Gene

KWMTBOMO13909

Annotation

PREDICTED:_probable_E3_SUMO-protein_ligase_RNF212_[Plutella_xylostella]

Location

Bomo_Chr23(+):12742843-12745021      View in EpiBrowser

Full name

Probable E3 SUMO-protein ligase RNF212      

Alternative Name

Probable E3 SUMO-protein transferase RNF212
RING finger protein 212

Location in the cell

Extracellular   Reliability : 2.899

CDS

ATGGATTGGATTCACTGTAATAAATGTTTTTCACAATTAGAACCAGGGATAACACTGCATCTCACATCATGTGGTCACATGTTCTGCAACAATTGTTTGGGCAACGGTCTAAAAGACAGCACGTGTCTAGTATGTCGAATGCCGTGTTCTGCTATGAAATTAGTGCCAGACATGAAACAAGAAATCCAAGATTACTTCACTGATCCTGAAGAGTTGATAAAGAAGTCTTGCGATGTGATACAGTTTCAAAGGCAGCATAGAAGGAGATTGCTCTCTTATCTATTACAATCGACAGAATATTTGGCCCTTCAACATACAATATTCCTCGTTATACCATAA

Protein

MDWIHCNKCFSQLEPGITLHLTSCGHMFCNNCLGNGLKDSTCLVCRMPCSAMKLVPDMKQEIQDYFTDPEELIKKSCDVIQFQRQHRRRLLSYLLQSTEYLALQHTIFLVIP

Description

SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity).
SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination.

Keywords

Alternative splicing   Chromosome   Coiled coil   Complete proteome   Meiosis   Metal-binding   Nucleus   Polymorphism   Reference proteome   Transferase   Ubl conjugation pathway   Zinc   Zinc-finger  

Feature

chain  Probable E3 SUMO-protein ligase RNF212
splice variant  In isoform 4.
sequence variant  In dbSNP:rs17728127.

Uniprot

A0A2H1VDU3   A0A212FLD2   A0A3S2PDX4   A0A0L7KYW6   A0A0L8HKF0   V4ACQ1   + More
E0VQH4   A0A2P8Z4H5   A0A210PJA5   A0A3Q7QM18   N6UIR4   A0A1B6K6J9   N6TMC8   W5MYF7   K1QA75   Q495C1-2   A0A2J8K6W5   A0A3Q0D2L6   A0A2J8SS90   A0A087TJL3   A0A1A9UZU5   A0A2U3ZBN5   G1MEN0   A0A2B4SQW2   A0A1U8C3M2   G1MEM9   A0A1X7VFA6   Q495C1-3   A0A067QNJ4   A0A2R9CIT1   A0A2I3SVD5   H2PCN2   J9P767   Q495C1-5   A0A1A9ZZQ6   A0A2J8SS60   A0A2J8K6W2   A0A2R9CLJ5   H2QP31   Q495C1   G3RU07   A0A2K5X0J2   A0A0D9RSM5   A0A3Q7UXW1   A0A1B6FPX5   A0A2I3LEY2   G5BCJ8   A0A1X7TAA9   A0A1S3WUU2   A0A287AWA2   A0A2K6CTJ7   A0A1D5QA59   A0A1X7UF31   A0A096MRK0   A0A2Y9G2V5   A0A2Y9LZH0   A0A091DSG2   A0A1B6D4S8   A0A2K5SH72   A0A2K5SH67   A0A0N8ESI7   C7BVP5   A0A2Y9JUJ1   M3YIG3   A0A3Q0DQK5   A0A1B0C2W0   A0A1A9XN25   A0A3Q2KLZ7   A0A1W3JQD8   A0A1B6DQQ5   F7APR6   A0A340Y868   A0A183CH91   A0A0G2JYP9   A0A1X7SZM7   A0A2Y9F343   A0A158P7H7   A0A091MLL2   F7GUW4   A0A0N4XXL8   F6TQD1   A0A1W5AKY9   A0A2J8SS78   A0A0P4W9L9   A0A0R3PBN3   A0A0N4U2A1   A0A2R8MHL8   D6X225   A0A091R8Q9   A0A384A2H2   A0A3P4S6I3   A0A2I2UL28   A0A2K5D1L6   A0A3R7QIU3   A0A091IEM4   A0A093EM11   A0A337RWQ1   A0A368FGJ1   A0A093P6V3  

EC Number

2.3.2.-

Pubmed

22118469    26227816    23254933    20566863    29403074    28812685    + More
23537049    22992520    14702039    15815621    15489334    18239089    20010809    24845553    22722832    16136131    16341006    22398555    21993625    17431167    19852860    19892987    12481130    15114417    15057822    23396135    16141072    19468303    24390283    18362917    19820115    17975172   

EMBL

ODYU01002016    SOQ38999.1    AGBW02007799    OWR54553.1    RSAL01000081    RVE48582.1    + More
JTDY01004398    KOB68214.1    KQ417924    KOF89682.1    KB202284    ESO91101.1    DS235430    EEB15630.1    PYGN01000200    PSN51377.1    NEDP02076567    OWF36567.1    APGK01018569    APGK01018570    KB740081    ENN81615.1    GECU01000923    JAT06784.1    ENN81614.1    AHAT01001562    AHAT01001563    JH817484    EKC30858.1    AK096160    AC019103    AC092535    BC036250    BC050356    BC101258    BC101259    BC101260    BC101261    NBAG03000389    PNI30760.1    NDHI03003552    PNJ23623.1    KK115511    KFM65302.1    ACTA01067697    ACTA01075697    ACTA01083697    ACTA01091697    LSMT01000025    PFX32291.1    KK853123    KDR11067.1    AJFE02035425    AJFE02035426    AJFE02035427    AJFE02035428    AJFE02035429    AJFE02035430    AC194569    PNI30756.1    ABGA01011469    ABGA01011470    ABGA01011471    ABGA01011472    AAEX03002646    PNJ23620.1    PNI30761.1    CABD030026647    CABD030026648    CABD030026649    AQIA01053416    AQIA01053417    AQIA01053418    AQIA01053419    AQIA01053420    AQIA01053421    AQIB01147700    GECZ01017504    JAS52265.1    AHZZ02026141    JH169543    EHB07009.1    AEMK02000062    JSUE03032726    JSUE03032727    KN123337    KFO25691.1    GEDC01016713    JAS20585.1    GEBF01007067    JAN96565.1    FM207699    CAR63560.1    AEYP01079023    JXJN01024710    GEDC01009298    JAS28000.1    EAAA01002659    AABR07072361    AC117047    KK831536    KFP76862.1    UYSL01019922    VDL71338.1    AK089585    AC123743    PNJ23624.1    GDRN01076925    JAI62823.1    UYYA01000150    VDM52709.1    UYYG01001151    VDN55179.1    KQ971371    EFA10202.1    KK715081    KFQ35836.1    CYRY02046175    VCX41821.1    AANG04001605    QCYY01002627    ROT68851.1    KL218617    KFP07064.1    KK371807    KFV43944.1    JOJR01001659    RCN30109.1    KL225479    KFW72653.1   

Proteomes

UP000007151    UP000283053    UP000037510    UP000053454    UP000030746    UP000009046    + More
UP000245037    UP000242188    UP000286641    UP000019118    UP000018468    UP000005408    UP000005640    UP000189706    UP000054359    UP000078200    UP000245340    UP000008912    UP000225706    UP000007879    UP000027135    UP000240080    UP000002277    UP000001595    UP000002254    UP000092445    UP000001519    UP000233100    UP000029965    UP000286642    UP000028761    UP000006813    UP000079721    UP000008227    UP000233120    UP000006718    UP000248481    UP000248483    UP000028990    UP000233040    UP000248482    UP000000715    UP000189704    UP000092460    UP000092443    UP000002281    UP000008144    UP000265300    UP000050741    UP000002494    UP000035642    UP000008225    UP000038043    UP000271162    UP000000589    UP000192224    UP000050601    UP000267027    UP000038040    UP000274756    UP000007266    UP000261681    UP000011712    UP000233020    UP000283509    UP000054308    UP000252519    UP000054081   

PRIDE

Q495C1    F6TQD1   

Pfam

PF14634   zf-RING_5

Interpro

IPR017907   Znf_RING_CS        + More
IPR042123   Vilya/Cst9/RNF212       
IPR013083   Znf_RING/FYVE/PHD       
IPR001841   Znf_RING       
IPR036572   Doublecortin_dom_sf       

SUPFAM

SSF89837   SSF89837       

Gene 3D

3.30.40.10    

ProteinModelPortal

A0A2H1VDU3   A0A212FLD2   A0A3S2PDX4   A0A0L7KYW6   A0A0L8HKF0   V4ACQ1   + More
E0VQH4   A0A2P8Z4H5   A0A210PJA5   A0A3Q7QM18   N6UIR4   A0A1B6K6J9   N6TMC8   W5MYF7   K1QA75   Q495C1-2   A0A2J8K6W5   A0A3Q0D2L6   A0A2J8SS90   A0A087TJL3   A0A1A9UZU5   A0A2U3ZBN5   G1MEN0   A0A2B4SQW2   A0A1U8C3M2   G1MEM9   A0A1X7VFA6   Q495C1-3   A0A067QNJ4   A0A2R9CIT1   A0A2I3SVD5   H2PCN2   J9P767   Q495C1-5   A0A1A9ZZQ6   A0A2J8SS60   A0A2J8K6W2   A0A2R9CLJ5   H2QP31   Q495C1   G3RU07   A0A2K5X0J2   A0A0D9RSM5   A0A3Q7UXW1   A0A1B6FPX5   A0A2I3LEY2   G5BCJ8   A0A1X7TAA9   A0A1S3WUU2   A0A287AWA2   A0A2K6CTJ7   A0A1D5QA59   A0A1X7UF31   A0A096MRK0   A0A2Y9G2V5   A0A2Y9LZH0   A0A091DSG2   A0A1B6D4S8   A0A2K5SH72   A0A2K5SH67   A0A0N8ESI7   C7BVP5   A0A2Y9JUJ1   M3YIG3   A0A3Q0DQK5   A0A1B0C2W0   A0A1A9XN25   A0A3Q2KLZ7   A0A1W3JQD8   A0A1B6DQQ5   F7APR6   A0A340Y868   A0A183CH91   A0A0G2JYP9   A0A1X7SZM7   A0A2Y9F343   A0A158P7H7   A0A091MLL2   F7GUW4   A0A0N4XXL8   F6TQD1   A0A1W5AKY9   A0A2J8SS78   A0A0P4W9L9   A0A0R3PBN3   A0A0N4U2A1   A0A2R8MHL8   D6X225   A0A091R8Q9   A0A384A2H2   A0A3P4S6I3   A0A2I2UL28   A0A2K5D1L6   A0A3R7QIU3   A0A091IEM4   A0A093EM11   A0A337RWQ1   A0A368FGJ1   A0A093P6V3  

KEGG

101742317    no KO assigned | (RefSeq) probable E3 SUMO-protein ligase RNF212

GO

GO:0016874   GO:0019789   GO:0016925   GO:0007129   GO:0000795   GO:0035556   GO:0006311   GO:0046872   GO:0051026   GO:0007131   GO:0005515   GO:0008270   GO:0045281   GO:0009055   GO:0016020   GO:0016627   GO:0016787   GO:0004713   GO:0016491   GO:0015930  

PANTHER

PTHR22663  

Subcellular location

Nucleus   Associates to the synaptonemal complex. Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema (By similarity).   With evidence from 1 publications.
Chromosome   Associates to the synaptonemal complex. Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema (By similarity).   With evidence from 1 publications.

Length:

112

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

3.54936

Exp number, first 60 AAs:

0.10563

Total prob of N-in:

0.48599

outside

1  -  112

 

 

Pi

187.255451

Theta

127.716559

Tajima's D

1.40331

CLR

0.138179

CSRT

0.758462076896155

Interpretation

Uncertain