Gene

KWMTBOMO13897  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011429

Annotation

cAMP-dependent_protein_kinase_C1_[Bombyx_mori]

Location

Bomo_Chr23(-):12537907-12539162      View in EpiBrowser

Full name

cAMP-dependent protein kinase catalytic subunit 1      

Alternative Name

Protein kinase DC0

Location in the cell

Cytoplasmic   Reliability : 3.687

CDS

ATGGGCAACAATGCTGCCACCGCTAATAAAAAGGTGGACGCCGCCGAAAGCGTCAAAGAATTCCTCGACCAGGCCAAAGAGGACTTCGAGGAGAAATGGAAGAAGAATCCTACCAACACCGCCGGACTGAACGATTTCGAACGGATAAAAACCCTAGGTACTGGCTCGTTTGGACGAGTCATGATAGTTCAACATAAACCTACTAAAGAATATTACGCTATGAAAATATTAGATAAACAGAAAGTGGTTAAATTGAAACAGGTGGAGCACACTCTAAACGAGAAACGTATCTTACAAGCCATCAACTTTCCGTTTTTGGTGAGCCTTAAATTCCATTTCAAGGACAACTCTAACTTGTACATGGTGTTGGAGTATGTGCCTGGAGGGGAAATGTTCTCGCATTTGCGCAAGGTGGGTCGGTTCTCGGAGCCGCATTCGCGATTCTACGCAGCTCAAATAGTCTTAGCATTTGAGTACCTTCACTATTTGGACCTTATTTATCGGGATCTGAAACCTGAAAACTTGCTAATTGATTCTCAGGGTTACTTAAAAGTTACAGATTTCGGATTCGCTAAACGTGTGAAAGGCCGCACGTGGACTTTGTGCGGCACTCCTGAGTATCTTGCACCTGAAATCATTCTATCCAAGGGATACAACAAAGCTGTGGATTGGTGGGCGTTAGGAGTGCTCGTGTATGAGATGGCGGCTGGCTACCCGCCCTTTTTCGCTGATCAACCCATTCAGATCTATGAAAAAATTGTGTCTGGCAAAGTACGATTTCCATCACATTTTGGTTCAGATCTGAAGGATCTGCTTCGTAACCTACTTCAAGTAGATTTGACCAAACGCTATGGTAACTTGAAGGCTGGTGTCAATGATATAAAAGGTCATAAATGGTTTGCCACCACCGACTGGATTGCCGTCTTCCAGAAGAAGATAGAGGCTCCATTCATACCTCGCTGCAAAGGACCCGGTGACACAAGCAATTTTGATGATTATGAAGAAGAAGCTCTTCGTATTTCTTCCACTGAAAAGTGTGCAAAGGAATTTGCAGAGTTCTGA

Protein

MGNNAATANKKVDAAESVKEFLDQAKEDFEEKWKKNPTNTAGLNDFERIKTLGTGSFGRVMIVQHKPTKEYYAMKILDKQKVVKLKQVEHTLNEKRILQAINFPFLVSLKFHFKDNSNLYMVLEYVPGGEMFSHLRKVGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYLKVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFGSDLKDLLRNLLQVDLTKRYGNLKAGVNDIKGHKWFATTDWIAVFQKKIEAPFIPRCKGPGDTSNFDDYEEEALRISSTEKCAKEFAEF

Description

Serine/threonine-protein kinase involved in memory formation (PubMed:29473541). Promotes long-term memory by phosphorylating meng and by regulating CrebB protein stability and activity (PubMed:29473541). As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology when anchored to the membrane (PubMed:29444420).

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Subunit

Composed of two regulatory chains and two catalytic chains.

Similarity

Belongs to the protein kinase superfamily.
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

Keywords

ATP-binding   cAMP   Complete proteome   Kinase   Lipoprotein   Myristate   Nucleotide-binding   Phosphoprotein   Reference proteome   Transferase  

Feature

chain  cAMP-dependent protein kinase catalytic subunit 1

Uniprot

A5JNM1   A0A0S2VHW6   A0A2A4K291   A0A194RME0   A0A212FLD3   A0A194PMX1   + More
A0A0L7L866   A0A1W4WWQ6   D6WC07   A0A1Y1MUE8   N6UW64   A0A1L8DM17   A0A0K8TSM1   A0A1L8DKK8   A0A1L8DLK2   T1DEF5   A0A1Q3FP44   Q1HQW4   A0A023EQD8   A0A0C9RJF4   B0XFG0   B4HW89   A0A1Y9IZU8   A0A3F2YVZ5   U5EXF6   A0A182LYM3   A0A182SXB9   A0A182VLF0   A0A182TV87   A0A182L915   Q7PXF7   A0A1A9XGX3   T1E804   A0A2M3ZG62   A0A2M4A7I4   W5JN41   A0A182JM51   A0A1A9UCN4   B4G7Y8   A0A1B0A4X0   A0A1B0C119   A0A1W4W8R0   B4M9H6   B4KH13   Q29NB1   B4NY66   B4MVA0   B4JCE3   B3N8G6   B4Q7V0   B3MUX5   A0A026WR62   P12370   A0A0G4AJS6   W8C0H4   A0A195EJF1   A0A2R7VYK8   F4X2B5   A0A195BCI3   A0A0J7KSG5   A0A195FN55   A0A158NJP0   A0A151X6H1   T1PGE9   A0A1I8NM79   E9IFT9   A0A2A3EBH8   E2BPC9   A0A2H8TN08   J9JK31   A0A2S2NEM0   A0A2S2PZY9   Q9NAS6   V9IMJ8   A0A087ZX62   A0A0A1X7C9   A0A0L7R929   A0A0C9RGE4   A0A0K8V0C2   A0A154P8G8   E0VMS0   A0A224XR64   A0A023F5V8   A0A0M9A1X7   A0A2J7PIG0   T1IA19   A0A0A9ZCM8   A0A067RHU0   A0A1B6LQI5   A0A1B6GP45   A0A1S3DFC7   A0A034VJA2   A0A182QBI4   E9GNI4   A0A1S3JH22   T1E265   A0A1S3JGA5   A0A0P6AK16   A0A076FKS1   A0A0P6DJB0  

EC Number

2.7.11.11

Pubmed

19121390    26354079    22118469    26227816    18362917    19820115    + More
28004739    23537049    26369729    24330624    17204158    17510324    24945155    26483478    17994087    20966253    12364791    14747013    17210077    20920257    23761445    15632085    17550304    22936249    18057021    24508170    30249741    2828348    3215511    10731132    12537572    12537569    29444420    29473541    26252388    24495485    21719571    21347285    25315136    21282665    20798317    11422513    25830018    20566863    25474469    25401762    26823975    24845553    25348373    21292972   

EMBL

BABH01015550    EF551340    ABQ41111.1    KT207930    ALP86605.1    NWSH01000246    + More
PCG78048.1    KQ460205    KPJ17156.1    AGBW02007798    OWR54554.1    KQ459601    KPI94079.1    JTDY01002374    KOB71550.1    KQ971309    EEZ99369.1    GEZM01025015    JAV87646.1    APGK01006540    APGK01007788    APGK01021688    KB740353    KB737454    KB736818    KB632345    ENN80824.1    ENN83018.1    ENN83127.1    ERL93117.1    GFDF01006704    JAV07380.1    GDAI01000658    JAI16945.1    GFDF01007169    JAV06915.1    GFDF01006746    JAV07338.1    GALA01001042    JAA93810.1    GFDL01005792    JAV29253.1    DQ440330    CH477432    ABF18363.1    EAT41043.1    EAT41044.1    EAT41045.1    JXUM01089160    GAPW01002290    KQ563750    JAC11308.1    KXJ73385.1    GBYB01008335    JAG78102.1    DS232922    EDS26798.1    CH480818    EDW52284.1    GANO01000978    JAB58893.1    AXCM01000734    AAAB01008987    EAA01109.4    GAMD01003173    JAA98417.1    GGFM01006732    MBW27483.1    GGFK01003432    MBW36753.1    ADMH02000631    GGFL01004203    ETN65541.1    MBW68381.1    AXCP01003648    CH479180    EDW28486.1    JXJN01023868    CH940654    EDW57852.2    CH933807    EDW12224.2    CH379060    EAL33431.3    CM000157    EDW88668.2    CH963857    EDW76445.2    CH916368    EDW03097.1    CH954177    EDV58389.2    CM000361    CM002910    EDX04382.1    KMY89299.1    CH902624    EDV33040.2    KPU74269.1    KK107144    QOIP01000003    EZA57589.1    RLU24862.1    M18655    X16969    AE014134    AY069425    KR133400    AKM70870.1    GAMC01004015    GAMC01004014    GAMC01004013    GAMC01004012    JAC02544.1    KQ978782    KYN28380.1    KK854174    PTY12587.1    GL888575    EGI59411.1    KQ976526    KYM81932.1    LBMM01003676    KMQ93256.1    KQ981424    KYN41831.1    ADTU01018100    KQ982482    KYQ55934.1    KA647769    AFP62398.1    GL762903    EFZ20550.1    KZ288292    PBC29085.1    GL449613    EFN82454.1    GFXV01003710    MBW15515.1    ABLF02039909    GGMR01002966    MBY15585.1    GGMS01001883    MBY71086.1    AJ271674    CAC00652.1    JR053189    AEY61871.1    GBXI01012766    GBXI01007088    JAD01526.1    JAD07204.1    KQ414628    KOC67375.1    GBYB01006111    JAG75878.1    GDHF01025164    GDHF01022334    GDHF01021782    GDHF01020628    GDHF01019942    GDHF01013839    GDHF01009740    GDHF01007804    GDHF01006993    GDHF01006140    GDHF01004604    JAI27150.1    JAI29980.1    JAI30532.1    JAI31686.1    JAI32372.1    JAI38475.1    JAI42574.1    JAI44510.1    JAI45321.1    JAI46174.1    JAI47710.1    KQ434844    KZC08162.1    AAZO01003698    DS235324    EEB14676.1    GFTR01005496    JAW10930.1    GBBI01002143    JAC16569.1    KQ435794    KOX74139.1    NEVH01025127    PNF16136.1    ACPB03017770    GBHO01004044    GBRD01009005    GDHC01004987    JAG39560.1    JAG56816.1    JAQ13642.1    KK852463    KDR23367.1    GEBQ01022333    GEBQ01014002    JAT17644.1    JAT25975.1    GECZ01005582    GECZ01000688    JAS64187.1    JAS69081.1    GAKP01016379    GAKP01016378    JAC42574.1    AXCN02000029    GL732555    EFX78769.1    GALA01001014    JAA93838.1    GDIP01028209    JAM75506.1    KF516617    AII16521.1    GDIQ01085762    JAN08975.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000053268    UP000037510    + More
UP000192223    UP000007266    UP000019118    UP000030742    UP000008820    UP000069940    UP000249989    UP000002320    UP000001292    UP000076407    UP000075884    UP000075883    UP000075901    UP000075903    UP000075902    UP000075882    UP000007062    UP000092443    UP000000673    UP000075880    UP000078200    UP000008744    UP000092445    UP000092460    UP000192221    UP000008792    UP000009192    UP000001819    UP000002282    UP000007798    UP000001070    UP000008711    UP000000304    UP000007801    UP000053097    UP000279307    UP000000803    UP000078492    UP000007755    UP000078540    UP000036403    UP000078541    UP000005205    UP000075809    UP000095301    UP000095300    UP000242457    UP000008237    UP000007819    UP000005203    UP000053825    UP000076502    UP000009046    UP000053105    UP000235965    UP000015103    UP000027135    UP000079169    UP000075886    UP000000305    UP000085678   

PRIDE

A5JNM1    P12370   

Pfam

PF00069   Pkinase

Interpro

IPR000961   AGC-kinase_C        + More
IPR000719   Prot_kinase_dom       
IPR039083   PKA_C-beta       
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       
IPR017441   Protein_kinase_ATP_BS       

SUPFAM

SSF56112   SSF56112       

ProteinModelPortal

A5JNM1   A0A0S2VHW6   A0A2A4K291   A0A194RME0   A0A212FLD3   A0A194PMX1   + More
A0A0L7L866   A0A1W4WWQ6   D6WC07   A0A1Y1MUE8   N6UW64   A0A1L8DM17   A0A0K8TSM1   A0A1L8DKK8   A0A1L8DLK2   T1DEF5   A0A1Q3FP44   Q1HQW4   A0A023EQD8   A0A0C9RJF4   B0XFG0   B4HW89   A0A1Y9IZU8   A0A3F2YVZ5   U5EXF6   A0A182LYM3   A0A182SXB9   A0A182VLF0   A0A182TV87   A0A182L915   Q7PXF7   A0A1A9XGX3   T1E804   A0A2M3ZG62   A0A2M4A7I4   W5JN41   A0A182JM51   A0A1A9UCN4   B4G7Y8   A0A1B0A4X0   A0A1B0C119   A0A1W4W8R0   B4M9H6   B4KH13   Q29NB1   B4NY66   B4MVA0   B4JCE3   B3N8G6   B4Q7V0   B3MUX5   A0A026WR62   P12370   A0A0G4AJS6   W8C0H4   A0A195EJF1   A0A2R7VYK8   F4X2B5   A0A195BCI3   A0A0J7KSG5   A0A195FN55   A0A158NJP0   A0A151X6H1   T1PGE9   A0A1I8NM79   E9IFT9   A0A2A3EBH8   E2BPC9   A0A2H8TN08   J9JK31   A0A2S2NEM0   A0A2S2PZY9   Q9NAS6   V9IMJ8   A0A087ZX62   A0A0A1X7C9   A0A0L7R929   A0A0C9RGE4   A0A0K8V0C2   A0A154P8G8   E0VMS0   A0A224XR64   A0A023F5V8   A0A0M9A1X7   A0A2J7PIG0   T1IA19   A0A0A9ZCM8   A0A067RHU0   A0A1B6LQI5   A0A1B6GP45   A0A1S3DFC7   A0A034VJA2   A0A182QBI4   E9GNI4   A0A1S3JH22   T1E265   A0A1S3JGA5   A0A0P6AK16   A0A076FKS1   A0A0P6DJB0  

PDB

3MVJ     E-value=6.67985e-168,     Score=1515

KEGG

100101210    K04345 protein kinase A [EC:2.7.11.11] | (RefSeq) cAMP-dependent protein kinase C1

PATHWAY

04140    Autophagy - animal - Bombyx mori (domestic silkworm)
04213    Longevity regulating pathway - multiple species - Bombyx mori (domestic silkworm)
04310    Wnt signaling pathway - Bombyx mori (domestic silkworm)
04341    Hedgehog signaling pathway - fly - Bombyx mori (domestic silkworm)

GO

GO:0004674   GO:0005524   GO:0007314   GO:0071361   GO:2000249   GO:0005829   GO:0040040   GO:0045880   GO:0008103   GO:0010628   GO:0045879   GO:0007317   GO:0030425   GO:0007448   GO:0007622   GO:0008355   GO:0008359   GO:0005886   GO:0048682   GO:0044297   GO:0046823   GO:0007615   GO:0050804   GO:0045187   GO:0007476   GO:0032436   GO:0042981   GO:0048477   GO:0006468   GO:0048749   GO:0019933   GO:0048149   GO:0004691   GO:0004672   GO:0005515   GO:0016787   GO:0004713   GO:0016491   GO:0015930  

PANTHER

PTHR24353:SF116  

Length:

353

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.87907

Exp number, first 60 AAs:

0.00043

Total prob of N-in:

0.09163

outside

1  -  353

 

 

Pi

190.714269

Theta

216.014928

Tajima's D

-0.412565

CLR

0.089181

CSRT

0.261586920653967

Interpretation

Uncertain