Gene

KWMTBOMO13835

Pre Gene Modal

BGIBMGA011563

Annotation

(11Z)-hexadec-11-enoyl-CoA_conjugase_[Bombyx_mori]

Location

Bomo_Chr23(+):10511886-10514189      View in EpiBrowser

Full name

(11Z)-hexadec-11-enoyl-CoA conjugase       + More
Acyl-CoA Delta(11) desaturase      

Alternative Name

Acyl-CoA Delta(11) desaturase
Acyl-CoA Z11/delta10,12 desaturase
Acyl-CoA Delta-11 desaturase
Acyl-CoA Z/E11 desaturase
SlsZ/E11

Location in the cell

PlasmaMembrane   Reliability : 3.466

CDS

ATGCCTCCTAATTCAGTGGATAAAACAAATGAAACAGAATACCTCAAGGATAATCATGTTGATTATGAAAAACTCATTGCACCCCAGGCCTCGCCCATCAAACACAAAATTGTAGTGATGAACGTGATACGTTTTAGCTATTTACATATTGCTGGTCTATATGGACTTTATCTCTGTTTCACCTCAGCAAAATTGGCTACATCGGTTTTTGCTATTGTGTTATTCTTCCTTGGGAACTTTGGTATTACAGCTGGAGCTCATCGTCTGTGGTCTCATAATGGTTACAAAGTCAAACTGCCCCTCGAGATCCTGTTGATGGTCTTCAACAGTATTGCTTTTCAGAACACCATTTTCACATGGGTGAGAGATCACAGGCTACATCACAAGTATACGGACACTGATGCAGACCCTCATAATGCTACGAGAGGTTTTTTTTTCTCACACATCGGCTGGTTGTTGGTGCGAAAACATCCAATGGTGAAAATTGCTGGAAAGAGCCTTGACATGTCAGATATTTATTGTAATCCTCTTTTAAGATTTCAGAAAAAGTACGCAATACCATTTATAGGAACAATATGTTTTATCATACCGACATTAGCTCCAATGTATTTTTGGGGTGAAAGCTTAAACAACGCTTGGCATATTACAGTTTTAAGATACATTTTCAGTCTCAATGGCACTTTTCTTGTAAATAGCGCTGCTCATTTGTGGGGATACAAACCGTACGATAAGAGCCTGAAAGCTACTCAAAGTGGCATGGCAAATGCATTTACTTTTGGTGAAGGATTTCACAATTACCATCACGTTTTTCCGTGGGATTATCGGGCAGACGAATTGGGGGACAGGTACATAAATTTGACAACAAGGTTCATAGATTTCTTTGCATGGATGGGATGGGCTTATGATCTGAAAACTGCTTCCACCAATATTATTGAGAAGAGGGCACTAAGAACAGGGGATGGGACTTACAAACGACCAAATGGAATGAATTGA

Protein

MPPNSVDKTNETEYLKDNHVDYEKLIAPQASPIKHKIVVMNVIRFSYLHIAGLYGLYLCFTSAKLATSVFAIVLFFLGNFGITAGAHRLWSHNGYKVKLPLEILLMVFNSIAFQNTIFTWVRDHRLHHKYTDTDADPHNATRGFFFSHIGWLLVRKHPMVKIAGKSLDMSDIYCNPLLRFQKKYAIPFIGTICFIIPTLAPMYFWGESLNNAWHITVLRYIFSLNGTFLVNSAAHLWGYKPYDKSLKATQSGMANAFTFGEGFHNYHHVFPWDYRADELGDRYINLTTRFIDFFAWMGWAYDLKTASTNIIEKRALRTGDGTYKRPNGMN

Description

Fatty acid desaturase that catalyzes 2 consecutive steps in the biosynthesis of bombykol, a sex pheromone produced by the moth. First acts as an acyl-CoA Delta(11) desaturase (1) by catalyzing the formation of Delta(11) fatty acyl precursors. Then acts as a (11Z)-hexadec-11-enoyl-CoA conjugase (2) by converting a single cis double bond at position 11 of (11Z)-hexadec-11-enoyl-CoA into conjugated 10 trans and 12 cis double bonds.
Catalyzes the formation of Delta(11) fatty acyl precursors in the pheromone gland, with a preference for myristic acid.
Catalyzes the formation of delta(11) fatty acyl precursors in the pheromone gland, and has high activity towards palmitic acid and stearic acid.
Catalyzes the formation of Delta(11) fatty acyl precursors in the pheromone gland.

Catalytic Activity

2 [Fe(II)-cytochrome b5] + an 11,12-saturated fatty acyl-CoA + 2 H(+) + O2 = 2 [Fe(III)-cytochrome b5] + an (11Z)-Delta(11)-fatty acyl-CoA + 2 H2O
(11Z)-hexadecenoyl-CoA + AH2 + O2 = (10E,12Z)-hexadecadienoyl-CoA + A + 2 H2O

Cofactor

Fe(2+)
Fe cation

Similarity

Belongs to the fatty acid desaturase type 1 family.

Keywords

Complete proteome   Fatty acid biosynthesis   Fatty acid metabolism   Iron   Lipid biosynthesis   Lipid metabolism   Membrane   Metal-binding   Oxidoreductase   Reference proteome   Transmembrane   Transmembrane helix   Endoplasmic reticulum  

Feature

chain  (11Z)-hexadec-11-enoyl-CoA conjugase

Uniprot

Q75PL7   Q9GU82   A0A1P1EST4   G8FQ78   Q4A181   D2SNV3   + More
T1RU40   A0A2A4JG15   G8FQ79   A0A1V0M868   Q75PL5   A0A0U2F3F2   Q9NB26   A0A0U2F3E1   Q8MZZ2   G8FQ76   Q6A4M5   Q2YHQ4   A0A291P0P5   Q95VE7   Q8ISS3   A0A068FKA4   G8FQ77   A0A076FRH6   A9YRX6   Q6US81   O44390   M4PTD0   A0A0K2GV16   A0A1L8D6M1   Q95UJ3   B7SB74   T1RTE1   U5KFQ4   H9JF74   A0A0N1PJV1   A8QVZ1   E3TMU8   S4WAY4   A0A212FJD3   E3UYX7   A0A075BRA0   E3UYX8   B6CBS5   A0A0K0N452   A0A0L7L2G4   W5QM97   Q8WPC0   Q7KEQ2   A0A0F7R1B4   A0A1L8D6B5   A0A0F7R6V4   Q2V0N6   A0A1L8D6L2   A0A0F7R1B9   B8Q500   Q95UU3   G8FQ82   G8FQ83   A0A0F7R6V7   D8L7A6   A0A0F7R2Q5   A4KWE7   D8UUU1   D8L626   C0STP4   A4KWE9   A0A1L8D6C0   A0A194Q9S9   A0A0E3VMW5   A0A023EPC8   G8FQ80   A0A182MQV9   D8UUT8   Q17G31   A0A182VZL7   A0A182Y3S6   B0X4F1   A0A2M4AGB5   A0A182FAQ2   A0A2M4BT31   A0A2M3YY30   A0A182K5W6   G8FQ74   A0A182PSJ2   W5J215   A0A182QY62   D6X4Z9   T1DNF2   A0A2M3YY13   A0A182RZM3   A0A1Q3FJ73   G8FQ73   A0A182IX38   A0A182UTT3   A0A182WSS9   A0A182LA27   F5HMH9   A0A182HLN2   A0A182NRU1  

EC Number

1.14.19.15
1.14.19.5

Pubmed

10767556    15173596    19121390    22291612    17517337    20074338    + More
24500170    28349297    28986331    11483431    12524345    12770579    15527989    26417103    15455060    26385554    24817326    18405835    25796477    15544945    9860961    11805319    20403437    24053512    26354079    17921252    20691782    24569486    22118469    21331247    18831750    26227816    24862548    12237399    16360168    19257880    12213232    17360547    21444802    24945155    17510324    25244985    20920257    23761445    18362917    20709164    19820115    20966253    12364791    14747013    17210077   

EMBL

AF157627    AB166851    BABH01015400    AAF80355.1    BAD18122.1    AF182405    + More
AAG16901.1    JN022488    AER29853.1    AM076339    CAJ27976.2    EZ407237    ACX53794.1    JX531654    AGO45839.1    NWSH01001511    PCG71017.1    JN022489    AER29854.1    KU755471    ARD71181.1    BABH01040457    AB166853    BAD18124.1    KP008124    MF687587    AKU76411.1    ATJ44513.1    AF272342    AAF81787.1    KP008117    AKU76404.1    AF482908    AAM28483.2    JN022486    AER29851.1    AF518014    AAQ12891.1    AM158251    CAJ43430.2    MF687528    ATJ44454.1    AF416738    AAL16642.1    AF545481    FJ999625    KJ622051    AID66659.1    JN022487    AER29852.1    KF960741    AII21943.1    EU285580    KM283200    ABX90049.1    AIU96339.1    AY362879    AF035375    AF297114    AF297113    KC422668    AGH12217.1    KP890026    ALA65425.1    GEYN01000135    JAV01994.1    AY049741    AAL11496.1    EU152400    FJ466458    ABX71809.1    ACS69071.1    JX531667    AGO45852.1    JX989153    AGR49312.1    BABH01026838    BABH01026839    BABH01026840    KQ460301    KPJ16138.1    EF150363    ABO43722.1    GU952763    ADO85596.1    JX964774    AGO96562.1    AGBW02008279    OWR53845.1    HM636633    ADP21587.1    JX679209    AGP26038.1    HM636634    ADP21588.1    EU152335    ABX71630.1    KM378664    AKJ32408.1    JTDY01003403    KOB69615.1    JQ978772    AGD98720.1    AF441861    AAL32060.1    AF441221    AAL35331.1    LC020021    BAR72981.1    GEYN01000136    JAV01993.1    LC020022    BAR72984.1    AB232855    BAE66602.1    GEYN01000122    JAV02007.1    LC020023    BAR72986.1    EU350083    EU350084    GQ166860    ACA81687.1    ACA81688.1    ADE97413.1    AY017379    AAG54077.1    JN022491    JN022492    AER29861.1    JN022493    AER29862.1    LC020024    BAR72989.1    FJ999626    ADC53486.1    BAR72990.1    EF113393    EF113394    ABO45226.1    ABO45227.1    GQ225753    ADE58526.1    FJ906800    ADB25212.1    AB465511    BAH56286.1    BAR72983.1    EF113395    EF113396    ABO45228.1    ABO45229.1    GEYN01000123    JAV02006.1    KQ459249    KPJ02273.1    AB910048    BAR45527.1    GAPW01002266    JAC11332.1    JN022490    AER29859.1    AXCM01000026    GQ225750    ADE58523.1    CH477266    EAT45554.1    EAT45555.1    DS232338    EDS40304.1    GGFK01006347    MBW39668.1    GGFJ01006787    MBW55928.1    GGFM01000428    MBW21179.1    JN022484    AER29858.1    ADMH02002143    ETN58292.1    AXCN02001148    HM234671    KQ971381    ADK13054.1    EEZ97602.1    GAMD01002940    JAA98650.1    GGFM01000421    MBW21172.1    GFDL01007467    JAV27578.1    JN022483    AER29857.1    AAAB01008987    EAA43119.4    EGK97500.1    EGK97501.1    EGK97502.1    APCN01000909   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000037510    UP000053268    + More
UP000075883    UP000008820    UP000075920    UP000076408    UP000002320    UP000069272    UP000075881    UP000075885    UP000000673    UP000075886    UP000007266    UP000075900    UP000075880    UP000075903    UP000076407    UP000075882    UP000007062    UP000075840    UP000075884   

PRIDE

Q75PL7    Q9GU82    Q75PL5    T1RTE1    H9JF74   

Pfam

PF00487   FA_desaturase

Interpro

IPR001522   FADS-1_CS        + More
IPR005804   FA_desaturase_dom       
IPR015876   Acyl-CoA_DS       

CDD

cd03505  Delta9-FADS-like

ProteinModelPortal

Q75PL7   Q9GU82   A0A1P1EST4   G8FQ78   Q4A181   D2SNV3   + More
T1RU40   A0A2A4JG15   G8FQ79   A0A1V0M868   Q75PL5   A0A0U2F3F2   Q9NB26   A0A0U2F3E1   Q8MZZ2   G8FQ76   Q6A4M5   Q2YHQ4   A0A291P0P5   Q95VE7   Q8ISS3   A0A068FKA4   G8FQ77   A0A076FRH6   A9YRX6   Q6US81   O44390   M4PTD0   A0A0K2GV16   A0A1L8D6M1   Q95UJ3   B7SB74   T1RTE1   U5KFQ4   H9JF74   A0A0N1PJV1   A8QVZ1   E3TMU8   S4WAY4   A0A212FJD3   E3UYX7   A0A075BRA0   E3UYX8   B6CBS5   A0A0K0N452   A0A0L7L2G4   W5QM97   Q8WPC0   Q7KEQ2   A0A0F7R1B4   A0A1L8D6B5   A0A0F7R6V4   Q2V0N6   A0A1L8D6L2   A0A0F7R1B9   B8Q500   Q95UU3   G8FQ82   G8FQ83   A0A0F7R6V7   D8L7A6   A0A0F7R2Q5   A4KWE7   D8UUU1   D8L626   C0STP4   A4KWE9   A0A1L8D6C0   A0A194Q9S9   A0A0E3VMW5   A0A023EPC8   G8FQ80   A0A182MQV9   D8UUT8   Q17G31   A0A182VZL7   A0A182Y3S6   B0X4F1   A0A2M4AGB5   A0A182FAQ2   A0A2M4BT31   A0A2M3YY30   A0A182K5W6   G8FQ74   A0A182PSJ2   W5J215   A0A182QY62   D6X4Z9   T1DNF2   A0A2M3YY13   A0A182RZM3   A0A1Q3FJ73   G8FQ73   A0A182IX38   A0A182UTT3   A0A182WSS9   A0A182LA27   F5HMH9   A0A182HLN2   A0A182NRU1  

PDB

4YMK     E-value=5.11683e-84,     Score=792

KEGG

692567    K21709 (11Z)-hexadec-11-enoyl-CoA conjugase [EC:1.14.19.15] | (RefSeq) Desat1, ACD, Bmpgdesat1, Desa

GO

GO:0016021   GO:0042811   GO:0046872   GO:0016717   GO:0006633   GO:0017105   GO:0006631   GO:0055114   GO:0004768   GO:0005789   GO:0005506   GO:0006636   GO:0006629   GO:0006468   GO:0016075   GO:0003677   GO:0005524   GO:0016787   GO:0004713   GO:0016491   GO:0015930  

PANTHER

PTHR11351  

Subcellular location

Membrane  
Endoplasmic reticulum membrane  

Length:

330

Number of predicted TMHs:

5

Exp number of AAs in TMHs:

107.90838

Exp number, first 60 AAs:

20.32011

Total prob of N-in:

0.06941

POSSIBLE N-term signal

sequence

outside

1  -  37

TMhelix

38  -  60

inside

61  -  66

TMhelix

67  -  89

outside

90  -  98

TMhelix

99  -  121

inside

122  -  183

TMhelix

184  -  206

outside

207  -  215

TMhelix

216  -  238

inside

239  -  330

 

 

Pi

189.59799

Theta

149.70327

Tajima's D

1.381563

CLR

0

CSRT

0.755512224388781

Interpretation

Uncertain