Gene

KWMTBOMO13694  Validated by peptides from experiments

Pre Gene Modal

BGIBMGA011087

Annotation

PREDICTED:_CAAX_prenyl_protease_1_homolog_[Plutella_xylostella]

Location

Bomo_Chr23(+):7146505-7148271      View in EpiBrowser

Full name

CAAX prenyl protease      

Location in the cell

PlasmaMembrane   Reliability : 4.821

CDS

ATGAATTTTGACGAAGATGCTATTCTATATTTGATTTTATTATTTACATGGGTGGAGTATCTATGGGAACAATATCTCTCCCTTCGACAGTTAAAGATTTACAAAACTAATAATACCATCCCAGAAGACTTGAAAGAAATGCTCAATGAGGACTTGTTTAAGAAGGCACGACTTTATGGAATTGATAAAGCGCAGTTCAAAATAGTCAAGGAACTGTACAGTACAATACTAACATCAGTAATATTGTACAATAAATGGATCTATGTTGCATGGAGGAAAAGTGAACAAATTGGAGCAATGTTCAACATCTCTCCAGATAGAGAGATAATTATAAGTTGCATTTTTATGACATTTATTACATTGTTCAACTTTATTGTTAACAAACCATTTACCATTTATGGTGTGTTTGTTCTTGAGGAACGACATGGATTTAATAAGCAAACTGTACGATTCTTTATTAAGGATCAAATAAAATCACTATTTTTAAGTTTAGTGATTACATTACCAATAATATCTGTAGCAATTTATATAATAATGCTTGGAGGAGACATGTTTGTGGTGTGGCTATGGCTATTTACTACTGTTGCAACACTCCTACTGTTAACATTATATCCAACAGTCATAGCCCCACTGTTTGACAAATTTGTACCTCTACCTGATGGATCGCTCAGGACAGCAATTGAAAATTTAGCATCAAGATTGAACTTCCCATTATCACAAGTTTTTATAGTTGAAGGTTCAAAACGATCAGCACATAGCAATGCTTACTTTAGTGGCTTATTTGGTGGAAAGAGAATTGTATTATTTGATACTTTAATTGAAAAATTTGATGAACAGAAGCAAGTGACCACCGGATGTACGGAGGATGAGATATTAGGGATTTTAGCTCACGAACTCGGACATTGGAGTTGTAGCCATATCTACAAATCAATTGCTCTCACTGAAGTGAACCTATTACTATTATTTAGTGCATTTGGAATCCTCTTCAAGTATTCAACGTTATACACAGCACTGGGCTTTCCATCAGGTCAAGAACCAATACTCATTGGCTTGATTGTAGTTTTACAAATGATTTTAGCACCATACAATTCCATACTTTCATTCTTTTCAACGGCTGTCTCTAGAATGTATGAATTTGAAGCTGATAATTTTGCTGTTTCCTTGTCTTATCCTAATGAATTACGATCAGCTCTCATTAAATTGGGAAAAGATAACTTAGATTATCCAATTTATGATAAGCTCTACTCTGCATGGTATCATTCTCATCCAACCTTATTACACAGAATCGAAAATATTAAGAGCCAAATAACTGCAAAAAGATCTGAATGA

Protein

MNFDEDAILYLILLFTWVEYLWEQYLSLRQLKIYKTNNTIPEDLKEMLNEDLFKKARLYGIDKAQFKIVKELYSTILTSVILYNKWIYVAWRKSEQIGAMFNISPDREIIISCIFMTFITLFNFIVNKPFTIYGVFVLEERHGFNKQTVRFFIKDQIKSLFLSLVITLPIISVAIYIIMLGGDMFVVWLWLFTTVATLLLLTLYPTVIAPLFDKFVPLPDGSLRTAIENLASRLNFPLSQVFIVEGSKRSAHSNAYFSGLFGGKRIVLFDTLIEKFDEQKQVTTGCTEDEILGILAHELGHWSCSHIYKSIALTEVNLLLLFSAFGILFKYSTLYTALGFPSGQEPILIGLIVVLQMILAPYNSILSFFSTAVSRMYEFEADNFAVSLSYPNELRSALIKLGKDNLDYPIYDKLYSAWYHSHPTLLHRIENIKSQITAKRSE

Description

Proteolytically removes the C-terminal three residues of farnesylated proteins.

Catalytic Activity

The peptide bond hydrolyzed can be designated -C-|-A-A-X in which C is an S-isoprenylated cysteine residue, A is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids.

Cofactor

Zn(2+)

Similarity

Belongs to the peptidase M48A family.

Uniprot

H9JNI3   S4NXY5   A0A2A4KAA5   A0A2H1VUA0   A0A212ES82   A0A194PL15   + More
A0A194QMQ3   A0A0L7LUR9   A0A0T6B4M1   U5EUQ9   A0A084VHR8   A0A0V0G3M2   Q1HQI2   Q16XQ8   A0A2M4BMS6   W5JD27   A0A069DTD7   A0A2M4BMV1   A0A182JGX8   A0A182RT53   A0A023F9Y9   A0A1W4X7A5   A0A182G721   A0A182FQW5   A0A1Q3FBX8   A0A182G3E1   A0A2M4AJJ0   A0A1B6M547   R4G4J9   A0A1Y1N6U8   A0A0P4VQ23   T1HRT3   A0A067RQK9   A0A182W3D8   B0WKM4   A0A2J7RBX4   A0A1I8MAT3   A0A1B6G267   A0A0A9Z3F8   A0A182KZL9   A0A0P4WV02   A0A0P5X708   Q7QA21   A0A182HYL7   A0A0P6AE68   A0A0N8EQ42   E9H7W5   A0A0P5RD66   A0A182NSG2   A0A2M4BNM3   A0A336N1B2   A0A0L0BYZ1   A0A034WIT7   A0A0A1XTJ6   L7NKT9   A0A1L8ED53   A0A336MK27   A0A0K8TMA6   A0A1A9X311   A0A0K8VYI8   A0A1I8PJE7   A0A182S868   A0A1B0FMW5   A0A1A9ZP21   D6WA54   B3MD80   W8BR88   A0A087Y6D4   A0A3B3UH42   A0A3Q2GQ54   A0A1A9X8G2   A0A1B0BAJ3   T2MI13   A0A3B3XL69   B4JW14   A0A3Q0RB17   R7UXY8   A0A3B5B9C6   A0A1A9VX36   A0A3Q1CKA8   A0A3P8TKQ5   A0A1B6BYZ3   Q7K172   H2MI53   I3J6J9   N6UMW7   B4HMF9   A0A3P9Q748   A0A3Q4G2Y0   A0A3B4GY31   A0A3P8Q5A7   A0A3P9B9A3   A0A3S3PVM3   A0A3P9M8B7   A0A3Q3CFG9   A0A0P4X058   A0A182Y8U6   A0A1B0DL37   M4A000   A0A3P9HSR4  

EC Number

3.4.24.84

Pubmed

19121390    23622113    22118469    26354079    26227816    24438588    + More
17204158    17510324    20920257    23761445    26334808    25474469    26483478    28004739    27129103    24845553    25315136    25401762    20966253    12364791    14747013    17210077    21292972    26108605    25348373    25830018    26369729    18362917    19820115    17994087    24495485    24065732    23254933    10731132    12537568    12537572    12537573    12537574    16110336    17569856    17569867    26109357    26109356    17554307    25186727    23537049    25244985    23542700   

EMBL

BABH01019590    GAIX01011972    JAA80588.1    NWSH01000020    PCG80723.1    ODYU01004489    + More
SOQ44421.1    AGBW02012844    OWR44352.1    KQ459600    KPI94126.1    KQ461195    KPJ06802.1    JTDY01000043    KOB79207.1    LJIG01009810    KRT82335.1    GANO01002211    JAB57660.1    ATLV01013213    KE524845    KFB37512.1    GECL01003452    JAP02672.1    DQ440462    ABF18495.1    CH477534    EAT39384.1    GGFJ01005245    MBW54386.1    ADMH02001863    ETN60800.1    GBGD01001546    JAC87343.1    GGFJ01005244    MBW54385.1    GBBI01000974    JAC17738.1    JXUM01045948    KQ561456    KXJ78516.1    GFDL01010042    JAV25003.1    JXUM01040820    KQ561260    KXJ79178.1    GGFK01007629    MBW40950.1    GEBQ01008932    JAT31045.1    GAHY01001295    JAA76215.1    GEZM01011773    JAV93439.1    GDKW01001490    JAI55105.1    ACPB03006764    KK852482    KDR22915.1    DS231974    EDS29955.1    NEVH01005889    PNF38343.1    GECZ01013247    JAS56522.1    GBHO01043597    GBHO01043594    GBHO01036543    GBHO01036535    GBHO01033302    GBHO01033301    GBHO01014937    GBHO01013143    GBHO01010076    GBHO01009847    GBHO01009846    GBHO01009845    GBHO01009844    GBHO01009843    GBHO01004620    JAG00007.1    JAG00010.1    JAG07061.1    JAG07069.1    JAG10302.1    JAG10303.1    JAG28667.1    JAG30461.1    JAG33528.1    JAG33757.1    JAG33758.1    JAG33759.1    JAG33760.1    JAG33761.1    JAG38984.1    GDIP01251782    JAI71619.1    GDIP01076466    LRGB01003325    JAM27249.1    KZS03243.1    AAAB01008898    EAA09255.4    APCN01005389    GDIP01031958    JAM71757.1    GDIQ01004932    JAN89805.1    GL732602    EFX72100.1    GDIQ01104143    JAL47583.1    GGFJ01005545    MBW54686.1    UFQS01003844    UFQT01003844    SSX15975.1    SSX35309.1    JRES01001139    KNC25211.1    GAKP01003458    GAKP01003456    JAC55496.1    GBXI01000129    JAD14163.1    JN215470    AEX33292.1    GFDG01002290    JAV16509.1    UFQT01001157    SSX29193.1    GDAI01002543    JAI15060.1    GDHF01014820    GDHF01008387    JAI37494.1    JAI43927.1    CCAG010018363    KQ971312    EEZ98057.1    CH902619    EDV37413.1    GAMC01002735    JAC03821.1    AYCK01015820    JXJN01011023    HAAD01005514    CDG71746.1    CH916375    EDV98152.1    AMQN01000857    KB296703    ELU11443.1    GEDC01031024    JAS06274.1    AE013599    AY069332    AAF57922.1    AAL39477.1    AERX01030649    APGK01017097    KB739995    KB630277    KB632201    ENN82041.1    ERL83507.1    ERL90056.1    CH480816    EDW48227.1    NCKU01000112    NCKU01000111    RWS17165.1    RWS17172.1    GDRN01040392    JAI67158.1    AJVK01016183   

Proteomes

UP000005204    UP000218220    UP000007151    UP000053268    UP000053240    UP000037510    + More
UP000030765    UP000008820    UP000000673    UP000075880    UP000075900    UP000192223    UP000069940    UP000249989    UP000069272    UP000015103    UP000027135    UP000075920    UP000002320    UP000235965    UP000095301    UP000075882    UP000076858    UP000007062    UP000075840    UP000000305    UP000075884    UP000037069    UP000091820    UP000095300    UP000075901    UP000092444    UP000092445    UP000007266    UP000007801    UP000028760    UP000261500    UP000265020    UP000092443    UP000092460    UP000261480    UP000001070    UP000261340    UP000014760    UP000261400    UP000078200    UP000257160    UP000265080    UP000000803    UP000001038    UP000005207    UP000019118    UP000030742    UP000001292    UP000242638    UP000261580    UP000261460    UP000265100    UP000265160    UP000285301    UP000265180    UP000264840    UP000076408    UP000092462    UP000002852    UP000265200   

PRIDE

H9JNI3    Q7K172   

Pfam

PF01435   Peptidase_M48        + More
PF16491   Peptidase_M48_N

Interpro

IPR027057   CAXX_Prtase_1        + More
IPR001915   Peptidase_M48       
IPR032456   Peptidase_M48_N       
IPR036259   MFS_trans_sf       

SUPFAM

SSF103473   SSF103473       

CDD

cd07343  M48A_Zmpste24p_like

ProteinModelPortal

H9JNI3   S4NXY5   A0A2A4KAA5   A0A2H1VUA0   A0A212ES82   A0A194PL15   + More
A0A194QMQ3   A0A0L7LUR9   A0A0T6B4M1   U5EUQ9   A0A084VHR8   A0A0V0G3M2   Q1HQI2   Q16XQ8   A0A2M4BMS6   W5JD27   A0A069DTD7   A0A2M4BMV1   A0A182JGX8   A0A182RT53   A0A023F9Y9   A0A1W4X7A5   A0A182G721   A0A182FQW5   A0A1Q3FBX8   A0A182G3E1   A0A2M4AJJ0   A0A1B6M547   R4G4J9   A0A1Y1N6U8   A0A0P4VQ23   T1HRT3   A0A067RQK9   A0A182W3D8   B0WKM4   A0A2J7RBX4   A0A1I8MAT3   A0A1B6G267   A0A0A9Z3F8   A0A182KZL9   A0A0P4WV02   A0A0P5X708   Q7QA21   A0A182HYL7   A0A0P6AE68   A0A0N8EQ42   E9H7W5   A0A0P5RD66   A0A182NSG2   A0A2M4BNM3   A0A336N1B2   A0A0L0BYZ1   A0A034WIT7   A0A0A1XTJ6   L7NKT9   A0A1L8ED53   A0A336MK27   A0A0K8TMA6   A0A1A9X311   A0A0K8VYI8   A0A1I8PJE7   A0A182S868   A0A1B0FMW5   A0A1A9ZP21   D6WA54   B3MD80   W8BR88   A0A087Y6D4   A0A3B3UH42   A0A3Q2GQ54   A0A1A9X8G2   A0A1B0BAJ3   T2MI13   A0A3B3XL69   B4JW14   A0A3Q0RB17   R7UXY8   A0A3B5B9C6   A0A1A9VX36   A0A3Q1CKA8   A0A3P8TKQ5   A0A1B6BYZ3   Q7K172   H2MI53   I3J6J9   N6UMW7   B4HMF9   A0A3P9Q748   A0A3Q4G2Y0   A0A3B4GY31   A0A3P8Q5A7   A0A3P9B9A3   A0A3S3PVM3   A0A3P9M8B7   A0A3Q3CFG9   A0A0P4X058   A0A182Y8U6   A0A1B0DL37   M4A000   A0A3P9HSR4  

PDB

5SYT     E-value=1.58089e-98,     Score=918

KEGG

101739205    K06013 STE24 endopeptidase [EC:3.4.24.84] | (RefSeq) CAAX prenyl protease 1 homolog

PATHWAY

00900    Terpenoid backbone biosynthesis - Bombyx mori (domestic silkworm)

GO

GO:0030176   GO:0046872   GO:0004222   GO:0071586   GO:0016021   GO:0006508   GO:0005515   GO:0051276   GO:0016491   GO:0016620   GO:0016787   GO:0003676   GO:0015930   GO:0008233  

PANTHER

PTHR10120  

Subcellular location

Endoplasmic reticulum membrane  

Length:

442

Number of predicted TMHs:

6

Exp number of AAs in TMHs:

134.35259

Exp number, first 60 AAs:

17.19425

Total prob of N-in:

0.70189

POSSIBLE N-term signal

sequence

inside

1  -  6

TMhelix

7  -  26

outside

27  -  108

TMhelix

109  -  126

inside

127  -  159

TMhelix

160  -  182

outside

183  -  185

TMhelix

186  -  208

inside

209  -  315

TMhelix

316  -  338

outside

339  -  347

TMhelix

348  -  370

inside

371  -  442

 

 

Pi

169.491297

Theta

167.854061

Tajima's D

-1.158183

CLR

0.091965

CSRT

0.105844707764612

Interpretation

Uncertain