Gene

KWMTBOMO13771  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011533

Annotation

PREDICTED:_BRCA1-A_complex_subunit_Abraxas-like_[Plutella_xylostella]

Location

Bomo_Chr23(+):8869443-8871158      View in EpiBrowser

Full name

BRCA1-A complex subunit Abraxas 1      

Alternative Name

Coiled-coil domain-containing protein 98
Protein FAM175A

Location in the cell

Nuclear   Reliability : 1.939

CDS

ATGGCTTACACAGAAAAGGTGTCGCTTAGCGGCACCGCACTGTCATTTTTGTTATATGAATGTGTAAATTCAGGATGCAGTCAGGAAGGTTTTCTAGTTGGAGATATAACATCTCAAATAACCAATCACATATCAGACTCTCAAAGTGATAATGCAAGGCTTGATACTCAAATCGTTATTAGAACTGTATTACCGCTGCCTTCGGTGTCACTTTTCTATTTTCCAACTGGAAGAATAAAAGAAGAAGTGTTGTCTGAATTACTCTCTAATACTGCCAAAGAAATTGTTGGATGGTACAAATATAGAAAGAATACCAACATCAAACCTACATTTCGAGATAAGTTAATTGCAAAAGGTCTACAAAAATACTTTGAAAAATATCATGGGAAGAAAACATTTGTAACTTGCAATCTAACAAACAGAACATCTTCTGCTGCATCAACCCACACATTTACTTACAGATTTGGAAAAATCAATTGTTTTGATATGTATGAATATATTGAAGATGTCACAGGTAATTTAGGTGAAAAAGTAACAGGCTACAAAAGAGCACATCAACTACCAGCAAATTGTGTATTCAATAAAATTGTAAAAGAAACAAATGTTCAGAATACAAACACAACTGAAGCAATACTGAGCATACAAGAAGCAGTTGATGTTAGGTTGATGATGGAAGCAAAAATTGCAGCAAAAAATGAAAGCACAATCAGGGAACTTCAGGCAGAAATAAAACAAATGACTTCTATTTTGACCGACAAACAGTCAGTAGAATTGTATGCTTCATATAGTAAAATGATTGAAGAAGAGACTCAGAGACAGAAAGCTGATATGGTTAAAGCTTGTGCGGAAGCCTTGAAAGCACCACAAAAACTAGATATGATGACCATCAACAATCTCAAAAATATGGCATCGACTAGCGGTCAATCGGCACAAGGAGAAAGTACAGCAGGTGTGGATGATGTTCCCAGTGATCGAAACCCAAGTCCATGCTTAATAACTACAAGTCCAACAAAGCAAATACTCAATTATGCAGCAGCTCTAAAAAATAGAAGTGACATGCCATCAACAAGTAAAGACACTACAATGAGTGAAGACTTAATTACATTTGATGTGGAAGACAGAAGATATATAAAAAAGACTATTGTTTTAAACAATGATGTGAAGTGTTTTGGTGATAGTTCACCAGAGTACTAA

Protein

MAYTEKVSLSGTALSFLLYECVNSGCSQEGFLVGDITSQITNHISDSQSDNARLDTQIVIRTVLPLPSVSLFYFPTGRIKEEVLSELLSNTAKEIVGWYKYRKNTNIKPTFRDKLIAKGLQKYFEKYHGKKTFVTCNLTNRTSSAASTHTFTYRFGKINCFDMYEYIEDVTGNLGEKVTGYKRAHQLPANCVFNKIVKETNVQNTNTTEAILSIQEAVDVRLMMEAKIAAKNESTIRELQAEIKQMTSILTDKQSVELYASYSKMIEEETQRQKADMVKACAEALKAPQKLDMMTINNLKNMASTSGQSAQGESTAGVDDVPSDRNPSPCLITTSPTKQILNYAAALKNRSDMPSTSKDTTMSEDLITFDVEDRRYIKKTIVLNNDVKCFGDSSPEY

Description

Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.

Subunit

Component of the ARISC complex, at least composed of UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. In the complex, interacts directly with UIMC1/RAP80, BRCC3/BRCC36 and BABAM2. Homodimer. Interacts directly (when phosphorylated at Ser-404) with BRCA1. The phosphorylated homodimer can interact directly with two BRCA1 chains, giving rise to a heterotetramer. Binds polyubiquitin.

Similarity

Belongs to the FAM175 family. Abraxas subfamily.

Keywords

Alternative splicing   Chromatin regulator   Coiled coil   Complete proteome   DNA damage   DNA repair   Nucleus   Phosphoprotein   Reference proteome  

Feature

chain  BRCA1-A complex subunit Abraxas 1
splice variant  In isoform 2.

Uniprot

H9JPS8   A0A2W1BG86   A0A2H1VVQ8   A0A2A4JR14   A0A194RQT3   S4PMH9   + More
A0A212FE95   A0A0L7LH05   A0A0L7LL71   A0A195FYK2   A0A151WEZ3   A0A151IW97   A0A158NZG4   F4WLA7   E9J728   A0A2K6LV46   G3QSQ4   K7ARP3   A0A2K6P0J9   Q8BPZ8   U3D986   A0A2A3EER9   A0A2K6P0L9   A0A0P6JTV2  

Pubmed

19121390    28756777    26354079    23622113    22118469    26227816    + More
21347285    21719571    21282665    22398555    25362486    16141072    15489334    21183079    25243066   

EMBL

BABH01015251    KZ150160    PZC72725.1    ODYU01004426    SOQ44284.1    NWSH01000798    + More
PCG74148.1    KQ459833    KPJ19842.1    GAIX01003545    JAA89015.1    AGBW02008970    OWR52028.1    JTDY01001165    KOB74680.1    JTDY01000716    KOB76114.1    KQ981169    KYN45382.1    KQ983238    KYQ46386.1    KQ980868    KYN12095.1    ADTU01004592    ADTU01004593    GL888207    EGI65070.1    GL768421    EFZ11353.1    CABD030031735    CABD030031736    GABC01008894    GABC01008893    GABF01005162    GABF01005161    GABE01008126    GABE01008125    GABE01008124    JAA02445.1    JAA16983.1    JAA36613.1    AK014420    AK042001    AK042339    AK051816    AK167540    BC029845    GAMT01005561    JAB06300.1    KZ288266    PBC30283.1    GEBF01006407    JAN97225.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000007151    UP000037510    UP000078541    + More
UP000075809    UP000078492    UP000005205    UP000007755    UP000233180    UP000001519    UP000233200    UP000000589    UP000242457   

PRIDE

H9JPS8    Q8BPZ8   

Interpro

IPR023238   FAM175        + More
IPR037518   MPN       
IPR023239   FAM175_Abraxas1       

ProteinModelPortal

H9JPS8   A0A2W1BG86   A0A2H1VVQ8   A0A2A4JR14   A0A194RQT3   S4PMH9   + More
A0A212FE95   A0A0L7LH05   A0A0L7LL71   A0A195FYK2   A0A151WEZ3   A0A151IW97   A0A158NZG4   F4WLA7   E9J728   A0A2K6LV46   G3QSQ4   K7ARP3   A0A2K6P0J9   Q8BPZ8   U3D986   A0A2A3EER9   A0A2K6P0L9   A0A0P6JTV2  

PDB

5CW5     E-value=7.81558e-18,     Score=222

KEGG

101744911    K20774 BRCA1-A complex subunit Abraxas | (RefSeq) BRCA1-A complex subunit Abraxas-like

PATHWAY

03440    Homologous recombination - Bombyx mori (domestic silkworm)

GO

GO:0045739   GO:0016604   GO:0010212   GO:0072425   GO:0031593   GO:0006302   GO:0070531   GO:0005634   GO:0006325  

PANTHER

PTHR31728  

Subcellular location

Nucleus   Localizes at sites of DNA damage at double-strand breaks (DSBs).   With evidence from 2 publications.

Length:

397

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.23205

Exp number, first 60 AAs:

0.07316

Total prob of N-in:

0.02086

outside

1  -  397

 

 

Pi

218.214639

Theta

226.797696

Tajima's D

0.066976

CLR

105.96134

CSRT

0.389280535973201

Interpretation

Uncertain