Gene

KWMTBOMO13803  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011466

Annotation

PREDICTED:_ubiquinone_biosynthesis_O-methyltransferase?_mitochondrial-like_isoform_X2_[Bombyx_mori]

Location

Bomo_Chr23(-):9528095-9532323      View in EpiBrowser

Full name

Ubiquinone biosynthesis O-methyltransferase, mitochondrial      

Alternative Name

3-demethylubiquinol 3-O-methyltransferase
Polyprenyldihydroxybenzoate methyltransferase

Location in the cell

Mitochondrial   Reliability : 1.904 PlasmaMembrane   Reliability : 1.299

CDS

ATGAGTACCAAAGCGCTAAACACTTGGCGACTTGCATGCTACCCTGCATCTCCAGTTATTAACCGAATAATCACATATCCAAAATGGAGATACTATGCAACAGCCAATTTATACAGTAAAGATGAGAATCATGGGCGTACTACACTTGATTCCTCCGAGATCAAAATGTTTTCAAAACAAATGAGTGAATGGTGGGATGTCAATGGTTATCTAAAATCATTACATGCTATGAATAAAGTGAGAATACCATTAATTAGAGATGGTCTCATACAAACATCGGAAAGAACCTTAACACCTTTGCAAGATAAAAAAATTCTCGATGTTGGTTGTGGGGGAGGCATCTTGGCAGAGGGCTTAGCTAGACTCGGAGCGAATGTGACAGGAATAGATGCAAGCGAAGATCTCATAAACTTAGCCAGAGAACACAGTGAAACTAATCCAAAAATAATTAACAATAAACCAACATATTATCACTGTACTATTGAGAATCACATTAAAACACATAAAGAACACTATGATGCTGTTGTTGCATCAGAGGTAATTGAACACATAACCGATAAGCAGTTATTTGTGAATTCGTGCGTTGCAGCAACGAAACCCGGAGGTAGATTATTCTTCACGACGCCAAATAAAACCAGGATATCGCAGTTCCTAACTATATTTGTTGTCGAAAATATTATAAAAATCGTAAAAAAAGGAACGCATCAGTACGATAAGTTCATTACACCTAATGAATTAACTTTCCTGTTAGAGAGAAATAACTGCCTAGTGGAATCGATATACGGCTTGTTCTACAATCCGTTAAACAACAGTTGGCATTTTACAAACTCACAACTTCTACTATACGCTTTACAGGCCATCAAACTGAAGTCATTGTAG

Protein

MSTKALNTWRLACYPASPVINRIITYPKWRYYATANLYSKDENHGRTTLDSSEIKMFSKQMSEWWDVNGYLKSLHAMNKVRIPLIRDGLIQTSERTLTPLQDKKILDVGCGGGILAEGLARLGANVTGIDASEDLINLAREHSETNPKIINNKPTYYHCTIENHIKTHKEHYDAVVASEVIEHITDKQLFVNSCVAATKPGGRLFFTTPNKTRISQFLTIFVVENIIKIVKKGTHQYDKFITPNELTFLLERNNCLVESIYGLFYNPLNNSWHFTNSQLLLYALQAIKLKSL

Description

O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway.

Catalytic Activity

3,4-dihydroxy-5-all-trans-polyprenylbenzoate + S-adenosyl-L-methionine = 3-methoxy,4-hydroxy-5-all-trans-polyprenylbenzoate + H(+) + S-adenosyl-L-homocysteine
a 3-demethylubiquinol + S-adenosyl-L-methionine = a ubiquinol + H(+) + S-adenosyl-L-homocysteine

Subunit

Component of a multi-subunit COQ enzyme complex.
Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.

Similarity

Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Uniprot

H9JPL1   A0A2W1BI06   A0A2H1VUK1   A0A2A4JEQ5   A0A2H1VL37   A0A212F8D8   + More
A0A194RRD2   S4PXP9   A0A1B6D5P4   A0A1B6DMM7   A0A1B6D2T0   A0A1Y1L8Q3   A0A087ZYC5   T1J1P0   A0A067RD09   A0A0M8ZY76   A0A182HFU4   A0A182LPZ8   Q7Q8W0   A0A182VMK4   A0A182TTG3   A0A182WUT5   A0A1B6FU63   A0A0C9QQG2   A0A3Q1FGP3   A0A154PHV5   A0A1B6FXD2   A0A084WAV4   W5NKG7   E0VD98   A0A091GXP4   A0A026VYR1   A0A3B4BG21   F6S6G8   A0A0B7A0T0   A0A0B7A3G2   M3WNZ6   A0A3Q2P9H7   A0A182QPY8   A0A341CL25   A0A1W4XDV8   A0A146MUN5   A0A146VZ00   A0A146NMG7   A0A3Q7WR53   A0A1B6K9N3   A0A146W230   A0A341CMG4   A0A0N7ZBX4   A0A3Q1CEN6   A0A3B3BI12   A0A139WE60   A0A1B6K8J6   W5JEG1   A0A2C9K5G7   A0A0S7EFQ7   A0A182K681   A0A182J4U1   A0A2U4AW48   A0A3B4U0V2   A0A3B3QL47   A0A3Q7X016   A0A3Q7WR47   A0A3P9JW48   A0A2U3V0H2   A0A2Y9EFG6   F1PEZ9   A0A3B4XCE5   A0A2Y9EGI2   A0A026VXQ4   A0A3Q7SDZ1   C3YXC3   A0A2U4AVP0   A0A182MYA7   A0A151IP29   A0A182WN26   A0A093I2I9   K7ISW5   K9IJX5   A0A3B5B0E5   K9K3S5   A0A1U7Q717   F1RXY4   A0A2Y9LP98   Q3UQM8   N6TQQ3   A0A1B0CUX1   A0A2D0T6D8   A0A3Q7NAT5   A0A3B3HNE1   G3WEX3   F7E229   A0A3P8TW20   A0A2U3ZMJ5   I3MRT0   Q3TLJ6   A0A2Y9LPA3   S7PR80   A0A2Y9LU90   A0A182MMR4  

Pubmed

19121390    28756777    22118469    26354079    23622113    28004739    + More
24845553    20966253    12364791    14747013    17210077    24438588    20566863    24508170    30249741    25463417    20431018    17975172    29451363    18362917    19820115    20920257    23761445    15562597    29240929    17554307    16341006    18563158    20075255    30723633    10349636    11042159    11076861    11217851    12466851    16141073    23537049    21709235   

EMBL

BABH01015309    KZ150150    PZC72847.1    ODYU01004521    SOQ44493.1    NWSH01001648    + More
PCG70565.1    ODYU01003166    SOQ41569.1    AGBW02009763    OWR49978.1    KQ459833    KPJ19865.1    GAIX01004658    JAA87902.1    GEDC01016291    JAS21007.1    GEDC01010357    JAS26941.1    GEDC01017308    JAS19990.1    GEZM01062047    GEZM01062046    GEZM01062045    JAV70093.1    JH431789    KK852716    KDR17839.1    KQ435826    KOX72023.1    APCN01005583    AAAB01008933    EAA09931.3    GECZ01016044    JAS53725.1    GBYB01002877    JAG72644.1    KQ434912    KZC11377.1    GECZ01014914    JAS54855.1    ATLV01022269    KE525331    KFB47348.1    AHAT01026706    AAZO01001263    DS235072    EEB11354.1    KL447928    KFO78832.1    KK107599    QOIP01000012    EZA48591.1    RLU16367.1    AAMC01037971    AAMC01037972    AAMC01037973    AAMC01037974    AAMC01037975    HACG01027629    CEK74494.1    HACG01027630    CEK74495.1    AANG04003966    AXCN02002043    GCES01162949    JAQ23373.1    GCES01063835    JAR22488.1    GCES01153404    JAQ32918.1    GEBQ01031821    JAT08156.1    GCES01063836    JAR22487.1    GDRN01076798    GDRN01076797    GDRN01076796    GDRN01076795    JAI62856.1    KQ971355    KYB26214.1    GEBQ01032196    JAT07781.1    ADMH02001479    ETN62431.1    GBYX01477859    GBYX01477858    GBYX01477854    GBYX01477853    JAO03831.1    AAEX03008557    EZA48588.1    RLU15930.1    GG666562    EEN55141.1    KQ976892    KYN07223.1    KL206733    KFV85392.1    AAZX01003334    GABZ01006648    JAA46877.1    JL615916    AEH58123.1    AEMK02000001    DQIR01282604    DQIR01321040    HDC38082.1    AK142287    BAE25011.1    APGK01055374    APGK01055375    APGK01055376    APGK01055377    APGK01055378    KB741264    ENN71545.1    AJWK01029739    AEFK01169957    AGTP01086439    AK166475    BAE38796.1    KE163131    EPQ10942.1    AXCM01000355   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053240    UP000005203    UP000027135    + More
UP000053105    UP000075840    UP000075882    UP000007062    UP000075903    UP000075902    UP000076407    UP000257200    UP000076502    UP000030765    UP000018468    UP000009046    UP000053760    UP000053097    UP000279307    UP000261520    UP000008143    UP000011712    UP000265000    UP000075886    UP000252040    UP000192223    UP000286642    UP000257160    UP000261560    UP000007266    UP000000673    UP000076420    UP000075881    UP000075880    UP000245320    UP000261420    UP000261540    UP000265180    UP000248484    UP000002254    UP000261360    UP000286640    UP000001554    UP000075884    UP000078542    UP000075920    UP000053584    UP000002358    UP000261400    UP000189706    UP000008227    UP000248483    UP000019118    UP000092461    UP000221080    UP000286641    UP000001038    UP000007648    UP000265080    UP000245340    UP000005215    UP000075883   

PRIDE

H9JPL1    F1RXY4   

Pfam

PF08241   Methyltransf_11        + More
PF00782   DSPc

Interpro

IPR013216   Methyltransf_11        + More
IPR029063   SAM-dependent_MTases       
IPR010233   UbiG_MeTrfase       
IPR020420   Atypical_DUSP_famB       
IPR029021   Prot-tyrosine_phosphatase-like       
IPR020417   Atypical_DUSP       
IPR000387   TYR_PHOSPHATASE_dom       
IPR020422   TYR_PHOSPHATASE_DUAL_dom       
IPR000340   Dual-sp_phosphatase_cat-dom       

SUPFAM

SSF53335   SSF53335        + More
SSF52799   SSF52799       

Gene 3D

3.90.190.10    

CDD

cd00127  DSPc

ProteinModelPortal

H9JPL1   A0A2W1BI06   A0A2H1VUK1   A0A2A4JEQ5   A0A2H1VL37   A0A212F8D8   + More
A0A194RRD2   S4PXP9   A0A1B6D5P4   A0A1B6DMM7   A0A1B6D2T0   A0A1Y1L8Q3   A0A087ZYC5   T1J1P0   A0A067RD09   A0A0M8ZY76   A0A182HFU4   A0A182LPZ8   Q7Q8W0   A0A182VMK4   A0A182TTG3   A0A182WUT5   A0A1B6FU63   A0A0C9QQG2   A0A3Q1FGP3   A0A154PHV5   A0A1B6FXD2   A0A084WAV4   W5NKG7   E0VD98   A0A091GXP4   A0A026VYR1   A0A3B4BG21   F6S6G8   A0A0B7A0T0   A0A0B7A3G2   M3WNZ6   A0A3Q2P9H7   A0A182QPY8   A0A341CL25   A0A1W4XDV8   A0A146MUN5   A0A146VZ00   A0A146NMG7   A0A3Q7WR53   A0A1B6K9N3   A0A146W230   A0A341CMG4   A0A0N7ZBX4   A0A3Q1CEN6   A0A3B3BI12   A0A139WE60   A0A1B6K8J6   W5JEG1   A0A2C9K5G7   A0A0S7EFQ7   A0A182K681   A0A182J4U1   A0A2U4AW48   A0A3B4U0V2   A0A3B3QL47   A0A3Q7X016   A0A3Q7WR47   A0A3P9JW48   A0A2U3V0H2   A0A2Y9EFG6   F1PEZ9   A0A3B4XCE5   A0A2Y9EGI2   A0A026VXQ4   A0A3Q7SDZ1   C3YXC3   A0A2U4AVP0   A0A182MYA7   A0A151IP29   A0A182WN26   A0A093I2I9   K7ISW5   K9IJX5   A0A3B5B0E5   K9K3S5   A0A1U7Q717   F1RXY4   A0A2Y9LP98   Q3UQM8   N6TQQ3   A0A1B0CUX1   A0A2D0T6D8   A0A3Q7NAT5   A0A3B3HNE1   G3WEX3   F7E229   A0A3P8TW20   A0A2U3ZMJ5   I3MRT0   Q3TLJ6   A0A2Y9LPA3   S7PR80   A0A2Y9LU90   A0A182MMR4  

PDB

4KDC     E-value=5.46671e-39,     Score=403

KEGG

101747145    K00591 polyprenyldihydroxybenzoate methyltransferase / 3-demethylubiquinol 3-O-methyltransferase [EC

PATHWAY

00130    Ubiquinone and other terpenoid-quinone biosynthesis - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0004395   GO:1990886   GO:0006744   GO:0008425   GO:0008689   GO:0031314   GO:0016021   GO:0017017   GO:0006071   GO:0006468   GO:0016075   GO:0003677   GO:0005524   GO:0016787   GO:0004713   GO:0016491   GO:0015930   GO:0008168  

Subcellular location

Mitochondrion inner membrane  

Length:

292

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0952

Exp number, first 60 AAs:

0.03497

Total prob of N-in:

0.11760

outside

1  -  292

 

 

Pi

254.172628

Theta

181.344029

Tajima's D

1.265538

CLR

0.000712

CSRT

0.730713464326784

Interpretation

Uncertain