537573 12537574 16110336 17569856 17569867 26109357 26109356 15632085 19144319 19468303 21183079 16141072 15489334 16914521 15057822 22673903 16136131 25362486

EMBL

BABH01009599 NWSH01000204 PCG78449.1 KQ460297 KPJ16198.1 CU681835 + More
CAY54151.1 KC469894 AGC92739.1 AGBW02009117 OWR51629.1 ODYU01010352 SOQ55399.1 KQ458761 KPJ05150.1 JTDY01007372 KOB65263.1 NEVH01002577 PNF41917.1 KK852705 KDR18011.1 GECZ01017213 JAS52556.1 GEDC01023332 JAS13966.1 GEDC01024474 GEDC01002790 JAS12824.1 JAS34508.1 GEBQ01022408 JAT17569.1 UFQT01000693 SSX26609.1 CVRI01000008 CRK88468.1 GEZM01076778 JAV63662.1 GDHC01005798 GDHC01001335 JAQ12831.1 JAQ17294.1 KQ971866 KYB24710.1 GBHO01020723 JAG22881.1 GBRD01007211 JAG58610.1 GECL01002595 JAP03529.1 GBGD01000481 JAC88408.1 JH432006 GFTR01008120 JAW08306.1 GFXV01002740 MBW14545.1 GDKW01000147 JAI56448.1 GEDC01027443 JAS09855.1 GDRN01083500 JAI61658.1 GGMR01008941 MBY21560.1 GACK01009619 JAA55415.1 GACK01005237 JAA59797.1 GGMS01007990 MBY77193.1 ABLF02038625 GEDV01005622 JAP82935.1 KQ982909 KYQ49344.1 GL453395 EFN76018.1 KQ981225 KYN44375.1 GEFH01003260 JAP65321.1 GFPF01010973 MAA22119.1 KQ977412 KYN02886.1 GBYB01005540 JAG75307.1 GEFM01003170 JAP72626.1 HACA01002461 CDW19822.1 GANP01006957 JAB77511.1 GL888730 EGI58244.1 GFWV01007499 MAA32229.1 GL442063 EFN63968.1 ACPB03006254 ADTU01010624 GFAA01003188 JAU00247.1 GGLE01002543 MBY06669.1 KK107128 EZA58274.1 QOIP01000006 RLU22138.1 DS235072 EEB11317.1 GL769168 EFZ10635.1 KK112194 KFM57018.1 GAKP01019339 GAKP01019337 JAC39613.1 GAMC01013177 GAMC01013175 JAB93378.1 GDHF01025377 JAI26937.1 CP012526 ALC45527.1 GDIQ01076092 JAN18645.1 LRGB01003123 KZS04491.1 GDIP01033586 JAM70129.1 CH940650 EDW68315.1 CH933806 EDW14930.1 GBXI01001731 JAD12561.1 GDIQ01068745 JAN25992.1 KQ434869 KZC09290.1 GL732524 EFX89231.1 CH902617 EDV43936.1 JRES01001250 KNC24226.1 CH916373 EDV95008.1 CM000160 EDW98359.1 AE014297 AY069624 AAF56841.1 AAL39769.1 CM000364 EDX14788.1 OUUW01000013 SPP88062.1 CH480819 EDW53299.1 CM000070 EAL27813.1 CH954182 EDV53279.1 SPP88064.1 KQ435916 KOX68782.1 GDIQ01148267 JAL03459.1 CH964251 EDW82967.1 KZ288353 PBC27306.1 AC127279 AK136092 AK139747 BC030932 BC042443 AABR07056572 AAQR03016667 AAQR03016668 AAQR03016669 AAQR03016670 AAQR03016671 AACZ04070422 GDIP01047195 JAM56520.1 ADFV01052462 ADFV01052463 ADFV01052464

Proteomes

UP000005204 UP000218220 UP000053240 UP000007151 UP000053268 UP000037510 + More
UP000235965 UP000027135 UP000183832 UP000007266 UP000007819 UP000075809 UP000008237 UP000078541 UP000078542 UP000007755 UP000000311 UP000015103 UP000005205 UP000053097 UP000279307 UP000009046 UP000079169 UP000054359 UP000092553 UP000076858 UP000008792 UP000009192 UP000076502 UP000095301 UP000000305 UP000007801 UP000037069 UP000001070 UP000002282 UP000000803 UP000095300 UP000192221 UP000000304 UP000268350 UP000001292 UP000001819 UP000008711 UP000053105 UP000007798 UP000242457 UP000233160 UP000000589 UP000002494 UP000005225 UP000002277 UP000233080 UP000001073 UP000233200

PRIDE

H9JP29 V5IGB9 Q9VAR0 G5E8J9 Q8CFE4 D4A1Y0 + More

Pfam

PF00069 Pkinase

Interpro

IPR011009   Kinase-like_dom_sf        + More
IPR011989   ARM-like
IPR016024   ARM-type_fold
IPR000719   Prot_kinase_dom

SUPFAM

SSF56112 SSF56112 + More
SSF48371 SSF48371

Gene 3D

1.25.10.10

ProteinModelPortal

H9JP29 A0A2A4K326 A0A194RED9 C3PPH8 L7X0U8 A0A212FD13 + More
A0A2H1WQQ2 A0A194QJQ9 A0A0L7KPN1 A0A2J7RM58 A0A067R4B3 A0A1B6FQS3 A0A1B6CKK9 A0A1B6E991 A0A1B6L1H8 A0A336MCG6 A0A1J1HM38 A0A1Y1KQG8 A0A146MC09 A0A139W9X6 A0A0A9XT86 A0A0K8T0C0 A0A0V0G6A0 A0A069DWJ5 T1JAW7 A0A224X7C4 A0A2H8TK89 A0A0N7Z9M3 A0A1B6C9B0 A0A0P4VZY6 A0A2S2NWJ9 L7LUC3 L7M7E6 A0A2S2QHM1 J9K2R0 A0A131YWQ4 A0A151WN99 E2C7N5 A0A151K152 A0A131XIG2 A0A224Z2D5 A0A151IJ43 A0A0C9RB40 A0A131Y3L7 A0A0K2T2K1 V5IGB9 F4X5N9 A0A293LWB3 E2ARF9 T1I7A7 A0A158NAZ5 A0A1E1XMD2 A0A2R5LB14 A0A026WT40 A0A3L8DQQ8 E0VD61 E9J980 A0A3Q0IN91 A0A087SVX9 A0A034VDI5 W8B8F6 A0A0K8UJQ0 A0A0M4EKC0 A0A0N8DZP7 A0A164LW88 A0A0P6A9J4 B4M065 B4KDT3 A0A0A1XNH0 A0A0P6E3A3 A0A154PDM1 A0A1I8NCI8 E9FSN2 B3LXP2 A0A0L0BW30 B4JTB8 B4PQM0 Q9VAR0 A0A1I8PT15 A0A1W4VUA4 B4QZF0 A0A3B0K5V9 B4HZ42 Q298Z1 B3P5M9 A0A3B0K1F1 A0A0N1IT31 A0A0N8BSU9 B4NFA0 A0A2A3E7W5 A0A2K6FUU1 G5E8J9 Q8CFE4 D4A1Y0 H0WX83 A0A2I3TKS2 A0A2K5IV03 A0A0P6A4U5 A0A2I3GZE9 A0A2K6RXR2

PDB

4X7O E-value=1.14461e-10, Score=163

KEGG

101743513 K17541 SCY1-like protein 2 | (RefSeq) SCY1-like protein 2

GO

GO:0004672 GO:0005524 GO:0032504 GO:0006468 GO:0030136 GO:0005794 GO:0010008 GO:2000286 GO:0048471 GO:2000370 GO:0090090 GO:0008333 GO:0002092 GO:0005102 GO:0005488 GO:0004888 GO:0007166 GO:0016020 GO:0004713 GO:0016491 GO:0015930

Subcellular location

Cytoplasm   Plasma membrane-associated in clathrin-coated vesicles. Colocalizes to the trans-Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes (By similarity).   With evidence from 3 publications.
Perinuclear region   Plasma membrane-associated in clathrin-coated vesicles. Colocalizes to the trans-Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes (By similarity).   With evidence from 3 publications.
Cytoplasmic vesicle   Plasma membrane-associated in clathrin-coated vesicles. Colocalizes to the trans-Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes (By similarity).   With evidence from 3 publications.
Clathrin-coated vesicle   Plasma membrane-associated in clathrin-coated vesicles. Colocalizes to the trans-Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes (By similarity).   With evidence from 3 publications.
Golgi apparatus   Plasma membrane-associated in clathrin-coated vesicles. Colocalizes to the trans-Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes (By similarity).   With evidence from 3 publications.
trans-Golgi network membrane   Plasma membrane-associated in clathrin-coated vesicles. Colocalizes to the trans-Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes (By similarity).   With evidence from 3 publications.
Endosome membrane   Plasma membrane-associated in clathrin-coated vesicles. Colocalizes to the trans-Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes (By similarity).   With evidence from 3 publications.

Length:

815

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.05054

Exp number, first 60 AAs:

0.00477

Total prob of N-in:

0.00064

outside

1 - 815

Pi

361.434942

Theta

223.570367

Tajima's D

2.06343

CLR

0.28007

CSRT

0.893905304734763

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics