Gene

KWMTBOMO13689

Pre Gene Modal

BGIBMGA011085

Annotation

putative_toll_[Operophtera_brumata]

Location

Bomo_Chr23(+):6976780-6980750      View in EpiBrowser

Full name

Toll-like receptor Tollo      

Alternative Name

Toll-like receptor 8

Location in the cell

Nuclear   Reliability : 1.717 PlasmaMembrane   Reliability : 1.619

CDS

ATGTATTCTACGTGGTTTGCGAATGCCTTGCTTGTGCTCAGCACGGCGTTTACCGCTAGGAGTGCATCACTATCGGCGACGACAAATACCCGTTATCAAGCACCAGATGAGTGTGGTTGGATGACAGATTATGATGGTGCTGGAGTGGCTTTACAATGTAGATTAAGAACCATAAACAGTGAATTAGAAAACACGAATTTTAGTGCGATACAGCCGCATCCAACAGTAAGATTGCGAATCGAATGCAGTGATGCACTGTTCTTCCAAAGTTCGTTAGCTCCCGGCAGTTTCCGGCAGTTGATAGAACTACGTGAACTAACCATAGAATACTGCAAAATCGGGAACTTGTCGGATAGTGCATTTACCGGTTTACGAGATCTTAGGAATTTGACAATCAGAACTCATAATACAGATTGGTCAACAATGTCACTTGAAATAACCCCGAGTGCTTTTTCAAGAGATGTTCAAAATTTAGAACGACTAGACTTGAGCGAAAATAATATGCTAGTTTTTCCTGATGGCGCTTTATGTTCTTTGAGAAATCTTGAGTATCTGAATATGACAGGTAACAGAATGCGAGACATAAGTCATTTTCAATTTTCTACTGCACACCGACATCCTACAGAAAAATGCGGTGACAACCTTCTGATTCTAGACCTATCGAGGAATGTTATTGATACTTTACCACCGAATCTATTAAATGGGCTAAGACGTCTGCAGAAATTTTACGTTCAAGGCAATGGATTAACATCAGTAGCGGATAGATCATTAGAAGGACTTATATCGTTGACGACGATAAGATTTTCAGATAATCAACTAGCTAGTTTGCCTCCCGAGCTTTTCAGTGATACGAAAGAATTAAAAGAAATATACTTAAATAATAATACTATCACAGTATTAGCACCAGGATTATTTAGCGATTTAGTACAACTCTTAGTACTTGATCTGTCTTATAATGAACTGACTTCGGACTGGATAAATACATCTACATTTTCCGGATTAAAAAGACTTGTATATTTGGACTTCTCCCATAATCGTGTGACTAAACTAGAAATTGCATTGTTCCGAGATTTACACAATTTGCAAATACTGAAGATGCAAGATAATTTTATAGAGCACATACCTGAAAATGTATTCGGCTCACTAAGCAATTTGCACACATTAACTTTATCAAACAATAGATTAACAAATATAGAAAGCCATGCATTTACAGGATTGCAAGCATTGTCGGTTCTTTCTGTAGATAGTAATCGTATTTCGCGAATAAATCCACAAGCACTCCGAAACTGTTCTAATTTACAAGACTTGCACATAAACGGTAATAGACTGGACGAAGTCCCAGAGGCTTTGAAGGAAATACCACAATTGAAAACGCTTGACCTAGGCGAGAACTTAATAGTGAGCATTGAAAATGCTTCATTTATGACAATGGAACAAATGTATGGATTGAGACTAACTGAAAATAATATCGGAAATATAAGTAAAGGAGTATTTGACAGGATGACGTCACTGAAAATTTTAAATTTATCGAGAAACAAAATACATAAGATTGAAGCCGGCTCGTTTGATGGCAATATCAATTTACAAGCAATAAGGCTAGACGGAAATTATTTAACGGATATCGGAGGGCTCTTCGCTAAGTTACCTAATTTGGTATGGTTGAATATCTCTGATAATCGACTAGAATGGTTCGACTATGCCATGATTCCTACTGGATTGCAGTGGTTGGACATACATGCGAACAGGATTGCTGAACTTGGAAATTACTTCGAGATCGAATCGCAACTGTCTCTCAGCACTTTCGATGCAAGTTCTAATAAACTGACTGAAATAACTGGAAGTGCGATACCTAACTCTGTGCAAATGCTATACTTAAACGATAATCTTATTTCAAAAGTGCAATCCTACACTTTCTTTAAGAAACCTAATCTGACGCGTGTTGATTTGTACGGTAATAAAATAACGAGCTTAGATCCGAATTCTTTAAGAATATCGGCCGTCCCGCAAGACAAATCAGTGCCAGAGTTTTTTATAGGTGGAAATCCATTAGAATGTGATTGTACAATGGAATGGCTGCAAAAAATTAATACCGGAAACAGAGCAAGAACACAGCCCAAGTTAATGGATTTGGATAGCATACACTGCAAATTACTTTACAGTCGTGGAAATGCTTTTGTGCCACTGATTGAAGCGGCTCCTCACCAGTTTCTCTGTAAATACGAGTCACATTGCCATGCTCTTTGTCATTGTTGTGATTTTGATGCCTGTGACTGTGAAATGACGTGCCCAAATAACTGTACGTGTTATCACGACCCGTCGTGGTCTGCTAATGTCGTTGAATGCTCGAATGCTGGTTACACGAATGATTTACCTGAGAAAATACCAATGGAGGCCACCGAGCTGTATCTTGACGGGAATAGTATTAAAGAACTCCCAAGTCACGCGTTTATCGGAAGAAAAAAATTAAAAATTCTATTTTTGAATGCATCTCACATAGAAATTGTACACAATAGAACATTTAACGGATTAAAAGAGTTGGAAGTACTTCATCTAGATCACAATAGCGTGACATCTATTGAAGGTCAAGAATTTAATGGCTTAGATAATTTACGTGAACTGTATTTGAACAACAATAAGATCAAAAACATAGGAAAGGAAATGTTTAATCATATGTCAAGGTTAAGGATATTACATCTACACCGTAATTATTTAATATCATTATCAGTATGGCAAATCAATCCGGCGATAACTGAAATAACACTTTCATACAATCCATGGTCATGTGATTGTGAATATACAGAAATGTTCCGGGAATGGACAAAACGAGTGAGTTCAGTTACAGATTTGTCAAATATACAATGCGTTTACACTCAAGGAAATACTTCTAATATTTTGGTATTGAATGACACTGTCTTTGATGATCCTAGTTCTGGATTTAAAATAGCCTACGAAAATGGTACACTGTGCACGGGATTGCCAAGCATCAACAACAGTATTAACGGCAATCTCACTGCCACGCGCACAATAATAACAAATGAAGATGTGCAAGATTACATACCTCTTCTTATCGCAACACTTGGAGGATTTTTATTGGTGTTGATATTAAGCGTTATGTTATTCATATACAGGCAAGAAATGAGAGTATGGTGTCATTCAAGATTCGGAGTACGGTTATTCTACAGAGCTAGTGACTTGGAGGATTCGGAAAAAATGTATGACGCTTTTGTGTGCTACAGCTCCAAAGACGAAGCTTGGGTTACTGAGGAACTCGCTTCGAGCTTGGAACGTGGAGACCCTTCTTATAAGCTTTGTCTACACTACCGTGACGTGGGCGGCTACGTTACTGACAAGATAAGACAAGCCGTGGAATCATCCCGGCGTACTATTATGATCCTTAGTGAAAATTTTTTGAGATCTGAGTGGGTTCGCTATGAACTAAAATCTGCTATGACCCATGTGTTAAGAGACCGACGGAAAAGACTGATCGTAGTGTTATTAGGACAAGTGTCACAAAAAGACTTAGACCAAGATCTAAGACTTTACATAAAAACTAACAAGTGTTTAAATGCTAACGATAGACTATTTTGGGAGAAGTTGAAGTTTGCACTACCGGACGTTAGATATAACCAGCGGTGTCGAGGCATGCCGAGTCCGAATTCTGGTGGCGGCATGCCCATGCACCGACATCATCATCCGAGGAACCACTTGGGCATGTTGCCACCGCCACCGGTGCACGGCGCCCATCCCGTGCTTCCACCACATCCGTCTCACGCTTCGCACCAGTTACCGCCCCGAGCCTCACCACGCACCATGTCCGTCCATGTGTAA

Protein

MYSTWFANALLVLSTAFTARSASLSATTNTRYQAPDECGWMTDYDGAGVALQCRLRTINSELENTNFSAIQPHPTVRLRIECSDALFFQSSLAPGSFRQLIELRELTIEYCKIGNLSDSAFTGLRDLRNLTIRTHNTDWSTMSLEITPSAFSRDVQNLERLDLSENNMLVFPDGALCSLRNLEYLNMTGNRMRDISHFQFSTAHRHPTEKCGDNLLILDLSRNVIDTLPPNLLNGLRRLQKFYVQGNGLTSVADRSLEGLISLTTIRFSDNQLASLPPELFSDTKELKEIYLNNNTITVLAPGLFSDLVQLLVLDLSYNELTSDWINTSTFSGLKRLVYLDFSHNRVTKLEIALFRDLHNLQILKMQDNFIEHIPENVFGSLSNLHTLTLSNNRLTNIESHAFTGLQALSVLSVDSNRISRINPQALRNCSNLQDLHINGNRLDEVPEALKEIPQLKTLDLGENLIVSIENASFMTMEQMYGLRLTENNIGNISKGVFDRMTSLKILNLSRNKIHKIEAGSFDGNINLQAIRLDGNYLTDIGGLFAKLPNLVWLNISDNRLEWFDYAMIPTGLQWLDIHANRIAELGNYFEIESQLSLSTFDASSNKLTEITGSAIPNSVQMLYLNDNLISKVQSYTFFKKPNLTRVDLYGNKITSLDPNSLRISAVPQDKSVPEFFIGGNPLECDCTMEWLQKINTGNRARTQPKLMDLDSIHCKLLYSRGNAFVPLIEAAPHQFLCKYESHCHALCHCCDFDACDCEMTCPNNCTCYHDPSWSANVVECSNAGYTNDLPEKIPMEATELYLDGNSIKELPSHAFIGRKKLKILFLNASHIEIVHNRTFNGLKELEVLHLDHNSVTSIEGQEFNGLDNLRELYLNNNKIKNIGKEMFNHMSRLRILHLHRNYLISLSVWQINPAITEITLSYNPWSCDCEYTEMFREWTKRVSSVTDLSNIQCVYTQGNTSNILVLNDTVFDDPSSGFKIAYENGTLCTGLPSINNSINGNLTATRTIITNEDVQDYIPLLIATLGGFLLVLILSVMLFIYRQEMRVWCHSRFGVRLFYRASDLEDSEKMYDAFVCYSSKDEAWVTEELASSLERGDPSYKLCLHYRDVGGYVTDKIRQAVESSRRTIMILSENFLRSEWVRYELKSAMTHVLRDRRKRLIVVLLGQVSQKDLDQDLRLYIKTNKCLNANDRLFWEKLKFALPDVRYNQRCRGMPSPNSGGGMPMHRHHHPRNHLGMLPPPPVHGAHPVLPPHPSHASHQLPPRASPRTMSVHV

Description

Toll-related receptor (PubMed:10973475). Probably specific to larval innate immunity (PubMed:22022271). Involved in the tracheal immune response of larvae to Gram-negative and perhaps Gram-positive bacteria; upon infection it negatively regulates the immune deficiency (Imd) signaling cascade specifically in the respiratory epithelium to prevent the overexpression of antimicrobial peptides (AMP) (PubMed:22022271). Involved in the NF-kappa-B-dependent apoptosis of unfit cells during cell competition (PubMed:25477468). Involved in neuron-specific glycosylation (PubMed:12588858, PubMed:17264077). Positively controls the neuromuscular junction (NMJ) growth in presynaptic motorneurons, probably via the JNK pathway (PubMed:24662564). During development of the peripheral nervous system, may function in the NF-kappa-B (rel) regulatory cascade to repress expression of the neuron-specific genes sc and ase in non-neuronal cells (PubMed:18000549). Promotes heterophilic cell adhesion with 18w in vitro (PubMed:25363762). May have a minor role in leg development (PubMed:21158756). May be involved in determining the proximal cell fate in the wing, possibly by negatively regulating the Dpp signaling pathway.(PubMed:17078066). May also be involved in the Dpp signaling pathway in the eye (PubMed:17078066). Possibly functions with 18w and Toll-6 during convergent extension, to help direct proper planar cell polarity, cell intercalation and axis elongation (PubMed:25363762).

Subunit

May interact (via the extracellular domain) with 18w (via the extracellular domain).

Similarity

Belongs to the Toll-like receptor family.

Keywords

Cell membrane   Complete proteome   Disulfide bond   Glycoprotein   Immunity   Innate immunity   Leucine-rich repeat   Membrane   Neurogenesis   Receptor   Reference proteome   Repeat   Signal   Transmembrane   Transmembrane helix  

Feature

chain  Toll-like receptor Tollo

Uniprot

H9JNI2   A0A2H1VMK6   A0A2A4K9I1   A0A346RAG2   A0A0L7LVK4   A0A194R9V8   + More
A0A194PLB9   A0A212ES74   A0A1Y1KGT6   D6WCH6   A0A2P8YSW8   N6TLF4   A0A1W4WT56   E0VDA3   A0A2J7QTA0   A0A067RGD1   B0XF31   B0XKB5   A0A1S4KCF5   Q17NJ1   A0A173ADV3   A0A182H9Z9   A0A336M128   A0A182PKB3   A0A182MAT2   A0A182WEZ2   A0A182Y1I9   A0A182RFG7   A0A182SQG3   A0A182MYV6   A0A182KSD0   A0A182WZS1   A0A182JW66   A0A182TSN5   A0A182HQB6   A0A182UW98   A0A1S4H942   A0A182IYV9   A0A182QF54   A0A084WQQ8   E9J102   A0A1B0DPR6   A0A026W8D8   A0A151WXL2   A0A195DF71   A0A0C9QL90   F4WCR4   A0A1B6M8J8   A0A158NHK6   A0A195ETV5   A0A0J7KNX1   E2B2J2   A0A1B6GX79   A0A1B6F2C8   E2AHF2   A0A088AAH6   T1HJ81   A0A286JZ76   A0A182FXJ7   A0A154PCN3   A0A146LFE4   A0A1I8MJQ9   A0A1I8NZ17   A0A173ADU2   Q8WRE2   Q5TMY4   M9ZRQ3   A0A1A9WFF8   A0A0N0U6V5   A0A1A9XRI6   A0A1B0BSY7   A0A1B0FAK7   A0A1A9Z376   A0A1A9V3M0   A0A0L0CDA2   A0A0K8UFD9   K7JAI2   A0A034WC06   W8AII0   A0A0A1X8I4   A0A1W4VNH9   B3M724   A0A0J9RWT7   Q2XXV9   B4PCE5   Q2XXV6   Q2XXV7   Q2XXV8   B4HI65   A0A1S3D687   B4L135   B4GUD4   Q9V477   Q2M1B0   B3NI06   B4N514   Q2XXV5   A0A3B0JRL4   B4LGV1   B4IZ24  

Pubmed

19121390    29910977    26227816    26354079    22118469    28004739    + More
18362917    19820115    29403074    23537049    20566863    24845553    17510324    26483478    25244985    20966253    12364791    24438588    21282665    24508170    30249741    21719571    21347285    20798317    26823975    25315136    12213252    23497397    26108605    20075255    25348373    24495485    25830018    17994087    22936249    16120803    17550304    10973475    10731132    12537572    12617819    12588858    17078066    17264077    18000549    21158756    22022271    22464169    24662564    25363762    25477468    15632085   

EMBL

BABH01019580    ODYU01003366    SOQ42037.1    NWSH01000020    PCG80719.1    MH243028    + More
AXS59162.1    JTDY01000043    KOB79206.1    KQ460473    KPJ14422.1    KQ459600    KPI94122.1    AGBW02012844    OWR44348.1    GEZM01084756    JAV60699.1    KQ971311    EEZ99353.2    PYGN01000379    PSN47339.1    APGK01019846    KB740134    KB632275    ENN81284.1    ERL91082.1    DS235072    EEB11359.1    NEVH01011197    PNF31819.1    KK852482    KDR22931.1    DS232893    EDS26444.1    DS233777    EDS31540.1    CH477198    EAT48324.1    KX086268    ANG08891.1    JXUM01121821    KQ566540    KXJ70047.1    UFQS01000304    UFQT01000304    SSX02657.1    SSX23031.1    AXCM01005245    APCN01003305    AAAB01008986    AXCN02001021    ATLV01025667    KE525397    KFB52552.1    GL767538    EFZ13578.1    AJVK01001633    KK107403    QOIP01000011    EZA51289.1    RLU16738.1    KQ982662    KYQ52620.1    KQ980905    KYN11550.1    GBYB01001357    JAG71124.1    GL888070    EGI68244.1    GEBQ01007720    JAT32257.1    ADTU01001700    KQ981979    KYN31342.1    LBMM01004824    KMQ92053.1    GL445145    EFN90107.1    GECZ01002740    JAS67029.1    GECZ01025435    JAS44334.1    GL439518    EFN67144.1    ACPB03003073    KU866524    AMQ10342.1    KQ434870    KZC09581.1    GDHC01011636    JAQ06993.1    KX086264    KK854398    ANG08887.1    PTY15457.1    AF444783    AAL37904.1    EAL38669.2    KC355237    AGK40937.1    KQ435727    KOX77951.1    JXJN01019935    CCAG010020412    JRES01000558    KNC30226.1    GDHF01032471    GDHF01027023    GDHF01015397    JAI19843.1    JAI25291.1    JAI36917.1    AAZX01012770    GAKP01007624    JAC51328.1    GAMC01018196    GAMC01018195    JAB88360.1    GBXI01006678    GBXI01004663    JAD07614.1    JAD09629.1    CH902618    EDV40889.2    CM002912    KMY99719.1    DQ138903    ABA86509.1    CM000159    EDW94855.1    DQ138906    ABA86512.1    DQ138905    ABA86511.1    DQ138904    ABA86510.1    CH480815    EDW41561.1    CH933809    EDW18192.1    CH479191    EDW26217.1    AF204158    AF247764    DQ138902    AE014296    AY118551    AAF18983.1    AAF49650.1    AAF86224.1    AAM49920.1    ABA86508.1    CH379069    EAL30665.2    CH954178    EDV52092.1    CH964101    EDW79453.1    DQ138907    ABA86513.1    OUUW01000002    SPP75996.1    CH940647    EDW70566.1    CH916366    EDV97732.1   

Proteomes

UP000005204    UP000218220    UP000037510    UP000053240    UP000053268    UP000007151    + More
UP000007266    UP000245037    UP000019118    UP000030742    UP000192223    UP000009046    UP000235965    UP000027135    UP000002320    UP000008820    UP000069940    UP000249989    UP000075885    UP000075883    UP000075920    UP000076408    UP000075900    UP000075901    UP000075884    UP000075882    UP000076407    UP000075881    UP000075902    UP000075840    UP000075903    UP000075880    UP000075886    UP000030765    UP000092462    UP000053097    UP000279307    UP000075809    UP000078492    UP000007755    UP000005205    UP000078541    UP000036403    UP000008237    UP000000311    UP000005203    UP000015103    UP000069272    UP000076502    UP000095301    UP000095300    UP000007062    UP000091820    UP000053105    UP000092443    UP000092460    UP000092444    UP000092445    UP000078200    UP000037069    UP000002358    UP000192221    UP000007801    UP000002282    UP000001292    UP000079169    UP000009192    UP000008744    UP000000803    UP000001819    UP000008711    UP000007798    UP000268350    UP000008792    UP000001070   

PRIDE

H9JNI2    Q9V477   

Pfam

PF13855   LRR_8        + More
PF01582   TIR
PF13676   TIR_2
PF00560   LRR_1
PF13306   LRR_5

Interpro

IPR000157   TIR_dom        + More
IPR001611   Leu-rich_rpt       
IPR035897   Toll_tir_struct_dom_sf       
IPR032675   LRR_dom_sf       
IPR003591   Leu-rich_rpt_typical-subtyp       
IPR000483   Cys-rich_flank_reg_C       
IPR026906   LRR_5       
IPR000372   LRRNT       

SUPFAM

SSF52200   SSF52200       

Gene 3D

3.40.50.10140     3.80.10.10    

ProteinModelPortal

H9JNI2   A0A2H1VMK6   A0A2A4K9I1   A0A346RAG2   A0A0L7LVK4   A0A194R9V8   + More
A0A194PLB9   A0A212ES74   A0A1Y1KGT6   D6WCH6   A0A2P8YSW8   N6TLF4   A0A1W4WT56   E0VDA3   A0A2J7QTA0   A0A067RGD1   B0XF31   B0XKB5   A0A1S4KCF5   Q17NJ1   A0A173ADV3   A0A182H9Z9   A0A336M128   A0A182PKB3   A0A182MAT2   A0A182WEZ2   A0A182Y1I9   A0A182RFG7   A0A182SQG3   A0A182MYV6   A0A182KSD0   A0A182WZS1   A0A182JW66   A0A182TSN5   A0A182HQB6   A0A182UW98   A0A1S4H942   A0A182IYV9   A0A182QF54   A0A084WQQ8   E9J102   A0A1B0DPR6   A0A026W8D8   A0A151WXL2   A0A195DF71   A0A0C9QL90   F4WCR4   A0A1B6M8J8   A0A158NHK6   A0A195ETV5   A0A0J7KNX1   E2B2J2   A0A1B6GX79   A0A1B6F2C8   E2AHF2   A0A088AAH6   T1HJ81   A0A286JZ76   A0A182FXJ7   A0A154PCN3   A0A146LFE4   A0A1I8MJQ9   A0A1I8NZ17   A0A173ADU2   Q8WRE2   Q5TMY4   M9ZRQ3   A0A1A9WFF8   A0A0N0U6V5   A0A1A9XRI6   A0A1B0BSY7   A0A1B0FAK7   A0A1A9Z376   A0A1A9V3M0   A0A0L0CDA2   A0A0K8UFD9   K7JAI2   A0A034WC06   W8AII0   A0A0A1X8I4   A0A1W4VNH9   B3M724   A0A0J9RWT7   Q2XXV9   B4PCE5   Q2XXV6   Q2XXV7   Q2XXV8   B4HI65   A0A1S3D687   B4L135   B4GUD4   Q9V477   Q2M1B0   B3NI06   B4N514   Q2XXV5   A0A3B0JRL4   B4LGV1   B4IZ24  

PDB

4KNG     E-value=3.38829e-25,     Score=290

KEGG

101738915    no KO assigned | (RefSeq) slit homolog 3 protein

GO

GO:0007165   GO:0016021   GO:0045087   GO:0004721   GO:0031012   GO:0005615   GO:0060026   GO:0048935   GO:0003401   GO:0060049   GO:0002227   GO:0016324   GO:0005515   GO:0043531   GO:0051276   GO:0016491   GO:0016620   GO:0016787   GO:0003676   GO:0015930  

Subcellular location

Cell membrane   In larvae, localizes to the apical cell membrane in trachea epithelial cells.   With evidence from 12 publications.
Apical cell membrane   In larvae, localizes to the apical cell membrane in trachea epithelial cells.   With evidence from 12 publications.

SignalP

Position:   1 - 21,         Likelihood:  0.969949

 

 

Length:

1275

Number of predicted TMHs:

1

Exp number of AAs in TMHs:

23.83202

Exp number, first 60 AAs:

1.08283

Total prob of N-in:

0.05351

outside

1  -  1018

TMhelix

1019  -  1041

inside

1042  -  1275

 

 

Pi

279.65369

Theta

228.06756

Tajima's D

0.558963

CLR

0

CSRT

0.531123443827809

Interpretation

Uncertain