Gene

KWMTBOMO13805

Pre Gene Modal

BGIBMGA011545

Annotation

cytochrome_P450_monooxygenase_CYP6AE22_[Bombyx_mori]

Location

Bomo_Chr23(+):9539884-9542582      View in EpiBrowser

Location in the cell

PlasmaMembrane   Reliability : 3.067

CDS

ATGTATCTGCTAACTTTTTTACTGCATTTTATTTTATTTCTTGTATTGGTTGTGTATTATATAACAAAACGAAACCATGATTACTGGAAAAATAAAAAAGTTCCATTTGAAAAACCATACCCGATTCTTGGAAACTACGGTGATTATATATTGTTGAAAATTTTTTTTGGGAATGTTACGAAGAGGCTCTGCGAAAAATTTCCGGAATCACCTTACGTGGGCACTTTTTATGGTACCGAACCAGCTCTTGTGGTCCAGGATCCTGATCTGATAAGATTGATTCTGGTAAAAGATTTTTTTTACTTTCATGGACGAGAGGTCTGCAAATATGTCGATAGAGAAATTACCACGCAAAGTATATTTTTTACGTACGGTGACGATTGGAGAGTTTTGAGGCATAGTTTAACCCCTTTGTTTACAACTTCAAAAATGAAAAACATGTTTCACTTGATAAAGAATTGTTGCCGAGTCTTCGAAAACGTATTGGAAGAAAAAGCCACTGTTAAAAGTTTCGAGATAAACTCTATAATAAAATATTTTATAATGGATTGTGTTGGTGCTTGTCTTTTCGGAGTAGAAATTAATGCCATGGAAAAGCACTCGCAAAATCCAATTGTGAAAATCAGTAAGGAAATTTTTCCGAAATCGACTACAAGAGGTATCATAAATGTATTAAGAGGAATTTGGCCCTCCTTATTTTATGCATTACGACTGAAACTTTTTCCGGAAGTCATTACAATGTTCTTTACTGACCTGCTAGAATGTGCATTTAAAGACCGACAAAGGAATTTATCACAGAGACAAGACTTTATTGATTTATTCATGAAGCTCAGACAGAATAAGTATCTGGTTGGTGATAGTATTCCAGATATAAAAAATGGCCGTGTACAGAAAGTGAATTTGGAAGTGACAGATGAATTACTGATTGCTCAGTGCGTTTCTTTTTTTGGGGCCGCTTTTGAGACTTCTTCGACTACCCTGAGTTTAACATTTTATGAACTCGCCAAAAATCCAAAATATCAAAAAAAAGCCATCGAAGAAGTTGATGATTATTTCGCTAAGCACAACAATGAAATTGAATTCGACATTGTTTCGGAAACTCCGTATTTAAATGCTTGCATTGACGAGACATTACGTCTTTATCCCTCATTAGCCAATTTAACTCGAGAGGTAATGGAAGACTACACATTCCCGACGGGCTTAAAAGTTGAAAAAGGCACCCGAATTCATATTCCTGTGTATCATCTTCAACGCAATCCGAAATATTTTCCCGAGCCAAATAAATTTGATCCTAGAAGATTTTTACCAGAAGCGAAGCAAACAATTTACCCTTTCACATATATGCCATTTGGGGAAGGCCATAGGATATGTATTGCCATGCGTTTTGCGAAGATGCAGATGTTAGCGGGCTTTGCAACTCTGTTGAAGAAATATGAAGTAGCTGTAGATGATACCACACCTCAGGAATTGACAATTGATCCAAGAATTATTGTTACTACTCCAATTGAAAATATTCAATTAAAGTTGATAGCGCGTCAACATGCACTATAA

Protein

MYLLTFLLHFILFLVLVVYYITKRNHDYWKNKKVPFEKPYPILGNYGDYILLKIFFGNVTKRLCEKFPESPYVGTFYGTEPALVVQDPDLIRLILVKDFFYFHGREVCKYVDREITTQSIFFTYGDDWRVLRHSLTPLFTTSKMKNMFHLIKNCCRVFENVLEEKATVKSFEINSIIKYFIMDCVGACLFGVEINAMEKHSQNPIVKISKEIFPKSTTRGIINVLRGIWPSLFYALRLKLFPEVITMFFTDLLECAFKDRQRNLSQRQDFIDLFMKLRQNKYLVGDSIPDIKNGRVQKVNLEVTDELLIAQCVSFFGAAFETSSTTLSLTFYELAKNPKYQKKAIEEVDDYFAKHNNEIEFDIVSETPYLNACIDETLRLYPSLANLTREVMEDYTFPTGLKVEKGTRIHIPVYHLQRNPKYFPEPNKFDPRRFLPEAKQTIYPFTYMPFGEGHRICIAMRFAKMQMLAGFATLLKKYEVAVDDTTPQELTIDPRIIVTTPIENIQLKLIARQHAL

Cofactor

heme

Similarity

Belongs to the cytochrome P450 family.

Uniprot

A5HG33   C1KJL7   H9JPU0   Q2XSW1   A0A068EVK6   D5L0M6   + More
A0A2A4J2E3   H2CZE9   A0A068F0X2   A0A068ETU4   H2CZF1   A0A2A4J918   A0A2H1V0E7   A0A068F1Z7   A0A248QHF4   H9JUM8   Q069I9   A0A0K0YD30   A4GUB8   A0A068EU65   F4YCW0   B3VT94   A0A248QEF8   A0A0A7DH57   A0A0L7KVL1   A0A068ETU8   A0A0L7LJH7   A0A2H1WID4   J7FJF2   C1LZ54   A0A248QEX7   A0A0C5C1I6   A0A068EWQ0   A0A222NX20   A0A172MF86   A0A068EVL0   A0A3S2LFF7   A0A068EWQ5   A0A2A4JAK3   A0A2A4J7V4   A0A3S2P9Y7   A0A068EU72   A0A2A4J698   A0A0K8TUL3   A0A0N1IP03   A0A2A4JAM9   A0A0A7DH10   A0A1V0D9D6   A0A068EVD2   Q7YZS2   A0A0N1ID06   H9JUM5   A0A1V0D9E0   A0A0A7DH65   A0A0A7DGX3   J7FKN2   A0A0K8TV92   L0N7C5   L0N766   D6MLU9   A0A0C5CGV6   C7U1L4   A0A1V0D9D9   X5D9B5   A9QW13   B6VFR9   J7FKN1   A0A0L7LRY0   A5HG34   A5JM34   A0A286QUG7   A0A0L7KJY7   L0N6H5   A3RIC0   D2JLK6   A9QW15   W5VY13   H9JUM4   A5HKM1   A9YXV8   A0A3S2LW02   A4GUB9   L0N6M3   H9JUM6   D5L0M5   A0A2H1VU17   A0A248QG18   A0A248QEH8   J7FJF3   A0A2W1BGY9   A0A2H1V048   A0A2A4JWC6   A0A068F0X7   A0A0A7DH14   A0A0K8TUI1   A9CS65   A0A2H1VSH4   Q4JHE4   A0A0A7DG86   Q52S21  

Pubmed

19121390    19909380    25315858    28881445    17982444    26227816    + More
22984814    26017144    26354079    15606809    24361403    19954531    28756777    17119627   

EMBL

EF528485    ABP99019.1    FJ843077    ACO55746.1    BABH01015309    DQ256407    + More
ABB69054.1    KM016736    AID54888.1    GU731531    ADE05581.1    NWSH01003425    PCG66327.1    JN375489    AEY75583.1    KM016738    AID54890.1    KM016735    AID54887.1    JN375491    AEY75585.1    NWSH01002369    PCG68451.1    ODYU01000082    SOQ34236.1    KJ671576    AID55428.1    KX443432    ASO98007.1    BABH01022705    DQ986461    JN176574    ABI84381.1    AET11931.1    KR095600    AKS48888.1    EF432656    ABO21682.1    KM016737    AID54889.1    GU937509    ADW23116.1    EU807990    ACF17813.2    KX443430    ASO98005.1    KJ645906    AIJ00763.1    JTDY01005369    KOB67074.1    KM016740    AID54892.1    JTDY01000942    KOB75351.1    ODYU01008863    SOQ52829.1    JX310078    AFP20589.1    FN356971    CAX94849.1    KX443435    ASO98010.1    KP001126    AJN91171.1    KM016739    AID54891.1    KX844829    ASQ44127.1    KU145393    ANC96676.1    KM016741    AID54893.1    RSAL01000158    RVE45547.1    KM016744    AID54896.1    PCG68452.1    NWSH01002736    PCG67604.1    RVE45548.1    KM016742    AID54894.1    PCG67605.1    GCVX01000058    JAI18172.1    KQ460655    KPJ12961.1    PCG68453.1    KJ645904    AIJ00761.1    KY212045    ARA91609.1    KJ671575    AID55427.1    AY295774    AAP83689.1    KQ459388    KPJ01135.1    BABH01022694    KY212044    ARA91608.1    KJ645905    AIJ00762.1    KJ645907    AIJ00764.1    JX310082    AFP20593.1    GCVX01000049    JAI18181.1    AK289291    AK343204    BAM73818.1    BAM73890.1    AK343205    BAM73891.1    GQ241737    ADD70250.1    KP001127    AJN91172.1    FN544262    CBB07053.1    KY212043    ARA91607.1    KF701137    AHW57307.1    EU273875    ABX64438.1    FJ387169    ACJ10074.1    JX310077    AFP20588.1    JTDY01000272    KOB77971.1    EF528486    ABP99020.1    EF547545    ABQ42339.1    KX443431    ASO98006.1    JTDY01009617    KOB63214.1    AK289290    BAM73817.1    EF415296    ABN71367.1    GQ915322    ACZ97416.2    EU273877    ABX64440.1    KF853191    AHH92929.1    EF535809    ABQ08711.1    EU309477    ABY40426.1    RVE45546.1    EF432657    ABO21683.1    AK343206    BAM73892.1    BABH01022698    GU731530    ADE05580.1    ODYU01004424    SOQ44278.1    KX443433    ASO98008.1    KX443434    ASO98009.1    JX310083    AFP20594.1    KZ150141    PZC72944.1    ODYU01000083    SOQ34238.1    NWSH01000502    PCG75998.1    KM016743    AID54895.1    KJ645909    AIJ00766.1    GCVX01000081    JAI18149.1    AB372008    BAF95609.1    ODYU01004193    SOQ43795.1    DQ088989    AAY89329.1    KJ645908    AIJ00765.1    AY971374    AAX84943.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000283053    UP000053240    UP000053268    + More

PRIDE

A5HG33    H9JPU0    H9JUM8    A4GUB8    H9JUM5    L0N7C5    + More
L0N766    D6MLU9    B6VFR9    A5HG34    A5JM34    L0N6H5    A3RIC0    H9JUM4    A5HKM1    A4GUB9    L0N6M3    H9JUM6   

Pfam

PF00067   p450        + More
PF09453   HIRA_B

Interpro

IPR036396   Cyt_P450_sf        + More
IPR002401   Cyt_P450_E_grp-I       
IPR001128   Cyt_P450       
IPR017972   Cyt_P450_CS       
IPR019015   HIRA_B_motif       
IPR002403   Cyt_P450_E_grp-IV       
IPR002402   Cyt_P450_E_grp-II       

SUPFAM

SSF48264   SSF48264       

Gene 3D

1.10.630.10    

ProteinModelPortal

A5HG33   C1KJL7   H9JPU0   Q2XSW1   A0A068EVK6   D5L0M6   + More
A0A2A4J2E3   H2CZE9   A0A068F0X2   A0A068ETU4   H2CZF1   A0A2A4J918   A0A2H1V0E7   A0A068F1Z7   A0A248QHF4   H9JUM8   Q069I9   A0A0K0YD30   A4GUB8   A0A068EU65   F4YCW0   B3VT94   A0A248QEF8   A0A0A7DH57   A0A0L7KVL1   A0A068ETU8   A0A0L7LJH7   A0A2H1WID4   J7FJF2   C1LZ54   A0A248QEX7   A0A0C5C1I6   A0A068EWQ0   A0A222NX20   A0A172MF86   A0A068EVL0   A0A3S2LFF7   A0A068EWQ5   A0A2A4JAK3   A0A2A4J7V4   A0A3S2P9Y7   A0A068EU72   A0A2A4J698   A0A0K8TUL3   A0A0N1IP03   A0A2A4JAM9   A0A0A7DH10   A0A1V0D9D6   A0A068EVD2   Q7YZS2   A0A0N1ID06   H9JUM5   A0A1V0D9E0   A0A0A7DH65   A0A0A7DGX3   J7FKN2   A0A0K8TV92   L0N7C5   L0N766   D6MLU9   A0A0C5CGV6   C7U1L4   A0A1V0D9D9   X5D9B5   A9QW13   B6VFR9   J7FKN1   A0A0L7LRY0   A5HG34   A5JM34   A0A286QUG7   A0A0L7KJY7   L0N6H5   A3RIC0   D2JLK6   A9QW15   W5VY13   H9JUM4   A5HKM1   A9YXV8   A0A3S2LW02   A4GUB9   L0N6M3   H9JUM6   D5L0M5   A0A2H1VU17   A0A248QG18   A0A248QEH8   J7FJF3   A0A2W1BGY9   A0A2H1V048   A0A2A4JWC6   A0A068F0X7   A0A0A7DH14   A0A0K8TUI1   A9CS65   A0A2H1VSH4   Q4JHE4   A0A0A7DG86   Q52S21  

PDB

6MJM     E-value=2.78294e-43,     Score=442

KEGG

100126549    K14999 cytochrome P450 family 6 [EC:1.14.-.-] | (RefSeq) Cyp6ae22; cytochrome P450 monooxygenase CYP

GO

GO:0020037   GO:0016021   GO:0005506   GO:0016705   GO:0004497   GO:0046872   GO:0016075   GO:0003677   GO:0005524   GO:0016787   GO:0004713   GO:0016491   GO:0015930   GO:0055114  

Length:

516

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

30.16085

Exp number, first 60 AAs:

23.59486

Total prob of N-in:

0.37318

POSSIBLE N-term signal

sequence

inside

1  -  1

TMhelix

2  -  21

outside

22  -  516

 

 

Pi

193.738884

Theta

178.164066

Tajima's D

0.339447

CLR

279.124711

CSRT

0.464476776161192

Interpretation

Uncertain