Gene

KWMTBOMO13833

Pre Gene Modal

BGIBMGA011562

Annotation

cyclin_dependent_kinase_8_[Bombyx_mori]

Location

Bomo_Chr23(+):10495716-10500695      View in EpiBrowser

Full name

Cyclin-dependent kinase 8      

Alternative Name

Cell division protein kinase 8
Mediator complex subunit Cdk8
Mediator of RNA polymerase II transcription subunit Cdk8

Location in the cell

Nuclear   Reliability : 3.824

CDS

ATGGGAGACAACTTTCAAAATAAGACCATGGCGGCTGTGATGATGGACTACGATTTCAAAATCAAGACTCAAAATGAACGTTCCAAAGTGGAAGACTTGTTCGACTATGAGGGCTGTAAAGTAGGTAGAGGTACATATGGCCATGTATATAAAGCCAGAAGGAAGGATGGCTCCGATACCAAAGATTATGCTTTGAAACAAATTGAAGGAACTGGACTTTCTATGTCAGCATGTAGGGAAATTGCTCTATTAAGAGAGTTGAAACATCCTAATGTCATAAATCTTATTAGAGTGTTTCTTTCACATACTGACCGAAAAGTCTGGCTGCTATTTGACTATGCAGAACATGATTTGTGGCATATAATCAAATTTCATAGAGCAGCTAAAGCTAATAAAAAATCAGTTATGGTGCCAAAAGGAATGGTGAAGAGCCTCCTCTATCAGATATTGGATGGGATACATTATTTACATTCAAACTGGGTTTTGCATCGAGATCTGAAACCAGCCAACATATTAGTAATGGGTGAAGGACCGGAGCGTGGCCGAGTTAAAATAGCTGACATGGGATTTGCAAGATTATTCAATGCACCTTTGAAACCACTTGCTGACTTAGATCCAGTAGTAGTCACATTTTGGTACAGAGCTCCTGAACTGTTGCTTGGTGCCAGACATTACACTAAGGCCATAGATATTTGGGCCATAGGATGTATATTCGCAGAACTATTAACATCTGAACCTATTTTCCATTGTCGCCAAGAAGACATTAAAACAAGCAATCCATATCATCATGATCAACTAGATAGAATATTTAATGTTATGGGATTTCCACTTGAAAAAGATTGGGAAGATATAAGGAAAATGCCAGAACATGCAACACTAGTTAAGGATTTCAAGAGATCAAACTACCAGAACTGCTCACTCAGCAAATATATGGACAGGCATAAGATTAAGCCAGATAGTAAAGCTTTTAGTTTATTACAAAGACTTTTACTGATGGATCCTAACAAAAGAATCACTTCAGAACAGGCTATGCAGGATCCATACTTTGCTGAAGACCCACTGCCTACTCAAGATGTGTTCGCCGGATGTACAATTCCATATCCGAAAAGAGAATTTTTGACTGATGACGATCAGGAAGACAAGAGTGATTCAAAAGCCAGACAAAATCAACAGCAACAACAACCAAATACCCAACAGAATCAAGTTCAACAGAACAGCCACGATCATGGTGCCAATAATGCCAAAAGGATGAGAATGACGGGTCCGAACCAAGGCAACAACACTGGTGGTGGCCAGCAGGAATTCCATCAACAGCAACAAATGATGTTCGGTAGTCAGCAGCAGGGAGGAAGCTCCCAACAACAAGGGAACTACCAACAAAGATTCTAA

Protein

MGDNFQNKTMAAVMMDYDFKIKTQNERSKVEDLFDYEGCKVGRGTYGHVYKARRKDGSDTKDYALKQIEGTGLSMSACREIALLRELKHPNVINLIRVFLSHTDRKVWLLFDYAEHDLWHIIKFHRAAKANKKSVMVPKGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPLEKDWEDIRKMPEHATLVKDFKRSNYQNCSLSKYMDRHKIKPDSKAFSLLQRLLLMDPNKRITSEQAMQDPYFAEDPLPTQDVFAGCTIPYPKREFLTDDDQEDKSDSKARQNQQQQQPNTQQNQVQQNSHDHGANNAKRMRMTGPNQGNNTGGGQQEFHQQQQMMFGSQQQGGSSQQQGNYQQRF

Description

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex (By similarity).
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May phosphorylate the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Required for leg and eye development and macrochaete specification or differentiation.

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]
[DNA-directed RNA polymerase] + ATP = ADP + H(+) + phospho-[DNA-directed RNA polymerase]

Cofactor

Mg(2+)

Subunit

Component of the Cdk8 module of the Mediator complex.
Component of the Cdk8 module of the Mediator complex, composed of CycC, Cdk8, kto and skd.

Similarity

Belongs to the protein kinase superfamily.
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Keywords

Activator   ATP-binding   Complete proteome   Kinase   Nucleotide-binding   Nucleus   Reference proteome   Repressor   Transcription   Transcription regulation   Transferase   Phosphoprotein  

Feature

chain  Cyclin-dependent kinase 8

Uniprot

D2IGZ6   A0A2W1BQQ7   A0A194PSS1   A0A194QP59   A0A212EH84   A0A212F319   + More
A0A2P8Z9K3   E0VLZ7   U4U5F9   A0A067R2B7   A0A2J7PV37   A0A1Y1K476   D6WCG4   A0A1B6M7E7   A0A1B6HXA2   T1HU26   A0A1W4X8G4   A0A2J7PV28   A0A0V0G9R0   A0A224XCC5   A0A182RRB5   A0A182W8X4   A0A1S4F1K7   A0A182Y6F0   A0A182PG46   A0A182NVH9   A0A182NAV5   A0A182R0I7   A0A182JXI9   A0A182XHT0   A0A182VL33   A0A1S4H3D9   A0A182HRE6   A0A182H4N2   A0A1B0CUW3   A0A182J7P6   A0A182H3V9   Q7PMH2   W5J441   A0A2M4CR67   A0A1Q3F7D7   A0A1Y9G9G8   A0A2M3ZFE3   A0A2M3Z3M7   A0A2M4AP10   A0A2M4BQE8   Q17IE8   B0W1D0   A0A232EHL3   A0A026WSE6   F4WFV1   A0A195F0R0   A0A158NL63   A0A154P3K7   E2AC03   A0A195C033   A0A1S4J336   A0A0J7L8Y4   A0A0L0CR59   U5EXF2   A0A0A9XNX9   A0A0N0BJ95   A0A2H8TVS8   A0A0K8SQ72   A0A151JT21   A0A195BFW8   A0A151WHG6   A0A1A9ZD44   A0A1B6D3B6   A0A1J1I141   A0A087U4S4   A0A1I8NT81   A0A1L8DXF4   J9K9C4   A0A2A3EAG1   A0A1I8N7T7   A0A2L2Y0S6   E9JB03   B3M7E9   B4KWL2   A0A1W4W1L5   B4IYW1   B4LEB7   B5DRF0   B4H405   W8BZY3   A0A3B0J5M9   K7J969   B4N6I4   C9QP81   A0A0K8W192   B4PDX1   B4HLQ4   B3NGM7   A0A0A1XHC1   B4QNQ1   A0A034VN31   Q9VT57   A0A2P2I6J7   W5U8M7  

Pubmed

19121390    28756777    26354079    22118469    29403074    20566863    + More
23537049    24845553    28004739    18362917    19820115    17510324    25244985    12364791    26483478    20920257    23761445    28648823    24508170    21719571    21347285    20798317    26108605    25401762    26823975    25315136    26561354    21282665    17994087    18057021    15632085    24495485    20075255    17550304    25830018    22936249    25348373    8730095    10731132    12537572    12537569    17290221    23127152   

EMBL

BABH01015400    GQ250578    ACT83403.2    KZ149950    PZC76651.1    KQ459600    + More
KPI94175.1    KQ461195    KPJ06760.1    AGBW02014956    OWR40831.1    AGBW02010636    OWR48135.1    PYGN01000136    PSN53174.1    DS235283    EEB14403.1    KB632050    ERL88302.1    KK852759    KDR17042.1    NEVH01020989    PNF20193.1    GEZM01095868    GEZM01095867    JAV55291.1    KQ971311    EEZ99022.2    GEBQ01008115    JAT31862.1    GECU01028397    JAS79309.1    ACPB03003109    PNF20192.1    GECL01001366    JAP04758.1    GFTR01006389    JAW10037.1    AXCN02000654    AAAB01008980    APCN01001697    JXUM01109897    KQ565364    KXJ71051.1    AJWK01029714    AJWK01029715    JXUM01108245    KQ565213    KXJ71214.1    EAA13852.4    ADMH02002127    ETN58616.1    GGFL01003652    MBW67830.1    GFDL01011565    JAV23480.1    GGFM01006472    MBW27223.1    GGFM01002378    MBW23129.1    GGFK01009194    MBW42515.1    GGFJ01006101    MBW55242.1    CH477240    DS231821    EDS45000.1    NNAY01004484    OXU17833.1    KK107111    EZA58898.1    GL888128    EGI66718.1    KQ981866    KYN34063.1    ADTU01019267    KQ434809    KZC06413.1    GL438389    EFN69021.1    KQ978501    KYM93531.1    LBMM01000249    KMR03007.1    JRES01000130    KNC33914.1    GANO01000983    JAB58888.1    GBHO01021975    GDHC01009241    JAG21629.1    JAQ09388.1    KQ435719    KOX78788.1    GFXV01006608    MBW18413.1    GBRD01010386    JAG55438.1    KQ978530    KYN30301.1    KQ976488    KYM83505.1    KQ983120    KYQ47257.1    GEDC01017165    JAS20133.1    CVRI01000037    CRK93474.1    KK118157    KFM72363.1    GFDF01003149    JAV10935.1    ABLF02015015    KZ288322    PBC28199.1    IAAA01007844    IAAA01007845    LAA01764.1    GL770707    EFZ09998.1    CH902618    EDV39847.1    CH933809    EDW19641.1    CH916366    CH924587    EDV97669.1    EDW05212.1    CH940647    EDW70093.1    CH379070    EDY74085.1    CH479208    EDW31120.1    GAMC01011686    JAB94869.1    OUUW01000002    SPP77127.1    AAZX01002214    AAZX01012760    CH964161    EDW79973.1    BT099963    ACX47664.1    GDHF01007460    JAI44854.1    CM000159    EDW93967.1    CH480815    EDW40936.1    CH954178    EDV51263.1    GBXI01003513    JAD10779.1    CM000363    CM002912    EDX09918.1    KMY98779.1    GAKP01015068    GAKP01015067    JAC43884.1    U33015    AE014296    AY119111    AAF50197.2    IACF01004029    LAB69628.1    JT408249    AHH38283.1   

Proteomes

UP000005204    UP000053268    UP000053240    UP000007151    UP000245037    UP000009046    + More
UP000030742    UP000027135    UP000235965    UP000007266    UP000015103    UP000192223    UP000075900    UP000075920    UP000076408    UP000075885    UP000075884    UP000075886    UP000075881    UP000076407    UP000075903    UP000075840    UP000069940    UP000249989    UP000092461    UP000075880    UP000007062    UP000000673    UP000069272    UP000008820    UP000002320    UP000215335    UP000053097    UP000007755    UP000078541    UP000005205    UP000076502    UP000000311    UP000078542    UP000036403    UP000037069    UP000053105    UP000078492    UP000078540    UP000075809    UP000092445    UP000183832    UP000054359    UP000095300    UP000007819    UP000242457    UP000095301    UP000007801    UP000009192    UP000192221    UP000001070    UP000008792    UP000001819    UP000008744    UP000268350    UP000002358    UP000007798    UP000002282    UP000001292    UP000008711    UP000000304    UP000000803    UP000221080   

PRIDE

D2IGZ6    Q17IE8    Q9VT57   

Pfam

PF00069   Pkinase        + More
PF06644   ATP11
PF03404   Mo-co_dimer
PF00174   Oxidored_molyb
PF00173   Cyt-b5
PF03109   ABC1

Interpro

IPR017441   Protein_kinase_ATP_BS        + More
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       
IPR000719   Prot_kinase_dom       
IPR010591   ATP11       
IPR001199   Cyt_B5-like_heme/steroid-bd       
IPR014756   Ig_E-set       
IPR008335   Mopterin_OxRdtase_euk       
IPR036400   Cyt_B5-like_heme/steroid_sf       
IPR000572   OxRdtase_Mopterin-bd_dom       
IPR036374   OxRdtase_Mopterin-bd_sf       
IPR005066   MoCF_OxRdtse_dimer       
IPR004147   UbiB_dom       

SUPFAM

SSF56112   SSF56112        + More
SSF56524   SSF56524       
SSF81296   SSF81296       
SSF55856   SSF55856       

Gene 3D

3.10.120.10     3.90.420.10    

ProteinModelPortal

D2IGZ6   A0A2W1BQQ7   A0A194PSS1   A0A194QP59   A0A212EH84   A0A212F319   + More
A0A2P8Z9K3   E0VLZ7   U4U5F9   A0A067R2B7   A0A2J7PV37   A0A1Y1K476   D6WCG4   A0A1B6M7E7   A0A1B6HXA2   T1HU26   A0A1W4X8G4   A0A2J7PV28   A0A0V0G9R0   A0A224XCC5   A0A182RRB5   A0A182W8X4   A0A1S4F1K7   A0A182Y6F0   A0A182PG46   A0A182NVH9   A0A182NAV5   A0A182R0I7   A0A182JXI9   A0A182XHT0   A0A182VL33   A0A1S4H3D9   A0A182HRE6   A0A182H4N2   A0A1B0CUW3   A0A182J7P6   A0A182H3V9   Q7PMH2   W5J441   A0A2M4CR67   A0A1Q3F7D7   A0A1Y9G9G8   A0A2M3ZFE3   A0A2M3Z3M7   A0A2M4AP10   A0A2M4BQE8   Q17IE8   B0W1D0   A0A232EHL3   A0A026WSE6   F4WFV1   A0A195F0R0   A0A158NL63   A0A154P3K7   E2AC03   A0A195C033   A0A1S4J336   A0A0J7L8Y4   A0A0L0CR59   U5EXF2   A0A0A9XNX9   A0A0N0BJ95   A0A2H8TVS8   A0A0K8SQ72   A0A151JT21   A0A195BFW8   A0A151WHG6   A0A1A9ZD44   A0A1B6D3B6   A0A1J1I141   A0A087U4S4   A0A1I8NT81   A0A1L8DXF4   J9K9C4   A0A2A3EAG1   A0A1I8N7T7   A0A2L2Y0S6   E9JB03   B3M7E9   B4KWL2   A0A1W4W1L5   B4IYW1   B4LEB7   B5DRF0   B4H405   W8BZY3   A0A3B0J5M9   K7J969   B4N6I4   C9QP81   A0A0K8W192   B4PDX1   B4HLQ4   B3NGM7   A0A0A1XHC1   B4QNQ1   A0A034VN31   Q9VT57   A0A2P2I6J7   W5U8M7  

KEGG

100316862    K02208 cyclin-dependent kinase 8/11 [EC:2.7.11.22 2.7.11.23] | (RefSeq) cdk8; cyclin dependent kinas

GO

GO:0004674   GO:0005524   GO:0008353   GO:0065003   GO:0004672   GO:0005739   GO:0051301   GO:0004693   GO:0016592   GO:0005634   GO:0006468   GO:0042128   GO:0030151   GO:0016491   GO:0000082   GO:0016021   GO:0010508   GO:0036011   GO:0045498   GO:0007411   GO:0022416   GO:0034472   GO:0016301   GO:0016075   GO:0003677   GO:0016787   GO:0004713   GO:0015930  

Subcellular location

Nucleus  

Length:

462

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03948

Exp number, first 60 AAs:

0

Total prob of N-in:

0.01230

outside

1  -  462

 

 

Pi

229.019458

Theta

193.533291

Tajima's D

0.855707

CLR

0

CSRT

0.615369231538423

Interpretation

Uncertain