Gene
KWMTBOMO13741
Pre Gene Modal
BGIBMGA011495
Annotation
moricin-2_precursor_[Bombyx_mori]
Full name
Moricin-2
+ More
Moricin-1
Moricin
Moricin-1
Moricin
Location in the cell
Extracellular Reliability : 1.357 Mitochondrial Reliability : 1.139
Sequence
CDS
ATGAATATTTTAAAACTTTTCTTTGTTTTTATTGTGGCAATGTCTCTGGTGTCATGTAGTACAGCCGCTCCAGCAAAAATACCTATCAAGGCCATTAAGACTGTAGGAAAGGCAGTCGGTAAAGGTCTAAGAGCCATCAATATCGCCAGTACAGCCAACGATGTTTTCAATTTCTTGAAACCGAAGAAAAGAAAGCATTAA
Protein
MNILKLFFVFIVAMSLVSCSTAAPAKIPIKAIKTVGKAVGKGLRAINIASTANDVFNFLKPKKRKH
Summary
Description
Has antibacterial activity against Gram-positive and Gram-negative bacteria. Probably acts by disturbing membrane functions with its amphipathic structure.
Antimicrobial peptide. Active against a broad spectrum of Gram-positive and Gram-negative bacteria including methicillin-resistant S.aureus ATCC 43 300, S.aureus BAA-39, pathogenic strains of L.monocytogenes, K.pneumoniae, E.coli O157:H7, S.typhimurium and multidrug-resistant S.typhimurium DT104 with minimum inhibitory concentration (MIC) of 1.4 uM for all except for S.aureus BAA-39 (PubMed:18265434). Also active against Serratia marcescens (PubMed:14728663). Probably acts by disturbing membrane functions with its amphipathic alpha-helical structure (PubMed:18265434). May protect a developing embryo from bacterial infection (Probable).
Antimicrobial peptide. Active against a broad spectrum of Gram-positive and Gram-negative bacteria including methicillin-resistant S.aureus ATCC 43 300, S.aureus BAA-39, pathogenic strains of L.monocytogenes, K.pneumoniae, E.coli O157:H7, S.typhimurium and multidrug-resistant S.typhimurium DT104 with minimum inhibitory concentration (MIC) of 1.4 uM for all except for S.aureus BAA-39 (PubMed:18265434). Also active against Serratia marcescens (PubMed:14728663). Probably acts by disturbing membrane functions with its amphipathic alpha-helical structure (PubMed:18265434). May protect a developing embryo from bacterial infection (Probable).
Subunit
Monomer.
Similarity
Belongs to the moricin family.
Keywords
Antibiotic
Antimicrobial
Complete proteome
Direct protein sequencing
Immunity
Innate immunity
Reference proteome
Secreted
Signal
3D-structure
Feature
chain Moricin-2
Uniprot
Pubmed
EMBL
Proteomes
Pfam
PF06451 Moricin
Gene 3D
ProteinModelPortal
PDB
1KV4
E-value=2.11896e-08,
Score=133
Ontologies
GO
Topology
Subcellular location
Secreted
SignalP
Position: 1 - 22,
Likelihood: 0.996052
Length:
66
Number of predicted TMHs:
0
Exp number of AAs in TMHs:
16.78228
Exp number, first 60 AAs:
16.78088
Total prob of N-in:
0.61466
POSSIBLE N-term signal
sequence
outside
1 - 66
Population Genetic Test Statistics
Pi
210.354185
Theta
166.804037
Tajima's D
0.732992
CLR
26.779069
CSRT
0.580070996450177
Interpretation
Uncertain
