Gene

KWMTBOMO13774  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA006641

Annotation

ras-related_GTP-binding_protein_4b_[Bombyx_mori]

Location

Bomo_Chr23(+):8895233-8896272      View in EpiBrowser

Full name

Dihydroorotate dehydrogenase (quinone), mitochondrial      

Location in the cell

Mitochondrial   Reliability : 1.295

CDS

ATGTCTGAATCGTACGAATATCTTTTCAAATTTCTTGTGATTGGAAGTGCAGGCACAGGAAAGTCAAGCTTACTAAATAATTTTATCGGAAATAAATTCAAGGAAGATCGATGTCACACTATTGGTGTTGAATTTGGTTCCAAAATTGTGAACATCGGTGGCAAATCAACTAAGTTGCAAATATGGGACACAGCTGGACAGGAACGGTTTCGATCTGTGACCAGATCATATTACCGCGGCGCAGCAGGAGCTCTGCTAGTGTATGATATTACATCTAGAGATTCATTCAATGCTCTTGCTAATTGGCTGAGAGATGCTCGCACTCTTGCAAGTCCTAATATCGTAATTTTGCTTGTGGGCAACAAGAAAGACTTAGAAGATTCCAGAGAAGTAACTTTTACTGAGGCAAGTCAGTTTGCTCTTGAAAATGAATTAATGTTTTTAGAAACAAGTGCTAAAACAGGAGAAAATGTTGAAGAAGCTTTTCTGAAATGCTCGAAAACAATTCTAGCTAAGATTGAAACTGGTGAATTGGATCCTGAAAGGATAGGTTCTGGTATTCAATATGGCACAAATACTACAAAGAGATTGACTGCTCCAAAGAGGCCAGCTAGAACCCCTTCAGAATGTGCTTGCCGTGTTTAA

Protein

MSESYEYLFKFLVIGSAGTGKSSLLNNFIGNKFKEDRCHTIGVEFGSKIVNIGGKSTKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRDSFNALANWLRDARTLASPNIVILLVGNKKDLEDSREVTFTEASQFALENELMFLETSAKTGENVEEAFLKCSKTILAKIETGELDPERIGSGIQYGTNTTKRLTAPKRPARTPSECACRV

Catalytic Activity

(S)-dihydroorotate + a quinone = a quinol + orotate

Cofactor

FMN

Similarity

Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

Uniprot

Q2F5W7   A0A2A4JRQ9   I3PL64   A0A2W1BEG0   A0A194RPR2   A0A212FE69   + More
A0A0K8TNV1   V5HWI8   A0A0A1WR81   A0A0K8UXV9   A0A034W9F3   A0A1I8Q9L5   G3MNH8   W8BND9   B4MIR7   A0A0N0P9Y4   A0A1B0GIN8   A0A1L8DV24   A0A1B0DL31   A0A0L0CH89   A0A224Z5J1   A0A131YU67   L7M4Y9   A0A131XET0   T1PG75   A0A067R2L0   A0A0M4EBT2   B4J4B2   A0A1W4VD77   A0A3B0JW07   Q291A4   B4GAZ9   B4P5E4   B3MIH3   B4HMX3   B3NMJ8   B4QBA1   Q7KY04   A0A2H1VTV9   B4KM01   B5RJE3   B4LIJ3   D3TP13   A0A1A9XWU7   A0A1A9VGP9   A0A1B0BAZ9   A0A1A9ZWT9   A0A087TB09   B7Q2W4   A0A2P8XX71   A0A0L7LJ17   A0A2R5LNQ3   A0A1Z5KYH7   A0A293LIE1   A0A1E1X5X4   A0A023FFP5   A0A1B6BX20   R7VCQ9   A0A0P4WC93   Q16SZ9   H9GK45   A0A3B4BXK3   W5NCH5   W5LM81   A0A182JLU4   A0A2J7PNS5   U5EJ77   A0A182Y5G8   A0A182UWJ2   A0A182U4A5   A0A182L773   A0A182XG84   Q7QB34   A0A182IDC9   A0A1Q3FDX9   G1K2H7   A0A151PE10   A0A182R0M6   W4YGM6   A0A182LV58   A0A1W5A2T8   A0A210PPX6   A0A182RZJ2   B0WU66   A0A182F7T8   G3TWS7   A0A2Y9ECN0   A0A023EMC6   A0A182NLF8   W5JLQ1   E3TEK2   A0A1B6MQC3   A0A2M4ACH7   A0A2M4BZ25   T1E7B2   A0A2M3Z7X2   H2U0D4   A0A182PLV9   G1U1H3   H3CQN7  

EC Number

1.3.5.2

Pubmed

19121390    28756777    26354079    22118469    26369729    25765539    + More
25830018    25348373    22216098    24495485    17994087    26108605    28797301    26830274    25576852    28049606    25315136    24845553    15632085    17550304    22936249    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    20353571    29403074    26227816    28528879    28503490    23254933    17510324    21881562    25329095    25244985    20966253    12364791    14747013    17210077    23594743    22293439    28812685    24945155    20920257    23761445    20634964    21551351    21993624    15496914   

EMBL

BABH01008418    DQ311306    ABD36250.1    NWSH01000798    PCG74153.1    JN634855    + More
AFA36651.1    KZ150160    PZC72721.1    KQ459833    KPJ19843.1    AGBW02008970    OWR52032.1    GDAI01001559    JAI16044.1    GANP01005645    JAB78823.1    GBXI01013141    JAD01151.1    GDHF01020951    GDHF01003666    JAI31363.1    JAI48648.1    GAKP01008001    GAKP01008000    JAC50952.1    JO843429    AEO35046.1    GAMC01006218    JAC00338.1    CH963719    EDW72006.1    KQ459037    KPJ04276.1    AJWK01015122    AJWK01015123    GFDF01003797    JAV10287.1    AJVK01069137    JRES01000408    KNC31615.1    GFPF01011215    MAA22361.1    GEDV01005784    JAP82773.1    GACK01005959    JAA59075.1    GEFH01003991    JAP64590.1    KA647684    AFP62313.1    KK852747    KDR17258.1    CP012524    ALC41052.1    CH916367    EDW00592.1    OUUW01000001    SPP75258.1    CM000071    EAL25208.2    CH479181    EDW32101.1    CM000158    EDW91775.1    CH902619    EDV37021.1    CH480816    EDW48323.1    CH954179    EDV54937.1    CM000362    CM002911    EDX07525.1    KMY94628.1    AE013599    AB035670    AAF57831.1    AAM68480.1    BAA88243.1    ODYU01004426    SOQ44281.1    CH933808    EDW10790.1    BT044417    ACH92482.1    CH940648    EDW60363.1    EZ423165    ADD19441.1    JXJN01011233    KK114378    KFM62298.1    ABJB010347534    ABJB010524691    ABJB010757334    DS846142    EEC13186.1    PYGN01001224    PSN36514.1    JTDY01000888    KOB75553.1    GGLE01007040    MBY11166.1    GFJQ02006793    JAW00177.1    GFWV01003544    GFWV01023018    MAA28274.1    GFAC01004519    JAT94669.1    GBBK01003681    JAC20801.1    GEDC01031748    JAS05550.1    AMQN01004321    KB293181    ELU16342.1    GDRN01074760    GDRN01074759    JAI63177.1    CH477662    EAT37591.1    AHAT01023914    AHAT01023915    NEVH01023316    PNF17978.1    GANO01002339    JAB57532.1    AAAB01008880    EAA08616.2    APCN01005106    GFDL01009316    JAV25729.1    CR384088    AKHW03000482    KYO47164.1    AXCN02000134    AAGJ04037203    AXCM01006741    NEDP02005562    OWF38555.1    DS232101    EDS34786.1    GAPW01004134    JAC09464.1    ADMH02000787    ETN65056.1    GU588784    ADO28738.1    GEBQ01001878    JAT38099.1    GGFK01005162    MBW38483.1    GGFJ01009113    MBW58254.1    GAMD01003192    JAA98398.1    GGFM01003866    MBW24617.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000095300    UP000007798    + More
UP000053268    UP000092461    UP000092462    UP000037069    UP000095301    UP000027135    UP000092553    UP000001070    UP000192221    UP000268350    UP000001819    UP000008744    UP000002282    UP000007801    UP000001292    UP000008711    UP000000304    UP000000803    UP000009192    UP000008792    UP000092443    UP000078200    UP000092460    UP000092445    UP000054359    UP000001555    UP000245037    UP000037510    UP000014760    UP000008820    UP000001646    UP000261440    UP000018468    UP000018467    UP000075880    UP000235965    UP000076408    UP000075903    UP000075902    UP000075882    UP000076407    UP000007062    UP000075840    UP000000437    UP000050525    UP000075886    UP000007110    UP000075883    UP000192224    UP000242188    UP000075900    UP000002320    UP000069272    UP000007646    UP000248480    UP000075884    UP000000673    UP000221080    UP000005226    UP000075885    UP000001811    UP000007303   

PRIDE

Q2F5W7    V5HWI8    G3MNH8    L7M4Y9    Q7KY04    B5RJE3    + More
B7Q2W4   

Pfam

PF00071   Ras        + More
PF01180   DHO_dh
PF18376   MDD_C
PF00288   GHMP_kinases_N

Interpro

IPR027417   P-loop_NTPase        + More
IPR001806   Small_GTPase       
IPR041819   Rab4       
IPR005225   Small_GTP-bd_dom       
IPR013785   Aldolase_TIM       
IPR005719   Dihydroorotate_DH_2       
IPR001295   Dihydroorotate_DH_CS       
IPR005720   Dihydroorotate_DH       
IPR036554   GHMP_kinase_C_sf       
IPR029765   Mev_diP_decarb       
IPR014721   Ribosomal_S5_D2-typ_fold_subgr       
IPR006204   GHMP_kinase_N_dom       
IPR020568   Ribosomal_S5_D2-typ_fold       
IPR041431   Mvd1_C       

SUPFAM

SSF52540   SSF52540        + More
SSF54211   SSF54211       
SSF55060   SSF55060       

Gene 3D

3.20.20.70     3.30.230.10     3.30.70.890    

CDD

cd04113  Rab4
cd04738  DHOD_2_like

ProteinModelPortal

Q2F5W7   A0A2A4JRQ9   I3PL64   A0A2W1BEG0   A0A194RPR2   A0A212FE69   + More
A0A0K8TNV1   V5HWI8   A0A0A1WR81   A0A0K8UXV9   A0A034W9F3   A0A1I8Q9L5   G3MNH8   W8BND9   B4MIR7   A0A0N0P9Y4   A0A1B0GIN8   A0A1L8DV24   A0A1B0DL31   A0A0L0CH89   A0A224Z5J1   A0A131YU67   L7M4Y9   A0A131XET0   T1PG75   A0A067R2L0   A0A0M4EBT2   B4J4B2   A0A1W4VD77   A0A3B0JW07   Q291A4   B4GAZ9   B4P5E4   B3MIH3   B4HMX3   B3NMJ8   B4QBA1   Q7KY04   A0A2H1VTV9   B4KM01   B5RJE3   B4LIJ3   D3TP13   A0A1A9XWU7   A0A1A9VGP9   A0A1B0BAZ9   A0A1A9ZWT9   A0A087TB09   B7Q2W4   A0A2P8XX71   A0A0L7LJ17   A0A2R5LNQ3   A0A1Z5KYH7   A0A293LIE1   A0A1E1X5X4   A0A023FFP5   A0A1B6BX20   R7VCQ9   A0A0P4WC93   Q16SZ9   H9GK45   A0A3B4BXK3   W5NCH5   W5LM81   A0A182JLU4   A0A2J7PNS5   U5EJ77   A0A182Y5G8   A0A182UWJ2   A0A182U4A5   A0A182L773   A0A182XG84   Q7QB34   A0A182IDC9   A0A1Q3FDX9   G1K2H7   A0A151PE10   A0A182R0M6   W4YGM6   A0A182LV58   A0A1W5A2T8   A0A210PPX6   A0A182RZJ2   B0WU66   A0A182F7T8   G3TWS7   A0A2Y9ECN0   A0A023EMC6   A0A182NLF8   W5JLQ1   E3TEK2   A0A1B6MQC3   A0A2M4ACH7   A0A2M4BZ25   T1E7B2   A0A2M3Z7X2   H2U0D4   A0A182PLV9   G1U1H3   H3CQN7  

PDB

2BME     E-value=4.73471e-79,     Score=746

KEGG

692901    K07880 Ras-related protein Rab-4B | (RefSeq) ras-related GTP-binding protein 4b

GO

GO:0003924   GO:0005525   GO:0055037   GO:0045202   GO:0007299   GO:0043025   GO:0006897   GO:0032482   GO:0005768   GO:0016192   GO:0031982   GO:0005886   GO:0004152   GO:0044205   GO:0005743   GO:0006207   GO:0030100   GO:0004767   GO:0006886   GO:0005524   GO:0019287   GO:0005829   GO:0004163   GO:0032593   GO:0007264   GO:0016070   GO:0016620   GO:0005216   GO:0006811   GO:0016787   GO:0003676   GO:0016491   GO:0015930  

Subcellular location

Mitochondrion inner membrane  

Length:

214

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.585819999999999

Exp number, first 60 AAs:

0.576409999999999

Total prob of N-in:

0.06524

outside

1  -  214

 

 

Pi

175.07345

Theta

195.410038

Tajima's D

-0.367249

CLR

87.171285

CSRT

0.271636418179091

Interpretation

Uncertain