Gene

KWMTBOMO13742

Annotation

PREDICTED:_moricin-1-like_[Bombyx_mori]

Location

Bomo_Chr23(+):8107085-8107721      View in EpiBrowser

Full name

Moricin       + More
Moricin-1      
Moricin-2      

Location in the cell

Extracellular   Reliability : 1.853 Mitochondrial   Reliability : 1.158

CDS

ATGTACTTCCTTAAGTATTTCATTGTTGTACTGGTAGCCCTGTCATTGATGATTTGCAGTGGACAGGCTGATCCGAAAATTCCTGTCAAAAGTCTGAAGAAGGGTGGGAAAGTTATTGCCAAAGGCTTTAAAGTTCTCACCGCAGCGGGAACAGCCCATGAAGTCTATAGCCACGTGCGTAACCGTGGGAATCAAGGTTAA

Protein

MYFLKYFIVVLVALSLMICSGQADPKIPVKSLKKGGKVIAKGFKVLTAAGTAHEVYSHVRNRGNQG

Description

Antimicrobial peptide. Active against a broad spectrum of Gram-positive and Gram-negative bacteria including methicillin-resistant S.aureus ATCC 43 300, S.aureus BAA-39, pathogenic strains of L.monocytogenes, K.pneumoniae, E.coli O157:H7, S.typhimurium and multidrug-resistant S.typhimurium DT104 with minimum inhibitory concentration (MIC) of 1.4 uM for all except for S.aureus BAA-39 (PubMed:18265434). Also active against Serratia marcescens (PubMed:14728663). Probably acts by disturbing membrane functions with its amphipathic alpha-helical structure (PubMed:18265434). May protect a developing embryo from bacterial infection (Probable).
Has antibacterial activity against Gram-positive and Gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure.

Subunit

Monomer.

Similarity

Belongs to the moricin family.

Keywords

3D-structure   Antibiotic   Antimicrobial   Immunity   Innate immunity   Secreted   Signal   Complete proteome   Direct protein sequencing   Reference proteome  

Feature

chain  Moricin

Uniprot

A0A1P8SNG6   A5JSV1   A5JSV0   A0A1P8SNG8   A0A194PKR9   A0A194RQN9   + More
A0A3G2BAH1   Q86MA1   A0A3S2MAQ4   A5JSU8   P82818   A5JSU9   A5JSU7   O96059   Q7YZB4   A0A3G2BAH2   E5D606   D3G9G4   A0A2W1BCF5   A0A212EZ82   Q5MAE8   A5JSU5   A0A0G3DPZ1   H9JPP0   G3D628   G3D647  

Pubmed

18207081    26354079    12706633    14728663    18265434    10229682    + More
8530391    11997013    16115804    28756777    22118469    25993013    19121390   

EMBL

KX164502    APY23986.1    EF564371    ABQ42579.1    EF564370    ABQ42578.1    + More
KX164501    APY23985.1    KQ459601    KPI94031.1    KQ459833    KPJ19802.1    MG770224    AYM26644.1    AY232301    AAO74637.1    RSAL01000002    RVE54920.1    EF564368    ABQ42576.1    AB006915    EF564369    ABQ42577.1    EF564367    ABQ42575.1    AB014092    AB019538    AB100428    BAC79440.1    MG770223    AYM26643.1    GU182911    ADR51149.1    FJ546342    ACR78444.1    KZ150490    PZC70696.1    AGBW02011357    OWR46790.1    AY847955    AY847956    AAW21269.1    EF564365    ABQ42573.1    KP056527    AKJ54509.1    BABH01015180    BABH01015187    BABH01015192    HQ204016    HQ204017    HQ204018    HQ204019    HQ204020    HQ204021    HQ204027    HQ204030    HQ204031    HQ204032    HQ204033    HQ204034    HQ204039    AEM66422.1    AEM66423.1    AEM66424.1    AEM66425.1    AEM66426.1    AEM66427.1    AEM66433.1    AEM66436.1    AEM66437.1    AEM66438.1    AEM66439.1    AEM66440.1    AEM66445.1    HQ204022    HQ204023    HQ204028    HQ204035    HQ204036    HQ204037    HQ204038    AEM66428.1    AEM66429.1    AEM66434.1    AEM66441.1    AEM66442.1    AEM66443.1    AEM66444.1   

Proteomes

UP000053268    UP000053240    UP000283053    UP000005204    UP000007151   

PRIDE

P82818    O96059    H9JPP0    G3D628   

Pfam

PF06451   Moricin

Interpro

IPR037043   Moricin_sf        + More
IPR009456   Moricin_fam       

Gene 3D

1.20.5.750    

ProteinModelPortal

A0A1P8SNG6   A5JSV1   A5JSV0   A0A1P8SNG8   A0A194PKR9   A0A194RQN9   + More
A0A3G2BAH1   Q86MA1   A0A3S2MAQ4   A5JSU8   P82818   A5JSU9   A5JSU7   O96059   Q7YZB4   A0A3G2BAH2   E5D606   D3G9G4   A0A2W1BCF5   A0A212EZ82   Q5MAE8   A5JSU5   A0A0G3DPZ1   H9JPP0   G3D628   G3D647  

PDB

2JR8     E-value=0.00308899,     Score=89

KEGG

101742127    no KO assigned | (RefSeq) moricin-1-like

GO

GO:0005576   GO:0042742   GO:0009617   GO:0050830   GO:0045087   GO:0050829   GO:0016021   GO:0031625   GO:0005515   GO:0000287   GO:0016620   GO:0016787   GO:0003676   GO:0016491   GO:0015930  

Subcellular location

Secreted  

SignalP

Position:   1 - 23,         Likelihood:  0.997017

 

 

Length:

66

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

13.96604

Exp number, first 60 AAs:

13.96577

Total prob of N-in:

0.69015

POSSIBLE N-term signal

sequence

outside

1  -  66

 

 

Pi

1.287282

Theta

4.080609

Tajima's D

-1.838166

CLR

0

CSRT

0.0199490025498725

Interpretation

Uncertain