Gene

KWMTBOMO13747  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011491

Annotation

PREDICTED:_3-ketodihydrosphingosine_reductase_[Amyelois_transitella]

Location

Bomo_Chr23(-):8197239-8199504      View in EpiBrowser

Full name

3-ketodihydrosphingosine reductase      

Alternative Name

3-dehydrosphinganine reductase
Follicular variant translocation protein 1
Short chain dehydrogenase/reductase family 35C member 1

Location in the cell

PlasmaMembrane   Reliability : 3.75

CDS

ATGTTGCTAACAGTTGGAATTTTAATAACATTTTTAGTACTGGTCTTATCATTAGTTTTATATTTAACGATAGAAAAAAAAGTTAGTTACAAGGACTTGTTGAATAAACATGTTCTAATTACCGGTGGATCTAGTGGAATTGGAAAATCCGCTGCTATTGAAGCTGCAAGACGTGGAGCTCATGTCTCTATCATCGGTCGAGACGAAAATAAACTTAAGTCAGCTGTGGAAGAAATAACTTCACAGTGTTTAGATAAGTCTGTTCAATCCATTCAATATGCAGTTCTGGATGTTACATCTGACTATTTCGTTATAGAAAAAGCGATAAATTCGTTAGAGGACAATGTAGGACCAATATTTATGTTGGTAAACTGCGCCGGCATGTGTATATGTGGTAAATTTGAACAAATGAAGGTAGAGGATATAAAACAGATGATTGACTTGAATTATTTTGGCAGTGCGTATATGACAAAATGTGTTTTGCCGGGCATGAAGAAAAAAAAAGAAGGATTGATCGTATTTGTATGTTCAGAAGCAGCTTTAATAGGCATTTATGGATACACAGCATACAGTGCTGGAAAATGGGCTGTGCGAGGTTTAGCTGAGGCCCTGAGTATGGAGTTAATTGGAACTGGTGTCCGAGTAATGATATCATATCCTCCTGATACAGACACCCCGGGTTTTAAGAATGAAGATCTTACAAAGCCTTTAGAAACCAAACTTATATCAGGCTCTGCTGGTCTACTTTCTCCAGATGTAGTTGGAAAGCAAATGATAGATGATGCATTGAATGGGAAAATGTATTCCGTGTATACTACATCTGGATCAATGTTAACAACACTGTTTGGTGGTTCAATTGATAGTGTACGTCAAATTTTACTACAAGTGTTTTCAATGGGAGTTTTACGTGCAGTTATGGTAGGGGTTCTATTGTCATTTCATAAAATTGTGCGAGACAATTTAAAGTTGCAAAACAATAGCAAAAACAAATAA

Protein

MLLTVGILITFLVLVLSLVLYLTIEKKVSYKDLLNKHVLITGGSSGIGKSAAIEAARRGAHVSIIGRDENKLKSAVEEITSQCLDKSVQSIQYAVLDVTSDYFVIEKAINSLEDNVGPIFMLVNCAGMCICGKFEQMKVEDIKQMIDLNYFGSAYMTKCVLPGMKKKKEGLIVFVCSEAALIGIYGYTAYSAGKWAVRGLAEALSMELIGTGVRVMISYPPDTDTPGFKNEDLTKPLETKLISGSAGLLSPDVVGKQMIDDALNGKMYSVYTTSGSMLTTLFGGSIDSVRQILLQVFSMGVLRAVMVGVLLSFHKIVRDNLKLQNNSKNK

Description

Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).

Catalytic Activity

NADP(+) + sphinganine = 3-oxosphinganine + H(+) + NADPH

Similarity

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Keywords

Alternative splicing   Chromosomal rearrangement   Complete proteome   Disease mutation   Endoplasmic reticulum   Lipid metabolism   Membrane   NADP   Oxidoreductase   Palmoplantar keratoderma   Proto-oncogene   Reference proteome   Signal   Sphingolipid metabolism   Transmembrane   Transmembrane helix  

Feature

chain  3-ketodihydrosphingosine reductase
splice variant  In isoform 2.
sequence variant  In EKVP4; loss of 3-dehydrosphinganine reductase activity.

Uniprot

H9JPN6   A0A2A4JB29   A0A2W1B0T9   A0A2H1VF95   A0A3S2MA56   A0A194RUJ6   + More
S4PH41   A0A212FFL4   A0A2J7R6X5   A0A067RUJ4   A0A0L7RFC7   A0A2P8XNT4   A0A1B6FIX8   A0A154PFB3   A0A1B6HYQ1   A0A087ZRV0   A0A2J7R6U9   T1J3U3   A0A026WWB1   A0A2A3EP45   A0A023F2N5   A0A0C9QE85   A0A1B6CKZ1   A0A310SBW5   A0A1Y1M237   A0A1L8E9M7   A0A0P4VRF5   A0A224XT62   A0A1L8ED16   A0A195DZY6   A0A1S4EXM3   Q17MF6   E2AQ98   V4AMH6   A0A195CR02   A0A1I8P0X5   A0A182GB89   A0A182N6G6   A0A3Q3K1S5   A0A182SW23   A0A182Q769   T1HQ05   E9IJB7   A0A195BWK1   A0A182XXP9   A0A158NEN3   A0A182XH49   F4WRR8   A0A151XJ90   E2B3B7   A0A182VQJ8   Q7Q282   A0A1I8N6V1   A0A182I8A3   A0A182KMR1   A0A182U3W7   A0A182V4V7   A0A2S2QUB2   D6W737   A0A195FKP8   A0A3P9N9B9   A0A087XH72   A0A3B4A3H2   A0A3B3UBU8   A0A3B3Y9H1   A0A2R9ASL0   A0A182RQR8   K7IVW1   H2MQK7   A0A2I4D1Z1   A0A2J8W3J5   H2QEM9   A0A024R292   Q06136   G3RBX4   M4APX0   A0A3B5M804   B4GEZ7   Q296L7   A0A3Q2PPP7   A0A182PF25   A0A182M1V8   A0A3Q3AMH0   A0A146NWA9   A0A3P9KR20   A0A2K6SUY2   G2HHD2   F7GGW4   S7Q8Y4   A0A0A9YHD7   A0A182JZT0   A0A182FL40   I1SRY0   A0A3B3BCX7   A0A3Q1I1S9   Q803B4   A0A3B5BAG1  

EC Number

1.1.1.102

Pubmed

19121390    28756777    26354079    23622113    22118469    24845553    + More
29403074    24508170    30249741    25474469    28004739    27129103    17510324    20798317    23254933    26483478    21282665    25244985    21347285    21719571    12364791    14747013    17210077    25315136    20966253    18362917    19820115    25463417    22722832    20075255    17554307    16136131    11181995    8417785    14702039    16177791    15489334    15328338    28575652    22398555    23542700    17994087    15632085    21484476    17495919    25401762    22445008    29451363   

EMBL

BABH01015193    BABH01015194    NWSH01002058    PCG69285.1    KZ150490    PZC70692.1    + More
ODYU01002254    SOQ39499.1    RSAL01000002    RVE54926.1    KQ459833    KPJ19811.1    GAIX01003402    JAA89158.1    AGBW02008806    OWR52522.1    NEVH01006750    PNF36566.1    KK852409    KDR24480.1    KQ414606    KOC69550.1    PYGN01001631    PSN33671.1    GECZ01019620    JAS50149.1    KQ434886    KZC10134.1    GECU01027914    JAS79792.1    PNF36564.1    JH431831    KK107078    QOIP01000011    EZA60332.1    RLU16485.1    KZ288202    PBC33470.1    GBBI01003413    JAC15299.1    GBYB01001614    JAG71381.1    GEDC01023263    JAS14035.1    KQ764228    OAD54575.1    GEZM01042532    GEZM01042531    JAV79793.1    GFDG01003361    JAV15438.1    GDKW01001601    JAI54994.1    GFTR01005275    JAW11151.1    GFDG01002274    JAV16525.1    KQ979999    KYN18267.1    CH477206    EAT47882.1    GL441701    EFN64432.1    KB201262    ESO98337.1    KQ977381    KYN03131.1    JXUM01157742    KQ572838    KXJ67985.1    AXCN02000286    ACPB03017380    GL763764    EFZ19326.1    KQ976401    KYM92341.1    ADTU01013565    GL888292    EGI63075.1    KQ982080    KYQ60280.1    GL445323    EFN89795.1    AAAB01008978    EAA13630.3    APCN01002684    GGMS01012122    MBY81325.1    KQ971307    EFA11415.2    KQ981490    KYN41240.1    AYCK01007797    AJFE02095804    AJFE02095805    AJFE02095806    AJFE02095807    AJFE02095808    ABGA01233288    ABGA01233289    ABGA01233290    ABGA01233291    ABGA01233292    ABGA01233293    ABGA01233294    ABGA01233295    NDHI03003401    PNJ64344.1    PNJ64347.1    AACZ04062422    GABC01005629    GABC01005628    GABF01002843    GABF01002842    GABF01002841    GABF01002840    GABD01007742    GABD01007741    GABD01007740    GABD01007739    GABD01007738    GABE01005347    GABE01005346    GABE01005345    GABE01005344    GABE01005343    GABE01005342    NBAG03000231    JAA05709.1    JAA19302.1    JAA25358.1    JAA39392.1    PNI69729.1    CH471096    EAW63141.1    X63657    BT006782    AK297670    AK312360    AC021803    AC036176    BC008797    CABD030109886    CABD030109887    CABD030109888    CH479182    EDW34182.1    CM000070    EAL28440.1    AXCM01002920    GCES01150575    JAQ35747.1    AK306146    BAK63140.1    KE164355    EPQ17382.1    GBHO01011117    GBRD01016859    JAG32487.1    JAG48968.1    HM137285    AEA51181.1    BC044552    AAH44552.1   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053240    UP000007151    UP000235965    + More
UP000027135    UP000053825    UP000245037    UP000076502    UP000005203    UP000053097    UP000279307    UP000242457    UP000078492    UP000008820    UP000000311    UP000030746    UP000078542    UP000095300    UP000069940    UP000249989    UP000075884    UP000261600    UP000075901    UP000075886    UP000015103    UP000078540    UP000076408    UP000005205    UP000076407    UP000007755    UP000075809    UP000008237    UP000075920    UP000007062    UP000095301    UP000075840    UP000075882    UP000075902    UP000075903    UP000007266    UP000078541    UP000242638    UP000028760    UP000261520    UP000261500    UP000261480    UP000240080    UP000075900    UP000002358    UP000001038    UP000192220    UP000001595    UP000002277    UP000005640    UP000001519    UP000002852    UP000261380    UP000008744    UP000001819    UP000265000    UP000075885    UP000075883    UP000264800    UP000265180    UP000233220    UP000002280    UP000075881    UP000069272    UP000261560    UP000257200    UP000261400   

PRIDE

H9JPN6    A0A024R292    Q06136   

Pfam

PF00106   adh_short

Interpro

IPR036291   NAD(P)-bd_dom_sf        + More
IPR002347   SDR_fam       
IPR020904   Sc_DH/Rdtase_CS       

SUPFAM

SSF51735   SSF51735       

ProteinModelPortal

H9JPN6   A0A2A4JB29   A0A2W1B0T9   A0A2H1VF95   A0A3S2MA56   A0A194RUJ6   + More
S4PH41   A0A212FFL4   A0A2J7R6X5   A0A067RUJ4   A0A0L7RFC7   A0A2P8XNT4   A0A1B6FIX8   A0A154PFB3   A0A1B6HYQ1   A0A087ZRV0   A0A2J7R6U9   T1J3U3   A0A026WWB1   A0A2A3EP45   A0A023F2N5   A0A0C9QE85   A0A1B6CKZ1   A0A310SBW5   A0A1Y1M237   A0A1L8E9M7   A0A0P4VRF5   A0A224XT62   A0A1L8ED16   A0A195DZY6   A0A1S4EXM3   Q17MF6   E2AQ98   V4AMH6   A0A195CR02   A0A1I8P0X5   A0A182GB89   A0A182N6G6   A0A3Q3K1S5   A0A182SW23   A0A182Q769   T1HQ05   E9IJB7   A0A195BWK1   A0A182XXP9   A0A158NEN3   A0A182XH49   F4WRR8   A0A151XJ90   E2B3B7   A0A182VQJ8   Q7Q282   A0A1I8N6V1   A0A182I8A3   A0A182KMR1   A0A182U3W7   A0A182V4V7   A0A2S2QUB2   D6W737   A0A195FKP8   A0A3P9N9B9   A0A087XH72   A0A3B4A3H2   A0A3B3UBU8   A0A3B3Y9H1   A0A2R9ASL0   A0A182RQR8   K7IVW1   H2MQK7   A0A2I4D1Z1   A0A2J8W3J5   H2QEM9   A0A024R292   Q06136   G3RBX4   M4APX0   A0A3B5M804   B4GEZ7   Q296L7   A0A3Q2PPP7   A0A182PF25   A0A182M1V8   A0A3Q3AMH0   A0A146NWA9   A0A3P9KR20   A0A2K6SUY2   G2HHD2   F7GGW4   S7Q8Y4   A0A0A9YHD7   A0A182JZT0   A0A182FL40   I1SRY0   A0A3B3BCX7   A0A3Q1I1S9   Q803B4   A0A3B5BAG1  

PDB

4YXF     E-value=8.472e-14,     Score=186

KEGG

101742996    K04708 3-dehydrosphinganine reductase [EC:1.1.1.102] | (RefSeq) 3-ketodihydrosphingosine reductase

PATHWAY

00600    Sphingolipid metabolism - Bombyx mori (domestic silkworm)
01100    Metabolic pathways - Bombyx mori (domestic silkworm)

GO

GO:0016491   GO:0016021   GO:0005789   GO:0006666   GO:0047560   GO:0005783   GO:0030148   GO:0016020   GO:0005615   GO:0018342   GO:0031625   GO:0005515   GO:0000287   GO:0016620   GO:0016787   GO:0003676   GO:0015930  

Subcellular location

Endoplasmic reticulum membrane  

Length:

330

Number of predicted TMHs:

3

Exp number of AAs in TMHs:

70.52327

Exp number, first 60 AAs:

20.44178

Total prob of N-in:

0.28939

POSSIBLE N-term signal

sequence

outside

1  -  4

TMhelix

5  -  24

inside

25  -  169

TMhelix

170  -  192

outside

193  -  290

TMhelix

291  -  313

inside

314  -  330

 

 

Pi

226.425879

Theta

202.228448

Tajima's D

0.394449

CLR

0.099968

CSRT

0.482725863706815

Interpretation

Possibly Positive selection