Gene

KWMTBOMO13749

Pre Gene Modal

BGIBMGA011524

Annotation

PREDICTED:_inhibitor_of_apoptosis_protein_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr23(+):8300555-8307800      View in EpiBrowser

Full name

Apoptosis inhibitor IAP       + More
E3 ubiquitin-protein ligase IAP-3      

Alternative Name

IAP-3
RING-type E3 ubiquitin transferase IAP-3

Location in the cell

Extracellular   Reliability : 1.732

CDS

ATGAATCAGGAAAATGAATCGACCGAAGTAAATTCAGAAAATATAGCAAGCACTTCAGGAGTTGCTAAAAATGGAGCTGCCGCCACGTTGGTGATGTTAAAAAATGCGCGGGATGCAAAAATGCGACCTTTCATTGGTCCGCTCATGTTATCCTCATGCGAGTCCTCAACGACATCCACACTCCCGTCACCGTCGTCGTCAGCTGATAAAACGGATAATCACGACACATTCAACTTCCTTCCTGATATGCCCGACATGCGTCGTGAAGAGGAACGTCTGAAAACATTTGATCAGTGGCCCGTTACGTTTTTGACGCCGGAACAATTGGCCCGCAACGGATTCTACTACCTCGGTCGCGGCGACGAGGTGTGCTGTGCTTTCTGTAAGGTAGAAATTATGAGGTGGGTCGAAGGCGACGATCCTGCCGCCGATCATCGGAGATGGGCGCCCCAGTGTCCCTTTGTACGAAAACAAATGTATGCCAACGCTGGGGGAGAGGCGGCCGCTGTCGGTAGAGACGAATGTGGGGCCAGTGCGGCCACGCAGCCTCCCCGCATGCCCGGCCCCGTGCACGCGCGGTACTCCACCGAGGCCGCGCGGCTCGCCACCTTCAAGGACTGGCCGAGATGTATGCGCCAAAAACCCGAGGAACTGGCAGAGGCCGGATTCTTCTATACAGGCCAAGGTGACAAAACGAAATGCTTCTATTGCGACGGAGGGCTAAAAGATTGGGAAAGCGATGACGTTCCGTGGGAACAGCACGCCAGATGGTTCGACCGCTGCGCGTACGTGCAATTGGTGAAAGGACGTGACTACATTCAGAAGGTTAAGTCGGAGGCCACTGCGATATCTGCTAGCGAAGAAGAACAGGCCGCCACCAATGATTCGACTAACAACGTCGCTCAAGAGGGCGAGAAACATTTGGATGACTCTAAAATATGTAAAATATGTTATTCCGAGGAGCGTAACGTGTGCTTCGTGCCGTGCGGCCACGTGGTGGCGTGCGCCAAGTGCGCGCTGTCGACGGACAAGTGCCCGATGTGTCGCAGGACGTTCACGAATGCGGTGCGGCTCTACTTCTCGTGA

Protein

MNQENESTEVNSENIASTSGVAKNGAAATLVMLKNARDAKMRPFIGPLMLSSCESSTTSTLPSPSSSADKTDNHDTFNFLPDMPDMRREEERLKTFDQWPVTFLTPEQLARNGFYYLGRGDEVCCAFCKVEIMRWVEGDDPAADHRRWAPQCPFVRKQMYANAGGEAAAVGRDECGASAATQPPRMPGPVHARYSTEAARLATFKDWPRCMRQKPEELAEAGFFYTGQGDKTKCFYCDGGLKDWESDDVPWEQHARWFDRCAYVQLVKGRDYIQKVKSEATAISASEEEQAATNDSTNNVAQEGEKHLDDSKICKICYSEERNVCFVPCGHVVACAKCALSTDKCPMCRRTFTNAVRLYFS

Description

RING-finger E3 ubiquitin ligase required to prevent cellular apoptosis in infected cells. Ubiquitinates and subsquently targets host pro-apoptotic cellular proteins such as HID for degradation by the proteasome.

Catalytic Activity

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.

Subunit

Interacts with human PDCL3.

Similarity

Belongs to the IAP family.

Keywords

Apoptosis   Complete proteome   Metal-binding   Reference proteome   Repeat   Zinc   Zinc-finger   Host-virus interaction   Modulation of host ubiquitin pathway by viral E3 ligase   Modulation of host ubiquitin pathway by virus   Transferase   Ubl conjugation   Ubl conjugation pathway  

Feature

chain  Apoptosis inhibitor IAP

Uniprot

H9JPR9   Q8IS31   Q968T8   A0A2A4JBD9   A8Y8J7   A0A194RPN4   + More
A0A2W1BFY2   E1AWM2   H6V6K5   Q9U492   A0A2H1WSM5   Q3HNF8   Q9NJ07   S4PC76   A0A1E1WV01   R4WEC7   K4PXW0   A0A097P1Q8   A0A097P0W7   P41436   A0A097P254   H9BE74   Q6E7G7   A0A0S3IY16   K4EQ13   A0A0S3IWW7   A0A0B4UL11   S5N9T9   A0A0R7EYS0   V9XTW8   D3GD96   Q6VTV9   A0A346RNV9   Q80SF4   Q9QES9   W5VSC3   Q9YNL8   A0A2I7MM30   O89744   A0A2Z4HI64   P41437   A0A0N7D8H0   S5MRD5   A0A162GUK6   Q9EN27   R4ZG59   Q1A4L2   A0A0E3Z5Z8   R4ZDX0   Q7T5S1   A0A2H4ZKC5   Q287F3   Q9J827   W0UY11   A0A193DTJ2   W0UX62   A0A346TQ48   B7SVZ2   R4ZFJ9   A0A1J1I6B1   A0A0K8TNJ1   A0A2S1M5L2   A0A1B6KJG8   A0A346TPH2   A0A1B6HZB8   A0A0V0GBD8   A0A0P4VHR6   A0A2A3E9Y0   A0A0A9XHP7   E3SVR2   A0A0A9XF98   A0A146LQQ7   A0A0A9XMJ6   A0A069DSG7   A0A3G2JU35   A0A161M817   A0A0N0BG20   A0A0L0BR05   A0A1L8DJ94   T1HCP5   A0A1L8DJA6   A0A0R9D109   A0A1B6ER91   A0A154PGM2   A0A1Y1KCG0   V5GHQ7   Q16WV1   Q7QJ55   Q8JM16   I3XME7   B6D642   A0A077CY68   B7SUI9   Q8QL95   A0A097DAP7   A0A1W4XE66   A0A288WJI1   A0A0A7KR98  

EC Number

2.3.2.27

Pubmed

19121390    11341966    17967343    26354079    28756777    10593985    + More
10677478    23622113    25331863    8445726    9237352    11562546    17030857    26615220    23051685    19651137    23861954    26537678    24482509    22975212    7595348    9035367    10423153    10683327    15784888    30102885    15051395    16894193    11038395    11907346    8345353    9037741    9634101    9820162    9712513    24475121    1413988    7778276    7778286    8610448    8806578    10814576    11864738    15784887    29895987    8139034    9126251    15371430    15325084    26449402    10936094    23678178    16760394    26021909    8021613    7996162    12124467    14698662    29099796    16055149    16476975    1431809    8509757    8811032    9292027    9400958    9634102    10567663    10564750    24854001    27321273    26369729    27129103    25401762    26823975    26334808    26108605    28004739    17510324    12364791    12083822    23712441    9010313    11886270    15604435    25280947    25471493   

EMBL

BABH01015205    AY155274    AAN46650.1    AF281073    AAK57560.1    NWSH01002058    + More
PCG69281.1    AM709785    CAM96614.1    KQ459833    KPJ19813.1    KZ150075    PZC73982.1    HQ011924    ADM32901.1    JN794536    AFA43941.1    AF195528    AAF19819.1    ODYU01010698    SOQ55976.1    DQ206460    ABA62322.1    AF186378    AAF35285.1    GAIX01004291    JAA88269.1    GDQN01000185    JAT90869.1    AB778567    BAM76810.1    AB758122    BAM63312.1    KM217575    KM217576    AIU36943.1    AIU37085.1    KM217573    KM217574    AIU36666.1    AIU36806.1    U53466    KM217577    AIU37227.1    JQ003555    AFD21867.1    AY525121    AAS92269.1    DQ813662    KR815455    KR815456    KR815457    KR815458    KR815460    KR815461    KR815462    KR815463    KR815464    KR815465    KR815466    KR815468    KR815469    KR815470    KR815471    MG746625    MG746626    ABI13818.1    ALR69934.1    ALR70092.1    ALR70249.1    ALR70406.1    ALR70719.1    ALR70876.1    ALR71034.1    ALR71191.1    ALR71349.1    ALR71507.1    ALR71663.1    ALR71976.1    ALR72133.1    ALR72292.1    ALR72449.1    AXE72156.1    AXE72304.1    JN408834    AER41437.1    KR815459    KR815467    ALR70562.1    ALR71819.1    KJ631623    AJD09274.1    KC961303    AGR57007.1    KP296186    AKN80731.1    KF894742    AHD25601.1    FJ643490    ACV04797.1    AY327402    AAQ91688.1    MH394321    AXS67756.1    AB088850    AP009046    BAC55952.1    BAE72409.1    AF180757    AY043265    AAD53953.1    AAK85590.1    KF611977    KM986882    AHH82682.1    AKN91066.1    U82510    AF512031    AAD00537.1    AAP29821.1    KY550224    AUR45139.1    AF045936    AAC34373.1    MH261376    AWW14463.1    L22564    U75930    KP747440    AKR14200.1    KC961304    AGR57154.1    KR011717    AKR17350.1    AF250284    AAG02727.1    HF679132    CCU55703.1    DQ333351    ABC61218.1    KP752043    AKC91666.1    HF679133    CCU56005.1    AY229987    AAQ21613.1    MF974563    AUF82010.1    DQ123841    AAZ38285.1    AF169823    AAF33639.1    HG425343    HG425344    HG425345    HG425347    HG425348    HG425349    CDG72451.1    CDG72588.1    CDG72725.1    CDG73014.1    CDG73151.1    CDG73289.1    KU697902    ANN45697.1    HG425346    CDG72862.1    MH320559    AXU41708.1    EU780426    ACI47483.1    HF679134    CCU56356.1    CVRI01000043    CRK95837.1    GDAI01001641    JAI15962.1    MG241499    AWG72114.1    GEBQ01028384    JAT11593.1    MH124167    AXU41482.1    GECU01027693    JAS80013.1    GECL01001474    JAP04650.1    GDKW01002431    JAI54164.1    KZ288324    PBC28092.1    GBHO01025261    GBHO01015515    GBRD01005936    JAG18343.1    JAG28089.1    JAG59885.1    GU108959    ADK56128.1    GBHO01029278    GBHO01025263    GDHC01010954    JAG14326.1    JAG18341.1    JAQ07675.1    GDHC01008456    JAQ10173.1    GBHO01025264    GBHO01025258    JAG18340.1    JAG18346.1    GBGD01001866    JAC87023.1    MH370144    AYN45059.1    GEMB01000451    JAS02674.1    KQ435793    KOX74162.1    JRES01001502    KNC22413.1    GFDF01007535    JAV06549.1    ACPB03006768    GFDF01007536    JAV06548.1    KP100065    ALB25537.1    GECZ01029295    GECZ01011168    JAS40474.1    JAS58601.1    KQ434899    KZC11009.1    GEZM01086653    GEZM01086652    GEZM01086651    JAV59129.1    GALX01004907    JAB63559.1    CH477553    EAT39096.2    AAAB01008807    EAA04007.5    AY126275    AAM95124.1    JQ798165    JX138237    AFL64980.1    AFP95849.1    EU839994    ACI28829.1    KJ871680    AIL25210.1    EU730893    ACH88653.1    U59461    AF539999    AAM09247.1    AAQ11158.1    KJ406702    KX859079    KX859080    KX859081    KX859082    KX859083    AIS92096.1    ARX71436.1    ARX71566.1    ARX71696.1    ARX71826.1    ARX71956.1    KX859084    ARX72086.1    KM102981    AIZ48674.1   

Proteomes

UP000005204    UP000218220    UP000053240    UP000009249    UP000201348    UP000201478    + More
UP000201571    UP000202427    UP000203433    UP000203482    UP000202937    UP000202376    UP000203221    UP000214366    UP000204418    UP000009248    UP000208100    UP000201861    UP000000872    UP000014934    UP000202317    UP000201190    UP000014941    UP000203359    UP000204644    UP000203151    UP000069390    UP000069458    UP000069469    UP000069541    UP000069838    UP000069875    UP000069454    UP000202531    UP000014926    UP000183832    UP000242457    UP000053105    UP000037069    UP000015103    UP000076502    UP000008820    UP000007062    UP000203400    UP000202136    UP000204251    UP000202529    UP000235290    UP000201628    UP000192223    UP000202327   

PRIDE

H9JPR9    Q8IS31    Q968T8   

Pfam

PF00653   BIR

Interpro

IPR001370   BIR_rpt        + More
IPR013083   Znf_RING/FYVE/PHD       
IPR001841   Znf_RING       
IPR017066   E3ligase_BOI-like       

Gene 3D

3.30.40.10    

CDD

cd00022  BIR

ProteinModelPortal

H9JPR9   Q8IS31   Q968T8   A0A2A4JBD9   A8Y8J7   A0A194RPN4   + More
A0A2W1BFY2   E1AWM2   H6V6K5   Q9U492   A0A2H1WSM5   Q3HNF8   Q9NJ07   S4PC76   A0A1E1WV01   R4WEC7   K4PXW0   A0A097P1Q8   A0A097P0W7   P41436   A0A097P254   H9BE74   Q6E7G7   A0A0S3IY16   K4EQ13   A0A0S3IWW7   A0A0B4UL11   S5N9T9   A0A0R7EYS0   V9XTW8   D3GD96   Q6VTV9   A0A346RNV9   Q80SF4   Q9QES9   W5VSC3   Q9YNL8   A0A2I7MM30   O89744   A0A2Z4HI64   P41437   A0A0N7D8H0   S5MRD5   A0A162GUK6   Q9EN27   R4ZG59   Q1A4L2   A0A0E3Z5Z8   R4ZDX0   Q7T5S1   A0A2H4ZKC5   Q287F3   Q9J827   W0UY11   A0A193DTJ2   W0UX62   A0A346TQ48   B7SVZ2   R4ZFJ9   A0A1J1I6B1   A0A0K8TNJ1   A0A2S1M5L2   A0A1B6KJG8   A0A346TPH2   A0A1B6HZB8   A0A0V0GBD8   A0A0P4VHR6   A0A2A3E9Y0   A0A0A9XHP7   E3SVR2   A0A0A9XF98   A0A146LQQ7   A0A0A9XMJ6   A0A069DSG7   A0A3G2JU35   A0A161M817   A0A0N0BG20   A0A0L0BR05   A0A1L8DJ94   T1HCP5   A0A1L8DJA6   A0A0R9D109   A0A1B6ER91   A0A154PGM2   A0A1Y1KCG0   V5GHQ7   Q16WV1   Q7QJ55   Q8JM16   I3XME7   B6D642   A0A077CY68   B7SUI9   Q8QL95   A0A097DAP7   A0A1W4XE66   A0A288WJI1   A0A0A7KR98  

PDB

5YUD     E-value=1.43218e-27,     Score=305

KEGG

692576    K16061 baculoviral IAP repeat-containing protein 7/8 | (RefSeq) Iap; inhibitor of apoptosis protein

PATHWAY

04120    Ubiquitin mediated proteolysis - Bombyx mori (domestic silkworm)
04215    Apoptosis - multiple species - Bombyx mori (domestic silkworm)

GO

GO:0046872   GO:0039648   GO:0016740   GO:0061630   GO:1990001   GO:0031398   GO:0043154   GO:0005634   GO:0043027   GO:0005737   GO:0005515   GO:0008270   GO:0031625   GO:0000287   GO:0016620   GO:0016787   GO:0003676   GO:0016491   GO:0015930  

Length:

361

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.0983699999999998

Exp number, first 60 AAs:

0.0959399999999999

Total prob of N-in:

0.02833

outside

1  -  361

 

 

Pi

285.421891

Theta

217.536384

Tajima's D

1.376167

CLR

0.242336

CSRT

0.753212339383031

Interpretation

Uncertain