Silkworm Genome Informatics Database

Gene

KWMTBOMO13946

Pre Gene Modal

BGIBMGA011316

Annotation

PREDICTED:_pre-mRNA-splicing_factor_Slu7_[Papilio_xuthus]

Location

Bomo_Chr23(+):14344038-14359051 View in EpiBrowser

Full name

alpha-1,2-Mannosidase + More
Pre-mRNA-splicing factor Slu7

Location in the cell

Nuclear Reliability : 4.728

CDS

ATGGCGACGACGTCTCGTGTACCTATATCACAAATTTTACGCAATAAAGATGACACCGAAGAAGACGATGAGCCCAAGAAGAAATCTAGGGAAGACTGGAGAAAAGCTAAAGAGTTAGAGGAGGCCAGAAAAGCTGGAACAGCACCAGCCGCTGTTGATGAAACAGGCAAAGACATAAATCCTCATATACCTCAGTATATTGCATCTGCTCCATGGTACTATGGGACTTCGGGACCTACTCTTAAACATCAGCGGCCTCAGGAGGACAGAGAGGGACAATTCACAAAGCTCGATAAATATTACAATAAAGGAGTTGATGTGACAAAAGTAGCAACAAAATTCAGGAAAGGGGCATGTGAAAACTGTGGTGCGATGACACACAAGAAGAAGGATTGCTTGGAGAGACCTAGAAAAATAGGTGCAAAATTCACTAATGCAGGAATTGCGGCTGACGAGTTTGCTCAACCTGACTTGAACCTCAGCTATGACGGAAAGAGAGACAGGTGGAATGGATATGATCCAGAGCAGCACAAAGCAATCATTGAGGAGTACCAGAAGGTAGAGGAAGCTAAACGAGAACTAAGAGCAAAGAAATTGGAGATAGATCCAACAGCTAAAGATGAAGACGATAAGGAGGAGGAAGACGAAGACAAATATGTGGATGAAGTGGACATGCCCGGCACAAAGGTGGATTCGAAGCAGCGCATCACAGTTCGTAACCTGCGTATCCGGGAGGACACAGCCAAGTACCTGCGGAATCTGGACCCCAATTCCGCCTACTACGACCCCAAGACTCGCTCTATGAGAGACAACCCCACTCCTAACGTACCCGAGTCTGAGTACGGCGGCGAGAACAGCGTCCGCGTGTCTGGGGACACGGCGCAGCACGCGGCGGCGCAGCTGTTCGCGTGGGAGGCGCGCGCGCACGGCCTCGACCTGCACCTGCTGGCCGAGCCCACCAAGCTGCAGATGCTGCAGGCGCACTACAAGCGCGACCAGCAGCGATACAAGTCGCAGGTGAAACAATCGATTCTGGAAAAGTATGGAGGTGAGGAGCACCTCCAGTCCGTACCCAGGGAGCTGCTGCTGGCCCAGACCGAAGTGTTCACCCGCTACAACAGGGACGGCACGCTCGTCAGCGGGGCAGAGAAGCAACTTGCCAAGAGTAAATATGAAGAGGATGCTCTAATAAACAACCACACCACAGTCTGGGGCTCGTACTGGCGCGACGGCCAGTGGGGCTACAAGTGCTGTCACTCCTTTATAAAGATGTCATACTGCGTTGGAGAAGCAGGAAAGACTGTCGTACTGCCCGTGTCGGATGACAAGAAATTGTCGACCAGCACCGATGGAATTAAACAAAAAGAGAAAAAACAAAAAGACAAAGAAGAAGACAGTTCATCGTCGTCGTCAAGTTCGTCAGAAAGCAGTTCATCCGATTCGGAACAAGATAAGAGATCGAAAACGGAAAAGACAAGTAAAAAGAAAAAAGACAAGAAGAAAATTAAGAAGAAGAAGAGGAAGAACGTTAAGAAAGAGAAGAAAACGGAGGATAAACTGAAAAAGGCTTTGGAAATGGAAGAAAGACAACAGAAACACGCTGAATATCTCCTTTCGATCGACGAGCGGAAACGTGGATATAATAGTATGGTAGAAGTCAAGGAGCCAACAGAGGATGAAATGGAAGCCTACAGAATGAAGAGGAAACGCGATGAAGATCCCATGAGTCAGTTTTTATAA

Protein

MATTSRVPISQILRNKDDTEEDDEPKKKSREDWRKAKELEEARKAGTAPAAVDETGKDINPHIPQYIASAPWYYGTSGPTLKHQRPQEDREGQFTKLDKYYNKGVDVTKVATKFRKGACENCGAMTHKKKDCLERPRKIGAKFTNAGIAADEFAQPDLNLSYDGKRDRWNGYDPEQHKAIIEEYQKVEEAKRELRAKKLEIDPTAKDEDDKEEEDEDKYVDEVDMPGTKVDSKQRITVRNLRIREDTAKYLRNLDPNSAYYDPKTRSMRDNPTPNVPESEYGGENSVRVSGDTAQHAAAQLFAWEARAHGLDLHLLAEPTKLQMLQAHYKRDQQRYKSQVKQSILEKYGGEEHLQSVPRELLLAQTEVFTRYNRDGTLVSGAEKQLAKSKYEEDALINNHTTVWGSYWRDGQWGYKCCHSFIKMSYCVGEAGKTVVLPVSDDKKLSTSTDGIKQKEKKQKDKEEDSSSSSSSSSESSSSDSEQDKRSKTEKTSKKKKDKKKIKKKKRKNVKKEKKTEDKLKKALEMEERQQKHAEYLLSIDERKRGYNSMVEVKEPTEDEMEAYRMKRKRDEDPMSQFL

Description

Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation.

Subunit

Component of pre-catalytic, catalytic and post-catalytic spliceosomes. Associates with the spliceosome prior to recognition of the 3'-splice site for step II, probably during catalysis of step I.

Similarity

Belongs to the glycosyl hydrolase 47 family.
Belongs to the SLU7 family.

Keywords

Complete proteome Cytoplasm Metal-binding mRNA processing mRNA splicing Nucleus Phosphoprotein Reference proteome Spliceosome Zinc Zinc-finger

Feature

chain alpha-1,2-Mannosidase

Uniprot

H9JP62 A0A2H1WRM1 A0A194QI16 A0A194RFW9 C3PPF5 L7X0T9 + More
A0A3S2NUE0 S4PGG9 A0A1E1WIW6 A0A212FD04 A0A1B0CWP0 D6WAL4 A0A2J7PN60 A0A1L8DGQ2 A0A1B0DLM9 A0A1B0DLD2 A0A067R8M6 A0A1W4WWZ4 A0A182HAN8 A0A1J1IYX0 A0A1S4G2Q1 Q16FY9 A0A0P6K0T0 Q16HM6 E2AML0 A0A1Y1N020 V5GJB0 A0A0J7NXF0 A0A3L8DE29 A0A151WEY3 F4WR65 A0A158NU89 A0A154P1Y5 A0A195FLI2 A0A310SSM4 A0A151J3I6 A0A151IQG1 A0A1Q3F8K7 A0A084VWL0 A0A0L7RJF6 A0A2M4ADC8 E9J2N4 A0A182F2Z6 A0A2M4BHF9 A0A2M4BHN9 W5JSE5 A0A2A3EEX7 E2B5E9 A0A0N1ITH6 A0A088ADG6 E2BKU2 A0A0Q9WU48 A0A0Q9WZD0 A0A1B6G9S8 A0A1A9X1U4 A0A1B6JB71 A0A182K7W9 I7LZD2 A0A1B6DB01 A0A146LZ13 A0A182PP08 A0A182WYJ8 A0A3B0KN96 Q7Q2R2 A0A182LI60 A0A182HXJ6 A0A182RXF2 A0A182NND6 A0A1A9US65 A0A0M5J4G8 A0A1I8QBC0 U4UK46 A0A0A1X7G2 N6TAR7 A0A182MNY6 D3TQQ0 A0A1B0GEA1 A0A182YI18 A0A0N8P1Q1 A0A034WWB0 A0A1D2N283 A0A1A9Z6X3 E9HE12 A0A182T4H0 E0VEC4 W8B6D7 A0A182Q1H8 A0A0R1E4U5 A0A0K8UJW1 A0A1B6LA25 A0A1W4VHD2 K7J9K1 A0A182WCM7 W8AZB6 A0A0P4VU85 A0A1I8MTI7 F3YDP8 A0A0V0G8B5 Q9VAQ7 A0A1B6E267

EC Number

3.2.1.-

Pubmed

19121390 26354079 23674305 23622113 22118469 18362917 + More
19820115 24845553 26483478 17510324 26999592 20798317 28004739 30249741 21719571 21347285 24438588 21282665 20920257 23761445 17994087 15632085 26823975 12364791 20966253 23537049 25830018 20353571 25244985 25348373 27289101 21292972 20566863 24495485 17550304 20075255 27129103 25315136 10731132 12537572 12537569 10908584 18327897

EMBL

BABH01009573 BABH01009574 ODYU01010475 SOQ55612.1 KQ458761 KPJ05152.1 + More
KQ460297 KPJ16200.1 CU467808 CAY54165.1 KC469894 AGC92729.1 RSAL01000075 RVE48893.1 GAIX01003677 JAA88883.1 GDQN01004217 JAT86837.1 AGBW02009117 OWR51619.1 AJWK01032721 KQ971312 EEZ97980.2 NEVH01023957 PNF17773.1 GFDF01008517 JAV05567.1 AJVK01016484 AJVK01036331 KK852811 KDR15939.1 JXUM01123025 KQ566670 KXJ69921.1 CVRI01000063 CRL04358.1 CH478356 EAT33159.1 GDUN01000828 JAN95091.1 CH478159 EAT33756.1 GL440824 EFN65330.1 GEZM01016601 JAV91244.1 GALX01004292 JAB64174.1 LBMM01001008 KMQ97075.1 QOIP01000009 RLU18740.1 KQ983238 KYQ46367.1 GL888284 EGI63292.1 ADTU01026290 KQ434803 KZC05945.1 KQ981512 KYN40849.1 KQ760549 OAD59876.1 KQ980298 KYN16825.1 KQ976780 KYN08387.1 GFDL01011169 JAV23876.1 ATLV01017653 KE525180 KFB42354.1 KQ414581 KOC71005.1 GGFK01005466 MBW38787.1 GL767899 EFZ12919.1 GGFJ01003331 MBW52472.1 GGFJ01003330 MBW52471.1 ADMH02000571 ETN65835.1 KZ288271 PBC29832.1 GL445816 EFN89099.1 KQ435812 KOX72752.1 GL448826 EFN83691.1 CH964251 KRF99701.1 CH933806 KRG01286.1 GECZ01010580 JAS59189.1 GECU01011292 GECU01003874 JAS96414.1 JAT03833.1 CM000070 EAL27810.2 GEDC01014434 GEDC01012616 JAS22864.1 JAS24682.1 GDHC01005805 GDHC01000892 JAQ12824.1 JAQ17737.1 OUUW01000013 SPP88059.1 AAAB01008968 EAA13299.4 APCN01005314 CP012526 ALC45524.1 KB632244 ERL90571.1 GBXI01007669 JAD06623.1 APGK01044966 KB741028 ENN74838.1 AXCM01002053 EZ423752 ADD20028.1 CCAG010012181 CH902617 KPU80548.1 GAKP01000864 JAC58088.1 LJIJ01000283 ODM99407.1 GL732626 EFX70018.1 DS235090 EEB11730.1 GAMC01012393 JAB94162.1 AXCN02001908 CM000160 KRK04236.1 GDHF01025483 JAI26831.1 GEBQ01019613 JAT20364.1 AAZX01000843 GAMC01012395 JAB94160.1 GDKW01000369 JAI56226.1 BT126409 AED99975.1 GECL01001706 JAP04418.1 AE014297 AY061470 GEDC01005299 JAS31999.1

Proteomes

UP000005204 UP000053268 UP000053240 UP000283053 UP000007151 UP000092461 + More
UP000007266 UP000235965 UP000092462 UP000027135 UP000192223 UP000069940 UP000249989 UP000183832 UP000008820 UP000000311 UP000036403 UP000279307 UP000075809 UP000007755 UP000005205 UP000076502 UP000078541 UP000078492 UP000078542 UP000030765 UP000053825 UP000069272 UP000000673 UP000242457 UP000008237 UP000053105 UP000005203 UP000007798 UP000009192 UP000091820 UP000075881 UP000001819 UP000075885 UP000076407 UP000268350 UP000007062 UP000075882 UP000075840 UP000075900 UP000075884 UP000078200 UP000092553 UP000095300 UP000030742 UP000019118 UP000075883 UP000092444 UP000076408 UP000007801 UP000094527 UP000092445 UP000000305 UP000075901 UP000009046 UP000075886 UP000002282 UP000192221 UP000002358 UP000075920 UP000095301 UP000000803

PRIDE

H9JP62 Q9VAQ7

Pfam

PF11708 Slu7 + More
PF01532 Glyco_hydro_47

Interpro

IPR039974   Splicing_factor_SLU7        + More
IPR021715   Slu7_dom
IPR001382   Glyco_hydro_47
IPR036026   Seven-hairpin_glycosidases
IPR012341   6hp_glycosidase-like_sf
IPR001878   Znf_CCHC

SUPFAM

SSF48225 SSF48225

Gene 3D

1.50.10.10

ProteinModelPortal

H9JP62 A0A2H1WRM1 A0A194QI16 A0A194RFW9 C3PPF5 L7X0T9 + More
A0A3S2NUE0 S4PGG9 A0A1E1WIW6 A0A212FD04 A0A1B0CWP0 D6WAL4 A0A2J7PN60 A0A1L8DGQ2 A0A1B0DLM9 A0A1B0DLD2 A0A067R8M6 A0A1W4WWZ4 A0A182HAN8 A0A1J1IYX0 A0A1S4G2Q1 Q16FY9 A0A0P6K0T0 Q16HM6 E2AML0 A0A1Y1N020 V5GJB0 A0A0J7NXF0 A0A3L8DE29 A0A151WEY3 F4WR65 A0A158NU89 A0A154P1Y5 A0A195FLI2 A0A310SSM4 A0A151J3I6 A0A151IQG1 A0A1Q3F8K7 A0A084VWL0 A0A0L7RJF6 A0A2M4ADC8 E9J2N4 A0A182F2Z6 A0A2M4BHF9 A0A2M4BHN9 W5JSE5 A0A2A3EEX7 E2B5E9 A0A0N1ITH6 A0A088ADG6 E2BKU2 A0A0Q9WU48 A0A0Q9WZD0 A0A1B6G9S8 A0A1A9X1U4 A0A1B6JB71 A0A182K7W9 I7LZD2 A0A1B6DB01 A0A146LZ13 A0A182PP08 A0A182WYJ8 A0A3B0KN96 Q7Q2R2 A0A182LI60 A0A182HXJ6 A0A182RXF2 A0A182NND6 A0A1A9US65 A0A0M5J4G8 A0A1I8QBC0 U4UK46 A0A0A1X7G2 N6TAR7 A0A182MNY6 D3TQQ0 A0A1B0GEA1 A0A182YI18 A0A0N8P1Q1 A0A034WWB0 A0A1D2N283 A0A1A9Z6X3 E9HE12 A0A182T4H0 E0VEC4 W8B6D7 A0A182Q1H8 A0A0R1E4U5 A0A0K8UJW1 A0A1B6LA25 A0A1W4VHD2 K7J9K1 A0A182WCM7 W8AZB6 A0A0P4VU85 A0A1I8MTI7 F3YDP8 A0A0V0G8B5 Q9VAQ7 A0A1B6E267

PDB

6QDV E-value=1.05129e-128, Score=1180

KEGG

101742271 K12819 pre-mRNA-processing factor SLU7 | (RefSeq) pre-mRNA-splicing factor Slu7

PATHWAY

03040 Spliceosome - Bombyx mori (domestic silkworm)

GO

GO:0000398 GO:0030628 GO:0000386 GO:0005681 GO:0016020 GO:0004571 GO:0005509 GO:0008152 GO:0008270 GO:0046872 GO:0016607 GO:0000389

PANTHER

PTHR12942

Subcellular location

Nucleus   Predominantly nuclear.   With evidence from 1 publications.
Nucleus speckle   Predominantly nuclear.   With evidence from 1 publications.
Cytoplasm   Predominantly nuclear.   With evidence from 1 publications.

Length:

579

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00127

outside

1 - 579

Pi

259.408646

Theta

202.539002

Tajima's D

1.803056

CLR

0.727992

CSRT

0.848757562121894

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics