Silkworm Genome Informatics Database

Gene

KWMTBOMO13901

Pre Gene Modal

BGIBMGA011428

Annotation

PREDICTED:_fez1_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr23(-):12569355-12667742 View in EpiBrowser

Full name

Leucine zipper putative tumor suppressor 2 homolog

Alternative Name

Protein LAPSER1

Location in the cell

Nuclear Reliability : 3.84

CDS

ATGACTCTGTACGGAAGCTCATCAGACGTACGTGAAGGTCGTTGGTGCAGTTCGCCCCAGCCCGCCTCGCTGTCCGCTCTTCCACCCGCCACGCTCTCCACTCCGCTTCATCAAAGACACCACTCAGCTATAGTAACGAAGTCCACGTCAGTACTAAGCGGGGACAGCAAGGAGCCCGCGCCTGCGCCCTCGCCGGCTGACTCCGGAGTCTCCGAACTGGAGAGAGACCACCATGACTATAGTACAACGGACCGTCTCCGGCATGAAGCTCGTCTCCGGGCTCCCCGTGGCCTCATGCTACAGAGCTTCGGCAGCCGTCGAGACGAGAGGGACGCCGAACTCGCCAGGGTCAGGCGAGACAGAGCGCTCTTACGACAGAGACTTGAGGATACCGAATGGAGTCTATGCCAGCGGGCGGGGGAAATCGCTCTGTTAAAGACACAACTGAAGGATGCTCAGAACGAGCAGACAACAAAGGGCCACGAATATCTCACACTAAAAGCTGACTGCCGCCAGCTGAGGGAGACGCTCGACAAAAAAGACAAAGAAATCATGAGACTCCGAGCCGAATCGGACGAGAAACAGAAAAACGTGAACAGACTCCAATCCGAAGTGGACAGACTCACGGCCGACCTGAGAGACAACATCGCCGACCTGAACAAAACAAAGGAAACGAACAAGAACGAAATAGACAAACTGAAGACCGAACTCAAGGAGCTAAGACAAGAACTGTCTGATGTTTCTCTTAGCGGATACGAGGGTATCGAATGCGGGAGGACCATGAGGGGGATATATGACGTTTGCAAAACAAATGAATATCACTGGACGTCCAGTGACTCGGCACTAGAAGACGCCGAAGTCCAAAGGCTGAATGGAGAGATGCCGGACGCGTGCGGAGACCACTGCCCCGCGAACTCAATCCTCGACCGCCTCAAGCACGAGTTGCAAAACAAAGAGACGCAATTCAACAACGAAAGGAGGAAATGGTCCGAGGAGAAGGACAAGGTGCTAAGATACCAGAAGCAGTTACAGATGAACTACGTGCAGATGTTCAAGAGGTCGCGCACGCTCGAAGCCGAAGTCGACGGACTGAGACTGGAGCTCGAGTTGAGCAACAAGAACATGAAGAACATAAACAAACACGGGAAGGCAATAGAACTTTAA

Protein

MTLYGSSSDVREGRWCSSPQPASLSALPPATLSTPLHQRHHSAIVTKSTSVLSGDSKEPAPAPSPADSGVSELERDHHDYSTTDRLRHEARLRAPRGLMLQSFGSRRDERDAELARVRRDRALLRQRLEDTEWSLCQRAGEIALLKTQLKDAQNEQTTKGHEYLTLKADCRQLRETLDKKDKEIMRLRAESDEKQKNVNRLQSEVDRLTADLRDNIADLNKTKETNKNEIDKLKTELKELRQELSDVSLSGYEGIECGRTMRGIYDVCKTNEYHWTSSDSALEDAEVQRLNGEMPDACGDHCPANSILDRLKHELQNKETQFNNERRKWSEEKDKVLRYQKQLQMNYVQMFKRSRTLEAEVDGLRLELELSNKNMKNINKHGKAIEL

Description

Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.

Similarity

Belongs to the LZTS2 family.

Uniprot

B3GQX4 H9JPH3 A0A212FLC3 A0A2H1VEZ8 A0A194PL80 A0A2A4K1A3 + More
A0A194RI94 S4PCQ3 E0VSM1 A0A3B4U390 A0A3B4YTF2 A0A2U9CBK5 A0A3P8UXB1 A0A060WA15 A0A3Q3IMB5 G3NZ56 A0A3P9HM66

Pubmed

19121390 22118469 26354079 23622113 20566863 24487278 + More
24755649 17554307

EMBL

EU722642 ACD93739.1 BABH01015552 AGBW02007799 OWR54544.1 ODYU01002207 + More
SOQ39399.1 KQ459601 KPI94082.1 NWSH01000246 PCG78051.1 KQ460205 KPJ17159.1 GAIX01005312 JAA87248.1 DS235751 EEB16377.1 CP026257 AWP13967.1 FR904456 CDQ63967.1

Proteomes

UP000005204 UP000007151 UP000053268 UP000218220 UP000053240 UP000009046 + More
UP000261420 UP000261360 UP000246464 UP000265120 UP000193380 UP000261600 UP000007635 UP000265200

PRIDE

B3GQX4 H9JPH3

Interpro

IPR028597 LZTS2

ProteinModelPortal

B3GQX4 H9JPH3 A0A212FLC3 A0A2H1VEZ8 A0A194PL80 A0A2A4K1A3 + More
A0A194RI94 S4PCQ3 E0VSM1 A0A3B4U390 A0A3B4YTF2 A0A2U9CBK5 A0A3P8UXB1 A0A060WA15 A0A3Q3IMB5 G3NZ56 A0A3P9HM66

KEGG

100174824 no KO assigned | (RefSeq) fez1

GO

GO:0030513 GO:0051013 GO:0060026 GO:0051168 GO:0000281 GO:0005813 GO:0005874 GO:0090090 GO:0042074 GO:0051255 GO:0009953 GO:0016055 GO:0005737 GO:0030496 GO:0008013 GO:0030178

PANTHER

PTHR19354:SF4

Subcellular location

Cytoplasm
Cytoskeleton
Microtubule organizing center
Centrosome

Length:

387

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.00021

Exp number, first 60 AAs:

0.00021

Total prob of N-in:

0.00533

outside

1 - 387

Pi

237.538335

Theta

188.121218

Tajima's D

0.56827

CLR

0.43208

CSRT

0.534523273836308

Interpretation

Uncertain

Sequence

Summary

Ontologies

Topology

Population Genetic Test Statistics