Gene

KWMTBOMO13706  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011014

Annotation

PREDICTED:_histone_deacetylase_complex_subunit_SAP18_[Papilio_machaon]

Location

Bomo_Chr23(-):7355191-7356084      View in EpiBrowser

Full name

Histone deacetylase complex subunit SAP18       + More
AP-3 complex subunit beta      

Alternative Name

18 kDa Sin3-associated polypeptide
Bicoid-interacting protein 1
dSAP18

Location in the cell

Cytoplasmic   Reliability : 1.297 Extracellular   Reliability : 1.203 Nuclear   Reliability : 1.611

CDS

ATGGCGGGATTAGAATCAATGGTAGTTGAAGAAATTAAACCGACAGAAAAACCGGTGGACAGAGAAAAGACCTGTCCTCTATTGCTCCGTGTGTTTTGTTCAACTGGCCGACATAATTCTCCTGGAGACTATGTTAGAGGAAACGTACCTCAGAATGAATTACAAATATATACATGGATGGATGCTACACTGCGAGAACTTACAGGACTTGTAAAAGAAGTTAATCCTGAGACGAGACGGAAAGGCACATACTTTGATTTTGCCATTGTGTATCCTGATATGCGTTCCCCTACATATCGTATGAGGGAAATAGGAGTTACATGTTCCGGACAGAGAGGAGGCGATGATAACAAGACACTTTCACAACTGAAATTTCAAATTGGGAACTATCTAGACATCTCAATAACACCCCCAAACAGAATGCCACCACCAATGAGGCGTCCACAACCATATATTAATAATCGTCAGTACTGA

Protein

MAGLESMVVEEIKPTEKPVDREKTCPLLLRVFCSTGRHNSPGDYVRGNVPQNELQIYTWMDATLRELTGLVKEVNPETRRKGTYFDFAIVYPDMRSPTYRMREIGVTCSGQRGGDDNKTLSQLKFQIGNYLDISITPPNRMPPPMRRPQPYINNRQY

Description

Involved in the tethering of the SIN3 complex to core histone proteins.
Involved in the tethering of the SIN3 complex to core histone proteins. Interacts with bicoid (bcd) to repress transcription of bicoid target genes in the anterior tip of the embryo; a process known as retraction. Interacts with Trl and binds to Polycomb response elements at the bithorax complex. May contribute to the regulation of other homeotic gene expressions.

Subunit

Forms a complex with SIN3 and histone deacetylase (By similarity). Interacts with the N-terminal residues of TRL. Interacts with BCD; in vitro and yeast cells.

Similarity

Belongs to the SAP18 family.
Belongs to the adaptor complexes large subunit family.

Keywords

Complete proteome   Cytoplasm   Developmental protein   Nucleus   Reference proteome   Repressor   Transcription   Transcription regulation  

Feature

chain  Histone deacetylase complex subunit SAP18

Uniprot

H9JNB1   A0A2H1VCD3   A0A212FJJ4   A0A2A4J8H3   S4PA87   A0A0L7LS92   + More
A0A1E1WB42   A0A194QP84   I4DLA8   A0A2J7RBZ4   A0A084VRE8   A0A182MMQ9   A0A182SMH3   A0A182NFN1   A0A182RNP0   A0A182QS34   A0A0K8TSH3   A0A182Y4D0   A0A182K2Q1   A0A182IZ79   A0A182LFR3   A0A182TEW6   A0A182HUA2   Q7PR28   A0A210Q1W2   E9IJQ7   A0A023EGW8   A0A2M3ZD68   A0A182F7F7   A0A2M4C2H2   A0A158ND33   A0A151XGE8   E2B7E5   A0A026VXI5   A0A195DUK5   F4X0G6   A0A195F7M0   A0A2M4AYH4   W5JHI1   A0A154PLG4   A0A2A3E3B0   A0A1Q3F8N6   A0A0L7QP96   B0XBD8   A0A1B0GCT3   A0A1A9XU91   A0A1A9VB00   A0A1B0BND1   A0A1A9ZM65   A0A1A9WHP5   A0A151ING1   B0XKQ7   A0A1J1HX58   A0A0L0BNU0   A0A182PAB1   A0A1I8N9K0   U5EXK6   A0A1B0C9K6   A0A1I8PWK3   A0A1L8DGB9   T1EA26   W8AXT2   A0A0K8VWW1   A0A034V189   B4QX67   E2A025   T1IHD1   B4PR29   B3P0Z2   B4HLC7   A0A126GUU7   Q9VEX9   A0A310SA59   A0A0N0U7P8   A0A232F990   K7JAE3   A0A182W084   B4GMJ9   A0A087TH09   V4A2F2   B4KA04   B4JG20   B4LY00   A0A0B7BRP6   A0A182H595   A0A2C9JZ69   A0A1W4VU25   A0A3B0JN61   B3LZX9   A0A0M4F2M6   T1IKX6   Q294V7   K1QH12   T1JKW2   B4NL01   A0A088AMR2   J9Q660   A0A1Q3F8G7   A0A0L8HF97   Q09JJ5  

Pubmed

19121390    22118469    23622113    26227816    26354079    22651552    + More
24438588    26369729    25244985    20966253    12364791    14747013    17210077    28812685    21282665    24945155    21347285    20798317    24508170    30249741    21719571    20920257    23761445    26108605    25315136    24495485    25348373    17994087    17550304    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    11455422    12537569    11256608    28648823    20075255    23254933    26483478    15562597    15632085    22992520    22833317    18070664   

EMBL

BABH01019612    ODYU01001804    SOQ38508.1    AGBW02008253    OWR53913.1    NWSH01002561    + More
PCG67978.1    GAIX01003359    JAA89201.1    JTDY01000250    KOB78066.1    GDQN01006842    JAT84212.1    KQ461195    KPJ06785.1    AK402076    KQ459600    BAM18698.1    KPI94143.1    NEVH01005889    PNF38349.1    ATLV01015610    KE525023    KFB40542.1    AXCM01000851    AXCN02000239    GDAI01000291    JAI17312.1    APCN01000613    AAAB01008859    EAA07931.3    NEDP02005224    OWF42743.1    GL763883    EFZ19150.1    GAPW01005512    JAC08086.1    GGFM01005733    MBW26484.1    GGFJ01010352    MBW59493.1    ADTU01012291    KQ982173    KYQ59381.1    GL446169    EFN88381.1    KK107609    QOIP01000014    EZA48518.1    RLU15103.1    KQ980341    KYN16437.1    GL888498    EGI59958.1    KQ981744    KYN36438.1    GGFK01012510    MBW45831.1    ADMH02001371    ETN62768.1    KQ434938    KZC12070.1    KZ288433    PBC25782.1    GFDL01011105    JAV23940.1    KQ414843    KOC60321.1    DS232629    EDS44229.1    CCAG010002226    JXJN01017337    KQ976933    KYN07002.1    DS233966    EDS32453.1    CVRI01000020    CRK91110.1    JRES01001582    KNC21755.1    GANO01000907    JAB58964.1    AJWK01002450    GFDF01008576    JAV05508.1    GAMD01001383    JAB00208.1    GAMC01012760    JAB93795.1    GDHF01008946    JAI43368.1    GAKP01022698    JAC36254.1    CM000364    EDX12721.1    GL435543    EFN73208.1    JH429868    CM000160    EDW97351.1    CH954181    EDV49111.1    CH480815    EDW41947.1    AE014297    KX671631    ALI30577.1    AOG29656.1    AF297546    AY070913    BT025229    AJ278500    KQ767242    OAD53481.1    KQ435689    KOX81302.1    NNAY01000604    OXU27424.1    AAZX01004373    CH479185    EDW38073.1    KK115199    KFM64398.1    KB202619    ESO89120.1    CH933806    EDW15652.1    CH916369    EDV92559.1    CH940650    EDW66866.1    HACG01048692    CEK95557.1    JXUM01110979    JXUM01110980    JXUM01110981    JXUM01110982    JXUM01110983    JXUM01110984    KQ565461    KXJ70939.1    OUUW01000008    SPP83654.1    CH902617    EDV44169.1    CP012526    ALC45357.1    JH430667    CM000070    EAL28856.1    JH818298    EKC36057.1    JH431633    CH964272    EDW84204.1    JN184771    AFK73705.1    GFDL01011209    JAV23836.1    KQ418297    KOF87911.1    DQ886851    ABI52768.1   

Proteomes

UP000005204    UP000007151    UP000218220    UP000037510    UP000053240    UP000053268    + More
UP000235965    UP000030765    UP000075883    UP000075901    UP000075884    UP000075900    UP000075886    UP000076408    UP000075881    UP000075880    UP000075882    UP000075902    UP000075840    UP000007062    UP000242188    UP000069272    UP000005205    UP000075809    UP000008237    UP000053097    UP000279307    UP000078492    UP000007755    UP000078541    UP000000673    UP000076502    UP000242457    UP000053825    UP000002320    UP000092444    UP000092443    UP000078200    UP000092460    UP000092445    UP000091820    UP000078542    UP000183832    UP000037069    UP000075885    UP000095301    UP000092461    UP000095300    UP000000304    UP000000311    UP000002282    UP000008711    UP000001292    UP000000803    UP000053105    UP000215335    UP000002358    UP000075920    UP000008744    UP000054359    UP000030746    UP000009192    UP000001070    UP000008792    UP000069940    UP000249989    UP000076420    UP000192221    UP000268350    UP000007801    UP000092553    UP000001819    UP000005408    UP000007798    UP000005203    UP000053454   

PRIDE

H9JNB1    Q9VEX9   

Pfam

PF06487   SAP18        + More
PF07004   SHIPPO-rpt
PF14796   AP3B1_C
PF01602   Adaptin_N
PF00806   PUF

Interpro

IPR010516   SAP18        + More
IPR017250   Hist_deAcase_cplx_SAP18       
IPR010736   SHIPPO-rpt       
IPR026739   AP_beta       
IPR016024   ARM-type_fold       
IPR026740   AP3_beta       
IPR002553   Clathrin/coatomer_adapt-like_N       
IPR029390   AP3B_C       
IPR001313   Pumilio_RNA-bd_rpt       
IPR033133   PUM-HD       
IPR011989   ARM-like       
IPR033712   Pumilio_RNA-bd       

SUPFAM

SSF48371   SSF48371       

Gene 3D

1.25.10.10    

CDD

cd07920  Pumilio

ProteinModelPortal

H9JNB1   A0A2H1VCD3   A0A212FJJ4   A0A2A4J8H3   S4PA87   A0A0L7LS92   + More
A0A1E1WB42   A0A194QP84   I4DLA8   A0A2J7RBZ4   A0A084VRE8   A0A182MMQ9   A0A182SMH3   A0A182NFN1   A0A182RNP0   A0A182QS34   A0A0K8TSH3   A0A182Y4D0   A0A182K2Q1   A0A182IZ79   A0A182LFR3   A0A182TEW6   A0A182HUA2   Q7PR28   A0A210Q1W2   E9IJQ7   A0A023EGW8   A0A2M3ZD68   A0A182F7F7   A0A2M4C2H2   A0A158ND33   A0A151XGE8   E2B7E5   A0A026VXI5   A0A195DUK5   F4X0G6   A0A195F7M0   A0A2M4AYH4   W5JHI1   A0A154PLG4   A0A2A3E3B0   A0A1Q3F8N6   A0A0L7QP96   B0XBD8   A0A1B0GCT3   A0A1A9XU91   A0A1A9VB00   A0A1B0BND1   A0A1A9ZM65   A0A1A9WHP5   A0A151ING1   B0XKQ7   A0A1J1HX58   A0A0L0BNU0   A0A182PAB1   A0A1I8N9K0   U5EXK6   A0A1B0C9K6   A0A1I8PWK3   A0A1L8DGB9   T1EA26   W8AXT2   A0A0K8VWW1   A0A034V189   B4QX67   E2A025   T1IHD1   B4PR29   B3P0Z2   B4HLC7   A0A126GUU7   Q9VEX9   A0A310SA59   A0A0N0U7P8   A0A232F990   K7JAE3   A0A182W084   B4GMJ9   A0A087TH09   V4A2F2   B4KA04   B4JG20   B4LY00   A0A0B7BRP6   A0A182H595   A0A2C9JZ69   A0A1W4VU25   A0A3B0JN61   B3LZX9   A0A0M4F2M6   T1IKX6   Q294V7   K1QH12   T1JKW2   B4NL01   A0A088AMR2   J9Q660   A0A1Q3F8G7   A0A0L8HF97   Q09JJ5  

PDB

4A90     E-value=7.65276e-43,     Score=432

KEGG

101739989    K14324 histone deacetylase complex subunit SAP18 | (RefSeq) histone deacetylase complex subunit SAP1

PATHWAY

03013    RNA transport - Bombyx mori (domestic silkworm)
03015    mRNA surveillance pathway - Bombyx mori (domestic silkworm)

GO

GO:0003714   GO:0008134   GO:0006342   GO:0045892   GO:0005737   GO:0007275   GO:0071011   GO:0000398   GO:0071013   GO:0016580   GO:0006886   GO:0030123   GO:0016192   GO:0003723  

PANTHER

PTHR13082   PTHR11134  

Subcellular location

Nucleus   Shuttles between the nucleus and the cytoplasm.   With evidence from 2 publications.
Cytoplasm   Shuttles between the nucleus and the cytoplasm.   With evidence from 2 publications.

Length:

157

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0

Exp number, first 60 AAs:

0

Total prob of N-in:

0.06210

outside

1  -  157

 

 

Pi

411.321213

Theta

228.284882

Tajima's D

2.524996

CLR

0.493795

CSRT

0.947152642367882

Interpretation

Uncertain