Gene

KWMTBOMO13691

Pre Gene Modal

BGIBMGA011022

Annotation

PREDICTED:_lysine-specific_histone_demethylase_1A_[Bombyx_mori]

Location

Bomo_Chr23(-):7125064-7137574      View in EpiBrowser

Full name

Probable lysine-specific histone demethylase 1       + More
Lysine-specific histone demethylase      

Location in the cell

Nuclear   Reliability : 3.665

CDS

ATGAGTCGCCGTAAGCGTGCTAAGGTAGAAAATCGTGAATTAGATGAGAAGCTCAAACAAGAAGATTCTGAATCCGATCAATCCGAGAGAAGTAAAGTCACATCTCCGAGTCCTACGTCAGTGGCAGGTCGCAGAGGGTCGTCCTCAAGTCGTACAGCCGACAACAGCAAGGAGCCTAAAAAAGAAGAAAAAGCTTCTCCAGAGGATCCAAAGAGTGACGATGTTGAAGAAATTAACTATAAAGAAATGCTTAATAGTCTTGAAGGAGCAGCATTTCAGTCGCGATTACCATTTGATAAGATGTCGTCACTTGAAGCAGAATGCTTTTCTGATTTACAAGGCCCTTCGAATTGCGCATTTATTCAAATTCGAAATCGGATTTTAAAAATGTGGTTTGCAGACCCTAAGAAACAGTTGACTCAAGAACAGGCTGTAAAAAAAATGGAGCCTCCCTATAATGGAGATCCAGCATTAATAATGAGAACTCATGCCTTTCTGGAGAGACATGGTTTTATCAACTATGGAATATATGAGCGCGTAACACCAATCCCAAGCCCTCCAAAAGGAAAACAACGCCCAAAAATTATAATTATTGGAGCAGGAGTGTCCGGCTTGGCAGCTGCTCGCCAACTTCAGTCCTTTGGCTGTGAAGTCGTGGTTTTAGAAGGAAGAGACAGAGTCGGAGGCCGAATAGTGACCTACCGGAAAGGACCCTATGTAGCTGACCTAGGTGCTATGGTAGTAACTGGACTAGGAGGTAACCCTGTGACAACGTTGTCAGTGCAAATGAACATGGAGCTTCATAAAATTAAACAAAAATGTCCCCTTTATGAAGCTAATGGGAACCAAGTACCTAAACATAAGGATGAAATGGTGGAACGCGAATTCAATCGTCTCCTAGATGCCACATCTTATCTGTCTCACCAAGTGGATTTCAATTATTATAACGACACGCCTGTCTCACTGGGTCAAGCTTTAGAGTGGGTCATCAAGCTGCAACAAAAAAATGTTAAACATAAACAGATACAGCATCTGAAAGCTCTCACAACGTTGCAAGAGAAAATGAAATCAAACATAAATAAAATGACCGACCTGCAGGATCTCCTCAAGTCCCTGAAATCGGAGAAGGAGGCTTTGCTCGCCGAGAAAGCGACCGGTAATACCGGGGATGCTAATATACAGCAAGAGTTCAATTTGCGGCGACTCAATAGGGAAATGAAACATCTTTGTAACGAATACGAGAATTTGGTCACTCAGAACTCGACTATTGAAGAGAAACTGACACATCTGGAAGCTAATCCGCCGAGTTCCGTGTATCTGTCGGTCCGGGATCGTCAGATATTGGATTGGCACTTTGCGAATTTGGAATTTGCGAACGCAACGCCTCTCGGGAACTTATCGCTGAAGCACTGGGACCAGGACGACGATTTCGAGTTCACCGGAAATCATTTAACAGAGGTAAAACATTACAAAACTTTATAA

Protein

MSRRKRAKVENRELDEKLKQEDSESDQSERSKVTSPSPTSVAGRRGSSSSRTADNSKEPKKEEKASPEDPKSDDVEEINYKEMLNSLEGAAFQSRLPFDKMSSLEAECFSDLQGPSNCAFIQIRNRILKMWFADPKKQLTQEQAVKKMEPPYNGDPALIMRTHAFLERHGFINYGIYERVTPIPSPPKGKQRPKIIIIGAGVSGLAAARQLQSFGCEVVVLEGRDRVGGRIVTYRKGPYVADLGAMVVTGLGGNPVTTLSVQMNMELHKIKQKCPLYEANGNQVPKHKDEMVEREFNRLLDATSYLSHQVDFNYYNDTPVSLGQALEWVIKLQQKNVKHKQIQHLKALTTLQEKMKSNINKMTDLQDLLKSLKSEKEALLAEKATGNTGDANIQQEFNLRRLNREMKHLCNEYENLVTQNSTIEEKLTHLEANPPSSVYLSVRDRQILDWHFANLEFANATPLGNLSLKHWDQDDDFEFTGNHLTEVKHYKTL

Description

Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3.
Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me.

Cofactor

FAD

Similarity

Belongs to the flavin monoamine oxidase family.

Uniprot

H9JNB9   A0A2H1VW42   A0A2A4KAF8   A0A3S2M9H5   A0A194PMA9   A0A212ESA4   + More
A0A0P6G371   A0A0N8ECW4   A0A087UR95   A0A067RQM1   A0A232FAV7   A0A2J7QTA8   A0A0P5EG14   E9FRK1   A0A2L2Y9V1   A0A0P5BDK1   A0A0N8ADD8   A0A0P5MZV8   A0A0P5SJV5   A0A0P5HAY8   A0A0P5TRG1   A0A0P6D054   B7PX42   A0A0P5HDB5   A0A0P5CQS7   A0A0P5GN72   A0A0P5Y0G1   A0A131XSP8   A0A0N7ZPJ6   A0A0P4YCL5   A0A0P5XXE8   A0A2P6LBY2   A0A0P6GBD1   A0A0N8CZ14   A0A0P5WGT4   A0A0N8DI44   A0A0N8CUD8   A0A1Z5L217   E0VDA2   A0A0P5LKM9   A0A2A3EK20   A0A093J4S8   A0A224Z3J6   A0A0P6I601   A0A0P5AR78   A0A0P5VYP3   A0A0P4Y249   A0A293LJU0   A0A1Z5L5L5   A0A146MDQ3   A0A139WNM3   A0A224YR83   A0A3L8D8C0   A0A091THR5   A0A093FL99   A0A0N0BIS0   A0A093QHP7   E2B2H0   A0A023GP06   A0A0L7R4L4   A0A2R5L6N5   A0A067RCK0   A0A154PCN1   A0A2P8XW97   A0A091P5C4   A0A1V4JCQ2   A0A2D4I895   A0A091I3T2   E2AM99   A0A091H8L9   A0A091JUT6   A0A093QUK5   A0A091LCQ0   A0A091G9L6   A0A158NQ99   R0JCF4   A0A293N5M7   A0A091W1H8   I3JBC0   A0A093G052   A0A2R8Q8P2   A0A093G3F3   A0A091EMG5   A0A091UL68   A0A091JPR1   A0A0A0B0G1   A0A087RGC1   A0A3B4GPL8   A0A0C9RC82   A0A1V4JCG5   A0A093KBC1   A0A093PTF6   A0A088AAG3   A0A226NQN8   A0A099ZEK4   A0A3Q2V816   A0A3L8S3J3   A0A218UY33   A0A3M0IRN7   U3IUI0  

EC Number

1.-.-.-

Pubmed

19121390    26354079    22118469    24845553    28648823    21292972    + More
26561354    28528879    20566863    28797301    26823975    18362917    19820115    30249741    20798317    29403074    21347285    25186727    23594743    24621616    30282656    23749191   

EMBL

BABH01019588    BABH01019589    ODYU01004489    SOQ44424.1    NWSH01000020    PCG80720.1    + More
RSAL01000008    RVE54040.1    KQ459600    KPI94123.1    AGBW02012844    OWR44349.1    GDIQ01039155    JAN55582.1    GDIQ01039156    JAN55581.1    KK121162    KFM79884.1    KK852482    KDR22930.1    NNAY01000500    OXU27976.1    NEVH01011197    PNF31816.1    GDIP01143631    JAJ79771.1    GL732523    EFX90178.1    IAAA01016543    LAA04952.1    GDIP01186028    JAJ37374.1    GDIP01158433    JAJ64969.1    GDIQ01171207    JAK80518.1    GDIP01142541    JAL61173.1    GDIQ01229184    JAK22541.1    GDIP01124954    JAL78760.1    GDIQ01084889    JAN09848.1    ABJB011053834    DS811420    EEC11164.1    GDIQ01229183    JAK22542.1    GDIP01168079    GDIP01165232    LRGB01003155    JAJ55323.1    KZS03945.1    GDIQ01239279    JAK12446.1    GDIP01064752    JAM38963.1    GEFM01005463    JAP70333.1    GDIP01225169    JAI98232.1    GDIP01232074    JAI91327.1    GDIP01078738    JAM24977.1    MWRG01000453    PRD36095.1    GDIQ01035910    JAN58827.1    GDIP01084935    JAM18780.1    GDIP01086542    JAM17173.1    GDIP01031495    JAM72220.1    GDIP01097943    JAM05772.1    GFJQ02005537    JAW01433.1    DS235072    EEB11358.1    GDIQ01172248    JAK79477.1    KZ288236    PBC31381.1    KK575219    KFW09965.1    GFPF01009496    MAA20642.1    GDIQ01009957    JAN84780.1    GDIP01195128    JAJ28274.1    GDIP01094384    JAM09331.1    GDIP01233562    JAI89839.1    GFWV01002350    MAA27080.1    GFJQ02004410    JAW02560.1    GDHC01001662    JAQ16967.1    KQ971311    KYB29466.1    GFPF01005955    MAA17101.1    QOIP01000011    RLU16747.1    KK453894    KFQ75217.1    KK634098    KFV57410.1    KQ435727    KOX77948.1    KL420603    KFW88473.1    GL445145    EFN90111.1    GBBM01000573    JAC34845.1    KQ414657    KOC65701.1    GGLE01000994    MBY05120.1    KK852727    KDR17628.1    KQ434870    KZC09583.1    PYGN01001252    PSN36278.1    KK844969    KFP86750.1    LSYS01008070    OPJ69880.1    IACK01081567    LAA80435.1    KL218157    KFP02852.1    GL440775    EFN65441.1    KL525914    KFO91172.1    KK529928    KFP27703.1    KL224637    KFW62424.1    KL310194    KFP52940.1    KL447872    KFO78046.1    ADTU01001694    ADTU01001695    KB744656    EOA94666.1    GFWV01022972    MAA47699.1    KK734538    KFR09507.1    AERX01059979    KK401037    KFV59999.1    AL844186    KL215167    KFV63658.1    KK718726    KFO58256.1    KL409720    KFQ91416.1    KK502227    KFP21745.1    KL873654    KGL99641.1    KL226349    KFM12525.1    GBYB01004546    JAG74313.1    OPJ69881.1    KL206966    KFV87619.1    KL669044    KFW75387.1    AWGT02002370    OXB70173.1    KL892829    KGL80197.1    QUSF01000067    RLV96807.1    MUZQ01000093    OWK58673.1    QRBI01000238    RMB91285.1    ADON01133313    ADON01133314   

Proteomes

UP000005204    UP000218220    UP000283053    UP000053268    UP000007151    UP000054359    + More
UP000027135    UP000215335    UP000235965    UP000000305    UP000001555    UP000076858    UP000009046    UP000242457    UP000007266    UP000279307    UP000053105    UP000008237    UP000053825    UP000076502    UP000245037    UP000190648    UP000054308    UP000000311    UP000054081    UP000053760    UP000005205    UP000053605    UP000005207    UP000000437    UP000053875    UP000052976    UP000053283    UP000053119    UP000053858    UP000053286    UP000261460    UP000053584    UP000053258    UP000005203    UP000198419    UP000053641    UP000264840    UP000276834    UP000197619    UP000269221    UP000016666   

PRIDE

H9JNB9   

Pfam

PF01593   Amino_oxidase        + More
PF04433   SWIRM

Interpro

IPR002937   Amino_oxidase        + More
IPR007526   SWIRM       
IPR009057   Homeobox-like_sf       
IPR036188   FAD/NAD-bd_sf       
IPR036388   WH-like_DNA-bd_sf       
IPR017366   Hist_Lys-spec_deMease       

SUPFAM

SSF51905   SSF51905        + More
SSF46689   SSF46689       

Gene 3D

1.10.10.10     3.50.50.60    

ProteinModelPortal

H9JNB9   A0A2H1VW42   A0A2A4KAF8   A0A3S2M9H5   A0A194PMA9   A0A212ESA4   + More
A0A0P6G371   A0A0N8ECW4   A0A087UR95   A0A067RQM1   A0A232FAV7   A0A2J7QTA8   A0A0P5EG14   E9FRK1   A0A2L2Y9V1   A0A0P5BDK1   A0A0N8ADD8   A0A0P5MZV8   A0A0P5SJV5   A0A0P5HAY8   A0A0P5TRG1   A0A0P6D054   B7PX42   A0A0P5HDB5   A0A0P5CQS7   A0A0P5GN72   A0A0P5Y0G1   A0A131XSP8   A0A0N7ZPJ6   A0A0P4YCL5   A0A0P5XXE8   A0A2P6LBY2   A0A0P6GBD1   A0A0N8CZ14   A0A0P5WGT4   A0A0N8DI44   A0A0N8CUD8   A0A1Z5L217   E0VDA2   A0A0P5LKM9   A0A2A3EK20   A0A093J4S8   A0A224Z3J6   A0A0P6I601   A0A0P5AR78   A0A0P5VYP3   A0A0P4Y249   A0A293LJU0   A0A1Z5L5L5   A0A146MDQ3   A0A139WNM3   A0A224YR83   A0A3L8D8C0   A0A091THR5   A0A093FL99   A0A0N0BIS0   A0A093QHP7   E2B2H0   A0A023GP06   A0A0L7R4L4   A0A2R5L6N5   A0A067RCK0   A0A154PCN1   A0A2P8XW97   A0A091P5C4   A0A1V4JCQ2   A0A2D4I895   A0A091I3T2   E2AM99   A0A091H8L9   A0A091JUT6   A0A093QUK5   A0A091LCQ0   A0A091G9L6   A0A158NQ99   R0JCF4   A0A293N5M7   A0A091W1H8   I3JBC0   A0A093G052   A0A2R8Q8P2   A0A093G3F3   A0A091EMG5   A0A091UL68   A0A091JPR1   A0A0A0B0G1   A0A087RGC1   A0A3B4GPL8   A0A0C9RC82   A0A1V4JCG5   A0A093KBC1   A0A093PTF6   A0A088AAG3   A0A226NQN8   A0A099ZEK4   A0A3Q2V816   A0A3L8S3J3   A0A218UY33   A0A3M0IRN7   U3IUI0  

PDB

5YJB     E-value=3.12166e-140,     Score=1278

KEGG

101739058    K11450 lysine-specific histone demethylase 1A [EC:1.-.-.-] | (RefSeq) lysine-specific histone demeth

GO

GO:0016491   GO:0003677   GO:0008168   GO:0050660   GO:0034720   GO:0006355   GO:0005634   GO:0008134   GO:0000122   GO:0003682   GO:0045944   GO:0034648   GO:0000790   GO:1903706   GO:0007399   GO:1900052   GO:0000784   GO:1903827   GO:0071480   GO:0019899   GO:0043518   GO:1902166   GO:0050681   GO:0043426   GO:0032454   GO:0010569   GO:0002039   GO:0034644   GO:0002052   GO:0005654   GO:0042162   GO:0030374   GO:0032091   GO:0061752   GO:0051091   GO:0033184   GO:1990391   GO:0043433   GO:0005515   GO:0051276   GO:0016620   GO:0016787   GO:0003676   GO:0015930   GO:0055114  

Subcellular location

Nucleus  

Length:

493

Number of predicted TMHs:

0

Exp number of AAs in TMHs:

1.93415

Exp number, first 60 AAs:

0

Total prob of N-in:

0.11275

outside

1  -  493

 

 

Pi

170.162057

Theta

147.101099

Tajima's D

1.311433

CLR

106.619063

CSRT

0.738763061846908

Interpretation

Uncertain