Gene

KWMTBOMO13765  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011482

Annotation

PREDICTED:_protein_unc-13_homolog_D_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr23(-):8737199-8765672      View in EpiBrowser

Full name

Protein unc-13 homolog 4B      

Alternative Name

Protein Staccato

Location in the cell

Cytoplasmic   Reliability : 2.654

CDS

ATGTACATAAATCAATGCAGACGTTTGCATTTATTGAGGAATCAAGCCTATGTGAACGGAGAATGGGTTAAGGCAAAAAGTAATTTGGTGTTTGCAGTTCATAATCCAGCTGACGACAGTGTAGTAGCAGAGGTGCCGGATATGGATTCAAAAGATGCACAGAACGCGTTACTAACCGCATCTAATGCGTTTCAAACATGGAAAGATACTACCGCAAAAGAACGGTCTCGTATTTTAAGGAGGTGGTTTGACTTATGTGAAAAAAATACCGATAATTTGGCAGAAGTGATAACAGCTGAATCTGGGAAACCACTCGCTGAGGCCAAAGGGGAAGTTGCTTATGGTAATTCGTTCCTGGAGTGGTTTGCGGATAGTGCTCGTCATATTAATGGAGAAATCATACCGAGCCCATGGCCGAATAAGCAGATACTTCTCACACGAAACCCTCTTGGAGTTGTTTCTGTAATTACTCCCTGGAACTTCCCCTTTGCAATGATAACTAGAAAAGTTGGGGCTTTAATGGCAGCTGGGTGTACCTGTGTCATTAAGCCTTCTGAAGACACACCATTATCTGCACTTGCAGCTGTTGAATTGGCTCATCAAGCTGGAGTTCCTAAAGGTGTAGTTAATGTTGTTACGACAAGTAGAAAAAATGCTCCTACAGTTGGAAAAGTCATGTGTGAAGATGAATATGTGAGGTGCATATCATTTACAGGTTCCACAACTGTAGGAAAAATTTTATATGGACTTGCAGCCAAAGGCATTAAAAGAGTTGCTTTGGAATTGGGAGGCAACGCTCCATTCATTGTTTTCCCAAGTGCTGATATTGATCATGCTGTTGATCAAGCAATGCTGGCTAAATTTAGAAATAATGGCCAAGCTTGTATTGGAGCAAATAGGTTTTTGATACATGAGATAGTATTTGATGACTTTGTTAAAAAGTTTAAGGCCAGAATTGAAAAAAAATGTGTATTAGGACCTGGTACAAAGGAAGGTGTCACTTGTGGACCACTTATAAATAATGAGCAAGCCAAGAAAGTATCCGGACTTGTTGATGATGCTGTTGCAAAAGGTGCCAAGGTGCTTTCAGGAGGGAAATTTGCAAAGAATCTGGGGAATAAGTTTTATGAATCCACTTTACTTGTTGATGTTAACCAGGATATGCAAATATTTAAAGAAGAAGTGTTTGGCCCAGTAGCTACTTGTATAAAAATGAAGAGTGAAGAGGAGGCATTAAAAATGGCCAATAGCACAAGAAGTGGATTAGCTGCTTACATTTTCACGAAAGATTTAGGTCAAGCATTTAGAATGTCTAAGAATCTTGAATTTGGCATGGTTGCTATAAATGATGGGATTTTGTCTGCAGCAGAACCAGCATTTGGAGGTGTTAAAGAGTCTGGTATAGGGCGTGAAGGCAGCCTCCATGGTGCAGTGGAGTATACTGATTTAAAGTACACACTAATAATACAAGAAGTCGATGACAGCTTTTTCGAGAAATTCGGCTCAATACTGAAACAGGCATCCCAGAGAGCTGCTCTAGAAGAATCTACGCCTTTGGCTCCTCTCAAAGAAATTGAAGAGGACGATAACGAGCAGAAGATCGGAGCAGAATTACGAAGCGAGCTTAGAACTGTAACCAGAGACACAGACAGTGGCAACGAGACATTATTGGACACAGATTCTGAACCTGATGAACATGATAAGATAGGACGGATAATCGAGGCAGTTGGCTGGAATATTGATGAACTATACTTGGAAATACTTTACGAGATCCTACACAATGTCGGGGGATGTGATGTAGGCTGTGAAGTCGGACAGCACGCGATGCTATCATACGTGCAAGAAGCATTTAAAATAGGCAATGATAAACACACGCAACTTCTTACCAAAGCGGAGGCTAAAGAGCCTCCGGAGTTGATGCTGAATGTCGAGGTGGTCGAAGCCAAAGATTTAGTTCCTAAAGACCCGAATGGTCTCAGCGATCCATTCGTTACGATTTATTTGATGTCGAACTCGTCACACCGGTACAACACATCGGTGAAGTCGGGAACTCTAAATCCTGTTTGGGAAGAACATTTTTCTTTACCCATGTCTGGCACTGTGAATGAAGATTCCCTTTGCTTAGAAGTGTGGGACTTCGATCCAGCAGAGACGGTCAAAGAGAAGATGACGAAAATATTTGATGTGAAGGGCGTGAAAGGTCTCCGTAAACTGGTCAAGGAGATCGCGATTACAGCCTCAACCGGAAAACATGACAACGAACTGATTGGAACATCTAATATACCACTCAAGTCCATTCCAGCCGGCGGTATGGCCATGTGGTTCAGTTTGAGCAAGAAGAGTAAGCTGCGTCGTCAGGGCGTCGTCAAAGTGCGGCTCAACTTTTCCTCGGAAAAGAATAATCAAGTGGCGGCACAGGAACATCGGCATTTGTTAAGGATCGTTCTGTTGCACGAACTTGAAAATTCAAAGGTGGCCCCGTATTGGTGGTGTGGAAACTTCAGCGCTCCAGCCGAAGCGATCCTCACTCAGCACGTGGCGCAGAGCGGCCTCTCGCAGCTCGACAACAGCCTCGTGCAGTGGTCCGTCTACTGCGCCGTGACACCCGACCATCCCTTAAGCTTCAACCTCTTCAACACGCTTCTGGATAAACTAACTAAACCATTGCAATCAAGTCTCGTTATAGAAGAGGATGTCAAGTTGTTCTGGGATGGCGCAAGAAAATTACTACCCACGTGTTATAGTCACATTAGAAAATTAAGAAAGAAGACAGCCGGTGATAAAACCGTTATGAAAACTCTTAGAGAAGTCCTTAAAATACTATACAAACTATCTATATTGGATGTTCCGGAGTGTATAGATTTGTTCCCTAAGACTTCTTATGGTTGGCTGAGAGATGACGCTGGGAAACTTAACGTGTACGAAGTATTGAATCAAGCAGTGATACAGGGCGCCTCCGACTGGTTCGTTCATATATTAGACAATAATGAATGCAAGGATAACACTGAAGAATCGCGTCTGCAGCATTTGATCAGGGTCATCCAGCTCGTGAGGTCCGATTTGCAAAGAGCTGTGGAATATTACGACAGAGTTTTCATAGAGGTTATGAGTTTTCCATACACGAAGGCCCTCTATGGTCTGTACGAGAGCAAGATAGCCTCGTTAGTCGAACCTGAGGTTATAGAAGTGTGCAAATGCCTTAAGAGGCTCCAATATAACGAGGGTTCCACTACAACCGTTCATTTGGCTGGAGGCATTGCCGGAGTTACAGGACTGGGTGCTCCGGAAGTGGCCAATGAACCTTTGTCTATGGGGACCACACTGTTTGAGCTATATTTGGCTTTACAGAGGTTTTTGCTGTTAGGCCAGGGCTTGAATGAGACTGAATGGAGTTCCTATGCGATATCTAAATTCCACGGATGGTTTTTCGGCGGTGTCGCCCAGTGGCTGGACATAGCGGCTTTCAAAGCTCTAACACGTATAGAAAAGGCAGTCGACTTAGACAATTTAGTTCCGGTCGACACTAACGTGAAGTACAGCAGTTCCGGAGTCGACACTCTCGCTATATTTTATCAGATTAAAATATTCTGGCAACAATTAGCGTGGCCTGACGTTGAAGGATGTTACACGTTCGTCGCTAAGATAATTGACGACATTTGTCGTTGTTGCGTATTCTATTCGGATAAAATGGCGAATAGAGTAGACAGTGTCGGGACTGTGACGACAGTGTATGAAGAGAGATTCGAGGTTACAACAGAATGGTGTGTCGCCATCAACAACATAGATTACGTTAGGCAAAGCTTGGAGCCATTCGTCGAGGAGCTGGGTATGGACGATATCATACAGAAGATGTGCGAAGCTAGATCGCCAATTGAAGCTCAAAGATGTAAAGAGACTCTACAAAACGTTATTGCCAATGCAATAGACACAGTTAAAAACAAAATCGTCGATCTCTTAGAGGTCATGATCAAAAAGATGATGCCATCCATTACCCGGTTCTTAGTGGAAGGTGCCGAACTACTACATCAAGACTGTTCAAGCATGGATCGCGTTATGCGATACCTAGAGGCGAATCTCGATACATTGTACCAGCATTTGAACAACGAAAACTTTTCTAGAACTCTAGATATCGTTTGGGAACAACTCGGAGAAGTCTTGTATGAATTGATACAAGCTAACTTAGAACACCGAAGGGCAAAGATAACTCGATTTATCGACCCGAGACGCTTGAGCAAATCGGCAGCCGCCCAGTTAGACGCGAAACGTCGTCCGCCATCTTTCTTTTCGAATCTCCACGAATGTTTGAAGATAATGATACGATCGTTTCGTCAAGACAACAAAGAGATGTACTCCTCGGATACCCTGAAACGCGTGGAGTATTTACTTAAATTACACGGTATGGAAACGAGGGAGCTAATTCACGAGTATCACCTTGGGAGGTGGCAAGAACAACAGTCTATTGTTGAACCGAAAATGGGTATTTTGACAGTCCGAGCTCAGTTCATCGATGACAATTTGAAAATCGAAGTCATGAACGCTAGAAACCTTGTGGCCACTGATTCGAATGGGTTGTGTGATTCGTATGTGCGTGTGGCACTGCTACCCGAAGATTCCTTCGCGAATGTTGTAAAACCAAAAACGCAGACGCACAGTAAGAATCTGTTCCCGTTGTACGATGAAATGTTTCTCATTCCTCTGAGTCCGGAGCAGCGTGGCATCGCCGACGGACTGTTGCATTTCGTTGTCAAGGACAAGGATATGTTCAGTGTGAGCAACACGTTTGTGGGGGAGGCGTATCTACACTTCAGCGAGATACCGGACACGCCCGCGCCCATCGGAAGCCTGCCGCAACAACATCTGCCTTTATCCAAACCCAACACTGTCGATGGCGATGCGATCAAGGCTTTGGACTCGCGACAGGGAGACAGGCAAGCTCGAGATTTCATCAAAAAACAAAGACAGAAAATGCCGAGCAAGCAATTCTTTTCGTTAGGTTAA

Protein

MYINQCRRLHLLRNQAYVNGEWVKAKSNLVFAVHNPADDSVVAEVPDMDSKDAQNALLTASNAFQTWKDTTAKERSRILRRWFDLCEKNTDNLAEVITAESGKPLAEAKGEVAYGNSFLEWFADSARHINGEIIPSPWPNKQILLTRNPLGVVSVITPWNFPFAMITRKVGALMAAGCTCVIKPSEDTPLSALAAVELAHQAGVPKGVVNVVTTSRKNAPTVGKVMCEDEYVRCISFTGSTTVGKILYGLAAKGIKRVALELGGNAPFIVFPSADIDHAVDQAMLAKFRNNGQACIGANRFLIHEIVFDDFVKKFKARIEKKCVLGPGTKEGVTCGPLINNEQAKKVSGLVDDAVAKGAKVLSGGKFAKNLGNKFYESTLLVDVNQDMQIFKEEVFGPVATCIKMKSEEEALKMANSTRSGLAAYIFTKDLGQAFRMSKNLEFGMVAINDGILSAAEPAFGGVKESGIGREGSLHGAVEYTDLKYTLIIQEVDDSFFEKFGSILKQASQRAALEESTPLAPLKEIEEDDNEQKIGAELRSELRTVTRDTDSGNETLLDTDSEPDEHDKIGRIIEAVGWNIDELYLEILYEILHNVGGCDVGCEVGQHAMLSYVQEAFKIGNDKHTQLLTKAEAKEPPELMLNVEVVEAKDLVPKDPNGLSDPFVTIYLMSNSSHRYNTSVKSGTLNPVWEEHFSLPMSGTVNEDSLCLEVWDFDPAETVKEKMTKIFDVKGVKGLRKLVKEIAITASTGKHDNELIGTSNIPLKSIPAGGMAMWFSLSKKSKLRRQGVVKVRLNFSSEKNNQVAAQEHRHLLRIVLLHELENSKVAPYWWCGNFSAPAEAILTQHVAQSGLSQLDNSLVQWSVYCAVTPDHPLSFNLFNTLLDKLTKPLQSSLVIEEDVKLFWDGARKLLPTCYSHIRKLRKKTAGDKTVMKTLREVLKILYKLSILDVPECIDLFPKTSYGWLRDDAGKLNVYEVLNQAVIQGASDWFVHILDNNECKDNTEESRLQHLIRVIQLVRSDLQRAVEYYDRVFIEVMSFPYTKALYGLYESKIASLVEPEVIEVCKCLKRLQYNEGSTTTVHLAGGIAGVTGLGAPEVANEPLSMGTTLFELYLALQRFLLLGQGLNETEWSSYAISKFHGWFFGGVAQWLDIAAFKALTRIEKAVDLDNLVPVDTNVKYSSSGVDTLAIFYQIKIFWQQLAWPDVEGCYTFVAKIIDDICRCCVFYSDKMANRVDSVGTVTTVYEERFEVTTEWCVAINNIDYVRQSLEPFVEELGMDDIIQKMCEARSPIEAQRCKETLQNVIANAIDTVKNKIVDLLEVMIKKMMPSITRFLVEGAELLHQDCSSMDRVMRYLEANLDTLYQHLNNENFSRTLDIVWEQLGEVLYELIQANLEHRRAKITRFIDPRRLSKSAAAQLDAKRRPPSFFSNLHECLKIMIRSFRQDNKEMYSSDTLKRVEYLLKLHGMETRELIHEYHLGRWQEQQSIVEPKMGILTVRAQFIDDNLKIEVMNARNLVATDSNGLCDSYVRVALLPEDSFANVVKPKTQTHSKNLFPLYDEMFLIPLSPEQRGIADGLLHFVVKDKDMFSVSNTFVGEAYLHFSEIPDTPAPIGSLPQQHLPLSKPNTVDGDAIKALDSRQGDRQARDFIKKQRQKMPSKQFFSLG

Description

Essential for tracheal development in embryos. Functions with the GTPase Rab39 and downstream of dnd, to regulate lumen fusion between previously separate tracheal branches (anastomosis). Essential component of secretory lysosome-related organelles (SLs) that are present in the tracheal fusion tip cells (FCs). Mediates intracellular fusion of the extending tracheal stalk cell lumen in the FCs by recruiting the SNARE complex component Syx1A to the SLs, this may then enable the SLs to interact with complementary SNAREs (such as Syb) present in the apical membrane of the FC-FC interface and the membranes of the separate tracheal stalk cells. May also function in the maturation and exocytosis of the SLs.

Subunit

Interacts with Cam.

Miscellaneous

'Staccato' means detached in Italian, referring to the unclosed gaps in the tracheal lumen of mutants.

Similarity

Belongs to the aldehyde dehydrogenase family.
Belongs to the unc-13 family.

Keywords

Alternative splicing   Cell projection   Complete proteome   Cytoplasm   Cytoskeleton   Developmental protein   Endosome   Exocytosis   Lysosome   Reference proteome   Repeat  

Feature

chain  Protein unc-13 homolog 4B
splice variant  In isoform D.

Uniprot

H9JPM7   A0A0L7LV53   A0A3S2LP11   A0A182PAH8   A0A336M5C1   A0A1W4WJ95   + More
A0A1W4WV31   A0A1L8DVL8   D6X3H8   F5HL09   A0A3F2Z0A2   A0A3F2Z0B4   A0A1Q3FKP8   A0A2M4CM83   A0A182LCB3   A0A067RHL4   A0A2J7PCQ1   A0A1Y1LRX2   A0A336M599   A0A1Y1LWI5   A0A1B6KG25   A0A1B6MMV1   A0A1B6KAE1   A0A1B6KRQ2   A0A1J1HLD3   A0A0C9RRX2   A0A023F2B3   T1IFE1   A0A0A9YAH0   A0A0K8T4B6   A0A1I8NGZ3   A0A1B0FQR4   A0A154PA48   A0A026WJ67   A0A3L8E085   A0A195DD47   A0A0L0BQW3   A0A151WKD2   A0A195EXY8   A0A1I8PQW5   A0A158NYT1   A0A2A3EST6   A0A0P8YDP3   A0A0P8ZY78   B3M1Y2   A0A195CE42   A0A1W4VKC7   A0A0Q9WGD8   A0A1W4V875   A0A0Q9WIU7   A0A0Q9WHU3   Q9VBY8-3   B4NIX8   Q9VBY8   A0A0R1E5K9   B4PUE9  

Pubmed

19121390    26227816    18362917    19820115    12364791    14747013    + More
17210077    20966253    24845553    28004739    25474469    25401762    26823975    25315136    24508170    30249741    26108605    21347285    17994087    10731132    12537572    9813038    27323327    17550304   

EMBL

BABH01015241    BABH01015242    JTDY01000067    KOB79071.1    RSAL01000042    RVE50828.1    + More
UFQT01000578    SSX25445.1    GFDF01003614    JAV10470.1    KQ971374    EEZ97425.2    AAAB01008879    EGK96970.1    GFDL01006864    JAV28181.1    GGFL01002258    MBW66436.1    KK852468    KDR23282.1    NEVH01027057    PNF14104.1    GEZM01048733    JAV76444.1    SSX25444.1    GEZM01048732    JAV76445.1    GEBQ01029555    JAT10422.1    GEBQ01002699    JAT37278.1    GEBQ01031565    JAT08412.1    GEBQ01030281    GEBQ01029373    GEBQ01025877    GEBQ01019266    JAT09696.1    JAT10604.1    JAT14100.1    JAT20711.1    CVRI01000006    CRK88354.1    GBYB01010141    JAG79908.1    GBBI01003471    JAC15241.1    ACPB03001634    ACPB03001635    GBHO01014430    GDHC01002024    JAG29174.1    JAQ16605.1    GBRD01005437    JAG60384.1    CCAG010018120    KQ434839    KZC08060.1    KK107226    EZA55124.1    QOIP01000002    RLU25893.1    KQ980979    KYN10808.1    JRES01001496    KNC22475.1    KQ983012    KYQ48318.1    KQ981909    KYN33150.1    ADTU01000749    ADTU01000750    ADTU01000751    KZ288186    PBC34805.1    CH902617    KPU79625.1    KPU79624.1    EDV42242.2    KQ977876    KYM99077.1    CH940674    KRF80897.1    KRF80894.1    KRF80895.1    AE014297    BT032798    BT089029    ACD81812.1    ACU00262.1    CH964272    EDW84880.2    CM000160    KRK04491.1    EDW98836.2   

Proteomes

UP000005204    UP000037510    UP000283053    UP000075885    UP000192223    UP000007266    + More
UP000007062    UP000075903    UP000075882    UP000027135    UP000235965    UP000183832    UP000015103    UP000095301    UP000092444    UP000076502    UP000053097    UP000279307    UP000078492    UP000037069    UP000075809    UP000078541    UP000095300    UP000005205    UP000242457    UP000007801    UP000078542    UP000192221    UP000008792    UP000000803    UP000007798    UP000002282   

PRIDE

H9JPM7    Q9VBY8   

Pfam

PF00168   C2        + More
PF00171   Aldedh

Interpro

IPR035892   C2_domain_sf        + More
IPR016161   Ald_DH/histidinol_DH       
IPR014770   Munc13_1       
IPR016163   Ald_DH_C       
IPR016160   Ald_DH_CS_CYS       
IPR029510   Ald_DH_CS_GLU       
IPR014772   Munc13_dom-2       
IPR000008   C2_dom       
IPR016162   Ald_DH_N       
IPR015590   Aldehyde_DH_dom       

SUPFAM

SSF53720   SSF53720       

Gene 3D

2.60.40.150     3.40.309.10     3.40.605.10    

ProteinModelPortal

H9JPM7   A0A0L7LV53   A0A3S2LP11   A0A182PAH8   A0A336M5C1   A0A1W4WJ95   + More
A0A1W4WV31   A0A1L8DVL8   D6X3H8   F5HL09   A0A3F2Z0A2   A0A3F2Z0B4   A0A1Q3FKP8   A0A2M4CM83   A0A182LCB3   A0A067RHL4   A0A2J7PCQ1   A0A1Y1LRX2   A0A336M599   A0A1Y1LWI5   A0A1B6KG25   A0A1B6MMV1   A0A1B6KAE1   A0A1B6KRQ2   A0A1J1HLD3   A0A0C9RRX2   A0A023F2B3   T1IFE1   A0A0A9YAH0   A0A0K8T4B6   A0A1I8NGZ3   A0A1B0FQR4   A0A154PA48   A0A026WJ67   A0A3L8E085   A0A195DD47   A0A0L0BQW3   A0A151WKD2   A0A195EXY8   A0A1I8PQW5   A0A158NYT1   A0A2A3EST6   A0A0P8YDP3   A0A0P8ZY78   B3M1Y2   A0A195CE42   A0A1W4VKC7   A0A0Q9WGD8   A0A1W4V875   A0A0Q9WIU7   A0A0Q9WHU3   Q9VBY8-3   B4NIX8   Q9VBY8   A0A0R1E5K9   B4PUE9  

PDB

2W8O     E-value=8.48463e-136,     Score=1245

KEGG

101744243    no KO assigned | (RefSeq) protein unc-13 homolog D

GO

GO:0016620   GO:0099503   GO:0035147   GO:0007269   GO:0005764   GO:0005856   GO:0030175   GO:0016082   GO:0005770   GO:0008021   GO:0008152   GO:0016491   GO:0005515   GO:0005216   GO:0006811   GO:0016787   GO:0003676   GO:0015930   GO:0055114  

Subcellular location

Cytoplasm   Expressed throughout the cytoplasm of embryonic tracheal cells, except in the tracheal fusion cells (FCs) where it localizes to discrete intracellular vesicles. These vesicles also accumulate Rab39 and display late-endosomal, lysosomal, and SNARE components (Syx1A), characteristics of lysosome-related organelles. Prior to contact between FCs the vesicles localize to the presumed fusion point and sometimes to the filopodia. On contact between FCs, the lysosomes accumulate and move along the cytoskeleton track in a dynein-dependent manner between the two apical domains, becoming densely packed around the interface between the fusion cells. Some of the puncta remain associated with the primary apical FC membrane.   With evidence from 4 publications.
Cytoskeleton   Expressed throughout the cytoplasm of embryonic tracheal cells, except in the tracheal fusion cells (FCs) where it localizes to discrete intracellular vesicles. These vesicles also accumulate Rab39 and display late-endosomal, lysosomal, and SNARE components (Syx1A), characteristics of lysosome-related organelles. Prior to contact between FCs the vesicles localize to the presumed fusion point and sometimes to the filopodia. On contact between FCs, the lysosomes accumulate and move along the cytoskeleton track in a dynein-dependent manner between the two apical domains, becoming densely packed around the interface between the fusion cells. Some of the puncta remain associated with the primary apical FC membrane.   With evidence from 4 publications.
Cell projection   Expressed throughout the cytoplasm of embryonic tracheal cells, except in the tracheal fusion cells (FCs) where it localizes to discrete intracellular vesicles. These vesicles also accumulate Rab39 and display late-endosomal, lysosomal, and SNARE components (Syx1A), characteristics of lysosome-related organelles. Prior to contact between FCs the vesicles localize to the presumed fusion point and sometimes to the filopodia. On contact between FCs, the lysosomes accumulate and move along the cytoskeleton track in a dynein-dependent manner between the two apical domains, becoming densely packed around the interface between the fusion cells. Some of the puncta remain associated with the primary apical FC membrane.   With evidence from 4 publications.
Filopodium   Expressed throughout the cytoplasm of embryonic tracheal cells, except in the tracheal fusion cells (FCs) where it localizes to discrete intracellular vesicles. These vesicles also accumulate Rab39 and display late-endosomal, lysosomal, and SNARE components (Syx1A), characteristics of lysosome-related organelles. Prior to contact between FCs the vesicles localize to the presumed fusion point and sometimes to the filopodia. On contact between FCs, the lysosomes accumulate and move along the cytoskeleton track in a dynein-dependent manner between the two apical domains, becoming densely packed around the interface between the fusion cells. Some of the puncta remain associated with the primary apical FC membrane.   With evidence from 4 publications.
Late endosome   Expressed throughout the cytoplasm of embryonic tracheal cells, except in the tracheal fusion cells (FCs) where it localizes to discrete intracellular vesicles. These vesicles also accumulate Rab39 and display late-endosomal, lysosomal, and SNARE components (Syx1A), characteristics of lysosome-related organelles. Prior to contact between FCs the vesicles localize to the presumed fusion point and sometimes to the filopodia. On contact between FCs, the lysosomes accumulate and move along the cytoskeleton track in a dynein-dependent manner between the two apical domains, becoming densely packed around the interface between the fusion cells. Some of the puncta remain associated with the primary apical FC membrane.   With evidence from 4 publications.
Lysosome   Expressed throughout the cytoplasm of embryonic tracheal cells, except in the tracheal fusion cells (FCs) where it localizes to discrete intracellular vesicles. These vesicles also accumulate Rab39 and display late-endosomal, lysosomal, and SNARE components (Syx1A), characteristics of lysosome-related organelles. Prior to contact between FCs the vesicles localize to the presumed fusion point and sometimes to the filopodia. On contact between FCs, the lysosomes accumulate and move along the cytoskeleton track in a dynein-dependent manner between the two apical domains, becoming densely packed around the interface between the fusion cells. Some of the puncta remain associated with the primary apical FC membrane.   With evidence from 4 publications.

Length:

1665

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.41445

Exp number, first 60 AAs:

0

Total prob of N-in:

0.07147

outside

1  -  1665

 

 

Pi

29.101097

Theta

225.473779

Tajima's D

0.473768

CLR

0.445526

CSRT

0.509024548772561

Interpretation

Uncertain