Gene

KWMTBOMO13697  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011089

Annotation

sex_combs_on_midleg_[Bombyx_mori]

Location

Bomo_Chr23(+):7189095-7194923      View in EpiBrowser

Full name

Polycomb protein Scm      

Alternative Name

Sex comb on midleg protein

Location in the cell

Nuclear   Reliability : 2.478

CDS

ATGTCGAATAATACTGTCGGCTCGTCGGGGCCAGCTCCCGGCAAAATACGTGGTCCTGGTAGACCTCCGAAACGTACTTGTACATGGTGTGCTGAAAGTAAGACTCCGTTAAAATATGTTCTACCGACGGAAAATGGTAAAAAAGAGTTTTGCTCCGAAACATGTCTCTCAGAGTTCAGACAGGCGTACAGCAAAGGCGCGTGTCTACATTGTGACACAGTTATACGCGGTAATGTACCTTCTAGCAGCAAAAATTTCTGCTCTACGCATTGTTTGAACATTTATCAGAAGAAAAATGAAAAACGTACCACATCACCACAGTCTGGAAACGGAGCAAACGGAACTGAAAGTAATTCTAACAACAATTCTACGGGTTCATTTTATGATATTTACCAACCTTTTGACTGGACTGAATACATGAAAGAAACAAACAGTGTACCCGCACCTCAAGAATGTTTTAAACAAGCACCAATGCCACCCATCAATGATTTTAAAGTTGGGATGAAGCTCGAAGCATTGGATCCCCGTAATCTGACATCAACATGCATTGCAACTGTTGTTGGTGTTTTGGGTCCAAGGTTGAGACTGAGATTGGACGGAAGCGATAATAAAAATGACTTTTGGCGACTCGTTGATGCTGGAGATATACACCCCATAGGACACTGTGAAAAACATGATGGAATGCTACAACCTCCACTCGGCTTTCGCATGAATGCAAGCAGTTGGCCTATGTTTTTGCTCAAGACTTTGAATGGAGCCCAAATGGCTCCTGCTAAAGTATTTCAAGATGAGCCACCTACTCCCAAATCAAATTTATTTTTTGTTGGTCAAAAGTTGGAAGCAGTTGATAAAAAGAACCCGCAGTTGATATGCTGTGCAACAGTTGGAGCAGTTAAAAATGACCAAATCCATGTTACATTTGATGGTTGGAGAGGAGCATTTGATTACTGGTGTAGATATGATTCTAGGGATATATTCCCTGTGGGGTGGTGTGCTCGAGCAGGTCATCCTTTGCAGCCACCTGGTCAGTGCTACAAAAGTGCTACAACTCCATCAAGGTTTAAACTTAGACCTACTGGTATACCTAATCCTGCTTTGCCAGAAGGTGGTTCTACTGGTGCTGGAAACTCCTCTACAACACCTACATCAACACCGGCTCCTCTAGTGAGACTTTGTATTCGAAACAGCTGTACTGGTGGAAATAGCTTGTTACCCAGTACAATTTCAGGGTCTGGGCCTTCAGGTGCTGCTGAAGCTCTTGCTAAGGAACTATTAATTGTACATCCAGACCCTCAAAGATTGACAAGAGCAATAATGACTGCATCAAGTAGCTATTCTAATAATAATAAAGTACAGGTCTCATCTGGAAGCAAAAATTATACAGTAAAAGTACCTTCAGAGCTTACAAATGATGACCTGAAGAATTGGTTGAAAGCTGTTTGTAGTGGTGTGGGAAGCTGTGTTGGTATGATAAAAATAGATACAGAGGATGCGCCTGGTCAACTATGTTCACTTTGTGGAGATTCATCATCTAATAATGTATCATCAGCTGTAAAGAGGCCCCTAAATGATGAGAATATCGCTAACGCAGAGGAGTGCTCTGCAAGCAAGGTGGGACGCGTGTCTCCAGAACGAGCAGAGCCTGCATCATCCACAACCACGACCAGTGGGGCACCTCCTCCACCGCCGCCGCAGACGCCGCCGGGGGACTGGTCTGTGGAAGACGTCATTGGGTTTATTGCTGCTGCTGATCAGGCTCTTGCAGCACACGCTGACTTGTTCAGGAAACATGAAATCGACGGGAAAGCATTACTATTGCTGAATTCTGTTGTATCAACAATTTTATCACATGTCATTGCCTGA

Protein

MSNNTVGSSGPAPGKIRGPGRPPKRTCTWCAESKTPLKYVLPTENGKKEFCSETCLSEFRQAYSKGACLHCDTVIRGNVPSSSKNFCSTHCLNIYQKKNEKRTTSPQSGNGANGTESNSNNNSTGSFYDIYQPFDWTEYMKETNSVPAPQECFKQAPMPPINDFKVGMKLEALDPRNLTSTCIATVVGVLGPRLRLRLDGSDNKNDFWRLVDAGDIHPIGHCEKHDGMLQPPLGFRMNASSWPMFLLKTLNGAQMAPAKVFQDEPPTPKSNLFFVGQKLEAVDKKNPQLICCATVGAVKNDQIHVTFDGWRGAFDYWCRYDSRDIFPVGWCARAGHPLQPPGQCYKSATTPSRFKLRPTGIPNPALPEGGSTGAGNSSTTPTSTPAPLVRLCIRNSCTGGNSLLPSTISGSGPSGAAEALAKELLIVHPDPQRLTRAIMTASSSYSNNNKVQVSSGSKNYTVKVPSELTNDDLKNWLKAVCSGVGSCVGMIKIDTEDAPGQLCSLCGDSSSNNVSSAVKRPLNDENIANAEECSASKVGRVSPERAEPASSTTTTSGAPPPPPPQTPPGDWSVEDVIGFIAAADQALAAHADLFRKHEIDGKALLLLNSVVSTILSHVIA

Description

Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility.

Subunit

Scm associates with the PRC1 core complex containing PSC, PC, PH and Sce/RING1. Forms homotypic and heterotypic interactions. Interacts with the SAM domain of ph-p via its SAM domain in vitro. Interacts with corto in vitro.

Similarity

Belongs to the SCM family.

Keywords

3D-structure   Chromatin regulator   Complete proteome   Developmental protein   Metal-binding   Nucleus   Phosphoprotein   Reference proteome   Repeat   Repressor   Transcription   Transcription regulation   Zinc   Zinc-finger  

Feature

chain  Polycomb protein Scm

Uniprot

E5RWX5   A0A3S2NQZ8   A0A194PSM9   A0A194QMP8   A0A2A4K925   A0A2H1VUA6   + More
E3UKP8   A0A212ES73   A0A0L7LL91   A0A0N1PHH6   A0A0T6B2N8   A0A1W4X7D4   A0A1Q2TRK4   A0A1Y1L370   A0A1B0GJY0   D6X4T6   A0A1L8DG99   N6TQN1   V5GUV3   Q172L2   A0A232FBI3   A0A0C9RTM8   E2CA63   K7JXF9   A0A1A9Y7F4   A0A1A9ZNV4   A0A1I8MQI6   A0A158P1U4   A0A195AWD0   A0A1I8Q302   A0A1B0G5G5   A0A1B0B3P3   A0A1A9VBE5   A0A1A9WJE5   A0A0A1XIJ3   A0A034WG00   A0A0L0CCD9   A0A1W4VZT5   B4M495   W8BXY5   A0A0M3QYM4   B3M1H4   B5DVX9   B4K640   B3NZN3   A0A224L1N5   A0A224L1B0   A0A3B0K2F4   A0A3B0K289   B4PUS4   B4N846   A0A224L3V3   E2AQL4   F4W613   A0A1J1ICW6   A0A3B0KRA0   A0A151ID15   B4JFG1   A0A1B6EGN3   A0A1B6CYZ9   A0A195EQ86   A0A0B4K6M7   Q9VHA0   A0A0A9WFW6   A0A146LRS7   U4TSI4   A0A182TRF7   A0A182JCR0   A0A1S3D8P2  

Pubmed

19121390    22485166    26354079    22118469    26227816    27956627    + More
28004739    18362917    19820115    23537049    17510324    28648823    20798317    20075255    25315136    21347285    25830018    25348373    26108605    17994087    24495485    15632085    17550304    21719571    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    8625848    12537569    9343432    12771214    15280237    18327897    15905166    25401762    26823975   

EMBL

BABH01019596    BABH01019597    AB607835    BAJ54069.1    RSAL01000008    RVE54033.1    + More
KQ459600    KPI94130.1    KQ461195    KPJ06797.1    NWSH01000020    PCG80707.1    ODYU01004489    SOQ44417.1    HM449922    ADO33057.1    AGBW02012844    OWR44356.1    JTDY01000698    KOB76180.1    KQ460793    KPJ12191.1    LJIG01016067    KRT81715.1    LC103191    BAW94266.1    GEZM01068059    JAV67241.1    AJWK01022435    KQ971381    EEZ97245.2    GFDF01008720    JAV05364.1    APGK01024639    KB740557    ENN80368.1    GALX01003029    JAB65437.1    CH477435    EAT40952.1    NNAY01000463    OXU28196.1    GBYB01012100    JAG81867.1    GL453920    EFN75218.1    ADTU01006884    KQ976731    KYM76357.1    CCAG010000320    JXJN01007940    GBXI01003515    GBXI01000907    JAD10777.1    JAD13385.1    GAKP01004436    JAC54516.1    JRES01000608    KNC29915.1    CH940652    EDW59456.1    GAMC01008375    GAMC01008374    JAB98181.1    CP012526    ALC47933.1    CH902617    EDV43265.1    CM000070    EDY68483.1    CH933806    EDW14090.1    CH954181    EDV49743.1    LN864806    CRL92702.1    LN864808    CRL92704.1    OUUW01000014    SPP88414.1    SPP88415.1    CM000160    EDW96691.1    CH964232    EDW81297.1    LN864807    CRL92703.1    GL441777    EFN64282.1    GL887707    EGI70148.1    CVRI01000047    CRK98127.1    SPP88416.1    KQ977995    KYM98260.1    CH916369    EDV93442.1    GEDC01000196    JAS37102.1    GEDC01018657    JAS18641.1    KQ982021    KYN30445.1    AE014297    AFH06324.1    U49793    BT001565    AAB57632.1    AAF54419.2    AAN71320.1    GBHO01036963    GBHO01036962    GBHO01036961    GBHO01036960    JAG06641.1    JAG06642.1    JAG06643.1    JAG06644.1    GDHC01009262    GDHC01009163    JAQ09367.1    JAQ09466.1    KB631581    ERL84469.1   

Proteomes

UP000005204    UP000283053    UP000053268    UP000053240    UP000218220    UP000007151    + More
UP000037510    UP000192223    UP000092461    UP000007266    UP000019118    UP000008820    UP000215335    UP000008237    UP000002358    UP000092443    UP000092445    UP000095301    UP000005205    UP000078540    UP000095300    UP000092444    UP000092460    UP000078200    UP000091820    UP000037069    UP000192221    UP000008792    UP000092553    UP000007801    UP000001819    UP000009192    UP000008711    UP000268350    UP000002282    UP000007798    UP000000311    UP000007755    UP000183832    UP000078542    UP000001070    UP000078541    UP000000803    UP000030742    UP000075902    UP000075880    UP000079169   

PRIDE

E5RWX5    Q9VHA0   

Pfam

PF06467   zf-FCS        + More
PF00536   SAM_1
PF02820   MBT
PF12140   SLED
PF09011   HMG_box_2
PF00505   HMG_box

Interpro

IPR010507   Znf_MYM        + More
IPR001660   SAM       
IPR004092   Mbt       
IPR013761   SAM/pointed_sf       
IPR012313   Znf_FCS       
IPR021987   SLED       
IPR038348   SLED_sf       
IPR009071   HMG_box_dom       
IPR036910   HMG_box_dom_sf       
IPR017967   HMG_boxA_CS       
IPR011017   TRASH_dom       

SUPFAM

SSF47769   SSF47769        + More
SSF47095   SSF47095       

Gene 3D

1.10.150.50     1.20.1380.20     1.10.30.10    

ProteinModelPortal

E5RWX5   A0A3S2NQZ8   A0A194PSM9   A0A194QMP8   A0A2A4K925   A0A2H1VUA6   + More
E3UKP8   A0A212ES73   A0A0L7LL91   A0A0N1PHH6   A0A0T6B2N8   A0A1W4X7D4   A0A1Q2TRK4   A0A1Y1L370   A0A1B0GJY0   D6X4T6   A0A1L8DG99   N6TQN1   V5GUV3   Q172L2   A0A232FBI3   A0A0C9RTM8   E2CA63   K7JXF9   A0A1A9Y7F4   A0A1A9ZNV4   A0A1I8MQI6   A0A158P1U4   A0A195AWD0   A0A1I8Q302   A0A1B0G5G5   A0A1B0B3P3   A0A1A9VBE5   A0A1A9WJE5   A0A0A1XIJ3   A0A034WG00   A0A0L0CCD9   A0A1W4VZT5   B4M495   W8BXY5   A0A0M3QYM4   B3M1H4   B5DVX9   B4K640   B3NZN3   A0A224L1N5   A0A224L1B0   A0A3B0K2F4   A0A3B0K289   B4PUS4   B4N846   A0A224L3V3   E2AQL4   F4W613   A0A1J1ICW6   A0A3B0KRA0   A0A151ID15   B4JFG1   A0A1B6EGN3   A0A1B6CYZ9   A0A195EQ86   A0A0B4K6M7   Q9VHA0   A0A0A9WFW6   A0A146LRS7   U4TSI4   A0A182TRF7   A0A182JCR0   A0A1S3D8P2  

PDB

2P0K     E-value=5.9473e-83,     Score=785

KEGG

100529125    K11461 polycomb protein SCMH1 | (RefSeq) SCM; sex combs on midleg

GO

GO:0008270   GO:0005634   GO:0006355   GO:0003677   GO:0140259   GO:0016458   GO:0048749   GO:0030713   GO:0005700   GO:0042802   GO:0045926   GO:0030708   GO:0007409   GO:0016021   GO:0007419   GO:0022008   GO:0035102   GO:0006325   GO:0045892   GO:0005515   GO:0000287   GO:0016620   GO:0016787   GO:0003676   GO:0016491   GO:0015930  

Subcellular location

Nucleus  

Length:

620

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.03668

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00073

outside

1  -  620

 

 

Pi

162.638843

Theta

145.010303

Tajima's D

0.502411

CLR

343.498022

CSRT

0.517674116294185

Interpretation

Uncertain