Gene

KWMTBOMO13695  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011088

Annotation

PREDICTED:_ribosomal_protein_S6_kinase?_90_kDa_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr23(+):7159725-7174890      View in EpiBrowser

Full name

Ribosomal protein S6 kinase       + More
Non-specific serine/threonine protein kinase      

Location in the cell

Cytoplasmic   Reliability : 2.614

CDS

ATGCCACTAGCTAACACCTCGGATCCTTGGCGAATGCAGAATGTGGGAGATAACACGCTAGGTGCATCAGCTCAACCGGCAAACAACCTTCCGATAGTAGTTGAGAATTCATCAGAGTCTAGACAGGCTTCAACAACTGAAAGCTTAGATTCAAATGCAGAAATAAACTATGAAAGGGAAGTGGAAATACAGGATGTTGTTAAAGAAGGTCATGACAAGGCTGATCCATCACAATTTGAATTGCTCAAAGTTCTGGGTGAAGGTTCCTTTGGTAAAGTATTCCTAGTGAGGAAAGTTGTTGGACTTGATGCTGGTACCCTGTATGCTATGAAGGTACTTAAAAAAGCTACTTTAAAAGTGAGAGATCGAGAACGTACAAAAATGGAAAGAAATATACTAGTTGAAATGGGTCATCCATTTATTGTAAAATTACATTATGCATTCCAAACAGCTGGTAAACTATATTTAATATTGGATTTTTTACGTGGTGGTGATTTATTTTCTCGTCTCAGTAAAGAGGTAATGTTCACAGAAGAAGATGTGAAGTTCTATTTAGCAGAGCTAGCATTAGCCTTAGAACATGTTCACAAATTGGGGATCATATACAGAGATCTCAAGCCAGAAAATATTCTCTTAGATGCCGATGGCCACATCGCACTTACCGATTTTGGCTTATCGAAATTGCCTCCAAGTAGTGACAAAGCTTATAGTTTTTGTGGTACTGTCGAATACATGGCTCCTGAAGTCGTGAACAGAAGGGGTCACACCTTTGCTGCTGATTGGTGGTCTTTTGGTGTACTTATGTTTGAAATGCTAACAGGAAATTTACCTTTCCATGGAGCTAACAGACACGAGACTATGACTCAAATTTTAAAAGCTAAACTTGGTATGCCTTCTAATTTAAGTGAAGAAGCTCAATCTTTACTTCGAGCCTTATTTAAGAGGAATCCTCAAAATAGATTGGGTGCCGGTCCCAATGGAATTGAGGACATAAAAAAACACGAATTTTTTGCTAGTATAGACTGGGATGGTCTTTATAAAAAAGAGGTTATTCCGCCTTTTCGACCGGCTGTATCGAGAGCTGACGACGCTTTTTATTTCGATTCAGAGTTCACCTGTAGAACGCCAAGAGACTCGCCTGGAGTGCCGGCCTCCGCAAACGCACACGAGCTATTCAGGGGCTTTAGCTTCGTTGCGCCTTGTCTGCTCCAAGAGGACGAGAACAAAACTGTCACCAATCAAAATCAAAACCACAATACGCAGAACCCAAAGACGTCCACTGAAGAATTTTGGTCCGGATTTGTCAACCGCAACAACTTCTTTGACGAGTACAGGTTGATGGGTGAATTGGGGACGGGTTCATTCTCGGTGGTGCGACTCTGTGAACATAAAACTTCTCGCGTACAATATGCCGTCAAAATCATGGACAAATTGCAGTACGATCCTCGGGAAGAAATAGAGATACTACTGAGGTACAGTCAGCACCAGCATATCATAACGCTCCGGGGTGTTTACGAGGAGGGCGGTCGTATACTGGCGGTCACGGAGCTGTGTCGCGGCGGGGAACTGTTGGAACACATAACGCAACGACGCTACCTGCCTGAACATGAAGCGGCTCCCATACTAAAGAATGTCTTGCATGCGGTACATTACTTGCATGCGCACACTGTTGTACACAGAGACATAAAGCCATCCAACATTCTCTTCGCAACGGCTGAAAAGCGTCCCGAGGATATACGTCTAGTCGACTTTGGTTTAGCGAAGCAACTTCGTGCCGAAAACGGTCTGCTCATGACGCCGTGTTACACCGCCAACTTCGTCGCTCCCGAAGTACTCAAAAGGGCAGGATACGACGCCGCCTGCGACATATGGAGCTTAGGTGTGTTAGCCTACATAATGCTTTCTGGTAGAACTCCTTTCGCCTCGACCGGAGACGACACTCCTGATGCTATATTAGAACGAATAGAATCCGGGAAGGTGGAATTATCAACGGGAATATGGCGTAGCGTTTCAACGGGCGCTAAGTCGTGCATTCGGCGGATGCTGCAGCTGGAGCCGTCGCTGCGTCCGCGCGCCGCCGACCTGCTGAAGGAGGCGTGGCTCACGGCGCCCGCCGCGCCGCGCGACGCCGCGCCGCCCGACGCAGAGCCCACGCCCCCTCCCGCCGACCTGCGACGGGCCGTCGACCTCACGTTCCAAGCGATGACCGCATCACCATTAACACCGCAGGTGCTGGGTCCTGTTTCTCAGTCGACCCTCGCACAGCGCCGCAACAAACCTCAACGACGTTTTCCGCCCACACAGATATAA

Protein

MPLANTSDPWRMQNVGDNTLGASAQPANNLPIVVENSSESRQASTTESLDSNAEINYEREVEIQDVVKEGHDKADPSQFELLKVLGEGSFGKVFLVRKVVGLDAGTLYAMKVLKKATLKVRDRERTKMERNILVEMGHPFIVKLHYAFQTAGKLYLILDFLRGGDLFSRLSKEVMFTEEDVKFYLAELALALEHVHKLGIIYRDLKPENILLDADGHIALTDFGLSKLPPSSDKAYSFCGTVEYMAPEVVNRRGHTFAADWWSFGVLMFEMLTGNLPFHGANRHETMTQILKAKLGMPSNLSEEAQSLLRALFKRNPQNRLGAGPNGIEDIKKHEFFASIDWDGLYKKEVIPPFRPAVSRADDAFYFDSEFTCRTPRDSPGVPASANAHELFRGFSFVAPCLLQEDENKTVTNQNQNHNTQNPKTSTEEFWSGFVNRNNFFDEYRLMGELGTGSFSVVRLCEHKTSRVQYAVKIMDKLQYDPREEIEILLRYSQHQHIITLRGVYEEGGRILAVTELCRGGELLEHITQRRYLPEHEAAPILKNVLHAVHYLHAHTVVHRDIKPSNILFATAEKRPEDIRLVDFGLAKQLRAENGLLMTPCYTANFVAPEVLKRAGYDAACDIWSLGVLAYIMLSGRTPFASTGDDTPDAILERIESGKVELSTGIWRSVSTGAKSCIRRMLQLEPSLRPRAADLLKEAWLTAPAAPRDAAPPDAEPTPPPADLRRAVDLTFQAMTASPLTPQVLGPVSQSTLAQRRNKPQRRFPPTQI

Catalytic Activity

ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]

Cofactor

Mg(2+)

Similarity

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.

Uniprot

E9JEJ4   A0A2H1VUA5   A0A212ESD2   A0A3S2P753   A0A194QP99   A0A2A4K9Z0   + More
A0A1B6EJE7   A0A1B6F4W9   A0A1B6GVP1   A0A1B6E7R3   A0A1L8DM20   A0A1L8DKF2   D6W9Y5   A0A1B6CU71   A0A1W4X595   A0A139WMZ3   W5JFB8   A0A1Q3EXS5   A0A182Q1V8   A0A182HUA8   A0A182WRG9   A0A182V5C0   A0A182LFQ5   A0A2M4AI41   A0A2M4CHP8   A0A2M4AIL6   Q7QDB4   A0A2M4CHR1   A0A2M4AI78   A0A182F7G5   A0A182U6R8   A0A2M4CHP5   A0A1W4WUE3   A0A1B0C9J5   A0A182ME49   A0A2J7QSY7   V5G5I2   A0A182IVP3   A0A0K8TLA7   A0A1Y1K9P9   A0A182Y4D7   Q17CS0   A0A1S4F7R6   A0A0H4TNU9   A0A2S2QXS0   A0A023F4P1   B0X4Q5   A0A182W091   A0A1Y1K9L0   T1HI54   A0A2H8TWR5   A0A0A9WQ54   A0A0K8T8Y7   A0A2S2PHI6   A0A2A3EKH5   A0A1D2NER8   A0A088A647   K7J440   E2A521   A0A026WCH9   A0A0L7R1U7   A0A3Q0J520   A0A232EYU8   E0W314   A0A0P4W0M9   A0A0N0BJF2   E2BHH8   A0A158NUR6   A0A195BBF4   A0A0V1JQ35   A0A0V0Z917   A0A151IV57   A0A226DYC1   A0A0V1B402   A0A0P4VWW3   A0A2T7P4U8   A0A154P3L5   F4WE08   A0A151I6I7   Q9PTN1   A0A0V0RNH0   A0A0V0Z9Q2   A0A1B0G241   A0A151K0I3   A0A0V1B3Q5   A0A0V1L0M7   A0A0V0V237   A0A151N034   A0A1W7RDQ3   A0A0V1EEB1   K7FRF3   A0A151N093   T1E4Z8   J3S531   F6YJ34   A0A151WNR4   A0A1V4JC22   A0A1D5NWT4   A0A1I8NBH0  

EC Number

2.7.11.1

Pubmed

19121390    21040523    22118469    26354079    18362917    19820115    + More
20920257    23761445    20966253    12364791    14747013    17210077    26369729    28004739    25244985    17510324    25474469    25401762    26823975    27289101    20075255    20798317    24508170    30249741    28648823    20566863    21347285    21719571    10558991    27762356    22293439    26358130    17381049    23758969    23025625    17495919    15592404    25315136   

EMBL

BABH01019591    BABH01019592    BABH01019593    GQ426311    ADM32537.1    ODYU01004489    + More
SOQ44419.1    AGBW02012844    OWR44354.1    RSAL01000008    RVE54035.1    KQ461195    KPJ06800.1    NWSH01000020    PCG80724.1    GECZ01031712    GECZ01029922    JAS38057.1    JAS39847.1    GECZ01024519    GECZ01002751    JAS45250.1    JAS67018.1    GECZ01015062    GECZ01003251    JAS54707.1    JAS66518.1    GEDC01003317    JAS33981.1    GFDF01006576    JAV07508.1    GFDF01007145    JAV06939.1    KQ971312    EEZ98563.1    GEDC01020266    JAS17032.1    KYB29263.1    ADMH02001371    ETN62776.1    GFDL01014955    JAV20090.1    AXCN02000238    APCN01000614    APCN01000615    APCN01000616    GGFK01007096    MBW40417.1    GGFL01000688    MBW64866.1    GGFK01007127    MBW40448.1    AAAB01008859    EAA07892.5    GGFL01000698    MBW64876.1    GGFK01007126    MBW40447.1    GGFL01000694    MBW64872.1    AJWK01002422    AJWK01002423    AJWK01002424    AJWK01002425    AJWK01002426    AJWK01002427    AJWK01002428    AJWK01002429    AJWK01002430    AJWK01002431    AXCM01001260    NEVH01011209    PNF31684.1    GALX01003136    JAB65330.1    GDAI01002471    JAI15132.1    GEZM01088480    JAV58173.1    CH477305    EAT44125.1    KP890676    AKQ09615.1    GGMS01013366    MBY82569.1    GBBI01002335    JAC16377.1    DS232350    EDS40472.1    GEZM01088481    JAV58172.1    ACPB03001248    ACPB03001249    GFXV01006881    MBW18686.1    GBHO01034053    GBHO01025746    GBHO01025745    GBHO01025744    GBHO01025743    GBHO01025742    GDHC01006991    JAG09551.1    JAG17858.1    JAG17859.1    JAG17860.1    JAG17861.1    JAG17862.1    JAQ11638.1    GBRD01003935    JAG61886.1    GGMR01015737    MBY28356.1    KZ288229    PBC31696.1    LJIJ01000064    ODN03751.1    AAZX01004540    GL436794    EFN71452.1    KK107273    QOIP01000012    EZA53780.1    RLU16038.1    KQ414667    KOC64813.1    NNAY01001595    OXU23479.1    DS235881    EEB20020.1    GDRN01101796    JAI58316.1    KQ435719    KOX78841.1    GL448301    EFN84831.1    ADTU01026686    KQ976532    KYM81557.1    JYDU01000053    JYDR01000051    JYDS01000326    JYDV01000063    KRX95643.1    KRY71919.1    KRZ13905.1    KRZ37080.1    JYDQ01000293    KRY09079.1    KQ980926    KYN11381.1    LNIX01000009    OXA50465.1    JYDH01000113    KRY31674.1    GDRN01101801    GDRN01101798    JAI58314.1    PZQS01000006    PVD28440.1    KQ434809    KZC06506.1    GL888102    EGI67446.1    KQ978473    KYM93706.1    AF165162    BC080017    CM004468    AAF15553.1    AAH80017.1    OCT94181.1    JYDL01000120    KRX15864.1    KRY09075.1    CCAG010022992    KQ981296    KYN43085.1    KRY31672.1    JYDW01000179    KRZ52903.1    JYDN01000104    KRX57309.1    AKHW03004278    KYO30193.1    GDAY02002156    JAV49276.1    KRY71921.1    AGCU01040273    AGCU01040274    AGCU01040275    AGCU01040276    AGCU01040277    AGCU01040278    AGCU01040279    KYO30194.1    GAAZ01002201    JAA95742.1    JU175808    GBEX01002990    AFJ51332.1    JAI11570.1    KQ982905    KYQ49506.1    LSYS01008075    OPJ69649.1    AADN05001050   

Proteomes

UP000005204    UP000007151    UP000283053    UP000053240    UP000218220    UP000007266    + More
UP000192223    UP000000673    UP000075886    UP000075840    UP000076407    UP000075903    UP000075882    UP000007062    UP000069272    UP000075902    UP000092461    UP000075883    UP000235965    UP000075880    UP000076408    UP000008820    UP000002320    UP000075920    UP000015103    UP000242457    UP000094527    UP000005203    UP000002358    UP000000311    UP000053097    UP000279307    UP000053825    UP000079169    UP000215335    UP000009046    UP000053105    UP000008237    UP000005205    UP000078540    UP000054632    UP000054805    UP000054815    UP000054826    UP000054783    UP000078492    UP000198287    UP000054776    UP000245119    UP000076502    UP000007755    UP000078542    UP000186698    UP000054630    UP000092444    UP000078541    UP000054721    UP000054681    UP000050525    UP000007267    UP000002280    UP000075809    UP000190648    UP000000539    UP000095301   

PRIDE

E9JEJ4   

Pfam

PF00433   Pkinase_C        + More
PF00069   Pkinase
PF00625   Guanylate_kin
PF04103   CD20
PF01176   eIF-1a

Interpro

IPR000961   AGC-kinase_C        + More
IPR016239   Ribosomal_S6_kinase_II       
IPR017892   Pkinase_C       
IPR000719   Prot_kinase_dom       
IPR041906   RSK_N       
IPR008271   Ser/Thr_kinase_AS       
IPR011009   Kinase-like_dom_sf       
IPR017441   Protein_kinase_ATP_BS       
IPR001309   Pept_C14_p20       
IPR027417   P-loop_NTPase       
IPR017665   Guanylate_kinase       
IPR008145   GK/Ca_channel_bsu       
IPR008144   Guanylate_kin-like_dom       
IPR020590   Guanylate_kinase_CS       
IPR041905   RPS6KA3_C       
IPR007237   CD20-like       
IPR006196   RNA-binding_domain_S1_IF1       
IPR018104   TIF_eIF-1A_CS       
IPR001253   TIF_eIF-1A       
IPR012340   NA-bd_OB-fold       

SUPFAM

SSF56112   SSF56112        + More
SSF52540   SSF52540       
SSF50249   SSF50249       

CDD

cd05582  STKc_RSK_N
cd14176  STKc_RSK2_C
cd05793  S1_IF1A

ProteinModelPortal

E9JEJ4   A0A2H1VUA5   A0A212ESD2   A0A3S2P753   A0A194QP99   A0A2A4K9Z0   + More
A0A1B6EJE7   A0A1B6F4W9   A0A1B6GVP1   A0A1B6E7R3   A0A1L8DM20   A0A1L8DKF2   D6W9Y5   A0A1B6CU71   A0A1W4X595   A0A139WMZ3   W5JFB8   A0A1Q3EXS5   A0A182Q1V8   A0A182HUA8   A0A182WRG9   A0A182V5C0   A0A182LFQ5   A0A2M4AI41   A0A2M4CHP8   A0A2M4AIL6   Q7QDB4   A0A2M4CHR1   A0A2M4AI78   A0A182F7G5   A0A182U6R8   A0A2M4CHP5   A0A1W4WUE3   A0A1B0C9J5   A0A182ME49   A0A2J7QSY7   V5G5I2   A0A182IVP3   A0A0K8TLA7   A0A1Y1K9P9   A0A182Y4D7   Q17CS0   A0A1S4F7R6   A0A0H4TNU9   A0A2S2QXS0   A0A023F4P1   B0X4Q5   A0A182W091   A0A1Y1K9L0   T1HI54   A0A2H8TWR5   A0A0A9WQ54   A0A0K8T8Y7   A0A2S2PHI6   A0A2A3EKH5   A0A1D2NER8   A0A088A647   K7J440   E2A521   A0A026WCH9   A0A0L7R1U7   A0A3Q0J520   A0A232EYU8   E0W314   A0A0P4W0M9   A0A0N0BJF2   E2BHH8   A0A158NUR6   A0A195BBF4   A0A0V1JQ35   A0A0V0Z917   A0A151IV57   A0A226DYC1   A0A0V1B402   A0A0P4VWW3   A0A2T7P4U8   A0A154P3L5   F4WE08   A0A151I6I7   Q9PTN1   A0A0V0RNH0   A0A0V0Z9Q2   A0A1B0G241   A0A151K0I3   A0A0V1B3Q5   A0A0V1L0M7   A0A0V0V237   A0A151N034   A0A1W7RDQ3   A0A0V1EEB1   K7FRF3   A0A151N093   T1E4Z8   J3S531   F6YJ34   A0A151WNR4   A0A1V4JC22   A0A1D5NWT4   A0A1I8NBH0  

KEGG

100529213    K04373 ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1] | (RefSeq) p90srk; ribosomal protein

PATHWAY

04150    mTOR signaling pathway - Bombyx mori (domestic silkworm)

GO

GO:0004674   GO:0005524   GO:0000287   GO:0035556   GO:0004711   GO:0004197   GO:0004385   GO:0016021   GO:0003743   GO:0043027   GO:0019901   GO:0032496   GO:0002224   GO:0045944   GO:0006468   GO:0004672   GO:0016620   GO:0016787   GO:0003676   GO:0016491   GO:0015930  

Length:

769

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

0.11439

Exp number, first 60 AAs:

0

Total prob of N-in:

0.00338

outside

1  -  769

 

 

Pi

256.495717

Theta

196.264523

Tajima's D

0.794737

CLR

0.144448

CSRT

0.593320333983301

Interpretation

Uncertain