Gene

KWMTBOMO13729  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011500

Annotation

translation_initiation_factor_2_gamma_subunit_[Bombyx_mori]

Location

Bomo_Chr23(-):7708586-7719554      View in EpiBrowser

Full name

Eukaryotic translation initiation factor 2 subunit 3      

Alternative Name

Eukaryotic translation initiation factor 2 subunit gamma

Location in the cell

Mitochondrial   Reliability : 2.25

CDS

ATGGCTTCGAACGAAGGGCGAACTACTCAATCAAACTTGCATCAGCAAGACTTATCTAAATTGGATGTCACAAAATTATCTGCTCTCTCTCCCGAAGTCATATCAAGGCAGGCGACGATTAACATCGGTACAATTGGACATGTAGCTCATGGAAAATCTACTGTTGTGAAGGCTATTTCAGGAGTACAAACTGTAAGGTTTAAGAATGAATTGGAAAGAAATATTACGATCAAATTAGGTTATGCAAATGCAAAAATCTACCAATGCGACAATCCTAAATGTCCGCGGCCAACCAGCTTTATATCCGGCGGCTCATCTAAGGATGACAGCTTTCCGTGTCTTCGGCCTGCGTGTACGGGTCGCTTCCAACTAGTTCGCCACGTGAGCTTTGTAGACTGCCCTGGTCACGACATCCTTATGGCAACTATGCTTAACGGTGCTGCCGTGATGGACGCAGCATTACTACTCATTGCGGGCAACGAATCTTGCCCACAGCCCCAAACTAGTGAACACTTAGCAGCCATTGAGATAATGAAACTGAAGCATATCTTGATATTACAAAACAAGATCGATTTAGTTAAAGAGGGACAAGCTAAAGAACAGCATGAGCAAATTGTAAAATTCGTTCAAGGGACTGTGGCTGAAGGTGCACCTATTATACCCATATCGGCTCAACTCAAATATAATATTGAGGTCCTCTGCGAGTATATAACAAAAAAGATTCCCGTACCCCTAAGGGATTTCACATCGCCTCCTCGTATGATTGTTATTCGTTCATTCGATGTAAATAAGCCTGGTTGCGAGGTTGACGATCTACGGGGTGGCGTGGCAGGAGGATCAATTCTTCAAGGAGTTCTAACTGTCGGTATGGAAATCGAAGTGCGGCCTGGTTTAGTCAGTAAGGATGCAGATGGTAAATTAACTTGCCGACCCATATTTTCACGCATCGTTTCGCTGTTTGCCGAGCAGAATGAGCTACAGTATGCCGTCCCTGGTGGTCTTATTGGCGTAGGAACGAAGATCGAACCAACGCTGTGCCGTGCTGATAGACTTGTGGGACAAGTATTAGGAGCAGTTGGATGTTTACCGGGAATTTTTGTCAAACTCGAAGTATCTTATTATCTTTTGAAACGTTTGCTTGGCGTGCGCACTGAAGGAGATAAAAAGGCTGCCAAAGTCCAAAAATTAGTCAAAAATGAGGTCCTCCTCGTAAATATTGGATCGTTAAGTACTGGCGGCCGAGTAATCGCCACAAAAGTTGATTTGGCTAAAATCGCCCTTACGAACCCTGTTTGCACGGAAATTGGAGAAAAAGTAGCATTGAGTAGAAGAGTAGAAAATCACTGGCGGTTAATTGGTTGGGGACAAATTCAAGGAGGTACAACTATAGAACCAGCCAACAACTAA

Protein

MASNEGRTTQSNLHQQDLSKLDVTKLSALSPEVISRQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELERNITIKLGYANAKIYQCDNPKCPRPTSFISGGSSKDDSFPCLRPACTGRFQLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKEGQAKEQHEQIVKFVQGTVAEGAPIIPISAQLKYNIEVLCEYITKKIPVPLRDFTSPPRMIVIRSFDVNKPGCEVDDLRGGVAGGSILQGVLTVGMEIEVRPGLVSKDADGKLTCRPIFSRIVSLFAEQNELQYAVPGGLIGVGTKIEPTLCRADRLVGQVLGAVGCLPGIFVKLEVSYYLLKRLLGVRTEGDKKAAKVQKLVKNEVLLVNIGSLSTGGRVIATKVDLAKIALTNPVCTEIGEKVALSRRVENHWRLIGWGQIQGGTTIEPANN

Description

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity).

Subunit

Heterotrimer composed of an alpha, a beta and a gamma chain.

Similarity

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.

Keywords

Alternative splicing   Complete proteome   GTP-binding   Initiation factor   Nucleotide-binding   Protein biosynthesis   Reference proteome  

Feature

chain  Eukaryotic translation initiation factor 2 subunit 3
splice variant  In isoform C.

Uniprot

Q684K3   Q684K4   I4DJL2   S4P9E5   A0A0T6B140   Q9NAR5   + More
A0A1W4X5V2   J3JYY1   A0A1B6H8G5   A0A1L8DRN2   Q9N9W0   A0A1Y1KJQ5   A0A232FFP6   K7IMQ9   Q684L1   Q684K5   T1DE69   A0A2A3EA31   A0A0C9RQZ7   A0A2M4A1J1   E0VWS1   A0A2M4CT05   A0A2M3YYY2   A0A2M4BM74   A0A158NT34   A0A182J245   F5HLB5   A0A026WVB1   A0A0K8TRR5   Q684K9   U5EUE9   A0A1B6C3T9   A0A1Q3FWU3   A0A023EV32   A0A0A9VXF7   Q684K7   A0A226EPT5   Q684L0   A0A0P4W0Q5   R4G8B0   A0A224XPH1   A0A0V0G300   A0A069DZ29   T1DE72   A0A0Q9X5F7   W8BYN8   A0A2S2QSH1   A0A1D2N4N4   A0A0Q9WG48   A0A0Q9X877   A0A2H8TQ64   A0A2S2PQ95   J9JTD7   A0A034VGU8   A0A0K8TYN3   A0A1L8EGX7   Q684L2   A0A3B0JNX4   I5APU1   A0A0R1E4U4   A0A1W4VRA7   A0A0B4KGP8   A0A0P8Y8M1   Q24208   B3P0T0   T1PDI5   A0A1I8PDI8   Q684K6   W4YX51   C3ZNT9   A0A1A9V2J9   E9GN88   A0A3Q3JXG2   A7SBR9   A0A0P5PBY7   A0A0P6BCZ9   Q24208-2   Q53XD3   A0A0N8E855   A0A3Q3B1G8   A0A0N8BSE6   A0A3Q3LVP7   A0A0N8A519   A0A3Q2FYI5   A0A0P4ZRB4   A0A0P5D865   Q4T3B4   A0A0P5SG74   A0A0P5L8B1   I3JNC5   H2S2P6   G1KGH9   D3TSF5   T1JPG6   A0A0P5I5P7   A0A3B3DVY7   A0A3S2NXS7   A0A0P5CYA9   A0A0P5FWZ2   A0A0P5MNQ3  

Pubmed

15356279    22651552    23622113    11063691    22516182    28004739    + More
28648823    20075255    24330624    20566863    21347285    12364791    14747013    17210077    24508170    26369729    24945155    25401762    26823975    27129103    26334808    17994087    24495485    27289101    25348373    15632085    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    7915232    12537569    25315136    18563158    21292972    17615350    15496914    25186727    21551351    20353571    29451363   

EMBL

AJ715870    CAG29676.1    AJ715869    CAG29675.1    AK401480    BAM18102.1    + More
GAIX01005526    JAA87034.1    LJIG01016274    KRT81094.1    AJ290961    AJ290962    AJ290963    CAB98197.1    BT128462    AEE63419.1    GECU01036718    JAS70988.1    GFDF01004985    JAV09099.1    AJ290964    CAB94834.1    GEZM01081401    JAV61649.1    NNAY01000314    OXU29278.1    AJ715862    CAG29668.1    AJ715868    CAG29674.1    GALA01001162    JAA93690.1    KZ288325    PBC28036.1    GBYB01009701    JAG79468.1    GGFK01001298    MBW34619.1    DS235824    EEB17827.1    GGFL01004272    MBW68450.1    GGFM01000715    MBW21466.1    GGFJ01004953    MBW54094.1    ADTU01025481    AAAB01008888    EGK97076.1    KK107109    EZA59044.1    GDAI01000544    JAI17059.1    AJ715864    CAG29670.1    GANO01002355    JAB57516.1    GEDC01029398    JAS07900.1    GFDL01003152    JAV31893.1    GAPW01001259    JAC12339.1    GBHO01042717    GBRD01008334    GDHC01018866    JAG00887.1    JAG57487.1    JAP99762.1    AJ715866    CAG29672.1    LNIX01000003    OXA58596.1    AJ715863    CAG29669.1    GDKW01001313    JAI55282.1    ACPB03002356    GAHY01001287    JAA76223.1    GFTR01006505    JAW09921.1    GECL01003625    JAP02499.1    GBGD01001360    JAC87529.1    GALA01001157    JAA93695.1    CH964232    KRF99458.1    GAMC01004787    JAC01769.1    GGMS01011257    MBY80460.1    LJIJ01000221    ODN00237.1    CH940650    KRF83186.1    CH933806    KRG01428.1    GFXV01004532    MBW16337.1    GGMR01018397    MBY31016.1    ABLF02034802    ABLF02034812    GAKP01018189    JAC40763.1    GDHF01032941    JAI19373.1    GFDG01000832    JAV17967.1    AJ715861    CAG29667.1    OUUW01000008    SPP83934.1    CM000070    EIM52976.1    CM000160    KRK03774.1    AE014297    AGB95968.1    CH902629    KPU75544.1    X80069    AJ290956    AY061102    CH954181    EDV48978.1    KA646195    AFP60824.1    AJ715867    CAG29673.1    AAGJ04152272    GG666653    EEN45821.1    GL732554    EFX79075.1    DS469618    EDO38840.1    GDIQ01140287    JAL11439.1    GDIP01023404    LRGB01003257    JAM80311.1    KZS03523.1    BT012446    AAS93717.1    GDIQ01052428    JAN42309.1    GDIQ01149491    JAL02235.1    GDIP01181785    JAJ41617.1    GDIP01209775    JAJ13627.1    GDIP01161533    JAJ61869.1    CAAE01010102    CAF92618.1    GDIP01140454    JAL63260.1    GDIQ01178712    JAK73013.1    AERX01040597    AERX01040598    EZ424357    ADD20633.1    JH431826    GDIQ01219055    GDIQ01219054    JAK32670.1    CM012456    RVE59153.1    GDIP01179982    JAJ43420.1    GDIQ01250504    JAK01221.1    GDIQ01176556    JAK75169.1   

Proteomes

UP000192223    UP000215335    UP000002358    UP000242457    UP000009046    UP000005205    + More
UP000075880    UP000007062    UP000053097    UP000198287    UP000015103    UP000007798    UP000094527    UP000008792    UP000009192    UP000007819    UP000268350    UP000001819    UP000002282    UP000192221    UP000000803    UP000007801    UP000008711    UP000095301    UP000095300    UP000007110    UP000001554    UP000078200    UP000000305    UP000261600    UP000001593    UP000076858    UP000264800    UP000261640    UP000265020    UP000007303    UP000005207    UP000005226    UP000001646    UP000261560   

PRIDE

Q684K3    Q24208    Q53XD3   

Pfam

PF09173   eIF2_C        + More
PF03144   GTP_EFTU_D2
PF00009   GTP_EFTU
PF00514   Arm
PF03188   Cytochrom_B561

Interpro

IPR000795   TF_GTP-bd_dom        + More
IPR009001   Transl_elong_EF1A/Init_IF2_C       
IPR004161   EFTu-like_2       
IPR009000   Transl_B-barrel_sf       
IPR027417   P-loop_NTPase       
IPR015256   TIF2_gsu_C       
IPR016024   ARM-type_fold       
IPR000225   Armadillo       
IPR011989   ARM-like       
IPR006593   Cyt_b561/ferric_Rdtase_TM       

SUPFAM

SSF50465   SSF50465        + More
SSF52540   SSF52540       
SSF50447   SSF50447       
SSF48371   SSF48371       

Gene 3D

1.25.10.10    

CDD

cd15490  eIF2_gamma_III

ProteinModelPortal

Q684K3   Q684K4   I4DJL2   S4P9E5   A0A0T6B140   Q9NAR5   + More
A0A1W4X5V2   J3JYY1   A0A1B6H8G5   A0A1L8DRN2   Q9N9W0   A0A1Y1KJQ5   A0A232FFP6   K7IMQ9   Q684L1   Q684K5   T1DE69   A0A2A3EA31   A0A0C9RQZ7   A0A2M4A1J1   E0VWS1   A0A2M4CT05   A0A2M3YYY2   A0A2M4BM74   A0A158NT34   A0A182J245   F5HLB5   A0A026WVB1   A0A0K8TRR5   Q684K9   U5EUE9   A0A1B6C3T9   A0A1Q3FWU3   A0A023EV32   A0A0A9VXF7   Q684K7   A0A226EPT5   Q684L0   A0A0P4W0Q5   R4G8B0   A0A224XPH1   A0A0V0G300   A0A069DZ29   T1DE72   A0A0Q9X5F7   W8BYN8   A0A2S2QSH1   A0A1D2N4N4   A0A0Q9WG48   A0A0Q9X877   A0A2H8TQ64   A0A2S2PQ95   J9JTD7   A0A034VGU8   A0A0K8TYN3   A0A1L8EGX7   Q684L2   A0A3B0JNX4   I5APU1   A0A0R1E4U4   A0A1W4VRA7   A0A0B4KGP8   A0A0P8Y8M1   Q24208   B3P0T0   T1PDI5   A0A1I8PDI8   Q684K6   W4YX51   C3ZNT9   A0A1A9V2J9   E9GN88   A0A3Q3JXG2   A7SBR9   A0A0P5PBY7   A0A0P6BCZ9   Q24208-2   Q53XD3   A0A0N8E855   A0A3Q3B1G8   A0A0N8BSE6   A0A3Q3LVP7   A0A0N8A519   A0A3Q2FYI5   A0A0P4ZRB4   A0A0P5D865   Q4T3B4   A0A0P5SG74   A0A0P5L8B1   I3JNC5   H2S2P6   G1KGH9   D3TSF5   T1JPG6   A0A0P5I5P7   A0A3B3DVY7   A0A3S2NXS7   A0A0P5CYA9   A0A0P5FWZ2   A0A0P5MNQ3  

PDB

6O85     E-value=0,     Score=1918

KEGG

692680    K03242 translation initiation factor 2 subunit 3 | (RefSeq) Eif2g, Eif2s3y, su(var)3-9; translation

PATHWAY

03013    RNA transport - Bombyx mori (domestic silkworm)

GO

GO:0003743   GO:0003924   GO:0005525   GO:0003746   GO:0016021   GO:0055114   GO:0018024   GO:0043614   GO:0001731   GO:0016282   GO:0005829   GO:0005737   GO:0005850   GO:0031625   GO:0005515   GO:0000287   GO:0016620   GO:0016787   GO:0003676   GO:0016491   GO:0015930  

Length:

468

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.21156

Exp number, first 60 AAs:

0.00279

Total prob of N-in:

0.02302

outside

1  -  468

 

 

Pi

2.852734

Theta

183.169328

Tajima's D

-2.447287

CLR

207.404934

CSRT

0.000899955002249887

Interpretation

Uncertain