Gene

KWMTBOMO13804

Annotation

PREDICTED:_ubiquinone_biosynthesis_O-methyltransferase?_mitochondrial-like_[Bombyx_mori]

Location

Bomo_Chr23(-):9534120-9537813      View in EpiBrowser

Full name

Ubiquinone biosynthesis O-methyltransferase, mitochondrial      

Alternative Name

3-demethylubiquinol 3-O-methyltransferase
Polyprenyldihydroxybenzoate methyltransferase

Location in the cell

PlasmaMembrane   Reliability : 3.46

CDS

ATGCGAAAAATATTTTTCCATTTAATTTTGGTAACAGTTATCGTTTTTTGGACACTAATAAAGGTCCCAAAGCTCCTGCATCAGTACCTCTCAGAAAGAAGAGTGACACACGAACGTAAAGTAACAGAATGCGATGAAAATTCAACAGTAATAGAACAAAACGTCGAAATTTTTGCAAATCTAGATGATTGGTGGAATCCTCGTGGAAAACTTTCTACATTACACAAATTCAACGTTATAAGAATTCCGTTCATTCAAAATGGTATACTTGCTCACACCGGAATAAACACTCTGAATAATATAAAAATACTAGACGTCGGCTGTGGTGGAGGAATACTGTCCGAGGGTTTAGCAAAAGCCGGAGCACTCGTGACCGGAATTGACGCAAGTGCAGCTTTAATTATGATAGCAAAGGAACATCGTAATCTCAGTTCAGGTCTACCAAACAGCAACCCTATTTATCACCATAATACTATTGAAGAGCACGTAAAAACACACCCAAACTATTACGATGCAGTCGTTGCTTCAGAAGTTATAGAACACGTGAACAATCCAAAATTATTCCTAAAATCCTGTGTTGAGACTCTCAAATCCGGAGGGGTTATATTTTTAACAACACCAAATAGAACGATATGGTCTTACCTAACTGTTATATTCTTTTGTGAGAAGGTTATATCGATAATACCGAAAGGCGCACACGAATACAGCAAACTGATCACTCCAAGAGAACTTTCCGAAATGCTGACTGAAAATAATTGCAGCGTTGTTTCAAATCAAGGAATTATTCTTAACATAATTACTCGGCACTGGCAATTTATAAAACCACGTAGCTTAATGTATGCAATTCAAGCAGTAAAACTGAATTAA

Protein

MRKIFFHLILVTVIVFWTLIKVPKLLHQYLSERRVTHERKVTECDENSTVIEQNVEIFANLDDWWNPRGKLSTLHKFNVIRIPFIQNGILAHTGINTLNNIKILDVGCGGGILSEGLAKAGALVTGIDASAALIMIAKEHRNLSSGLPNSNPIYHHNTIEEHVKTHPNYYDAVVASEVIEHVNNPKLFLKSCVETLKSGGVIFLTTPNRTIWSYLTVIFFCEKVISIIPKGAHEYSKLITPRELSEMLTENNCSVVSNQGIILNIITRHWQFIKPRSLMYAIQAVKLN

Description

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

Catalytic Activity

3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + H(+) + S-adenosyl-L-homocysteine

Subunit

Component of a multi-subunit COQ enzyme complex.
Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.

Similarity

Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.

Uniprot

A0A2H1VUK1   A0A2H1VL37   A0A2W1BI06   A0A2A4JEQ5   A0A212F8D8   H9JPL1   + More
A0A194RRD2   S4PXP9   A0A1B6D5P4   A0A1B6DMM7   A0A1B6K9N3   A0A1B6K8J6   A0A2H8TEM3   A0A1B6FU63   A0A195E5S0   A0A1B6FXD2   A0A026VXQ4   C4WXE5   A0A0A1XPA7   A0A087ZYC5   A0A2S2P0D0   K7ISW5   A0A151IP29   A0A2S2Q7A1   A0A0V1CKF5   A0A336KST0   A0A067RD09   A0A195FVN1   A0A182HFU4   A0A182LPZ8   Q7Q8W0   A0A182VMK4   A0A182WUT5   A0A0V0S756   A0A195B9G5   A0A026VYR1   A0A151J1B6   A0A182TTG3   A0A0M8ZY76   A0A1B6D2T0   A0A158NJT7   A0A1Y3EH06   A0A195ED63   A0A1A9V9S6   A0A0V1HYG9   A0A084WAV4   A0A0V0XTN1   A0A182QPY8   A0A1B6FCI2   A0A0K8TV91   A0A154PHV5   A0A0K8TTB7   A0A3L8D7D5   A0A151XC01   W5JEG1   A0A158NVH2   A0A1J1J3H8   A0A182MYA7   A0A034WEJ4   A0A2L2YNC2   A0A182MMR4   A0A1B3PDK8   A0A1J1J1P9   A0A182WN26   A0A2L2YN73   A0A1B0CQ57   A0A093C128   A0A131Y3K3   A0A091WR90   A0A1B3PD89   A0A026WC62   A0A0K8R8Y5   A0A0K8WID7   A0A2A3E688   A0A195B7P5   A0A0J7KVZ7   A0A182J4U1   A0A1Y1N1F3   E9HTS6   A0A2P6K0G0   A0A131XRJ0   A0A151WP14   A0A182H3X8   A0A182K681   G1NLE3   A0A0C9QQG2   F4X585   E0VD98   A0A2R5LB16   F6S6G8   A0A023F0Y7   B4N7C3   A0A0A1XS60   A0A1B3PDK7   A0A224YX00   A0A131Z5Y2   A0A0V1EAF9   A0A195E853   A0A1A9ZDD2   A0A195D742  

Pubmed

28756777    22118469    19121390    26354079    23622113    24508170    + More
30249741    25830018    20075255    24845553    20966253    12364791    14747013    17210077    21347285    24438588    26369729    20920257    23761445    25348373    26561354    28004739    21292972    28049606    26483478    20838655    21719571    20566863    20431018    25474469    17994087    28797301    26830274   

EMBL

ODYU01004521    SOQ44493.1    ODYU01003166    SOQ41569.1    KZ150150    PZC72847.1    + More
NWSH01001648    PCG70565.1    AGBW02009763    OWR49978.1    BABH01015309    KQ459833    KPJ19865.1    GAIX01004658    JAA87902.1    GEDC01016291    JAS21007.1    GEDC01010357    JAS26941.1    GEBQ01031821    JAT08156.1    GEBQ01032196    JAT07781.1    GFXV01000724    MBW12529.1    GECZ01016044    JAS53725.1    KQ979608    KYN20237.1    GECZ01014914    JAS54855.1    KK107599    QOIP01000012    EZA48588.1    RLU15930.1    ABLF02034105    AK342595    BAH72565.1    GBXI01001577    JAD12715.1    GGMR01010215    MBY22834.1    AAZX01003334    KQ976892    KYN07223.1    GGMS01004268    MBY73471.1    JYDI01000173    KRY49518.1    UFQS01000960    UFQT01000960    SSX07958.1    SSX28192.1    KK852716    KDR17839.1    KQ981215    KYN44518.1    APCN01005583    AAAB01008933    EAA09931.3    JYDL01000030    KRX22558.1    KQ976542    KYM81178.1    EZA48591.1    RLU16367.1    KQ980555    KYN15567.1    KQ435826    KOX72023.1    GEDC01017308    JAS19990.1    ADTU01018253    LVZM01012740    OUC44351.1    KQ979074    KYN22784.1    JYDP01000016    KRZ15763.1    ATLV01022269    KE525331    KFB47348.1    JYDU01000142    KRX91235.1    AXCN02002043    GECZ01021945    JAS47824.1    GDHF01033915    JAI18399.1    KQ434912    KZC11377.1    GDAI01000200    JAI17403.1    RLU16146.1    KQ982316    KYQ57840.1    ADMH02001479    ETN62431.1    ADTU01002888    CVRI01000066    CRL06356.1    GAKP01005833    JAC53119.1    IAAA01030475    LAA09559.1    AXCM01000355    KU660014    AOG17812.1    CRL06373.1    IAAA01030476    LAA09562.1    AJWK01023127    KL451444    KFV05967.1    GEFM01002856    JAP72940.1    KK736148    KFR17635.1    KU659891    AOG17690.1    KK107275    EZA53650.1    GADI01006869    JAA66939.1    GDHF01001505    JAI50809.1    KZ288369    PBC26792.1    KQ976565    KYM80536.1    LBMM01002559    KMQ94662.1    GEZM01020131    JAV89377.1    GL732783    EFX64862.1    MWRG01051081    PRD19819.1    GEFH01000275    JAP68306.1    KQ982893    KYQ49570.1    JXUM01025151    KQ560713    KXJ81190.1    GBYB01002877    JAG72644.1    GL888693    EGI58413.1    AAZO01001263    DS235072    EEB11354.1    GGLE01002588    MBY06714.1    AAMC01037971    AAMC01037972    AAMC01037973    AAMC01037974    AAMC01037975    GBBI01003557    JAC15155.1    CH964182    EDW80264.2    GBXI01000919    JAD13373.1    KU660019    AOG17817.1    GFPF01007206    MAA18352.1    GEDV01003016    JAP85541.1    JYDR01000067    KRY70783.1    KQ979479    KYN21383.1    KQ976750    KYN08696.1   

Proteomes

UP000218220    UP000007151    UP000005204    UP000053240    UP000078492    UP000053097    + More
UP000279307    UP000007819    UP000005203    UP000002358    UP000078542    UP000054653    UP000027135    UP000078541    UP000075840    UP000075882    UP000007062    UP000075903    UP000076407    UP000054630    UP000078540    UP000075902    UP000053105    UP000005205    UP000243006    UP000078200    UP000055024    UP000030765    UP000054815    UP000075886    UP000076502    UP000075809    UP000000673    UP000183832    UP000075884    UP000075883    UP000075920    UP000092461    UP000053605    UP000242457    UP000036403    UP000075880    UP000000305    UP000069940    UP000249989    UP000075881    UP000001645    UP000007755    UP000009046    UP000008143    UP000007798    UP000054632    UP000092445   

PRIDE

H9JPL1   

Pfam

PF08241   Methyltransf_11        + More
PF08242   Methyltransf_12
PF08696   Dna2
PF13087   AAA_12
PF13086   AAA_11
PF15433   MRP-S31

Interpro

IPR029063   SAM-dependent_MTases        + More
IPR010233   UbiG_MeTrfase       
IPR013216   Methyltransf_11       
IPR013217   Methyltransf_12       
IPR041679   DNA2/NAM7-like_AAA       
IPR026851   Dna2       
IPR027417   P-loop_NTPase       
IPR041677   DNA2/NAM7_AAA_11       
IPR014808   DNA_replication_fac_Dna2_N       
IPR026299   MRP-S31       

SUPFAM

SSF53335   SSF53335        + More
SSF52540   SSF52540       

ProteinModelPortal

A0A2H1VUK1   A0A2H1VL37   A0A2W1BI06   A0A2A4JEQ5   A0A212F8D8   H9JPL1   + More
A0A194RRD2   S4PXP9   A0A1B6D5P4   A0A1B6DMM7   A0A1B6K9N3   A0A1B6K8J6   A0A2H8TEM3   A0A1B6FU63   A0A195E5S0   A0A1B6FXD2   A0A026VXQ4   C4WXE5   A0A0A1XPA7   A0A087ZYC5   A0A2S2P0D0   K7ISW5   A0A151IP29   A0A2S2Q7A1   A0A0V1CKF5   A0A336KST0   A0A067RD09   A0A195FVN1   A0A182HFU4   A0A182LPZ8   Q7Q8W0   A0A182VMK4   A0A182WUT5   A0A0V0S756   A0A195B9G5   A0A026VYR1   A0A151J1B6   A0A182TTG3   A0A0M8ZY76   A0A1B6D2T0   A0A158NJT7   A0A1Y3EH06   A0A195ED63   A0A1A9V9S6   A0A0V1HYG9   A0A084WAV4   A0A0V0XTN1   A0A182QPY8   A0A1B6FCI2   A0A0K8TV91   A0A154PHV5   A0A0K8TTB7   A0A3L8D7D5   A0A151XC01   W5JEG1   A0A158NVH2   A0A1J1J3H8   A0A182MYA7   A0A034WEJ4   A0A2L2YNC2   A0A182MMR4   A0A1B3PDK8   A0A1J1J1P9   A0A182WN26   A0A2L2YN73   A0A1B0CQ57   A0A093C128   A0A131Y3K3   A0A091WR90   A0A1B3PD89   A0A026WC62   A0A0K8R8Y5   A0A0K8WID7   A0A2A3E688   A0A195B7P5   A0A0J7KVZ7   A0A182J4U1   A0A1Y1N1F3   E9HTS6   A0A2P6K0G0   A0A131XRJ0   A0A151WP14   A0A182H3X8   A0A182K681   G1NLE3   A0A0C9QQG2   F4X585   E0VD98   A0A2R5LB16   F6S6G8   A0A023F0Y7   B4N7C3   A0A0A1XS60   A0A1B3PDK7   A0A224YX00   A0A131Z5Y2   A0A0V1EAF9   A0A195E853   A0A1A9ZDD2   A0A195D742  

PDB

4KDC     E-value=6.60437e-31,     Score=333

KEGG

101747146    K00591 polyprenyldihydroxybenzoate methyltransferase / 3-demethylubiquinol 3-O-methyltransferase [EC

PATHWAY

00130    Ubiquinone and other terpenoid-quinone biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004395   GO:0006744   GO:1990886   GO:0008689   GO:0031314   GO:0008425   GO:0016021   GO:0043142   GO:0004386   GO:0017108   GO:0033567   GO:0006071   GO:0042060   GO:0003735   GO:0005763   GO:0006468   GO:0016075   GO:0003677   GO:0005524   GO:0016787   GO:0004713   GO:0016491   GO:0015930  

PANTHER

PTHR10887:SF433  

Subcellular location

Mitochondrion inner membrane  

Length:

288

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

18.32617

Exp number, first 60 AAs:

16.78392

Total prob of N-in:

0.60701

POSSIBLE N-term signal

sequence

inside

1  -  4

TMhelix

5  -  20

outside

21  -  288

 

 

Pi

206.042587

Theta

179.111478

Tajima's D

0.280443

CLR

0.697618

CSRT

0.449077546122694

Interpretation

Uncertain