SGID Silkworm Genome Informatics Database
Gene
KWMTBOMO13908  Validated by peptides from experiments
Pre Gene Modal
BGIBMGA011424
Annotation
transferrin_precursor_[Bombyx_mori]
Location
Bomo_Chr23(-):12725565-12738822      View in EpiBrowser
Full name
Transferrin      
Location in the cell
Extracellular   Reliability : 3.61
 

Sequence

CDS
ATGGCTCTAAAATATTTCATTTTGATAACCCTGATTTGTGCATGTGTGAACGCAGCGAAAACTACATATAAAATATGCGTGCCATCACAACACCTGAAAGCGTGTCAGGACATGGTGGATATTCCGACCAAATCCAAGGTCACACTAGACTGCATTCCCGCCAGAGATAGAATGGAGTGTCTGAATTACGTTCAGCAGAGGCAAGCCGATTTCGTTCCAGTTGACCCCGAAGACATGTACGTGGCCGCCAAAATACCCAATCAGGACTTCGTCGTTTTCCAGGAGTACAGAACCGATGAAGAACCGGATGCGCCTTTCCGTTACGAAGCAGTAATTGTCATCCATAAGGATTTACCGATAAACAATCTGGACCAGCTGAAAGGCTTGAAGTCCTGTCATACTGGAGTTAACAGAAACGTGGGATACAAGATCCCTCTAACAATGCTGATGAAGCGTGCAGTTTTCCCAAAAATGAACGACCACAGCATTTCGCCGAAGGAAAACGAACTAAAAGCCTTGTCGACGTTCTTCACGAAATCTTGCATCGTAGGTAAATGGTCTCCGGATCCGAAAACAAACTCGGCTTGGAAGGCCCAATACAACAAGCTATGCTCTATGTGCGAACATCCAGAGAGATGCGACTATCCCGACGAATTCAGCGGCTACGTGGGCGCATTGAAGTGTCTCGCTCACAACAACGGACAAGTCGCCTTCACCAAAGTCATATTCACCAGGAAATTCTTCGGATTGCCCGTCGGTACCACTCCAGCGAGTCCTTCAAACGAGAACCCTGATGAATACAGGTATCTCTGCGTGGACGGTTCTAAAGTGCCGATAAGGGACAAGGCCTGCTCTTGGGCAGCTAGACCGTGGCAGGGACTGATCGGACATAACGACGTTCTGGCTAAACTTAGCCCGCTGAGGGAGAAAATAAAGCAGTTGGCTGATGCCGGTTCCTCAAACCAACCCGAGTGGTTCACCAAAGTTCTAGGGCTATCAGACAAAATCCACTACGTGGCCGACAATATTCCGATCAAAGCCATTGACTATTTGAACAAGGCCAACTACACCGAAGTCATTGAAAGAGGTCACGGTGCTCCCGAATTAGTCGTCAGATTGTGTGTCACATCAAACGTGGCTTTAGCCAAATGCAGAGCTATGTCCGTGTTCGCGTTCAGTAGAGACATCAGACCCATCCTGGATTGTGTTCAAGAGGCTTCAGAAACCGACTGCCTTAAAAGCGTTCAAGACAATGGCTCCGATTTGGCATCAGTCGACGACATGAGGGTAGCTGCAGCAGCAAAGAAATACGTCTTGCACCCGGTCTTCCACGAGGTATACGGAGAAAAGAAAACTCCTAACTACGCTGTGGCTGTCGTCAAAAAAGGAACATCCTTCAATAAGATGGAAGATTTAAGAGGAAAGAAATCTTGTCACAGTTCGTACGGCACTTTCAGTGGACTTGACGCTCCATTGTATTATCTCATAAACAAGAGGATCATAAAACCTGATCAATGCATTAAGAACTTTGGTGATTTCTTCTCCGGCGGTTCATGTTTGCCAGGCGTCGACAAACCAGAGAACAATCCCAGCGGTGATGATGTATCATCATTAAAGAAACAATGCGGAAGTGACAGCAGTCCTTGGAAATGTCTTCAGGAAGATCGTGGCGATGTCGCTTTTGTGTCGAGTGCTGATTTATCAAACTTTGATGCTTCACAATATGAGTTGCTCTGTGTGAACCGAGAGACGGGAGGCCGTGACACTCTGTCCAACTATCCTACTTGTAACATAGCGATGGCTCCATCCAGAACCTGGCTATCAGCCAAGGACTTTTTATCAGATGTCTCTATTGCCCACACTCCACTCAGCTTAGCACAGTTATTGGACACCAGAACTGACCTGTTCAACATTTACGGAGAATTCTTGAAGAACAACAATGTCATTTTCAATAATGCTGCCAAAGGATTAGCCACAGTTGAAAATCTTGACTTTGAGAAATTCAAGTCAATCCATGATGTTATTTCTTCATGTGGCATAGCTTAA
Protein
MALKYFILITLICACVNAAKTTYKICVPSQHLKACQDMVDIPTKSKVTLDCIPARDRMECLNYVQQRQADFVPVDPEDMYVAAKIPNQDFVVFQEYRTDEEPDAPFRYEAVIVIHKDLPINNLDQLKGLKSCHTGVNRNVGYKIPLTMLMKRAVFPKMNDHSISPKENELKALSTFFTKSCIVGKWSPDPKTNSAWKAQYNKLCSMCEHPERCDYPDEFSGYVGALKCLAHNNGQVAFTKVIFTRKFFGLPVGTTPASPSNENPDEYRYLCVDGSKVPIRDKACSWAARPWQGLIGHNDVLAKLSPLREKIKQLADAGSSNQPEWFTKVLGLSDKIHYVADNIPIKAIDYLNKANYTEVIERGHGAPELVVRLCVTSNVALAKCRAMSVFAFSRDIRPILDCVQEASETDCLKSVQDNGSDLASVDDMRVAAAAKKYVLHPVFHEVYGEKKTPNYAVAVVKKGTSFNKMEDLRGKKSCHSSYGTFSGLDAPLYYLINKRIIKPDQCIKNFGDFFSGGSCLPGVDKPENNPSGDDVSSLKKQCGSDSSPWKCLQEDRGDVAFVSSADLSNFDASQYELLCVNRETGGRDTLSNYPTCNIAMAPSRTWLSAKDFLSDVSIAHTPLSLAQLLDTRTDLFNIYGEFLKNNNVIFNNAAKGLATVENLDFEKFKSIHDVISSCGIA

Summary

Description
Transferrins are iron binding transport proteins which bind Fe(3+) ion in association with the binding of an anion, usually bicarbonate.
Similarity
Belongs to the transferrin family.
Keywords
Direct protein sequencing   Disulfide bond   Glycoprotein   Ion transport   Iron   Iron transport   Metal-binding   Repeat   Secreted   Signal   Transport  
Feature
chain  Transferrin
Uniprot
O97158   H9JPG9   P22297   A7IT76   A0A194RH67   A0A194PSJ1   + More
A0A212FLE3   A0JCK0   Q6F4J2   S4NYG0   A0A0B5H6A8   Q6UQ29   Q6Q2Z2   D5M9Y5   A0A2A4IY79   I4DNC0   A0A1W4WDU6   Q8MU80   Q02942   A0A067R8G2   A0A1V1FYW4   A0A2H4N2F8   A0A172WCD8   A0A2J7RCH3   H2F490   Q5FX34   Q0GB80   A0A395LHF4   A0A139WAX1   A0A1Y1MQU6   A0A1B6IXU6   A0A0L7KTB1   Q6USR2   A0A2Z6FI57   A0A0E4AVN5   A8D919   A0A0M9A935   A0A2K8JLE0   V9IAX8   Q86PH6   A0A088AFH7   A0A1B6CDF0   A0A1B6DSL2   A0A0J7KZU0   J7F1T1   A0A0L7QKR3   A0A2J7RCG2   F4W957   A0A195EDU2   A0A026WB04   A0A195B5L1   A0A158P0A5   A0A151WU63   A0A2A3ECB1   A0A151ID51   A0A146LNB5   E9I8L1   A0A0K8TJC0   A0A0A9WNT8   A0A224XL75   Q3MJL5   A0A195F369   O96418   E2B326   A0A170Y4Q2   M4WMH6   A0A3Q0IQ04   A0A1Q1NPJ1   A0A154PIR0   R4WJB4   B8LJ43   A0A310S6K8   R4G8W6   K7J4P3   A0A0C9RQZ4   A0A2Z5BV72   A0A0C9RMV8   A0A1B6J4K1   A0A146LKV4   A0A1L8DJA2   A0A1J1IUB7   Q16894   A0A3G5BIM0  
Pubmed
19467259    19121390    2254322    26354079    22118469    23622113    + More
25430818    15110871    22229520    22651552    12542630    7679500    24845553    28410430    16962940    18362917    19820115    28004739    26227816    18824242    11864369    15110862    21719571    24508170    30249741    21347285    26823975    21282665    25401762    16039806    10790182    20798317    23442387    28130397    23691247    20075255    29272461    7957753    9356450    30400621   
EMBL
AF119098    DQ375762    AAD18032.2    ABD35289.1    BABH01015561    BABH01015562    + More
M62802    DQ470073    ABF21123.1    KQ460205    KPJ17168.1    KQ459601    KPI94090.1    AGBW02007799    OWR54552.1    AB282638    BAF36818.1    AB158473    BAD27263.1    GAIX01013820    JAA78740.1    KJ641611    AJF35009.1    AY364430    AAQ63970.2    AY563106    AAT08022.1    HM026347    ADF35768.1    NWSH01005123    PCG64426.1    AK402830    BAM19410.1    AF535146    AAN03488.1    L05340    KK852636    KDR19744.1    FX985456    BAX07469.1    KY653081    ATU47275.1    KU213914    ANF07122.1    NEVH01005885    PNF38525.1    JQ257002    AEX92027.1    AY894342    DQ386641    AAW70172.1    DQ882181    ABI31834.1    QRBB01000009    RDS75647.1    KQ971380    KYB25049.1    GEZM01024024    JAV88052.1    GECU01015967    JAS91739.1    JTDY01006095    KOB66291.1    AY362358    AAQ62963.2    LC384923    BBE27867.1    LC009513    BAQ94504.1    EU144233    ABV68876.1    KQ435710    KOX79720.1    MF683360    ATU82501.1    JR036928    JR036929    JR036930    JR036931    JR036932    JR036933    AEY57479.1    AEY57480.1    AEY57481.1    AEY57482.1    AEY57483.1    AEY57484.1    AY217097    AY336528    AY336529    AAO39761.1    AAQ02339.1    AAQ02340.1    GEDC01025826    JAS11472.1    GEDC01008637    JAS28661.1    LBMM01001777    KMQ95759.1    HQ828073    JF330111    AET36535.1    AET85185.1    KQ414940    KOC59155.1    PNF38524.1    GL888002    EGI69239.1    KQ979039    KYN23276.1    KK107293    QOIP01000005    EZA53240.1    RLU22580.1    KQ976598    KYM79560.1    ADTU01000981    KQ982736    KYQ51459.1    KZ288287    PBC29375.1    KQ977989    KYM98331.1    GDHC01009954    JAQ08675.1    GL761587    EFZ23092.1    GBRD01000119    JAG65702.1    GBHO01033507    JAG10097.1    GFTR01007645    JAW08781.1    AY940115    AY940116    AAY21643.1    AAY21644.1    KQ981855    KYN34908.1    AF046126    AAD02419.1    GL445255    EFN89912.1    GEMB01003665    JAR99553.1    JX560434    AGI17578.1    KX459692    AQM58443.1    KQ434902    KZC11090.1    AK417595    BAN20810.1    ACPB03016283    EF634463    ABU96701.1    KQ780658    OAD51936.1    GAHY01000257    JAA77253.1    AAZX01010569    GBYB01009696    JAG79463.1    MF627744    AXA98484.1    GBYB01009695    JAG79462.1    GECU01013606    JAS94100.1    GDHC01009926    JAQ08703.1    GFDF01007644    JAV06440.1    CVRI01000059    CRL03704.1    AF019117    AAB87414.1    MK075223    AYV99626.1   
Proteomes
UP000005204    UP000053240    UP000053268    UP000007151    UP000218220    UP000192223    + More
UP000027135    UP000235965    UP000254101    UP000007266    UP000037510    UP000053105    UP000005203    UP000036403    UP000053825    UP000007755    UP000078492    UP000053097    UP000279307    UP000078540    UP000005205    UP000075809    UP000242457    UP000078542    UP000078541    UP000008237    UP000079169    UP000076502    UP000015103    UP000002358    UP000183832   
PRIDE
O97158    H9JPG9    P22297    Q86PH6   
Pfam
PF00405   Transferrin
Interpro
IPR001156   Transferrin-like_dom        + More
IPR016357   Transferrin       
IPR018195   Transferrin_Fe_BS       
ProteinModelPortal
O97158   H9JPG9   P22297   A7IT76   A0A194RH67   A0A194PSJ1   + More
A0A212FLE3   A0JCK0   Q6F4J2   S4NYG0   A0A0B5H6A8   Q6UQ29   Q6Q2Z2   D5M9Y5   A0A2A4IY79   I4DNC0   A0A1W4WDU6   Q8MU80   Q02942   A0A067R8G2   A0A1V1FYW4   A0A2H4N2F8   A0A172WCD8   A0A2J7RCH3   H2F490   Q5FX34   Q0GB80   A0A395LHF4   A0A139WAX1   A0A1Y1MQU6   A0A1B6IXU6   A0A0L7KTB1   Q6USR2   A0A2Z6FI57   A0A0E4AVN5   A8D919   A0A0M9A935   A0A2K8JLE0   V9IAX8   Q86PH6   A0A088AFH7   A0A1B6CDF0   A0A1B6DSL2   A0A0J7KZU0   J7F1T1   A0A0L7QKR3   A0A2J7RCG2   F4W957   A0A195EDU2   A0A026WB04   A0A195B5L1   A0A158P0A5   A0A151WU63   A0A2A3ECB1   A0A151ID51   A0A146LNB5   E9I8L1   A0A0K8TJC0   A0A0A9WNT8   A0A224XL75   Q3MJL5   A0A195F369   O96418   E2B326   A0A170Y4Q2   M4WMH6   A0A3Q0IQ04   A0A1Q1NPJ1   A0A154PIR0   R4WJB4   B8LJ43   A0A310S6K8   R4G8W6   K7J4P3   A0A0C9RQZ4   A0A2Z5BV72   A0A0C9RMV8   A0A1B6J4K1   A0A146LKV4   A0A1L8DJA2   A0A1J1IUB7   Q16894   A0A3G5BIM0  
PDB
6D05     E-value=7.32964e-40,     Score=414

Ontologies

KEGG
692564    no KO assigned | (RefSeq) Tf, BmTf; transferrin
GO
GO:0005615   GO:0006811   GO:0055072   GO:0046872   GO:0005576   GO:0016021   GO:0045281   GO:0009055   GO:0016020   GO:0016627   GO:0016787   GO:0004713   GO:0016491   GO:0015930  

Topology

Subcellular location
Secreted  
SignalP
Position:   1 - 18,         Likelihood:  0.997399
 
 
Length:
681
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
0.545289999999996
Exp number, first 60 AAs:
0.54221
Total prob of N-in:
0.02691
outside
1  -  681
 
 

Population Genetic Test Statistics

Pi
227.311911
Theta
193.269268
Tajima's D
0.263317
CLR
0.956434
CSRT
0.44312784360782
Interpretation
Uncertain
Peptides ×
Source Sequence Identity Evalue
31223520 SCHSSYGTFSGLDAPLYYLINKR 100.00 1e-15
29197581 IPNQDFVVFQEYR 100.00 1e-10
31223520 KFFGLPVGTTPASPSNENPDEYR 100.00 1e-10
31223520 DIRPILDCVQEASETDCLK 100.00 2e-10
31223520 SCHSSYGTFSGLDAPLYYLINK 100.00 3e-10
31223520 DTLSNYPTCNIAMAPSR 100.00 3e-10
26822097 YICVDGSK 95.65 6e-10
25860555 GSSDDRIIYGDSTADTFK 95.65 6e-10
26280517 KAISGGVQIEDIK 95.65 6e-10
25044914 KFFDANYGGAAYDAVAQR 95.65 6e-10
24402669 KFDTPFYR 95.65 6e-10
28467696 KFFDANYGGAAYDAVAQR 95.65 6e-10
29197581 IPNQDFVVFQEYRTDEEPDAPFR 95.65 6e-10
31223520 DFLSDVSIAHTPLSLAQLLDTR 100.00 9e-10
20822545 YFILITLICACVNAAKITYK 100.00 9e-10
31223520 ACSWAARPWQGLIGHNDVLAK 100.00 9e-10
26822097 TPNYAVAVVK 95.45 2e-09
26280517 FFGAYSK 95.45 2e-09
24402669 FFGCTDIPENK 95.45 2e-09
28467696 FFGCTDIPENK 95.45 2e-09
29197581 ETGGRDTISNYPTCNIAMAPSR 95.45 2e-09
26280517 ERVEVANQAEAVIHDTDTK 95.45 4e-09
24402669 ETEVVDSANNNIFDGVSIFVGDGCPAGYDR 95.45 4e-09
28467696 ETGDNTGPVVVR 95.45 4e-09
29197581 DTISNYPTCNIAMAPSR 95.45 4e-09
31223520 FFGLPVGTTPASPSNENPDEYR 100.00 2e-08
20822545 IKQLADAGSSSQPEWFTK 100.00 3e-07
31223520 DTLSNYPTCNIAMAPSR 100.00 3e-07
25860555 SFFIDKYEVSNQDFK 100.00 3e-07
26280517 TDDQVTIDCAEAIKK 100.00 3e-07
24402669 TDEEPDAPFR 100.00 3e-07
28467696 TDEEPDAPFR 100.00 3e-07
29197581 TDEEPDAPFR 100.00 3e-07
29197581 SVQDNGSDIASVDDMR 95.45 9e-07
31223520 TDEEPDAPFRYEAVIVIHK 100.00 1e-06
31223520 DTLSNYPTCNIAMAPSR 100.00 2e-05
31223520 QADFVPVDPEDMYVAAK 100.00 2e-05
31223520 SVQDNGSDLASVDDMR 100.00 2e-05
31223520 CDYPDEFSGYVGALK 100.00 3e-05
20822545 YVLHPVFHEVYGEK 100.00 3e-05
31223520 QLADAGSSNQPEWFTK 100.00 3e-05
31223520 KYVLHPVFHEVYGEK 100.00 5e-05
26822097 YVIHPVFHEVYGEK 100.00 5e-05
25860555 CPPSIVIIDIK 100.00 5e-05
26280517 PTASAVEATIIQYYAYNK 100.00 5e-05
25044914 QADDIISWIK 100.00 5e-05
24402669 QADDIISWIK 100.00 5e-05
28467696 QADDIISWIK 100.00 5e-05
29197581 PWQGIIGHNDVIAK 100.00 5e-05
20822545 SVQDNGSDLASVDDMR 100.00 1e-04
31223520 SVQDNGSDLASVDDMR 100.00 1e-04
31223520 IPNQDFVVFQEYR 100.00 1e-04
31223520 YVLHPVFHEVYGEK 100.00 2e-04
20822545 IPNQDFVVFQEYR 100.00 8e-04
31223520 IPNQDFVVFQEYR 100.00 8e-04
31223520 YVLHPVFHEVYGEK 100.00 8e-04
20822545 TDLFNIYGEFLK 100.00 0.002
31223520 DRMECLNYVQQR 100.00 0.002
31223520 GLATVENLDFEK 100.00 0.002
26822097 QADFVPVDPEDMYVAAK 100.00 0.002
25860555 YVIHPVFHEVYGEK 100.00 0.002
26280517 IIVPYICEAIR 100.00 0.002
25044914 IPNGQTRPIDIDTIGNMIESSAISPNR 100.00 0.002
24402669 IPNGQTRPIDIDTIGNMIESSAISPNR 100.00 0.002
27102218 IIAFPCNQFAGQEPGNPEEIVCFASER 100.00 0.002
28467696 IPNITEIYRTSYK 100.00 0.002
29197581 IIKPDQCIK 100.00 0.002
28556443 NNNVIFNNAAK 100.00 0.002
31223520 KGTSFNKMEDLR 100.00 0.004
31223520 TDLFNIYGEFLK 100.00 0.010
20822545 GTSFNKMEDLR 100.00 0.031
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