Gene

KWMTBOMO13798

Pre Gene Modal

BGIBMGA011468

Annotation

juvenile_hormone_epoxide_hydrolase-like_protein_1_[Bombyx_mori]

Location

Bomo_Chr23(-):9471330-9479303      View in EpiBrowser

Full name

Epoxide hydrolase       + More
Juvenile hormone epoxide hydrolase      
Glutathione peroxidase      
Juvenile hormone epoxide hydrolase 2      
Juvenile hormone epoxide hydrolase 1      

Alternative Name

Juvenile hormone-specific epoxide hydrolase
CfEH2
Juvenile hormone epoxide hydrolase II
Juvenile hormone-specific epoxide hydrolase II
CfEH1
Juvenile hormone epoxide hydrolase I
Juvenile hormone-specific epoxide hydrolase I

Location in the cell

PlasmaMembrane   Reliability : 1.354

CDS

ATGATACCAACACTTATAGCGACGTTCGGTTTAGCATCGGGTTTGGCAATTACATATTACTTATTTAAGTCGCCGAACCCACCAGAATTAGATCTCCAAAAATGGTGGGGCAGTGGATCTCCTGTTGCAGTAGTAGACACATCTATTAGACCCTTCAAAATTGAATTTAATTATACGATGATTAAAGACTTAAAAGAGAGATTGCATAATCGTCGAACATTTACAAAACCGCTTCAAGGTATCCAATCTGAATACGGTATTAATACCATCTATTTGGAAACGGTCCTCGATTATTGGGTTGAAGATTACGACTTTAAAAAAAGAGCGGACCTATTGAATATGTTTCCCCATTACAAAACAAATATTCAAGGGCTCGACATTCATTTCATCAGAGTAAAGCCCGACGTGGAGGATGTCGAGGTTCTGCCGCTTTTGATGTTGCACGGATGGCCTAGTTCTTCGAAAGAGTTCGACAAAGTTATACCAATGCTGACGAGGCCTAGAGTAGGCTATAATTTTGTTTTCGAAGTAATCGCCGCCGATTTACCTGGTTACGGATTTTCTGAAGGTACGAACAAACCCGGTCTCAATCCAGTTCAAATTGGTGTAATAATGCGAAATTTAATGATGCGGCTAGGCTTCGAAAAGTTCTACATTCAGGCTGGAGACTGGGGTTCGCAATGCGCAACGCATATGGCCACCTTGTTCCCTGAACAAGTCCTAGGATTGCACACAAACATGCCACTGTCATCGAAGCCAGTTAGTACGTTAAAATTAATATTAGGCGCTTTAGTACCAAGATTAGCCGTCGACCGGAAGTATGCTGACAGAATATATCCATTAAAAAATCTTTTCTCGTATTTGCTCAGAGAAAGTGGATATTTTCATATTCAAGCTACGAAACCAGATACGATTGGGGTGGCACTAACGGATTCGCCGTCAGGTTTAGCAGCGTATATAATTGAAAAGATGGCCATTTGCAGCAGTAGAATAGAACTCGACACGCCACACGGAGGCCTTCAACATTTAGACTTGGACGACGTTTTGGATACAGTCACTATAACGTGGATGAACAATTGCATTGTTACATCCATGAGACTGTATGCAGAAGGATTCGCACTGCCCGAAGTGCAGACAGTTCATGACATACCGACCTACGTACCTACTGCTGCAATAAACTTCTTATACGAAGTTATTTACCAACCGGACTGGATTCTGAGGGACAAATTCAAGAACTTGGTTAGGTCAACCGTTATAGAATCGGGAGGGCATTTCGCCGCCATGCAGACACCCAACTTGCTGACCGACGACATTTTCGATTCCGCTGTGGAATTCTTGAAGTTTCACGAGAAAAACAAACGAATTCGAGACCAAAATTATTAG

Protein

MIPTLIATFGLASGLAITYYLFKSPNPPELDLQKWWGSGSPVAVVDTSIRPFKIEFNYTMIKDLKERLHNRRTFTKPLQGIQSEYGINTIYLETVLDYWVEDYDFKKRADLLNMFPHYKTNIQGLDIHFIRVKPDVEDVEVLPLLMLHGWPSSSKEFDKVIPMLTRPRVGYNFVFEVIAADLPGYGFSEGTNKPGLNPVQIGVIMRNLMMRLGFEKFYIQAGDWGSQCATHMATLFPEQVLGLHTNMPLSSKPVSTLKLILGALVPRLAVDRKYADRIYPLKNLFSYLLRESGYFHIQATKPDTIGVALTDSPSGLAAYIIEKMAICSSRIELDTPHGGLQHLDLDDVLDTVTITWMNNCIVTSMRLYAEGFALPEVQTVHDIPTYVPTAAINFLYEVIYQPDWILRDKFKNLVRSTVIESGGHFAAMQTPNLLTDDIFDSAVEFLKFHEKNKRIRDQNY

Description

Catalyzes juvenile hormone hydrolysis.
Catalyzes juvenile hormone hydrolysis. Degrades juvenile hormone III (JH III) about 3 times and 5 times slower than juvenile hormone I (JH I) and II (JH II), respectively. Degrades cis-stilbene oxide and trans-stilbene oxide about 18 and 43 times slower than JH III, respectively.

Catalytic Activity

1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol
cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin

Biophysicochemical Properties

0.52 uM for juvenile hormone III

Subunit

Homodimer.

Similarity

Belongs to the peptidase S33 family.
Belongs to the glutathione peroxidase family.

Keywords

Aromatic hydrocarbons catabolism   Direct protein sequencing   Endoplasmic reticulum   Hydrolase   Membrane   Microsome   Transmembrane   Transmembrane helix   3D-structure   Complete proteome   Reference proteome  

Feature

chain  Juvenile hormone epoxide hydrolase

Uniprot

C6KWM5   H9JPL3   Q25489   A0A2A4JGM0   A0A2W1BA00   A0A346LWB4   + More
A0A1Z2RRH4   A0A2H1VIT3   A0A212EN45   A0A0N0PAA2   A0A194RRC7   A0A2W1B2C5   A0A194Q5D4   Q1W696   O44124   A0A194PZ48   A0A0N1IBG8   A0A2A4K9D8   L7R9X8   A0A3S2LEJ8   A0A2W1BCV7   A0A0N1IIM0   A0A0T6BH94   A0A194PZ55   A0A194PZ44   A0A212F9W9   Q8MZR5   A0A3S2NYE4   Q8MZR6   A0A2A4JKY8   A0A088M9L0   D4Q9H4   H9JWL6   Q94806   A0A2J7PHG7   A0A0N0PEI4   D6WGJ2   A0A2W1B6Y8   Q6U6J0   A0A2H1VS44   D0W012   C0KH33   A0A1Y1K345   A0A0N0PD06   A0A194PZZ0   A0A067QLM6   A0A2C9DK11   A0A0P0ELB6   A0A195DS73   A0A1V0M8A5   A0A1Y1K079   A0A3S2P9A9   A0A2A4K8F5   A0A0T6B3Y6   A0A0N1ICQ7   R4G4K1   A0A0L7QRY7   A0A1W5KJY8   A0A194Q0T4   U5EUG0   A0A087ZVE8   A0A3G6VF49   V5G055   A0A0V0G516   A0A1S4EFE4   A0A2A3E8M7   A0A0F6SIA8   A0A224XNL2   A0A0T6BDK1   F4WV40   A0A151I9X6   A0A310SIX1   A0A1W4XE43   A0A2A4J6Z6   A0A2W1B693   A0A069DUW8   A0A3S2NQU9   C6KWM7   H9JWT0   B3U0E6   A0A151WUE8   A0A154PRH0   A0A1I8JUR7   D0W015   A0A212F9X4   A0A0T6BDP9   A0A2M3Z944   E2A3G1   K7IW06   A0A182USI7   I4DKH4   A0A2C9GS53   A0A182ME36   A0A1B6CXB2   A0A182KYJ1   A0A2M3ZA99   A0A084VCN8   Q7Q8D4   A0A195EXA2   A0A182QWG9  

EC Number

3.3.2.9

Pubmed

20622465    19121390    8645304    28756777    28605547    22118469    + More
26354079    23276675    12125060    26385554    9927177    18362917    19820115    15681225    25143157    28004739    24845553    28536442    26445454    28349297    21719571    26334808    18579785    20075255    20798317    22651552    20966253    24438588    12364791    14747013    17210077   

EMBL

AB293554    BAH97088.1    BABH01015301    U46682    NWSH01001648    PCG70570.1    + More
KZ150192    PZC72389.1    MF996338    AXQ01059.1    KY938806    ASA46447.1    ODYU01002601    SOQ40322.1    AGBW02013730    OWR42903.1    KQ459037    KPJ04294.1    KQ459833    KPJ19860.1    KZ150418    PZC70942.1    KQ459583    KPI98605.1    DQ431847    ABD85119.1    AF035482    AAB88192.1    KPI98607.1    KQ459630    KPJ20526.1    NWSH01000031    PCG80508.1    JX681816    AGC00788.1    RSAL01000177    RVE45005.1    KZ150476    PZC70740.1    KQ459764    KPJ20091.1    LJIG01000290    KRT86650.1    KPI98601.1    KPI98602.1    AGBW02009550    OWR50536.1    AF503909    AAM22695.1    RSAL01000025    RVE52162.1    AF503908    AAM22694.1    NWSH01001212    PCG72103.1    KJ579233    AIN34709.1    AB299279    BAI94514.1    BABH01018379    U73680    AAB18243.1    NEVH01025136    PNF15772.1    KPJ20089.1    KQ971321    EFA00568.1    PZC70941.1    AY377854    AB362775    AAQ87024.1    BAF81491.1    ODYU01004100    SOQ43618.1    AB534186    BAI49687.1    FJ602793    ACM78602.2    GEZM01096422    JAV54921.1    KQ460417    KPJ14867.1    KPI98603.1    KK853182    KDR10172.1    KX855995    ARE68677.1    KT261710    ALJ30250.1    KQ980530    KYN15652.1    KU755500    ARD71210.1    GEZM01096421    JAV54922.1    RVE45007.1    PCG80507.1    LJIG01009934    KRT82088.1    KPJ20092.1    ACPB03008739    GAHY01001290    JAA76220.1    KQ414766    KOC61382.1    KU941586    AMR44689.1    KPI98604.1    GANO01002338    JAB57533.1    MH932586    AZB52850.1    GALX01005126    JAB63340.1    GECL01002991    JAP03133.1    KZ288345    PBC27632.1    KP271046    AKF11871.1    GFTR01006406    JAW10020.1    LJIG01001532    KRT85408.1    GL888384    EGI61928.1    KQ978260    KYM95872.1    KQ762207    OAD56030.1    NWSH01002656    PCG67731.1    KZ150284    PZC70943.1    PZC71622.1    GBGD01001402    JAC87487.1    RSAL01000008    RVE53920.1    AB293556    BAH97090.1    BABH01018608    EU441215    ACC55233.1    KQ982745    KYQ51387.1    KQ435007    KZC13710.1    AB534189    BAI49690.1    OWR50537.1    LJIG01001533    KRT85407.1    GGFM01004306    MBW25057.1    GL436428    EFN72025.1    AK401792    BAM18414.1    APCN01000682    AXCM01002766    GEDC01019435    GEDC01007715    JAS17863.1    JAS29583.1    GGFM01004705    MBW25456.1    ATLV01010838    KE524620    KFB35732.1    AAAB01008944    EAA10122.2    KQ981953    KYN32509.1    AXCN02002199   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000053240    UP000283053    + More
UP000235965    UP000007266    UP000027135    UP000078492    UP000015103    UP000053825    UP000005203    UP000079169    UP000242457    UP000007755    UP000078542    UP000192223    UP000002358    UP000075809    UP000076502    UP000075900    UP000000311    UP000075903    UP000075840    UP000075883    UP000075882    UP000030765    UP000007062    UP000078541    UP000075886   

PRIDE

C6KWM5    H9JPL3    D4Q9H4    H9JWL6    Q6U6J0    A0A087ZVE8    + More
C6KWM7    H9JWT0   

Pfam

PF06441   EHN        + More
PF00255   GSHPx
PF14529   Exo_endo_phos_2
PF00078   RVT_1

Interpro

IPR016292   Epoxide_hydrolase        + More
IPR010497   Epoxide_hydro_N       
IPR029058   AB_hydrolase       
IPR000639   Epox_hydrolase-like       
IPR036249   Thioredoxin-like_sf       
IPR000889   Glutathione_peroxidase       
IPR029760   GPX_CS       
IPR029759   GPX_AS       
IPR005135   Endo/exonuclease/phosphatase       
IPR036691   Endo/exonu/phosph_ase_sf       
IPR000477   RT_dom       

SUPFAM

SSF53474   SSF53474        + More
SSF52833   SSF52833       
SSF56219   SSF56219       

Gene 3D

3.40.50.1820     3.60.10.10    

CDD

cd00340  GSH_Peroxidase

ProteinModelPortal

C6KWM5   H9JPL3   Q25489   A0A2A4JGM0   A0A2W1BA00   A0A346LWB4   + More
A0A1Z2RRH4   A0A2H1VIT3   A0A212EN45   A0A0N0PAA2   A0A194RRC7   A0A2W1B2C5   A0A194Q5D4   Q1W696   O44124   A0A194PZ48   A0A0N1IBG8   A0A2A4K9D8   L7R9X8   A0A3S2LEJ8   A0A2W1BCV7   A0A0N1IIM0   A0A0T6BH94   A0A194PZ55   A0A194PZ44   A0A212F9W9   Q8MZR5   A0A3S2NYE4   Q8MZR6   A0A2A4JKY8   A0A088M9L0   D4Q9H4   H9JWL6   Q94806   A0A2J7PHG7   A0A0N0PEI4   D6WGJ2   A0A2W1B6Y8   Q6U6J0   A0A2H1VS44   D0W012   C0KH33   A0A1Y1K345   A0A0N0PD06   A0A194PZZ0   A0A067QLM6   A0A2C9DK11   A0A0P0ELB6   A0A195DS73   A0A1V0M8A5   A0A1Y1K079   A0A3S2P9A9   A0A2A4K8F5   A0A0T6B3Y6   A0A0N1ICQ7   R4G4K1   A0A0L7QRY7   A0A1W5KJY8   A0A194Q0T4   U5EUG0   A0A087ZVE8   A0A3G6VF49   V5G055   A0A0V0G516   A0A1S4EFE4   A0A2A3E8M7   A0A0F6SIA8   A0A224XNL2   A0A0T6BDK1   F4WV40   A0A151I9X6   A0A310SIX1   A0A1W4XE43   A0A2A4J6Z6   A0A2W1B693   A0A069DUW8   A0A3S2NQU9   C6KWM7   H9JWT0   B3U0E6   A0A151WUE8   A0A154PRH0   A0A1I8JUR7   D0W015   A0A212F9X4   A0A0T6BDP9   A0A2M3Z944   E2A3G1   K7IW06   A0A182USI7   I4DKH4   A0A2C9GS53   A0A182ME36   A0A1B6CXB2   A0A182KYJ1   A0A2M3ZA99   A0A084VCN8   Q7Q8D4   A0A195EXA2   A0A182QWG9  

PDB

4QLA     E-value=1.81768e-110,     Score=1021

KEGG

100307008    K10719 juvenile hormone epoxide hydrolase | (RefSeq) Jheh-lp1; juvenile hormone epoxide hydrolase-li

PATHWAY

00981    Insect hormone biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0019439   GO:0033961   GO:0005789   GO:0016021   GO:0016787   GO:0004602   GO:0006979   GO:0004601   GO:0016740   GO:0003824   GO:0006396   GO:0005515   GO:0016891   GO:0003677   GO:0005524   GO:0004713   GO:0016491   GO:0015930  

Subcellular location

Endoplasmic reticulum membrane  
Microsome membrane  

Length:

460

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

7.94578999999997

Exp number, first 60 AAs:

7.87467

Total prob of N-in:

0.41538

outside

1  -  460

 

 

Pi

213.146378

Theta

165.056054

Tajima's D

0.917046

CLR

0.082082

CSRT

0.635018249087546

Interpretation

Uncertain