Gene

KWMTBOMO13801

Pre Gene Modal

BGIBMGA011544

Annotation

PREDICTED:_uncharacterized_aarF_domain-containing_protein_kinase_1_[Papilio_xuthus]

Location

Bomo_Chr23(+):9514784-9520457      View in EpiBrowser

Full name

Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial      

Location in the cell

Cytoplasmic   Reliability : 3.07

CDS

ATGTTCTCCAGAAAGTTGACTAGGATCATAAAATACGGCTTTTATGGTGGTGTTGCTGTTGGTGGTTGTGTAACTGCTTTAAAATTTCATGATGGTGATTATAATTCGTTAGCCATCGTCAGAATCACGAGGACAGCATGTACTGCTGTGGACATAGGCAGGACTTACCAGTCTTTGTTGTACAGCAAAGATTGGGATAGATCGTCCCCCGAGTATTTAGAAGTGAAGAAACAAGCTCATCAAATTGGGGCAGAGAAACTGCTTGAATTATGCAAAGCTAACAAAGGTGTGTACATTAAAGTTGGACAGCACGTAGGCGCGTTAGATTACTTGTTGCCTACTGAATATGTCAAAACAATGCGTGTTTTGCATAAAGATGCGCCTCAAAACACAGTCGAAGAACTATACAATGTCATCAGGGAAGATTTGAAAAAGGATCCAAAGGAACTGTTTGACGACTTTGAACCTGAGCCTCTGGGCACAGCGTCACTAGCACAAGTTCATAAAGCAAAATTAAAAGATGGTACTGAAGTTGCGGTCAAAGTACAACATCATTTTGTGAGGAAAAATATTAAGATTGACTTAAAATGGATGGAATTTATTATAAACACAATGTCAAAAGTATTTCCTGACTTCCAAATGCAATGGCTAGTGGATGAAACGAAGAAAAACATTGCAAAAGAGCTGGATTTCCTGCAAGAGGGTCAAAATGCAGAGAAGGTAGCTGAATTGTTCAGTAATTACAAATGGCTGAAGGTTCCAAAGATTTTCTGGGATTACAGTACAGAGAGAGTGCTGGTCATGGAATATGTTTACGGTGGACAAGTTAATGATGTTAATTATATTGATACACATAAAATCAACAGATATGATTTATGTAAGAAGCTTGGTGATCTCTACTCCCACATGATCTTCATAACTGGTTTTGTGCACAGTGATCCACATCCAGGGAATATACTGGTTAAAAAAGCTCCAGGAGACAAGGATGTAACAGTTTATTTGCTGGACCATGGGTTATATGCTCAACTTTCGGATAAATTCAGATATCACTATTCAAAATTGTGGCTATCCATTATAGACAGAAATCGTCAAGAAATGAAAGTACATGCAGAGCAGCTAGGTATTCGAAATGAATTGTATGGTTTGTTTGCTTGTATGGTAACGGGTAGACCTTGGGATTCTATTATGAAAGGAATTGGCAAAACTAAGCCATCTTCAGAAGAGAAATCAACTTTTCAAAACGAATTGCCTAACATCCTCCACCATATCACTGATTGCCTGGAGCATGTGGACCGGCAAGCATTATTGGTTCTCAAAACCAATGATTTAATCCGTAGCATAGAATATGCTCTAGGAACACAAGAGAGAATGTGTGGTTTTGTTGTAATGAGCAAATGCTGCATACAAAGCGCATATAGAGAAGAAATTAACAAAGAGAAGTCTATATTTAGAAGACAATACTTAAATTTAAAATTTAGTTGGACCATGCTGGTGCTTTACTTGTACAGTGTATATTTAAATTTATGTGATACATTAATTTTATAA

Protein

MFSRKLTRIIKYGFYGGVAVGGCVTALKFHDGDYNSLAIVRITRTACTAVDIGRTYQSLLYSKDWDRSSPEYLEVKKQAHQIGAEKLLELCKANKGVYIKVGQHVGALDYLLPTEYVKTMRVLHKDAPQNTVEELYNVIREDLKKDPKELFDDFEPEPLGTASLAQVHKAKLKDGTEVAVKVQHHFVRKNIKIDLKWMEFIINTMSKVFPDFQMQWLVDETKKNIAKELDFLQEGQNAEKVAELFSNYKWLKVPKIFWDYSTERVLVMEYVYGGQVNDVNYIDTHKINRYDLCKKLGDLYSHMIFITGFVHSDPHPGNILVKKAPGDKDVTVYLLDHGLYAQLSDKFRYHYSKLWLSIIDRNRQEMKVHAEQLGIRNELYGLFACMVTGRPWDSIMKGIGKTKPSSEEKSTFQNELPNILHHITDCLEHVDRQALLVLKTNDLIRSIEYALGTQERMCGFVVMSKCCIQSAYREEINKEKSIFRRQYLNLKFSWTMLVLYLYSVYLNLCDTLIL

Description

FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.

Cofactor

FAD

Subunit

Component of a multi-subunit COQ enzyme complex.

Similarity

Belongs to the UbiH/COQ6 family.

Uniprot

H9JPT9   A0A2W1BC34   A0A2A4JES8   S4P7Q4   A0A194RPT1   A0A0N1IC13   + More
A0A3S2LCC9   A0A212EN49   B4KSZ2   B4LML0   A0A1B0GQQ8   Q174U0   A0A0M3QUL2   B4MQI3   A0A1I8PXL0   Q28XA0   B4H573   A0A0A1WTQ8   A0A1I8NBD7   B4QCH3   A0A1W4W0J2   Q9W133   T1PBJ4   B4PBE5   B3NQW0   A0A182HE87   A0A0K8UD15   A0A3B0JNU3   A0A1B0CL95   B0WTN9   B4IH55   B3MEA3   W8BUU5   D7EID2   A0A182Y1T3   A0A1Q3FDJ0   A0A2M4AFN4   A0A182R5E6   A0A182PBR2   A0A182V7L8   A0A084WHW7   A0A1B0AZL7   A0A0L0C2K8   A0A1A9ZE16   A0A182FU32   A0A182XD70   A0A182MYJ6   A0A182KSN2   A0A182UBI8   A0A182HQ26   A0A2M4BKF9   A0A1A9VID0   W5JBQ8   A0A2M4BKD6   Q7Q071   A0A182SHR8   A0A182Q9J0   A0A1B0FJQ8   A0A182JUX9   A0A182JC41   A0A1A9W9R5   A0A1A9YE92   A0A1L8DN33   A0A182W965   A0A182MM32   U4U281   N6UFA2   A0A067RDK5   B4J4X4   E2APB4   A0A1B6D1A7   A0A195C072   A0A154P4Z7   A0A0J7KY00   A0A0C9PPS8   A0A0C9QI43   A0A310SM22   A0A0L7QXF6   A0A088A362   A0A195FEZ9   A0A2A3E8X7   A0A195AWY0   A0A195EH71   A0A158NHX4   A0A1W4WI66   E2C8K7   A0A2J7QSZ4   E9JB45   A0A1Y1MAX0   A0A026WIF8   A0A1B6MKA0   A0A1B6INZ9   A0A0M9A7E4   A0A023F2D9   A0A1W4WUC7   A0A3Q0IXR1   A0A1B0CL93   E0VQ85   F4WPR5  

EC Number

1.14.13.-

Pubmed

19121390    28756777    23622113    26354079    22118469    17994087    + More
18057021    17510324    15632085    25830018    25315136    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17550304    26483478    24495485    18362917    19820115    25244985    24438588    26108605    20966253    20920257    23761445    12364791    14747013    17210077    23537049    24845553    20798317    21347285    21282665    28004739    24508170    30249741    25474469    20566863    21719571   

EMBL

BABH01015307    BABH01015308    BABH01015309    KZ150150    PZC72849.1    NWSH01001648    + More
PCG70567.1    GAIX01004489    JAA88071.1    KQ459833    KPJ19863.1    KQ459037    KPJ04297.1    RSAL01000242    RVE43640.1    AGBW02013730    OWR42906.1    CH933808    EDW08489.1    CH940648    EDW59997.1    KRF79188.1    KRF79189.1    AJVK01007787    CH477406    EAT41561.1    CP012524    ALC40823.1    CH963849    EDW74372.1    CM000071    EAL26416.1    CH479210    EDW32909.1    GBXI01011838    JAD02454.1    CM000362    CM002911    EDX08589.1    KMY96393.1    AE013599    AY118660    AAF47244.2    AAM50029.1    AHN56646.1    KA646039    AFP60668.1    CM000158    EDW92577.1    CH954179    EDV57043.1    JXUM01035328    KQ561055    KXJ79848.1    GDHF01027742    JAI24572.1    OUUW01000001    SPP75006.1    AJWK01017050    DS232090    EDS34497.1    CH480838    EDW49231.1    CH902619    EDV36509.1    KPU76265.1    KPU76266.1    GAMC01005821    GAMC01005820    GAMC01005819    GAMC01005818    GAMC01005817    JAC00739.1    DS497676    EFA11786.1    GFDL01009422    JAV25623.1    GGFK01006252    MBW39573.1    ATLV01023892    KE525347    KFB49811.1    JXJN01006363    JRES01000975    KNC26560.1    APCN01003288    GGFJ01004396    MBW53537.1    ADMH02001693    ETN61401.1    GGFJ01004395    MBW53536.1    AAAB01008986    EAA00298.2    AXCN02001041    CCAG010016144    AXCP01006766    GFDF01006253    JAV07831.1    AXCM01014079    KB631815    ERL86393.1    APGK01029188    KB740727    ENN79306.1    KK852771    KDR16899.1    CH916367    EDW01680.1    GL441504    EFN64713.1    GEDC01017841    JAS19457.1    KQ978501    KYM93566.1    KQ434809    KZC06394.1    LBMM01002197    KMQ95158.1    GBYB01003208    JAG72975.1    GBYB01003209    JAG72976.1    KQ761039    OAD58345.1    KQ414704    KOC63290.1    KQ981636    KYN38797.1    KZ288322    PBC28177.1    KQ976725    KYM76555.1    KQ978957    KYN27222.1    ADTU01016101    GL453666    EFN75737.1    NEVH01011202    PNF31716.1    GL770938    EFZ09920.1    GEZM01036375    JAV82751.1    KK107185    QOIP01000012    EZA55832.1    RLU16344.1    GEBQ01003597    JAT36380.1    GECU01019048    GECU01017567    JAS88658.1    JAS90139.1    KQ435719    KOX78760.1    GBBI01003267    JAC15445.1    AJWK01017049    DS235402    EEB15541.1    GL888255    EGI63806.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000053268    UP000283053    UP000007151    + More
UP000009192    UP000008792    UP000092462    UP000008820    UP000092553    UP000007798    UP000095300    UP000001819    UP000008744    UP000095301    UP000000304    UP000192221    UP000000803    UP000002282    UP000008711    UP000069940    UP000249989    UP000268350    UP000092461    UP000002320    UP000001292    UP000007801    UP000007266    UP000076408    UP000075900    UP000075885    UP000075903    UP000030765    UP000092460    UP000037069    UP000092445    UP000069272    UP000076407    UP000075884    UP000075882    UP000075902    UP000075840    UP000078200    UP000000673    UP000007062    UP000075901    UP000075886    UP000092444    UP000075881    UP000075880    UP000091820    UP000092443    UP000075920    UP000075883    UP000030742    UP000019118    UP000027135    UP000001070    UP000000311    UP000078542    UP000076502    UP000036403    UP000053825    UP000005203    UP000078541    UP000242457    UP000078540    UP000078492    UP000005205    UP000192223    UP000008237    UP000235965    UP000053097    UP000279307    UP000053105    UP000079169    UP000009046    UP000007755   

PRIDE

H9JPT9    Q9W133   

Pfam

PF03109   ABC1        + More
PF08147   DBP10CT
PF00271   Helicase_C
PF00270   DEAD
PF01494   FAD_binding_3

Interpro

IPR004147   UbiB_dom        + More
IPR011009   Kinase-like_dom_sf       
IPR000719   Prot_kinase_dom       
IPR018488   cNMP-bd_CS       
IPR012541   DBP10_C       
IPR027417   P-loop_NTPase       
IPR014014   RNA_helicase_DEAD_Q_motif       
IPR011545   DEAD/DEAH_box_helicase_dom       
IPR001650   Helicase_C       
IPR014001   Helicase_ATP-bd       
IPR000629   RNA-helicase_DEAD-box_CS       
IPR036188   FAD/NAD-bd_sf       
IPR000689   UbQ_mOase_COQ6       
IPR002938   FAD-bd       
IPR018168   Ubi_Hdrlase_CS       
IPR010971   UbiH/COQ6       
IPR006311   TAT_signal       

SUPFAM

SSF56112   SSF56112        + More
SSF52540   SSF52540       
SSF51905   SSF51905       

Gene 3D

3.50.50.60    

CDD

cd00079  HELICc

ProteinModelPortal

H9JPT9   A0A2W1BC34   A0A2A4JES8   S4P7Q4   A0A194RPT1   A0A0N1IC13   + More
A0A3S2LCC9   A0A212EN49   B4KSZ2   B4LML0   A0A1B0GQQ8   Q174U0   A0A0M3QUL2   B4MQI3   A0A1I8PXL0   Q28XA0   B4H573   A0A0A1WTQ8   A0A1I8NBD7   B4QCH3   A0A1W4W0J2   Q9W133   T1PBJ4   B4PBE5   B3NQW0   A0A182HE87   A0A0K8UD15   A0A3B0JNU3   A0A1B0CL95   B0WTN9   B4IH55   B3MEA3   W8BUU5   D7EID2   A0A182Y1T3   A0A1Q3FDJ0   A0A2M4AFN4   A0A182R5E6   A0A182PBR2   A0A182V7L8   A0A084WHW7   A0A1B0AZL7   A0A0L0C2K8   A0A1A9ZE16   A0A182FU32   A0A182XD70   A0A182MYJ6   A0A182KSN2   A0A182UBI8   A0A182HQ26   A0A2M4BKF9   A0A1A9VID0   W5JBQ8   A0A2M4BKD6   Q7Q071   A0A182SHR8   A0A182Q9J0   A0A1B0FJQ8   A0A182JUX9   A0A182JC41   A0A1A9W9R5   A0A1A9YE92   A0A1L8DN33   A0A182W965   A0A182MM32   U4U281   N6UFA2   A0A067RDK5   B4J4X4   E2APB4   A0A1B6D1A7   A0A195C072   A0A154P4Z7   A0A0J7KY00   A0A0C9PPS8   A0A0C9QI43   A0A310SM22   A0A0L7QXF6   A0A088A362   A0A195FEZ9   A0A2A3E8X7   A0A195AWY0   A0A195EH71   A0A158NHX4   A0A1W4WI66   E2C8K7   A0A2J7QSZ4   E9JB45   A0A1Y1MAX0   A0A026WIF8   A0A1B6MKA0   A0A1B6INZ9   A0A0M9A7E4   A0A023F2D9   A0A1W4WUC7   A0A3Q0IXR1   A0A1B0CL93   E0VQ85   F4WPR5  

PDB

5YK2     E-value=9.8125e-25,     Score=282

KEGG

101746873    K08869 aarF domain-containing kinase | (RefSeq) uncharacterized aarF domain-containing protein kinas

GO

GO:0004672   GO:0005524   GO:0016021   GO:0055088   GO:0007005   GO:0005743   GO:0006468   GO:0016301   GO:0004004   GO:0003723   GO:0005634   GO:0031314   GO:0006744   GO:0016709   GO:0071949   GO:0016712   GO:0016075   GO:0003677   GO:0016787   GO:0004713   GO:0016491   GO:0015930  

Subcellular location

Mitochondrion inner membrane  

Length:

514

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

18.68416

Exp number, first 60 AAs:

6.51053

Total prob of N-in:

0.38918

outside

1  -  514

 

 

Pi

272.658804

Theta

204.377697

Tajima's D

1.30258

CLR

0

CSRT

0.741062946852657

Interpretation

Uncertain