Gene

KWMTBOMO13692

Pre Gene Modal

BGIBMGA011022

Annotation

PREDICTED:_bursicon_isoform_X1_[Bombyx_mori]

Location

Bomo_Chr23(-):7138033-7138904      View in EpiBrowser

Full name

Bursicon      

Alternative Name

Bursicon subunit alpha
Cuticle-tanning hormone
Single-chain bursicon

Location in the cell

Extracellular   Reliability : 4.008

CDS

ATGTCCGTATTGAATACTTTTTTAGTCATAGTGGCTTTAATCTTATGTTACGTAAATGATTTCCCTGTTACTGGGCATGAAGTTCAACTACCTCCAGGCCAGGAATGTCAAATGACCGCAGTCATTCATGTTTTAAAACACCGAGGATGTAAACCTAAAGCAATTCCGTCGTTTGCTTGCATTGGAAAATGCACAAGCTACGTTCAGGTATCGGGTAGTAAAATATGGCAAATGGAGCGTACCTGCAACTGCTGTCAAGAATCAGGAGAAAGAGAAGCTACAGTTGTCTTGTTTTGTCCGGATGCTCAAAATGAAGAAAAGCGATTCAGAAAGGTTTCAACGAAAGCTCCGCTTCAATGCATGTGTCGTCCTTGCGGAAGTATAGAAGAGAGTTCCATTATTCCTCAGGAAGTTGCTGGATACTCCGAAGAAGGACCGCTGTATAACCATTTCAGGAAGTCTCTTTAA

Protein

MSVLNTFLVIVALILCYVNDFPVTGHEVQLPPGQECQMTAVIHVLKHRGCKPKAIPSFACIGKCTSYVQVSGSKIWQMERTCNCCQESGEREATVVLFCPDAQNEEKRFRKVSTKAPLQCMCRPCGSIEESSIIPQEVAGYSEEGPLYNHFRKSL

Description

Final heterodimeric neurohormone released at the end of the molting cycle, involved in the sclerotization (tanning) of the insect cuticle, melanization and wing spreading.
Final heterodimeric neurohormone released at the end of the molting cycle, involved in the sclerotization (tanning) of the insect cuticle, melanization and wing spreading. Heterodimer specifically activates the G protein-coupled receptor rk.

Subunit

Heterodimer of burs and pburs.
Heterodimer of Burs and Pburs.

Miscellaneous

The bursicon gene is encoded by two loci: burs124 contains exons 1, 2 and 4, and burs3 contains exon 3. Exon 3 is trans-spliced into position in the mature transcript. This unusual gene arrangement has existed for at least the 150 million years (MY) of mosquito evolution since the split of the culicid and anophelid family lineages, but is younger than the 250 MY split of the dipteran suborders Nematocera and Brachycera (containing the Culicidea and Drosophilidae, respectively).
The bursicon gene is encoded by two loci: burs124 on chromosome arm 2L contains exons 1, 2 and 4, and burs3 on arm 2R contains exon 3. Exon 3 is trans-spliced into position in the mature transcript. This unusual gene arrangement has existed for at least the 150 million years (MY) of mosquito evolution since the split of the culicid and anophelid family lineages, but is younger than the 250 MY split of the dipteran suborders Nematocera and Brachycera (containing the Culicidea and Drosophilidae, respectively).

Keywords

Complete proteome   Disulfide bond   Hormone   Reference proteome   Secreted   Signal  

Feature

chain  Bursicon

Uniprot

Q566B1   Q4FCM6   A0A2H1WNT1   A0A385H8U1   A0A212ES77   A0A0S1U1M9   + More
A0A2H1VUC7   A0A2A4K923   A0A3S2TSN9   W8RXF2   A0A0C5BEX6   A0A194PN16   A0A194QN72   V5NFD5   A0A0L7K2C7   A0A067R3X7   A0A2P8YCI2   A0A143WDY5   A0A2J7PJC7   W8C890   A0A034V006   A0A1B6GB49   A0A0A1WZR0   A0A1B0GDZ7   A0A1B0AHG7   A0A1A9Y4J5   A0A1B0BBC4   B4K981   B4JHI8   B4M141   B4HM41   A0APK7   C0MK54   Q9VD83   B4PKV0   A0A1I8M3F5   A0A1W4W143   A0A0H3YID2   B4NIZ9   B3NZY3   B3LVH1   Q29AR9   B4G615   A0A1B0CEW8   A0A3B0K4N7   U3U8R1   A0A0M4F2F2   A0A1I8NY16   A0A345BED3   A0RZD3   A0A1W4W3Y0   E0VXD8   B5FX32   A0A1E1G7Q6   A3RL96   A0A3Q8KJL9   A0A336KB63   A0A336KZK4   P85316   A0A0K8TGB5   Q66Q82   P85315   A0A1S3CW54   A0A2R4SUG4   J9JXY0   A0A2S2Q949   A0A2H8TSR9   A0A2S2PBD6   A0A154NY08   A0A151IK56   A0A151WRJ9   A0A0N0U3I1   A2VB89   A0A310SSL9   E2A3Q3   A0A195B087   A0A195FC54   A0A151JB20   A0A3L8DDW9   A0A1A9VM32   A0A2A3E9R4   E9J7U4   A0A026WU74   E2BTT5   A0A158NKI9   I3VN95   B0LI27   E9FYK9   A0A164WQ02   A0A0P5FVZ6   A0A0P5IV69   A0A3R7MBC0   A0A0G3EW09   F1AQ58   T1JJS2   A0A0K2UN46   D9I4C3   A0A2P2I1H7   A0A2P6KMT9  

Pubmed

15141943    15811337    30171635    22118469    25640113    26354079    + More
26227816    24845553    29403074    26706852    24495485    25348373    25830018    17994087    16951084    19126864    15242619    10731132    12537572    15703293    17550304    25315136    26036749    18057021    15632085    23932938    18362917    19820115    20566863    30467353    17435221    17510324    12364791    17275819    20798317    30249741    21282665    24508170    21347285    18221939    21292972    20691691   

EMBL

BAAB01143969    BN000691    CAH89262.2    DQ094149    AAZ04374.1    ODYU01009965    + More
SOQ54731.1    MH028069    AXY04238.1    AGBW02012844    OWR44350.1    KT005955    ALM30306.1    ODYU01004489    SOQ44423.1    NWSH01000020    PCG80721.1    RSAL01000008    RVE54039.1    KJ002445    AHM02472.1    KJ783481    AJM76770.1    KQ459600    KPI94124.1    KQ461195    KPJ06804.1    KF498645    AHA86938.1    JTDY01014723    JTDY01000043    KOB52000.1    KOB79213.1    KK852914    KDR13886.1    PYGN01000705    PSN41953.1    LN901328    CUT08823.1    NEVH01024949    PNF16418.1    GAMC01000052    JAC06504.1    GAKP01023486    JAC35472.1    GECZ01010127    JAS59642.1    GBXI01009995    JAD04297.1    CCAG010012076    JXJN01011407    CH933806    EDW14494.1    CH916369    EDV92815.1    CH940650    EDW67452.1    CH480815    EDW43089.1    AM294595    CM000364    CAL26578.1    EDX13824.1    BT122042    BT132842    FM245726    FM245727    FM245728    FM245729    FM245730    FM245731    FM245732    FM245733    FM245734    FM245735    FM245736    ADD31622.1    AEU10774.1    CAR93652.1    CAR93653.1    CAR93654.1    CAR93655.1    CAR93656.1    CAR93657.1    CAR93658.1    CAR93659.1    CAR93660.1    CAR93661.1    CAR93662.1    AY672905    AY672906    AJ862523    AM294583    AM294584    AM294585    AM294586    AM294587    AM294588    AM294589    AM294590    AM294591    AM294592    AM294593    AM294594    AE014297    AAF55915.1    AAT72327.1    CM000160    EDW97899.2    KP895534    AKN21233.1    CH964272    EDW84901.1    CH954462    CH954181    EDV45165.1    EDV49981.1    CH902617    EDV42541.1    CM000070    EAL27280.1    CH479179    EDW23769.1    AJWK01009369    OUUW01000007    SPP82960.1    AB817240    BAO00937.1    CP012526    ALC45612.1    MF765465    AXF48185.1    DQ138189    KQ971342    ABA03053.1    EFA04634.1    DS235830    EEB18044.1    DQ156996    ABA40402.1    LC146489    BAV78793.1    EF424614    ABO20870.1    MH971162    AZC86174.1    UFQS01000224    UFQT01000224    SSX01647.1    SSX22027.1    UFQS01001316    UFQT01001316    SSX10316.1    SSX30004.1    CH477322    CH477412    GBRD01001302    JAG64519.1    AY735442    AY735443    AAAB01008859    AAAB01008900    MF083566    AVZ65957.1    ABLF02027799    GGMS01005041    MBY74244.1    GFXV01005471    MBW17276.1    GGMR01014141    MBY26760.1    KQ434772    KZC03908.1    KQ977294    KYN03905.1    KQ982805    KYQ50474.1    KQ435881    KOX69832.1    AM420631    AADG06006208    BN000692    CAH89263.2    CAM06631.1    KQ759843    OAD62600.1    GL436457    EFN71945.1    KQ976692    KYM77871.1    KQ981693    KYN37782.1    KQ979182    KYN22332.1    QOIP01000009    RLU18680.1    KZ288311    PBC28465.1    GL768630    EFZ11126.1    KK107119    EZA58629.1    GL450531    EFN80834.1    ADTU01018857    ADTU01018858    JQ864194    AFK81932.1    EU139431    ABX55998.1    GL732527    EFX87546.1    LRGB01001151    KZS13469.1    GDIQ01271102    JAJ80622.1    GDIQ01208625    JAK43100.1    QCYY01001562    ROT77167.1    KP191597    KT072701    AKJ74864.1    ALO17551.1    GU937434    ADY80040.1    JH431954    HACA01022343    CDW39704.1    HM113369    ADI86242.1    IACF01002186    LAB67849.1    MWRG01008500    PRD27627.1   

Proteomes

UP000005204    UP000007151    UP000218220    UP000283053    UP000053268    UP000053240    + More
UP000037510    UP000027135    UP000245037    UP000235965    UP000092444    UP000092445    UP000092443    UP000092460    UP000009192    UP000001070    UP000008792    UP000001292    UP000000304    UP000000803    UP000002282    UP000095301    UP000192221    UP000007798    UP000008711    UP000007801    UP000001819    UP000008744    UP000092461    UP000268350    UP000092553    UP000095300    UP000007266    UP000192223    UP000009046    UP000008820    UP000007062    UP000079169    UP000007819    UP000076502    UP000078542    UP000075809    UP000053105    UP000005203    UP000000311    UP000078540    UP000078541    UP000078492    UP000279307    UP000078200    UP000242457    UP000053097    UP000008237    UP000005205    UP000000305    UP000076858    UP000283509   

PRIDE

Q566B1    Q9VD83    P85315   

Pfam

PF03045   DAN        + More
PF11838   ERAP1_C
PF01433   Peptidase_M1

Interpro

IPR029034   Cystine-knot_cytokine        + More
IPR004133   DAN       
IPR006207   Cys_knot_C       
IPR034441   Bursicon_suB       
IPR014782   Peptidase_M1_dom       
IPR024571   ERAP1-like_C_dom       
IPR042097   Aminopeptidase_N-like_N       
IPR034016   M1_APN-typ       
IPR001930   Peptidase_M1       

Gene 3D

2.10.90.10     2.60.40.1730    

CDD

cd09601  M1_APN_2

ProteinModelPortal

Q566B1   Q4FCM6   A0A2H1WNT1   A0A385H8U1   A0A212ES77   A0A0S1U1M9   + More
A0A2H1VUC7   A0A2A4K923   A0A3S2TSN9   W8RXF2   A0A0C5BEX6   A0A194PN16   A0A194QN72   V5NFD5   A0A0L7K2C7   A0A067R3X7   A0A2P8YCI2   A0A143WDY5   A0A2J7PJC7   W8C890   A0A034V006   A0A1B6GB49   A0A0A1WZR0   A0A1B0GDZ7   A0A1B0AHG7   A0A1A9Y4J5   A0A1B0BBC4   B4K981   B4JHI8   B4M141   B4HM41   A0APK7   C0MK54   Q9VD83   B4PKV0   A0A1I8M3F5   A0A1W4W143   A0A0H3YID2   B4NIZ9   B3NZY3   B3LVH1   Q29AR9   B4G615   A0A1B0CEW8   A0A3B0K4N7   U3U8R1   A0A0M4F2F2   A0A1I8NY16   A0A345BED3   A0RZD3   A0A1W4W3Y0   E0VXD8   B5FX32   A0A1E1G7Q6   A3RL96   A0A3Q8KJL9   A0A336KB63   A0A336KZK4   P85316   A0A0K8TGB5   Q66Q82   P85315   A0A1S3CW54   A0A2R4SUG4   J9JXY0   A0A2S2Q949   A0A2H8TSR9   A0A2S2PBD6   A0A154NY08   A0A151IK56   A0A151WRJ9   A0A0N0U3I1   A2VB89   A0A310SSL9   E2A3Q3   A0A195B087   A0A195FC54   A0A151JB20   A0A3L8DDW9   A0A1A9VM32   A0A2A3E9R4   E9J7U4   A0A026WU74   E2BTT5   A0A158NKI9   I3VN95   B0LI27   E9FYK9   A0A164WQ02   A0A0P5FVZ6   A0A0P5IV69   A0A3R7MBC0   A0A0G3EW09   F1AQ58   T1JJS2   A0A0K2UN46   D9I4C3   A0A2P2I1H7   A0A2P6KMT9  

PDB

4YU8     E-value=0.000920618,     Score=95

KEGG

100049169    no KO assigned | (RefSeq) burs, Burs-alpha; bursicon alpha subunit

GO

GO:0005179   GO:0005576   GO:0016021   GO:0005184   GO:0030709   GO:0007593   GO:0046982   GO:0043195   GO:0036335   GO:0071855   GO:0031395   GO:0007298   GO:0048067   GO:0001664   GO:0008270   GO:0008237  

PANTHER

PTHR41151  

Subcellular location

Secreted  

SignalP

Position:   1 - 25,         Likelihood:  0.993676

 

 

Length:

155

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

6.44567

Exp number, first 60 AAs:

6.39357

Total prob of N-in:

0.33462

outside

1  -  155

 

 

Pi

189.572945

Theta

135.894926

Tajima's D

1.934077

CLR

0

CSRT

0.873106344682766

Interpretation

Uncertain